检索结果-南通市图书馆

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

1147例肝移植单中心经验

中华普通外科杂志 2024年第5期39卷 333-338页

作者：熊骁鹏徐庆国苗小龙王昊刘鹏李新强周鑫王新王峰张勇孙延东蔡金贞吴力群许传屾王建红郭庆军青岛大学附属医院器官移植中心青岛266000

目的:分析青岛大学附属医院行肝移植手术的1 147例患者的预后情况,总结提高肝移植疗效的措施。方法:回顾性分析青岛大学附属医院1 147例肝移植患者的临床及随访资料。结果:1 147例肝移植患者术后1、3、5年总体生存率分别为87.20%、73.40... 详细信息

目的:分析青岛大学附属医院行肝移植手术的1 147例患者的预后情况,总结提高肝移植疗效的措施。方法:回顾性分析青岛大学附属医院1 147例肝移植患者的临床及随访资料。结果:1 147例肝移植患者术后1、3、5年总体生存率分别为87.20%、73.40%、65.60%。良性疾病肝移植受者组术后1、3、5年生存率分别为88.01%、84.98%、81.39%。恶性疾病肝移植受者组术后1、3、5年生存率分别为78.11%、64.41%、60.06%。良性疾病肝移植受者组生存率显著优于恶性疾病肝移植受者组( P<0.001)。中后期手术组患者术后1、3年的生存率分别为84.20%、70.80%;90.50%、71.70%,后期的生存率要优于中期( P=0.022)。复杂手术组患者术后1、3、5年的存活率分别为82.70%、65.50%、56.70%;普通手术组患者术后1、3、5年的存活率分别为89.00%、76.50%、69.20%。普通手术组生存率显著优于复杂手术组( P<0.001)。良性疾病受者死亡原因主要为多器官功能衰竭(4.1%),恶性疾病受者死亡原因主要为恶性肿瘤复发(23.7%)。术后原发性移植物无功能、移植肝功能延迟恢复、门静脉栓塞、肝动脉栓塞、胆管狭窄、移植后淋巴组织增生性疾病、移植物抗宿主病发生率分别为1.05%、6.89%、1.92%、0.44%、2.00%、0.61%、0.44%。结论:本中心随着手术技术及围手术期处理水平日益提高,受者近3年生存率有所升高。恶性疾病及复杂肝移植是影响受者预后的重要因素。

关键词：肝移植预后术后并发症

Power transformer fault diagnosis considering data imbalance and data set fusion

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High Voltage 2021年第3期6卷 543-554页

作者： Yang Zhang Hong cai Chen Yaping Du Min Chen Jie Liang jianhong Li Xiqing Fan Xin Yao Department of Building Service Engineering Hong Kong Polytechnic UniversityHong KongChina Academy for Advanced Interdisciplinary Studies and Department of Electrical and Electronic Engineering Southern University of Science and TechnologyShenzhenChina Research Institute State Grid Zhejiang Electric Power Co.LtdHangzhouChina Zhejiang Huayun Information Technology Co. LtdHangzhouChina State Grid Zhejiang Electric Power Co. LtdLishui Power Supply BureauLishuiChina Guangdong Provincial Key Laboratory of Brain‐inspired Intelligent Computation Department of Computer Science and EngineeringSouthern University of Science and TechnologyShenzhenChina

Improving the accuracy of transformer dissolved gas analysis is always an important demand for power ***,the requirement for large numbers of fault samples becomes an obstacle to this *** article creatively uses a large number of health data,which is much easier to obtain by power companies,to improve diagnosis *** investigations from the view of both data set and methodology to deal with this problem are presented.A data set consists of 9595 health samples and 993 fault samples is used for *** characteristics of the data set and the influence of the health data on diagnostic accuracy are *** performance of many state‐of‐art algorithms that handle the imbalanced prob-lem is ***,an efficient fault diagnosis algorithm named self‐paced ensemble(SPE)is *** SPE,classification hardness is proposed to include the data characteristic in the *** method can guarantee the diversity of the data set and keep high *** to the experiment results,the superior of SPE is confirmed and also proves that involving more health samples can improve transformer diagnosis when fault data are limited.

关键词： handle fault diagnosis

Carboxylesterase genes in nitenpyram-resistant brown planthoppers,Nilaparvata lugens

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2021年第4期28卷 1049-1060页

作者： Kaikai Mao Zhijie Ren Wenhao Li Tingwei cai Xueying Qin Hu Wan Byung Rae Jin Shun He jianhong Li Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhanChina College of Natural Resources and Life Science Dong-A UniversityBusanRepublic of Korea

Carboxylesterases(CarEs)represent one of the major detoxification enzyme families involved in insecticide ***,the function of specific CarE genes in insecticide resistance is still unclear in the insect Nilaparvata lugens(Stål),a notorious rice crop pest in *** this study,a total of 29 putative CarE genes in *** were identified,and they were divided into seven clades;further,theβ-esterase clade was significantly ***-specific expression analysis found that 17 CarE genes were abundantly distributed in the midgut and fat body,while 12 CarE genes were highly expressed in the *** expression of most CarE genes was significantly induced in response to the challenge of nitenpyram,triflumezopyrim,chlorpyrifos,isoprocarb and *** these,the expression levels of NlCarE2,NlCarE4,NlCarE9,NlCarE17 and NlCarE24 were increased by each ***-time quantitative polymerase chain reaction and RNA interference assays revealed the NlCarE1 gene to be a candidate gene mainly involved in nitenpyram resistance,while simultaneously silencing NlCarE1 and NlCarE19 produced a stronger effect than silencing either one individually,suggesting a cooperative relationship in resistance *** findings lay the foundation for further clarification of insecticide resistance mediated by CarE in ***.

关键词： carboxylesterase expression profiling insecticide induction Nilaparvata lugens nitenpyram resistance

Characterization of Synonymous Codon Usage Bias in the Pseudorabies Virus US1 Gene

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Virologica Sinica 2012年第5期27卷 303-315页

作者： Meili Li Zhiyao Zhao jianhong Chen Bingyun Wang Zi Li Jian Li Mingsheng cai Department of Pathogenic Biology and Immunology Guangzhou Medical UniversityGuangzhou 510182China Department of Veterinary Medicine Foshan Science and Technology UniversityFoshan 528231China

In the present study, we examined the codon usage bias between pseudorabies virus (PRV) US1 gene and the US1-like genes of 20 reference alphaherpesviruses. Comparative analysis showed noticeable disparities of the synonymous codon usage bias in the 21 alphaherpesviruses, indicated by codon adaptation index, effective number of codons (ENc) and GC3s value. The codon usage pattern of PRV US1 gene was phylogenetically conserved and similar to that of the US1-like genes of the genus Varicellovirus of alphaherpesvirus, with a strong bias towards the codons with C and G at the third codon position. Cluster analysis of codon usage pattern of PRV US1 gene with its reference alphaherpesviruses demonstrated that the codon usage bias of US1-like genes of 21 alphaherpesviruses had a very close relation with their gene functions. ENc-plot revealed that the genetic heterogeneity in PRV US1 gene and the 20 reference alphaherpesviruses was constrained by G+C content, as well as the gene length. In addition, comparison of codon preferences in the US1 gene of PRV with those of E. coli, yeast and human revealed that there were 50 codons showing distinct usage differences between PRV and yeast, 49 between PRV and human, but 48 between PRV and E. coli. Although there were slightly fewer differences in codon usages between *** and PRV, the difference is unlikely to be statistically significant, and experimental studies are necessary to establish the most suitable expression system for PRV US1. In conclusion, these results may improve our understanding of the evolution, pathogenesis and functional studies of PRV, as well as contributing to the area of herpesvirus research or even studies with other viruses.

关键词：同义密码子使用伪狂犬病病毒 S1基因疱疹病毒表征 PRV 大肠杆菌遗传异质性

MEMOIR: A Novel System for Neural Lineage Tracing

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2017年第6期33卷 763-765页

作者： Zhifu Wang jianhong Zhu Department of Neurosurgery Fudan University Huashan Hospital National Key Laboratory of Medical Neurobiology The Institutes of Brain Science and The Collaborative Innovation Center for Brain Science Shanghai Medical College Fudan University Translational Medical Center for Stem Cell Therapy Shanghai East Hospital

Memory by Engineered Mutagenesis with Optical In situ Readout（MEMOIR）is a novel strategy for lineage tracing that combines Cas9/g RNA and sequential multiplexed single-molecule RNA fluorescence hybridization（seqFISH）[1],which was created by cai Long et *** the California Institute of Technology[2].In MEMOIR,dynamic cellular event histories are recorded,then read out in single cells using seq ***,we introduce the

关键词： MEMOIR A Novel System for Neural Lineage Tracing

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

极隙区一次长时间ELDI事件的观测研究

地球物理学报 2022年第12期65卷 4583-4592页

作者：谷骏蔡红涛胡坤潘建宏高顺祖张宏武汉大学电子信息学院武汉430072

E层占优电离层(ELDI)是一种特殊的电离层垂直结构,表现出与偶发Es明显不同的时空分布和形态特征,但其形成机理尚不清楚.本文报道了发生在2001年7月15日的一次长持续时间(~2.3 h)的ELDI事件.地面雷达观测表明,该ELDI事件可以按照电子密... 详细信息

E层占优电离层(ELDI)是一种特殊的电离层垂直结构,表现出与偶发Es明显不同的时空分布和形态特征,但其形成机理尚不清楚.本文报道了发生在2001年7月15日的一次长持续时间(~2.3 h)的ELDI事件.地面雷达观测表明,该ELDI事件可以按照电子密度剖面不同的变化特征分为两个阶段.在第1个阶段里,E层密度大幅度增强而F层密度未有明显变化;在第2个阶段里,E层密度回落至正常水平而F层密度强烈耗空.卫星及其他地面设备的协同观测数据表明,高能离子沉降是ELDI第1阶段的主导形成机制,而强等离子体对流是第2阶段的主导机制.

关键词： E层占优电离层离子沉降 F层耗空等离子体对流

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

赤道附近局地激发LS-TAD的事例观测

地球物理学报 2022年第3期65卷 853-861页

作者：潘建宏蔡红涛谷骏周康俊罗逸楠高顺组武汉大学电子信息学院武汉430072

大尺度行进式大气扰动(LS-TAD)通常被认为起源于极区高纬,本文报道了一起激发于低纬赤道地区、在北半球向高纬传播的LS-TAD观测事例.2002年8月10日07∶30 UT,CHAMP卫星在30°W磁赤道附近观测到显著的大气密度增强,在随后的2个连续轨道上... 详细信息

大尺度行进式大气扰动(LS-TAD)通常被认为起源于极区高纬,本文报道了一起激发于低纬赤道地区、在北半球向高纬传播的LS-TAD观测事例.2002年8月10日07∶30 UT,CHAMP卫星在30°W磁赤道附近观测到显著的大气密度增强,在随后的2个连续轨道上,该密度增强依次出现在北半球更高纬度上,表现出明显的极向位移,是典型的LS-TAD事件.北美洲的2条地面GNSS子午台链也同时记录到了与之相伴随的大尺度行进式电离层扰动(LS-TID)印记.CHAMP卫星和地面GNSS台站在南半球均没有记录到与上述LS-TAD/TID相关联的前序行扰.我们认为该极向传播的LS-TAD事件起源于赤道低纬地区,突然增强的离子垂直漂移是其可能的激发源.

关键词：赤道区域离子垂直漂移 LS-TAD LS-TIDI

Therapeutic effect of hyperoside on rats with TNBS-induced ulcerative colitis by regulating autophagy

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Therapeutic effect of hyperoside on rats with TNBS-induced u...

Metabolomics Analysis of Tall Fescue Leaves under Drought Stress

中国药理学会化疗药理专业委员会第十五届学术大会暨2018重庆化疗药物基础与前沿国际论坛

作者： Yongqing cai Xiaoli Li jianhong Chen Department of Pharmacy Institute of Surgery ResearchDaping HospitalThird Military Medical University College of Pharmacy Chongqing Medical University

This study investigated the therapeutic effect and the underlying mechanism of hyperoside on rats with ulcerative colitis(UC) induced by 2,4,6-trinitr-obenzene sulfonic acid(TNBS).Our study demonstrated that hyperoside significantly improveded colon weight/length ratio,attenuated macroscopic and histopathological scores,reduced colon levels of IL-1β,TNF-α,MDA and MPO,and improved SOD activities in *** addition,hyperoside significantly decreased nuclear NF-κB p65 and TRAF6 levels in colon in TNBS-induced ***,hyperoside inhibited the apoptosis,and the expression of LC3,Beclinl and p62 in TNBS-induced *** conclusion,hyperoside improves TNBS-induced ulcerative colitis in association with restoration of autophagy flux to promote autophagic degradation of TRAF6 to suppress inflammation and oxidative *** findings may offer new therapeutic interventions for UC.

关键词： hyperoside ulcerative colitis autophagy flux anti-inflammatory antiox

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Animal Husbandry and Feed Science 2017年第2期9卷 122-126页

作者： Li Xiaodong cai Lu Wang Xiaoli Shu jianhong Chen Xi cai Yiming Guizhou Institute of Prataculture Guiyang 550006China Guizhou Institute of Biotechnology Guiyang 550006China

Abstract The metabolites of tall fescue leaves under normal and drought conditions were analyzed with LC-ESI-MS （ liquid chromatography tandem mass spec- trometry）. A total of 282 metabolites were stably detected in the two groups using OPI.S-DA （orthogonal partial least squares discriminant analysis） method; 148 of which were down-regulated while 134 were up-regulated. After analyzed with MZ-minc software, 10 major metabolites （4 down, 6 up） were identified through searehing public database. Aromatic compounds, 3-p-eoumaroyll, 5-quinolaetone, aromatic free amino acids, styraxin mad methanofuran, were up-regulated ; grease metabolites, methyl 15-hydroperoxy-9Z, 12Z, 16E-octadecatrienoate, 9,12,13-Tri-HOME （10）, 3-oxo-dodecanoic acid, and 13 （S）-HpOTrE acid ester, were down-regulated; piperanine （alkaloids） was down-regulated while Methyl 7-epi-12-hydroxyjasmonate glucoside （indicant） was up-regulated. In a word, aromatic compounds and liquid metabolites may play vital roles in drought-resistant regulation of tall fescue.

关键词： Tall fescue Drought stress Metabolome Aromatic compounds