检索结果-南通市图书馆

Retrospective analysis of interventional treatment of hepatic metastasis from gastroenteropancreatic neuroendocrine tumors

引用

Chinese Journal of Cancer Research 2017年第6期29卷 581-586页

作者： Peng Liu Xu Zhu Jie Li Ming Lu Jiahua Leng Ying Li jiangyuan yu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Interventional Therapy Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Department of Gastroenterological Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Center of Gastrointestinal Surgery Unit III Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Department of Radiolog Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Department of NuclearMedicine Peking University Cancer Hospital&InstituteB eijing 100142China

Objective： To analyze the angiography appearance of liver metastases from gastroenteropancreatic neuroendocrine tumors （GEP-NETs）, and evaluate the clinical efficacy and prognostic factors of interventional treatment for hepatic metastases. Methods： Fifty GEP-NETs patients with hepatic metastases were treated from January 2012 to December 2016, and received transarterial embolization （TAE） in the hepatic tumor or hepatic arterial infusion chemotherapy （HAIC）. All patients received 179 times of the intervention therapy in total. Results： Blood supplies were identified in the 50 eases with angiography, which showed that 35 cases had abundant vessels, while 15 eases had poor blood supply. Twenty-two cases were found either collateral blood supply, or portal vein invasion or arterial-portal vein fistula. The best curative efficacy was complete remission （CR） in 4 cases, partial remission （PR） in 28 cases and stable disease （SD） in 18 eases during the process of treatment. The angiography （P=0.047） and the frequency of intervention （P=0.037） showed significantly statistical difference with Kaplan-Meier analysis. The Cox analysis showed that more than 3 times of interventional therapy was an independent prognostic factor. Conclusions： Interventional treatment is safe and effective for GEP-NETs, and is beneficial to patients with main hepatic metastases after endocrine therapy.

关键词： Gastroenteropancreatic neuroendocrine tumors hepatic metastasis angiography interventionaltreatment retrospective analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A 18FDG PET/CT-based volume parameter is a predictor of overall survival in patients with local advanced gastric cancer

引用

Chinese Journal of Cancer Research 2019年第4期31卷 632-640页

作者： Jinling Song Zhongwu Li Puyun Chen jiangyuan yu Feng Wang Zhi Yang Xuejuan Wang Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Nuclear MedicinePeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of PathologyPeking University Cancer Hospital&InstituteBeijing 100142China

Objective: The present study investigated the prognosis value of preoperative fluorodeoxyglucose(FDG)positron emission tomography/computed tomography(PET/CT) in patients with local advanced gastric cancer(LAGC).Methods: In total, 144 patients [median age 63(range: 48-80) years old] with LAGC underwent 18 F-FDG PET/CT prior to any treatment. The maximum standardized uptake values(SUVmax), mean standardized uptake values(SUVmean), metabolic tumor volume(MTV) and total lesion glycolysis(TLG) of the primary lesion were measured on PET/CT and correlated with clinicopathological features and ***: Significant differences in SUVmean, SUVmax, MTV and TLG were found according to Lauren’s classification, histologic grade and T category(P<0.05). During the 26.5-month follow-up, 51(35.4%) patients died and 70(48.6%) exhibited disease progression. The optimal thresholds of MTV and TLG were 15.1 cm^3 and 47.3 cm^3, respectively. The 3-year progression-free survival(PFS) and overall survival(OS) for patients with high TLG values were 30% and 38% compared to 38% and 47% for low TLG values, respectively(P<0.05). Univariate and multifactor analyses demonstrated that lymph node metastasis and T stage were independent prognostic factors for PFS;T stage, histologic grade and TLG were independent prognostic factors for OS(P<0.05). Molecular markers had no relationship with patient’s ***: Metabolic activity of primary gastric tumors from 18 F-FDG PET/CT is a prognostic factor in patients with LAGC.

关键词： Gastric cancer 18F-FDG PET/CT metabolic parameters prognosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Favorable response to immunotherapy in a pancreatic neuroendocrine tumor with temozolomide-induced high tumor mutational burden

引用

Cancer Communications 2020年第12期40卷 746-751页

作者： Yanshuo Cao yutong Ma jiangyuan yu yu Sun Tingting Sun Yang Shao Jie Li Lin Shen Ming Lu Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital&InstituteBeijing 100142P.R.China Translational Medicine Research Institute Geneseeq Technology Inc.Toronto M5T1K5Canada Department of Nuclear Medicine Peking University Cancer Hospital&InstituteKey Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Beijing 100142P.R.China Department of Pathology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital&InstituteBeijing 100142P.R.China Nanjing Geneseeq Technology Inc. NanjingJiangsu 210032P.R.China School of Public Health Nanjing Medical UniversityNanjingJiangsu 210029P.R.China Department of Early Drug Development Center Peking University Cancer Hospital&InstituteKey Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Beijing 100142P.R.China

Neuroendocrine neoplasm of the pancreas is a rare tumor with limited treatment *** such tumors,treatment for pancreatic neuroendocrine tumor(PanNET)G3 is the most ***(TMZ)is commonly used to treat ***,TMZ may cause tumor gene alkylation,which induces drug resistance and rapid disease ***,we present a case of a female who was diagnosed with PanNET G3 and achieved a partial response to toripalimab,an anti-programmed cell death-ligand 1(anti-PD-L1)monoclonal antibody,after multiple cycles of TMZ *** profiling revealed that compared with the patient’s samples collected at baseline,the postTMZ-treatment samples had markedly higher levels of tumor mutational burden(TMB)associated with characteristic alkylating mutational signature representing a positive correlation with favorable response to anti-PD-1 *** addition,we observed a germline truncating mutation of MUTYH(W156*)that was considered to be pathogenic and potentially conferred to genomic *** case suggests that anti-PD-1 therapy could be a treatment option for PanNET patients with increased TMB after TMZ-based treatment.

关键词： gene expression profiling mutational signature neuroendocrine tumors programmed cell death 1 receptor temozolomide tumor mutational burden

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Novel gold nanoparticles targeting somatostatin receptor subtype two with near-infrared light for neuroendocrine tumour therapy

引用

Nano Research 2022年第10期15卷 9149-9159页

作者： Qichen Chen Zilin Li jiangyuan yu Qing Xie Haizhen Lu Yiqiao Deng Jinghua Chen Wenjia Zhu Li Huo Yizhou Zhang Wei Song Jianqiang Lan Jianqiang Cai Zhen Huang Zixi Wang Hong Zhao Department of Hepatobiliary Surgery State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Gene Editing Screening and R&D of Digestive System Tumor Drugs Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Department of Nuclear Medicine Key Laboratory of Carcinogenesis and Translational ResearchMinistry of EducationPeking University Cancer Hospital&InstituteBeijing 100142China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeNo.17Panjiayuan NanliBeijing 100021China Nuclear Medicine Department State Key Laboratory of Complex Severe and Rare DiseasesCenter for Rare Diseases ResearchBeijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear MedicinePeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100005China Department of Biochemistry and Molecular Biology State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China Guangdong Research Center of Organoid Engineering and Technology Accurate International Biotechnology Co.Ltd.Guangzhou 510650China

Neuroendocrine tumours(NETs)are rare cancers with positive somatostatin receptor 2(SSTR2)expression,and treatment strategies for NETs are not ***-mediated therapy targeting SSTR2 in NETs is very *** study firstly combined mesoporous silica-coated gold nanorods(AuNRs@mSiO_(2))and targeting-SSTR2 dodecane tetraacetic acidtyrosine3-octreotate(DOTA-TATE)into AuNRs@mSiO_(2)@DOTA-TATE to investigate NETs inhibition under near-infrared ***@mSiO_(2)@DOTA-TATE showed good photothermal conversion *** vitro,under light irradiation,the cell viability significantly decreased with increasing AuNR@mSiO_(2)@DOTA-TATE concentration;in two successfully established neuroendocrine tumour organoids with SSTR2 expression,AuNRs@mSiO_(2)@DOTA-TATE with light inhibited tumours significantly better than AuNRs@mSiO_(2) with *** vivo,the SSTR2-targeting ability and biodistribution of AuNRs@mSiO_(2)@DOTA-TATE were confirmed with AuNRs@mSiO_(2)@64Cu-DOTA-TATE under micro-positron emission tomography/computed tomography(micro-PET/CT);in the AuNRs@mSiO_(2)@DOTA-TATE with laser group,the tumour surface temperature increased rapidly,with tumour volumes similar to those in the octreotide group and significantly lower than those in other *** was no significant difference in mice body weight between the AuNRs@mSiO_(2)@DOTA-TATE with laser group and other *** significant inflammatory lesions or cell necrosis was found in the main *** summary,we presented a feasible strategy to construct AuNRs@mSiO_(2)@DOTA-TATE with good photothermal conversion efficiency,targetingSSTR2 ability,significant antitumour effects,and good biocompatibility,warranting further explorations of AuNRs@mSiO_(2)@DOTA-TATE for NETs therapy applications.

关键词： neuroendocrine tumours somatostatin receptor 2 nanoparticles photothermal therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asymptotic Behavior of Slender Flying Vehicle with a Finite Controller

引用

Systems Science and Systems Engineering 1996年第2期6卷 246-249页

作者： LI Shengjia(Department of Mathematics, Shanxi University, Taiyuan, China, 030006)yu jiangyuan(Istitute of information and Control, Beijing , China, 100037)

In this paper, it is proved that there exists a finite controller such that the aymptoticbehavior of a slender space vehicle with the effect of aerodynamic power exponentially stablizes to atable state.

关键词： beam equation finite control exponential stability.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

英国驻喀什噶尔领事马继业与新疆文物的外流

引用

吐鲁番学研究 2024年第4期 108-116,154,155页

作者：于江源新疆大学历史学院

1908年英国在喀什噶尔建立了第一个驻新疆地区领事馆,马继业为喀什噶尔领事馆首任总领事,工作时长长达28年(1890-1918)。在任期间马继业与俄国领事彼得罗夫斯基展开文书争夺,广泛搜集、盗取古文书,其中他搜集到的“库车文书”写本残片... 详细信息

1908年英国在喀什噶尔建立了第一个驻新疆地区领事馆,马继业为喀什噶尔领事馆首任总领事,工作时长长达28年(1890-1918)。在任期间马继业与俄国领事彼得罗夫斯基展开文书争夺,广泛搜集、盗取古文书,其中他搜集到的“库车文书”写本残片更是推动了欧洲东方学家对新疆龟兹学的研究。同时他又利用职务之便和多年来累积的人脉及影响力,帮助许多国外探险队进行新疆考察,为其提供住所、安排运输、交换信息等。例如:斯坦因、斯文赫定、伯希和、勒柯克等探险家都接受过马继业的帮助,也正是有了马继业所提供的便利,才使得这些人在新疆的考古活动更加顺利。这些考古队对新疆及西北文物造成了不可估量的伤害,马继业的行为不仅鼓励了更多欧洲考察队前来新疆盗取文物,而且直接造成了大批新疆及西北文物的外流。

关键词：马继业新疆文物文物外流

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

血糖监测用植入式传感器的研究进展

引用

生物医学工程学杂志 2016年第5期33卷 991-997页

作者：余江渊李崭虹陈诚陈云霞朱志刚上海第二工业大学工学部环境与材料工程学院上海201209 景德镇陶瓷学院材料科学与工程学院景德镇333001

连续血糖监测对于重症糖尿病患者至关重要,但目前仍然没有可供临床使用的长效植入式葡萄糖传感器面世。本文介绍了连续血糖监测用传感器分类,重点探讨了传感器植入后的失效机制,指出了提高传感器植入寿命的途径及注意事项,并展望了植入... 详细信息

连续血糖监测对于重症糖尿病患者至关重要,但目前仍然没有可供临床使用的长效植入式葡萄糖传感器面世。本文介绍了连续血糖监测用传感器分类,重点探讨了传感器植入后的失效机制,指出了提高传感器植入寿命的途径及注意事项,并展望了植入式葡萄糖传感器的未来研究方向。

关键词：连续血糖监测葡萄糖传感器植入器件异物反应

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

PET/CT显像在化疗相关心肌损伤中的应用

引用

中华核医学与分子影像杂志 2020年第3期40卷 179-182页

作者：孟天宇于江媛李囡杨志北京大学肿瘤医院暨北京市肿瘤防治研究所核医学科、恶性肿瘤发病机制及转化研究教育部重点实验室 100142

心肌损伤是肿瘤化疗常见的并发症,是肿瘤患者预后的影响因素之一。早期识别并干预化疗相关心肌损伤十分重要。目前常用的临床、影像学及实验室检查方法均存在不足之处,而PET/CT显像目前尚未广泛应用于化疗相关心肌损伤。该文就目前PET/C... 详细信息

心肌损伤是肿瘤化疗常见的并发症,是肿瘤患者预后的影响因素之一。早期识别并干预化疗相关心肌损伤十分重要。目前常用的临床、影像学及实验室检查方法均存在不足之处,而PET/CT显像目前尚未广泛应用于化疗相关心肌损伤。该文就目前PET/CT显像在化疗相关心肌损伤动物实验及人体试验中的应用及不足进行综述。

关键词：心脏毒性药物疗法正电子发射断层显像术体层摄影术,X线计算机发展趋势

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于螺旋型铂铱合金电极的植入式葡萄糖生物传感器

引用

传感技术学报 2016年第1期29卷 9-14页

作者：余江渊朱志刚陈诚李崭虹陈云霞上海第二工业大学工学部环境与材料工程学院上海201209 景德镇陶瓷学院材料科学与工程学院江西景德镇333001

采用螺旋型铂铱合金电极设计,旨在提高植入式葡萄糖生物传感器的葡萄糖氧化酶担载量并增大工作电极的电化学活性面积。以扫描电镜(SEM)观察聚氨酯(Polyurethane,PU)半透膜的形貌,采用循环伏安法(CV)和计时电流法(I-T)考察PU涂覆厚度、P... 详细信息

采用螺旋型铂铱合金电极设计,旨在提高植入式葡萄糖生物传感器的葡萄糖氧化酶担载量并增大工作电极的电化学活性面积。以扫描电镜(SEM)观察聚氨酯(Polyurethane,PU)半透膜的形貌,采用循环伏安法(CV)和计时电流法(I-T)考察PU涂覆厚度、PU含量以及酶含量等参数对传感器电化学性能的影响,结果表明:所制备的螺旋型传感器灵敏度在20 n A/(mmol/L)~30 n A/(mmol/L),可在人体生理条件范围内线性检测(2 mmol/L^30 mmol/L)葡萄糖浓度,并且具有良好的重现性、稳定性和选择性,符合电极长期植入式需求,有望作为今后糖尿病患者血糖连续监测的关键器件。

关键词：葡萄糖生物传感器螺旋线圈电极聚氨酯半透膜选择性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于多源感知技术的智能应用体系在灌区中的应用

引用

水利技术监督 2023年第6期 33-35,51页

作者：余江远邵冠军马跃浙江颐川科技有限公司浙江杭州310000 绍兴市上虞区上浦闸运行管理中心浙江绍兴312000

灌区现代化建设是灌区续建配套与节水改造的重要工作内容,为建成“设施安全、节水高效、生态健康、智慧管理、人水和谐”的现代化灌区,采用多源物联感知、自动化集成、数字孪生、数据资源整合等技术,建立灌区智能应用体系,开发灌区信息... 详细信息

灌区现代化建设是灌区续建配套与节水改造的重要工作内容,为建成“设施安全、节水高效、生态健康、智慧管理、人水和谐”的现代化灌区,采用多源物联感知、自动化集成、数字孪生、数据资源整合等技术,建立灌区智能应用体系,开发灌区信息化智能管理平台,实现灌区数据采集智能化、传输网络化、管理智慧化、用水高效化,为推动灌区向智慧灌区、生态灌区、安全灌区及和谐灌区方向发展提供经验和借鉴。

关键词：灌区多源感知智能应用信息化系统现代化管理

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：