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A Polyvinyl Alcohol/Acrylamide Hydrogel with Enhanced Mechanical Properties Promotes Full-Thickness Skin Defect Healing by Regulating Immunomodulation and Angiogenesis Through Paracrine Secretion

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Engineering 2024年第6期37卷 138-151页

作者： Peng Wang Liping Qian Huixin Liang jianhao huang Jing Jin Chunmei Xie Bin Xue Jiancheng Lai Yibo Zhang Lifeng Jiang Lan Li Qing Jiang State Key Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive SurgeryDepartment of Orthopedic SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing UniversityNanjing 210008China Jiangsu Engineering Research Center for 3D Bioprinting Nanjing 210008China Institute of Medical 3D Printing Nanjing UniversityNanjing 210093China Centre for Experimental Animals Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing UniversityNanjing 210008China College of Aeroplane Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China National Laboratory of Solid State Microstructures Department of PhysicsNanjing UniversityNanjing 210093China Department of Chemical Engineering Stanford UniversityStanfordCA 94305USA Department of Orthopedic Surgery The Second Affiliated Hospital Zhejiang University School of MedicineOrthopedic Research Institute of Zhejiang UniversityKey Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang ProvinceHangzhou 310009China

Hydrogel-based tissue-engineered skin has attracted increased attention due to its potential to restore the structural integrity and functionality of ***,the mechanical properties of hydrogel scaffolds and natural skin are substantially ***,we developed a polyvinyl alcohol(PVA)/acrylamide based interpenetrating network(IPN)hydrogel that was surface modified with polydopamine(PDA)and termed *** Dopa-gel exhibited mechanical properties similar to native skin tissue and a superior ability to modulate paracrine ***,a tough scaffold with tensile resistance was fabricated using this hydrogel by three-dimensional *** results showed that the interpenetration of PVA,alginate,and polyacrylamide networks notably enhanced the mechanical properties of the *** modification with PDA endowed the hydrogels with increased secretion of immunomodulatory and proangiogenic *** an in vivo model,Dopa-gel treatment accelerated wound closure,increased vascularization,and promoted a shift in macrophages from a proinflammatory M1 phenotype to a prohealing and anti-inflammatory M2 phenotype within the wound ***,the focal adhesion kinase(FAK)/extracellular signal-related kinase(ERK)signaling pathway may mediate the promotion of skin defect healing by increasing paracrine secretion via the ***,proangiogenic factors can be induced through Rho-associated kinase-2(ROCK-2)/vascular endothelial growth factor(VEGF)-mediated paracrine secretion under tensile stress *** together,these findings suggest that the multifunctional Dopa-gel,which has good mechanical properties similar to those of native skin tissue and enhanced immunomodulatory and angiogenic properties,is a promising scaffold for skin tissue regeneration.

关键词： Polyvinyl alcohol/acrylamide hydrogel Mechanical property enhancement Paracrine effect Skin regeneration Signaling pathways

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合并急性胰腺炎的2型糖尿病患者胰岛素强化治疗后转换为德谷门冬双胰岛素1例

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中华糖尿病杂志 2024年第Z1期16卷 13-15页

作者：蒋嘉钦黄建皓广西医学科学院广西壮族自治区人民医院内分泌科南宁

报道1例合并急性胰腺炎的2型糖尿病(T2DM)患者在住院期间使用胰岛素强化治疗后转换为德谷门冬双胰岛素(IDegAsp)序贯治疗的过程。患者为45岁男性, 主因"发现血糖升高2年余, 腹痛3 d"入院, 入院后完善相关检查, 结果显示, 空腹及餐后2 h... 详细信息

报道1例合并急性胰腺炎的2型糖尿病(T2DM)患者在住院期间使用胰岛素强化治疗后转换为德谷门冬双胰岛素(IDegAsp)序贯治疗的过程。患者为45岁男性, 主因"发现血糖升高2年余, 腹痛3 d"入院, 入院后完善相关检查, 结果显示, 空腹及餐后2 h血糖分别为8.9、15.8 mmol/L, 空腹及餐后2 h C肽分别为0.69、0.93 ng/ml, 糖化血红蛋白(HbA1c)9.7%, 尿白蛋白/肌酐比值8.9 mg/g, 抗胰岛细胞抗体、抗胰岛素抗体、抗谷氨酸脱羧酶抗体均为阴性;总胆固醇(TC)10.63 mmol/L, 甘油三酯(TG)>12.50 mmol/L, 血淀粉酶64 U/L, 血脂肪酶160 U/L。结合病史及检查结果, 患者明确诊断为T2DM和高甘油三酯性急性胰腺炎。入院后予降糖、降TG等对症治疗, 血糖平稳后予德谷门冬双胰岛素早餐前12 U及晚餐前18 U降糖治疗。患者出院后继续予早、晚餐前皮下注射德谷门冬双胰岛素控制血糖, 2个月后门诊复查HbA1c 7.1%。该患者使用德谷门冬双胰岛素治疗(住院及院外随访)期间均未出现低血糖事件, 血糖控制达标, 患者对治疗效果满意。

关键词：糖尿病, 2型德谷门冬双胰岛素胰岛素强化治疗平稳降糖高甘油三酯性急性胰腺炎

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Design of Energy Modulation Massive SIMO Transceivers via Machine Learning

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Journal of Communications and Information Networks 2020年第3期5卷 358-368页

作者： Muhang Lan jianhao huang Han Zhang Chuan huang National Key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of ChinaChengdu 611731China The Future Network of Intelligence Institute and the School of Science and Engineering the Chinese University of Hong KongShenzhen 518172China Department of Electrical and Computer Engineering University of CaliforniaDavis 95616USA

This paper considers a massive single-input multiple-output(SIMO)system,where multiple singleantenna transmitters simultaneously communicate with a receiver equipped with a large number of *** from the conventional noncoherent transceivers which require a certain level of the statistical information on the channel fading,we propose a joint transceiver design method based on machine learning,requiring a limited number of channel *** the proposed method,the multiple transmitters,the channel,and the receiver are represented with a deep neural network(NN),and an autoencoder is adopted to minimize the end-to-end transmission error ***,the relationship between the number of training samples and the transmission error probability is analyzed based on the confidence interval *** results show that the proposed NN-based transceiver achieves lower transmission error probability in typical scenarios,and is more robust against the channel parameters variation compared with the existing methods.

关键词： neural network(NN) energy modulation massive single-input multiple-output(SIMO) joint transceiver design confidence interval

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Towards human-leveled vision systems

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Science China(Technological Sciences) 2024年第8期67卷 2331-2349页

作者： DING jianhao huang TieJun State Key Laboratory of Multimedia Information Processing School of Computer SciencePeking UniversityBeijing 100871China

The human visual system is a complex and interconnected network comprising billions of neurons. It plays an essential role in translating environmental light stimuli into information that guides and shapes human perception and action. Research on the visual system aims to uncover the underlying neural structure principles of human visual perception and their possible ***, there are two main approaches: biological system analysis and simulation, artificial intelligence models based on deep learning. Here we aim to discuss the two approaches to human-level vision systems. Deep learning has significantly impacted the field of vision with achievements in representation, modeling, and hardware design. However, there is still a significant gap between deep learning models and the human visual system in terms of scalability, transferability, and sustainability. The progress of the biological visual system can help fill the gap by further understanding the properties and functions of different components of the system. We take the efforts of reconstructing the retina as an example to illustrate that even if we are unable to replicate the visual system on a computer right now, we can still learn a lot by combining existing research outcomes in neuroscience. At the end of the paper, we suggest tracing back to gradually build visual systems from the computational counterpart of biological structures to achieve a human-level vision system in the future.

关键词： human-leveled vision system deep learning biological visual system

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Fundamental Limitation of Semantic Communications:Neural Estimation for Rate-Distortion

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Journal of Communications and Information Networks 2023年第4期8卷 303-318页

作者： Dongxu Li jianhao huang Chuan huang Xiaoqi Qin Han Zhang Ping Zhang School of Science and Engineering and the Fu-ture Network of Inelligence Institute the Chinese University of Hong KongShenzhen 518172China Department of Electrical and Electronic Engineering the University of Hong KongHong Kong 999077China School of Information and Communication Engineering and the State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing 100876China

This paper studies the fundamental limit of semantic communications over the discrete memoryless *** consider the scenario to send a semantic source consisting of an observation state and its corresponding semantic state,both of which are recovered at the *** derive the performance limitation,we adopt the semantic rate-distortion function(SRDF)to study the relationship among the minimum compression rate,observation distortion,semantic distortion,and channel *** the case with unknown semantic source distribution,while only a set of the source samples is available,we propose a neural-network-based method by leveraging the generative networks to learn the semantic source ***,for a special case where the semantic state is a deterministic function of the observation,we design a cascade neural network to estimate the *** the case with perfectly known semantic source distribution,we propose a general Blahut-Arimoto(BA)algorithm to effectively compute the ***,experimental results validate our proposed algorithms for the scenarios with ideal Gaussian semantic source and some practical datasets.

关键词： Semantic communications semantic ratedistortion generative network Blahut-Arimoto algorithm

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针药结合调枢柔筋法治疗中重度颈源性头痛临床观察

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中国中医急症 2024年第3期33卷 494-497页

作者：黄剑浩谢宇锋王俏刘毅冯军广州中医药大学深圳医院(福田) 广东深圳518000 冯军名中医学术传承工作室广东深圳518000

目的比较针药结合调枢柔筋法与颈2背根神经节脉冲射频治疗中重度颈源性头痛(CEH)的临床疗效。方法将68例CEH患者随机分为针药组(36例,脱落2例)与射频组(36例,脱落2例)。针药组予颅项针联合瓜芍柴胡汤,射频组予颈2背根神经节脉冲射频治... 详细信息

目的比较针药结合调枢柔筋法与颈2背根神经节脉冲射频治疗中重度颈源性头痛(CEH)的临床疗效。方法将68例CEH患者随机分为针药组(36例,脱落2例)与射频组(36例,脱落2例)。针药组予颅项针联合瓜芍柴胡汤,射频组予颈2背根神经节脉冲射频治疗。分别于治疗前、治疗后、随访1个月、随访2个月时观察两组VAS评分、颈椎ROM评分、不良反应发生率及临床疗效。结果针药组总有效率为82.35%,高于射频组的55.88%(P<0.05)。针药组VAS评分比较,治疗后、随访1个月、随访2个月针药组均低于射频组(P<0.05),重复测量方差分析显示,评定时间主效应显著(F=483.024,P=0.000),两组治疗后、随访1个月、随访2个月的VAS评分均较治疗前降低,评定时间组别的交互作用显著(F=35.485,P=0.000),组间效应显著(F=18.342,P=0.000)。针药组颈椎ROM评分比较,治疗后、随访1个月、随访2个月针药组均低于射频组(P<0.05),重复测量方差分析显示,评定时间主效应显著(F=353.384,P=0.000),两组治疗后、随访1个月、随访2个月的颈椎ROM评分均较治疗前降低,评定时间组别的交互作用显著(F=7.972,P=0.000),组间效应显著(F=3.453,P=0.000)。结论针药结合调枢柔筋法治疗中重度CEH疗效显著。

关键词：颈源性头痛颅项针瓜芍柴胡汤调枢柔筋法针药结合

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Yolov7-pose识别运动员姿态时关键点异常的消除方法

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井冈山大学学报（自然科学版） 2024年第3期45卷 71-78页

作者：黄建浩钟映春张钢赖志飞杨铠康张永恒广东工业大学自动化学院广东广州510006 广州市番禺职业技术学院广东广州511483 深圳云动家体育科技有限公司广东深圳518115

本研究首先构建了深度聚合网络(deep layer aggregation,DLA),用于替换Yolov7-pose算法中原有的特征融合网络,增强了特征的表达;其次,将高效聚合网络(efficient layer aggregation Net, ELAN)和尺度感知注意力网络(scale-aware attention Net, SAAN)融合在一起,引入到Yolov7-pose算法中;然后,引入尺度因子到Yolov7-pose算法的损失函数中,并通过实验确定尺度因子最佳值。实验结果表明,经过本法改进的方法识别篮球比赛视频流中的多名运动员姿态时,不再出现关键点异常现象,姿态识别的精度达到95%以上,运行效率达到24 FPS以上,综合性能显著优于原始Yolov7-pose算法等算法。

关键词：篮球比赛姿态检测深层聚合网络注意力机制

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Revealing the Multifunctional Electrocatalysis of Indium-Modulated Phthalocyanine for High-Performance Lithium-Sulfur Batteries

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Energy & Environmental Materials 2024年第1期7卷 5-12页

作者： Yang Guo Zhaoqing Jin jianhao Lu Zilong Wang Zihao Song Anbang Wang Weikun Wang Yaqin huang Beijing Key Laboratory of Electrochemical Process and Technology for Materials Key Laboratory of Biomedical Materials of Natural Macromolecules Ministry of Education Beijing University of Chemical Technology Research Institute of Chemical Defense Beijing Key Laboratory of Advanced Chemical Energy Storage Technology and Materials

The sluggish kinetics of complicated multiphase conversions and the severe shuttling effect of lithium polysulfides（LiPSs） significantly hinder the applications of Li-S battery,which is one of the most promising candidates for the next-generation energy storage ***,a bifunctional electrocatalyst,indium phthalocyanine self-assembled with carbon nanotubes（InPc@CNT） composite material,is proposed to promote the conversion kinetics of both reduction and oxidation processes,demonstrating a bidirectional catalytic effect on both nucleation and dissolution of Li2S species.

关键词： bidirectional catalyst indium phthalocyanine lithium−sulfur batteries pouch cells

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东莞配电网谐波对配电变压器危害分析

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电力自动化设备 2011年第7期31卷 146-149页

作者：叶建新黄健豪张禄亮曾江广东电网公司东莞供电局广东东莞523000 华南理工大学电力学院广东广州510640

为了掌握电网运行的谐波状况及其危害,采用便携式电能质量分析仪FLUKE435对配电网变压器运行状况进行谐波普查,得到了大量典型负荷的实测数据。根据相关文献和标准中,对谐波造成配电变压器损耗增加(最高增加0.06%的损耗)、利用率下降(降... 详细信息

为了掌握电网运行的谐波状况及其危害,采用便携式电能质量分析仪FLUKE435对配电网变压器运行状况进行谐波普查,得到了大量典型负荷的实测数据。根据相关文献和标准中,对谐波造成配电变压器损耗增加(最高增加0.06%的损耗)、利用率下降(降容15%)、寿命减少(可减少寿命一半)和维修费用增加(最高增加一倍的费用)等问题进行了定量的分析计算,并统一折算为电耗,计算结果表明谐波给供电部门造成了巨大损失,年增加电耗数千万度,相关企业及部门应给予高度重视。

关键词：谐波分析配电变压器损耗降容运行寿命缩短

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商品砂浆的推广应用

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广州建筑 2003年第3期31卷 29-31页

作者：黄剑豪广州市第四建筑工程有限公司广州510220

随着建设工程中新型墙体材料普遍应用,墙体的开裂和渗漏问题也日益突出,而商品砂浆恰好可有效地克服这些问题。为配合墙体改革的进行,推动企业的技术进步,有必要积极推广商品砂浆的应用。

关键词：商品砂浆预拌砂浆干粉砂浆推广应用

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