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基于NOD1/RIP2/NF-κB信号通路探讨“秩边透水道”针法对原发性痛经大鼠的镇痛作用

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中国针灸 2025年第2期45卷 209-216页

作者：金旭张艳林常博雅任佳郝健亨曹玉霞王海军冀来喜山西中医药大学第二临床学院晋中030619 天津中医药大学针灸推拿学院山西中医药大学附属针灸推拿医院太原030012

目的:观察“秩边透水道”针法对原发性痛经(PD)大鼠核苷酸结合寡聚化结构域1(NOD1)/受体相互作用蛋白2(RIP2)/核转录因子κB(NF-κB)信号通路相关蛋白和促炎细胞因子表达的影响,探讨其缓解PD疼痛的可能机制。方法:将30只SPF级雌性SD大鼠... 详细信息

目的:观察“秩边透水道”针法对原发性痛经(PD)大鼠核苷酸结合寡聚化结构域1(NOD1)/受体相互作用蛋白2(RIP2)/核转录因子κB(NF-κB)信号通路相关蛋白和促炎细胞因子表达的影响,探讨其缓解PD疼痛的可能机制。方法:将30只SPF级雌性SD大鼠(动情周期正常)随机分为空白组、模型组和针刺组,每组10只。模型组和针刺组大鼠采用苯甲酸雌二醇联合缩宫素腹腔注射法制备PD模型,针刺组大鼠在造模同时予“秩边透水道”针法干预,每次20 min,每天1次,连续10 d。于第11天观察各组大鼠腹腔注射缩宫素注射液30 min内扭体反应(扭体潜伏期、扭体次数、扭体评分);HE染色法观察大鼠子宫组织形态;ELISA法检测大鼠血清前列腺素E_(2)(PGE_(2))、前列腺素F_(2α)(PGF_(2α))、白细胞介素(IL)-1β、IL-18、环氧合酶-2(COX-2)、肿瘤坏死因子-α(TNF-α)含量;Western blot法检测各组大鼠子宫组织NOD1、RIP2、NF-κB p65、磷酸化核转录因子κB p65(p-NF-κB p65)蛋白表达;实时荧光定量PCR法检测各组大鼠子宫组织NOD1、RIP2、NF-κBp65m RNA表达。结果:与空白组比较,模型组大鼠扭体潜伏期延长(P<0.01),扭体次数增加及扭体评分升高(P<0.01);子宫内膜上皮细胞大量变性、坏死,子宫内膜严重水肿且大范围脱落,伴有中性粒细胞浸润;血清PGE2含量降低(P<0.01),血清PGF2α、IL-1β、IL-18、COX-2、TNF-α含量升高(P<0.01);子宫组织NOD1、RIP2、NF-κBp65、p-NF-κBp65蛋白表达及NOD1、RIP2、NF-κB p65 mRNA表达升高(P<0.01)。与模型组比较,针刺组大鼠扭体潜伏期延长(P<0.01),扭体次数减少及扭体评分降低(P<0.01);子宫内膜上皮组织少量变性、坏死,子宫内膜轻度水肿,少有中性粒细胞浸润;血清PGE2含量升高(P<0.01),血清PGF2α、IL-1β、IL-18、COX-2、TNF-α含量降低(P<0.01);子宫组织NOD1、RIP2、NF-κB p65、p-NF-κB p65蛋白表达及NOD1、RIP2、NF-κB p65 mRNA表达降低(P<0.05,P<0.01)。结论:“秩边透水道”针法能够缓解PD大鼠的疼痛症状,其作用机制可能与抑制PD大鼠子宫组织中NOD1/RIP2/NF-κB信号通路的活性,进而减轻其炎性反应有关。

关键词：原发性痛经针刺秩边透水道 NOD1/RIP2/NF-κB信号通路炎性反应疼痛

氟、磷与重金属离子共掺对C_(3)S烧成及水化进程的协同影响机理

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硅酸盐通报 2024年第10期43卷 3510-3523页

作者：杜欢达永琪何廷树郝建恒西安建筑科技大学材料科学与工程学院西安710055

含氟污泥作为半导体行业精细化生产的主要副产品,是一种危险固废。在水泥窑协同处置含氟污泥的过程中,含氟污泥中含有的氟、磷和多种重金属离子会不可避免地引入到水泥生料中,这些离子会显著影响并改变水泥生料矿物的煅烧过程及其性能,... 详细信息

含氟污泥作为半导体行业精细化生产的主要副产品,是一种危险固废。在水泥窑协同处置含氟污泥的过程中,含氟污泥中含有的氟、磷和多种重金属离子会不可避免地引入到水泥生料中,这些离子会显著影响并改变水泥生料矿物的煅烧过程及其性能,然而它们共存时对水泥熟料性能的影响研究尚不多见,为此,本文系统研究了氟、磷与重金属离子共掺对硅酸三钙(C_(3)S)煅烧过程、微观结构以及水化特性的协同影响机理。研究表明,与磷酸盐单掺相比,磷和重金属离子复掺不利于C_(3)S烧成,而氟、磷与重金属离子共掺对C_(3)S的烧成有显著的协同促进作用,同时明显提高了C_(3)S晶型对称性,使C_(3)S矿物表面出现更多不同种类的缺陷。与磷酸盐单掺相比,磷和重金属离子复掺有利于提高C_(3)S初始和后期水化速率,降低棒状水化硅酸钙(C-S-H)的长径比,而氟、磷和重金属离子共掺对C_(3)S水化性能的影响取决于各离子的掺比,但随着各离子掺量的增加,C_(3)S水化加速期却会不断推迟,且三者共掺会促进棒状C-S-H长径比增加。

关键词：硅酸三钙共掺杂协同影响磷酸盐水化放热水化产物

丹参酮ⅡA治疗自身免疫性肝炎的网络分析及实验验证

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陆军军医大学学报 2022年第10期44卷 1033-1040页

作者：郝健亨李振城孙薇丽山西中医药大学基础医学院中西医结合基础实验室山西晋中030619 晋中市中医院风湿免疫科山西晋中030619

目的基于网络药理学方法分析丹参酮ⅡA(tanshinoneⅡA,TanⅡA)治疗自身免疫性肝炎(autoimmune hepatitis,AIH)的潜在靶点与通路之间关系,并通过实验验证TanⅡA治疗AIH的作用机制。方法依托多个数据库检索筛选TanⅡA以及AIH的相关靶点基... 详细信息

目的基于网络药理学方法分析丹参酮ⅡA(tanshinoneⅡA,TanⅡA)治疗自身免疫性肝炎(autoimmune hepatitis,AIH)的潜在靶点与通路之间关系,并通过实验验证TanⅡA治疗AIH的作用机制。方法依托多个数据库检索筛选TanⅡA以及AIH的相关靶点基因,取药物和疾病的交集基因,借助String平台构建PPI网络,并对交集基因进行GO和KEGG通路富集分析。随后选择富集基因数最多信号通路通过动物实验进行验证,将小鼠按随机数字表法分为正常组、模型组和TanⅡA治疗组,每组6只;建模完成后检测各组小鼠血清谷丙转氨酶(alanine aminotransferase,ALT)、谷草转氨酶(aspartate aminotransferase,AST)的水平,并利用Western blot与qRT-PCR检测各组小鼠肝组织中PI3K、AKT和NF-κB蛋白及mRNA的表达。结果从TanⅡA中筛选得出有效作用靶点208个,收集到AIH的靶点基因7128个。两者得到174个交集基因靶点。KEGG通路分析指出多条信号通路参与AIH的发病,其中PI3K-AKT信号通路可能在TanⅡA治疗AIH中起重要作用。动物实验结果显示,与正常组比较,模型组小鼠血清中ALT、AST水平均显著升高(P<0.05),肝组织中PI3K、AKT mRNA和蛋白表达均显著降低(P<0.05),NF-κB mRNA和蛋白表达均显著升高(P<0.05);与模型组比较,TanⅡA治疗组小鼠血清ALT、AST水平有不同程度减低(P<0.05),肝组织中PI3K、AKT mRNA和蛋白表达均显著升高(P<0.05),NF-κB mRNA水平和蛋白表达均显著降低(P<0.05)。结论TanⅡA中包含许多可能直接靶向AIH相关信号通路的有效基因靶点,其中TanⅡA可能通过调节PI3K-AKT信号通路改善AIH小鼠肝脏炎症反应。

关键词：网络药理学丹参酮ⅡA 自身免疫性肝炎 PI3K-AKT信号通路

以史为鉴面向未来——读《早期中俄关系史研究》

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俄罗斯东欧中亚研究 2002年第3期 90-90页

作者：郝建恒

有确凿史料依据的中俄外交关系开始于17世纪中叶,从17世纪中叶到19世纪中叶这大约两个世纪的时间通常被称为中俄关系史的早期阶段.

关键词：中俄关系史互市通商以史为鉴传教士团《恰克图条约》中俄两国清廷外交关系面向未来

“秩边透水道”针刺对卵巢低反应小鼠PI3K/AKT/FOXO3a通路的影响

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中国针灸 2024年第7期44卷 821-830页

作者：郝健亨王海军曹玉霞冀来喜成都中医药大学针灸推拿学院四川成都610075 山西中医药大学第二临床学院晋中030619

目的:基于磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(AKT)/叉头蛋白O3a(FOXO3a)通路观察“秩边透水道”针刺对卵巢低反应(POR)小鼠卵巢功能的保护作用,探析针刺抑制POR卵巢颗粒细胞凋亡的可能机制。方法:将动情周期规律的45只小鼠随机分成空白... 详细信息

目的:基于磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(AKT)/叉头蛋白O3a(FOXO3a)通路观察“秩边透水道”针刺对卵巢低反应(POR)小鼠卵巢功能的保护作用,探析针刺抑制POR卵巢颗粒细胞凋亡的可能机制。方法:将动情周期规律的45只小鼠随机分成空白组、模型组和针刺组,每组15只。模型组和针刺组小鼠予雷公藤多苷混悬液(50 mg·kg^(-1)·d^(-1))灌胃2周制备POR模型。造模成功后针刺组小鼠予“秩边透水道”针刺干预连续2周,每日1次,每次20 min。干预结束次日开始促排卵,各组促排卵后完成取材。采用阴道脱落细胞涂片观察小鼠动情周期变化,记录小鼠取卵数、卵巢湿重、末次体质量与卵巢指数;ELISA法检测小鼠血清抗缪勒管激素(AMH)、卵泡刺激素(FSH)、雌二醇(E2)、黄体生成素(LH)含量;HE染色法观察小鼠卵巢组织形态;TUNEL染色法观察小鼠卵巢颗粒细胞凋亡情况;实时荧光定量PCR法检测小鼠卵巢组织PI3K、AKT、FOXO3a mRNA表达;Western blot法检测卵巢组织B淋巴细胞瘤-2(Bcl-2)关联X的蛋白(BAX),半胱氨酸天冬氨酸蛋白酶-3(Caspase-3)、磷酸化磷脂酰肌醇3-激酶(p-PI3K)和磷酸化蛋白激酶B(p-AKT)蛋白表达。结果:与空白组比较,模型组小鼠动情周期紊乱率升高(P0.05)。与空白组比较,模型组小鼠血清FSH、LH含量升高(P<0.01),血清AMH、E2含量降低(P<0.01);与模型组比较,针刺组小鼠血清FSH、LH含量降低(P<0.01,P<0.05),血清AMH、E2含量升高(P<0.01,P<0.05)。与空白组比较,模型组小鼠卵巢组织各级正常发育卵泡数量减少且形态较差,各级闭锁卵泡增多;与模型组比较,针刺组小鼠卵泡数量、形态和颗粒细胞结构有不同程度改善,各级闭锁卵泡减少。与空白组比较,模型组小鼠卵巢颗粒细胞凋亡率升高(P<0.01);与模型组比较,针刺组小鼠卵巢颗粒细胞凋亡率降低(P<0.01)。与空白组比较,模型组小鼠卵巢组织FOXO3a mRNA及Caspase-3、BAX蛋白表达升高(P<0.01),卵巢组织PI3K、AKT mRNA及p-PI3K、p-AKT和p-FOXO3a蛋白表达降低(P<0.01);与模型组比较,针刺组小鼠卵巢组织FOXO3am RNA及Caspase-3、BAX蛋白表达降低(P<0.05,P<0.01),卵巢组织PI3K、AKT mRNA及p-PI3K、p-AKT、p-FOXO3a蛋白表达升高(P<0.01,P<0.05)。结论:“秩边透水道”针刺可以抑制POR小鼠卵巢颗粒细胞凋亡,改善卵巢功能,其机制可能与调节PI3K/AKT/FOXO3a通路中的关键因子有关。

关键词：卵巢低反应针刺秩边透水道卵巢功能 PI3K/AKT/FOXO3a信号通路细胞凋亡

Omnidirectional simulation analysis of thermomechanical coupling mechanism in inertia friction welding of Ni-based superalloy

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Chinese Journal of Aeronautics 2025年第1期38卷 202-216页

作者： Chang-an LI Guoliang QIN hao WANG School of Materials Science and Engineering Shandong UniversityJinan 250061China

The coupling between heat and pressure is the kernel of inertia friction welding(IFW)and is still not fully understood.A novel 3D fully coupled finite element model based on a plastic friction pair was developed to simulate the IFW process of a Ni-based superalloy and reveal the omnidirectional thermo-mechanical coupling mechanism of the friction *** numerical model successfully simulated the deceleration,deformation processes,and peak torsional moments in IFW and captured the evolution of temperature,contact pressure,and *** simulated results were validated through measured thermal history,optical macrography,and axial *** results indicated that interfacial friction heat was the primary heat source,and plastic deformation energy only accounted for 4%of the *** increase in initial rotational speed and friction pressure elevated the peak temperature,reaching a maximum of 1525.5K at an initial rotational speed of 2000 r/min and friction pressure of 400 *** interface heat generation could form an axial temperature gradient exceeding 320K/*** radial inhomogeneities of heat generation and temperature were manifested in a concentric ring distribution with maximum heat flux and temperature ranging from 2/5 to 2/3 *** radial inhomogeneities were caused by increasing linear velocity along the radius and an opposite distribution of contact pressure,which could reach 1.7 times the set pressure at the *** circumferential inhomogeneity of thermomechanical distribution during rotary friction welding was revealed for the first time,benefiting from the 3D *** deflection and transformation of distribution in contact pressure and Mises stress were indicators of plastic deformation and transition of quasi-steady state *** critical Mises stress was 0.5 times the friction pressure in this *** presented modeling provides a reliable insight into the thermo-mechanical coupling mechanism of IFW and lays a solid found

关键词： Inertia friction welding Thermo-mechanical coupling Inhomogeneity Numerical simulation Ni-based superalloy

Three-dimensional line-of-sight-angle-constrained leader-following cooperative interception guidance law with prespecified impact time

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Chinese Journal of Aeronautics 2025年第1期38卷 491-506页

作者： hao YOU Xinlong CHANG Jiufen Zhao Rocket Force University of Engineering Xi’an 710025China

To address the problem of multi-missile cooperative interception against maneuvering targets at a prespecified impact time and desired Line-of-Sight(LOS)angles in ThreeDimensional(3D)space,this paper proposes a 3D leader-following cooperative interception guidance ***,in the LOS direction of the leader,an impact time-controlled guidance law is derived based on the fixed-time stability theory,which enables the leader to complete the interception task at a prespecified impact ***,in the LOS direction of the followers,by introducing a time consensus tracking error function,a fixed-time consensus tracking guidance law is investigated to guarantee the consensus tracking convergence of the ***,in the direction normal to the LOS,by combining the designed global integral sliding mode surface and the second-order Sliding Mode Control(SMC)theory,an innovative 3D LOS-angle-constrained interception guidance law is developed,which eliminates the reaching phase in the traditional sliding mode guidance laws and effectively saves energy ***,it effectively suppresses the chattering phenomenon while avoiding the singularity issue,and compensates for unknown interference caused by target maneuvering online,making it convenient for practical engineering ***,theoretical proof analysis and multiple sets of numerical simulation results verify the effectiveness,superiority,and robustness of the investigated guidance law.

关键词： Three-dimensional cooperative interception Leader-following missiles Prespecified impact time LOS-angle-constrained Fixed-time stability Global integral sliding mode

Unusual roles of ceria as the support of a single-atom catalyst in hydroisomerization of n-heptane:Phase boundary acts as transport channels between different active centers

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Journal of Rare Earths 2025年第2期43卷 276-283,I0002页

作者： hao Qin Hui Wan Guofeng Guan State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringJiangsu National Synergetic Innovation Center for Advanced MaterialsNanjing Tech UniversityNanjing211816China

Hydroisomerization of n-alkanes plays an important role in fuel and lubricants *** catalysts with ultralow platinum loading have recently been reported successively for ***,the catalysts were prepared successfully with different methods to improve the catalytic *** conversion of 0.01%Pt1@CeOx/SAPO-11 prepared by co-calcination method(0.01%Pt1@CS-c)is 71.4%,25%higher than the other prepared by precipitation *** turnover frequency per active surface platinum site(TOFPt)of 0.01%Ptl@CS-c is as high as 13115 h^(-1).Revealed by the X-ray photoelectron spectroscopy(XPS)results,the quality of phase boundary/intersurface between ceria and zeolite is found significantly *** conjunction quality of phase boundary directly affects the spillover rate of intermediate species,which further leads to an apparent activity *** addition,the possible role of ceria in the reaction is discussed,rather than just as a carrier for the active metal atoms.

关键词： Rare earths Hydroisomerization Spillover Proximity Single-atom catalysis Intermediate

Late Paleozoic to early Mesozoic volcanic-sedimentary history of the southeastern margin of the Central Asian Orogenic Belt:Timing of uplift of the Inner Mongolia paleo-uplift

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Science China Earth Sciences 2025年第1期68卷 297-309页

作者： Wenxing hao Jin-Hui YANG Guang ZHU State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China School of Resource and Environmental Engineering Hefei University of TechnologyHefei230009China

The Kulun region is located in the eastern Bainaimiao arc belt on the southeastern margin of the Central Asian Orogenic Belt(CAOB),adjacent to the North China Craton(NCC)to the *** region records the closure of the PaleoAsian Ocean during the Paleozoic to early Mesozoic and is key to study the tectonic evolution of the northern margin of the *** conducted zircon U-Pb geochronology and Hf isotope analysis of volcanic-sedimentary and intrusive rocks in the Kulun *** volcanic-sedimentary rocks were previously assigned an early Carboniferous age,but include volcanic rocks with ages of 267–266 Ma and sedimentary rocks with youngest detrital zircon age peaks of 265–244 Ma,which were intruded by a granite with an age of 242 *** indicates that these rocks are actually middle Permian to Middle Triassic in age(267–242Ma)and correspond to the Qingfengshan and Liujiagou ***,two volcanic rock samples have highεHf(t)values(+1.6 to+16.1)and relatively young two-stage Hf model ages(1095–327 Ma),indicating their sources associated with the *** age spectra and Hf isotopic characteristics of detrital zircons from the sedimentary rocks suggest that,during the middle Permian to Middle Triassic,the sedimentary provenance in the Kulun region was mainly the ***,by the Early Jurassic,the provenance changed to the NCC(i.e.,the Inner Mongolia Paleo-uplift,IMPU).This result,combined with the development of a series of conglomerates on the northern margin of the NCC in the Late Triassic(i.e.,Xingshikou,Xiaoyingzi,and Xiaohekou formations),indicates the Kulun region experienced an abrupt change in paleogeography during the Late Triassic,with the IMPU undergoing significant uplift and thus becoming the main sediment source in the Kulun *** on the Late Triassic alkaline igneous belt(235–215 Ma)in the IMPU,we speculate that this uplift was caused by detachment of the southward-subducting Paleo-Asian oceanic plate,which occurred in a post-o

关键词： Central Asian Orogenic Belt the North China Craton Zircon geochronology Hf isotopes Inner Mongolia Paleo-uplift