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Chinese Chemical Letters 2021年第12期32卷 4038-4040页

作者： jiangyan tian Wendian Li Ruihao Li Lin He Hui Lv key Laboratory of Biomedical Polymers of Ministry of Education&College of Chemistry and Molecular Sciences Engineering Research Center of Organosilicon Compounds&MaterialsMinistry of EducationSauvage Center for Molecular SciencesWuhan UniversityWuhan 430072China Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan School of Chemistry and Chemical EngineeringShihezi UniversityShihezi 832000China

Nickel/(S)-t-Bu-PHOX complex catalyzed asymmetric arylative cyclization of N-alkynones has been achieved, delivering 1,2,3,6-tetrahydropyridines containing a chiral tertiary alcohol in high yields and excellent enanti... 详细信息

关键词： Asymmetric catalysis Alkynones Cyclization Nickel

Proteomics Uncovers a Role for Enhanced Ultraviolet-B Radiation on Wheat Leaves

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American Journal of Plant Sciences 2013年第6期4卷 1227-1232页

作者： jiangyan Duan Xue tian Zhenhu Jia College of Life Science Shanxi Normal University Linfen China

Wheat (Triticum aestivum), as a kind of important economic crop cultured in the Northern China, is affected by present-day enhanced ultraviolet-B (UV-B) radiation. To get the information of the impact by UV-B radiation on it, the proteins of wheat (Jin mai NO.8) leaves, which were divided into the normal light group (CK) and UV-B radiation group (B), were extracted and ran at SDS-PAGE at different treatment days (5, 6, 7). The proteins were also analyzed by run two-dimensional gel electrophoresis (2-DE), which allowed the identification of some significantly different gel spots. The proteins spots were further verified by Matrix-Assisted Laser Desorption/lonization-time of Flight Mass Spectrometry. The results showed: 1) the enhanced UV-B affects the growth of the wheat, as the visual changes appear on the sixth day;2) the proteins expressions between the B group and the CK group were remarkably different on the sixth day;3) the proteins of wheat leaves of the sixth day were further analyzed by 2-DE revealed that twenty-one protein points were identificated between the B group and the CK group. Among these twenty-one proteins, six proteins of them were up-regulated and twelve proteins of them were down-regulated, three new proteins were expressed only in the B group. Three proteins among six proteins, which were up-regulated, were further verified as RuBisCo large subunit binding protein;SOD;Calmodulin. The result indicates wheat could improve genes encoding proteins in their leaves and protect themselves, when enhanced UV-B affects the growth of the wheat.

关键词： Wheat Ultraviolet-B Radiation 2-DE

PD-L1 is a direct target of cancer-FOXP3 in pancreatic ductal adenocarcinoma(PDAC),and combined immunotherapy with antibodies against PD-L1 and CCL5 is effective in the treatment of PDAC

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2043-2054页

作者： Xiuchao Wang Xin Li Xunbin Wei Haiping Jiang Chungen Lan Shengyu Yang Han Wang Yanhui Yang Caijuan tian Zanmei Xu jiangyan Zhang Jihui Hao He Ren Department of Gastroenterology Center of Tumor Immunology and CytotherapyThe Affiliated Hospital of Qingdao University266003 QingdaoChina Department of Cellular and Molecular Physiology Penn State College of MedicineHersheyPA 17033USA Department of Pancreatic Cancer Tianjin Medical University Cancer Institute and Hospital300060 TianjinChina Department of Geriatric Dentistry Beijing Laboratory of Biomedical MaterialsPeking University School and Hospital of Stomatologyand Biomedical Engineering DepartmentPeking University100081 BeijingChina Department of Applied Statistics College of ScienceHebei University of Technology300401 TianjinChina NHC Key Laboratory of Hormones and Development(tianjin Medical University) Tianjin Key Laboratory of Metabolic DiseasesTianjin Medical University Chu Hsien-I Memorial Hospital&Tianjin Institute of Endocrinology300134 TianjinChina tianjin Marvel Medical Laboratory Tianjin Marvelbio Technology Co.Ltd300381 TianjinChina

High expression of PD-L1 marks the poor prognosis of pancreatic ductal adenocarcinomas(PDAC).However,the regulatory mechanism of PD-L1 remains *** recently reported that cancer Forkhead box protein 3(Cancer-FOXP3 or C-FOXP3)promoted immune evasion of PDAC by recruiting Treg cells into PDAC via upregulation of *** this study,we confirmed that PD-L1 was overexpressed in PDAC samples from two independent cohorts of patients with radical ***,C-FOXP3 was colocalized and correlated with the expression of PD-L1 in tumor cells at the mRNA and protein levels,and this finding was confirmed by the The Cancer Genome Atlas(TCGA)*** immunoprecipitation(ChIP)revealed that C-FOXP3 directly bound to the promoter region of PD-L1 in pancreatic cancer ***,overexpression of C-FOXP3 activated the luciferase reporter gene under the control of the PD-L1 ***,mutation of the binding motif-a completely reversed the luciferase *** addition,C-FOXP3-induced upregulation of PD-L1 effectively inhibited the activity of CD8+T *** on our recent finding that the CCL-5 antibody achieved a better response to PDAC models with high C-FOXP3 levels,we further demonstrated that the PD-L1 antibody strengthened the antitumor effect of CCL-5 blockade in xenograft and orthotopic mouse models with high C-FOXP3 *** conclusion,C-FOXP3 directly activates PD-L1 and represents a core transcription factor that mediates the immune escape of *** blockade of PD-L1 and CCL-5 may provide an effective therapy for patients with PDAC that have high C-FOXP3 levels.

关键词： CCL5 FOXP3 adenocarcinoma

Construction Progress of Chinese Meridian Project PhaseⅡ

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空间科学学报 2022年第4期42卷 539-545页

作者： WANG Chi XU Jiyao LÜDaren YUE Xinan XUE Xianghui CHEN Gang YAN Jingye YAN Yihua LAN Ailan WANG jiangyan WANG Xin tian Yufang State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190 LAGEO Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029 Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100191 School of Earth and Space Sciences University Science and Technology of ChinaHefei 230026 Department of Space Physics School of Electronic InformationWuhan UniversityWuhan 430072

The Chinese Meridian Project(CMP)is the Space Environment Ground Based Comprehensive Monitoring Network of China,a national major science and technology infrastructure *** CMP consists of the Space Environment Monitoring System,Data Communication System,and Science Application *** construction has been divided into two steps:the PhaseⅠwas from 2008 to 2012;the PhaseⅡstarted at the end of 2019,expected to be completed at the end of *** 2023,the CMP as a whole will be in operation to make *** report introduces the construction progress of CMP PhaseⅡin the past two years,covering the construction progress of both the Data Communication System and the Science Application *** for the Space Environment Monitoring System,this report mainly gives an introduction to the construction progress of large-scale advanced monitoring equipment,such as,the solar radio telescope,interplanetary scintillation telescope,incoherent scatter radar,high frequency radar,MST radar,and large-aperture Helium *** addition,this paper presents the construction plan for the next two years and the future outlook as well.

关键词： Chinese Meridian Project(CMP) Ground-based observation network Space weather Solar-terrestrial physics

鄂尔多斯盆地三叠系延长组7段深水碎屑流沉积特征及成因

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石油与天然气地质 2021年第5期42卷 1063-1077页

作者：周新平何青刘江艳李士祥杨田低渗透油气田勘探开发国家工程实验室陕西西安710018 中国石油长庆油田分公司勘探开发研究院陕西西安710018 成都理工大学油气藏地质及开发工程国家重点实验室四川成都610059 成都理工大学沉积地质研究院四川成都610059

为了明确不同类型深水碎屑流沉积特征及其成因,以鄂尔多斯盆地三叠系延长组7段深水重力流沉积为研究对象,综合测录井资料、岩心观察分析、薄片分析和定量统计,分析碎屑流沉积特征、总结沉积序列和探讨成因机制。研究表明:研究区的深水... 详细信息

为了明确不同类型深水碎屑流沉积特征及其成因,以鄂尔多斯盆地三叠系延长组7段深水重力流沉积为研究对象,综合测录井资料、岩心观察分析、薄片分析和定量统计,分析碎屑流沉积特征、总结沉积序列和探讨成因机制。研究表明:研究区的深水碎屑流主要发育砂质碎屑流、泥质碎屑流和泥流3种类型。砂质碎屑流沉积以块状砂岩最为常见,漂浮状泥质碎屑发育,单层厚度分布在0.24~1.10 m,平均厚度为0.55 m。泥质碎屑流沉积包含孤立块状沉积和与下伏块状砂岩成对产出两种类型,前者内部大量发育漂浮状泥岩撕裂屑及软沉积物变形构造,后者富含漂浮状泥质碎屑与砂质团块,单层厚度分布在0.21~1.29 m,平均厚度为0.60 m。泥流沉积包含孤立块状沉积和与下伏块状砂岩成对产出两种类型,前者整体为泥质砂岩或砂质泥岩,后者内部可见漂浮状成层排列的毫米级泥质碎片,单层厚度分布在0.20~0.60 m,平均厚度为0.30 m。高浓度砂质沉积物或泥质沉积物搬运过程中环境水体卷入导致的流体转化是形成砂质碎屑流、孤立块状泥质碎屑流和泥流沉积的主要原因。与下部块状砂岩相伴生的泥质碎屑流沉积多为流体侵蚀成因或砂体液化成因;与下部块状砂岩相伴生的泥流沉积包含流体减速膨胀导致的流体转化和碎屑颗粒的差异沉降等成因。

关键词：砂质碎屑流泥质碎屑流泥流流体转化成因机制深水重力流沉积特征鄂尔多斯盆地

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油茶黄酮化合物对核桃油氧化稳定性的影响

中国粮油学报 2023年第1期38卷 101-107页

作者：邢江艳田洋成琴林奇包媛媛云南农业大学昆明650201

将油茶黄酮化合物添加到核桃油中,通过体外抗氧化实验,探究其对核桃油稳定性的影响。以油茶叶、油茶籽壳为原料,提取黄酮类化合物并通过高效液相色谱法定性定量分析;将黄酮类提取物按照油茶籽壳中杨梅素∶槲皮素∶山奈酚=1.15∶1.00∶1.... 详细信息

将油茶黄酮化合物添加到核桃油中,通过体外抗氧化实验,探究其对核桃油稳定性的影响。以油茶叶、油茶籽壳为原料,提取黄酮类化合物并通过高效液相色谱法定性定量分析;将黄酮类提取物按照油茶籽壳中杨梅素∶槲皮素∶山奈酚=1.15∶1.00∶1.05,油茶叶中杨梅素∶槲皮素∶山奈酚=2.36∶1.00∶1.60的比例添加到核桃油中,以200 mg/kg的TBHQ、BHA、VE做对照组,测定过氧化值、酸价、总抗氧化能力、还原能力等指标,研究杨梅素、槲皮素、山奈酚不同配比对核桃油氧化稳定性的影响。结果表明:油茶籽壳中杨梅素、槲皮素和山奈酚含量分别为:68.71、59.77、62.71 mg/100 g;油茶叶中杨梅素、槲皮素和山奈酚含量分别为:74.51、31.58、50.58 mg/100 g。对核桃油的抗氧化效果为:TBHQ>杨梅素∶槲皮素∶山奈酚=1.15∶1.00∶1.05>BHA>杨梅素∶槲皮素∶山奈酚=2.36∶1.00∶1.60>VE。油茶中的黄酮化合物作为一种天然抗氧化剂能有效延长核桃油的货架期;油茶籽壳黄酮化合物的抗氧化效果优于BHA、VE;油茶叶黄酮化合物的抗氧化效果优于VE,且对核桃油抗氧化起主要影响的是槲皮素的含量,研究结果可为核桃油绿色安全抗氧化剂的开发提供实验依据。

关键词：油茶叶油茶籽壳黄酮抗氧化核桃油

Mitochondrial Quality Control Mechanisms Activation by Resveratrol Attenuates Mitochondrial Damage Induced by Cerebral Ischemia Reperfusion Injury

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Mitochondrial Quality Control Mechanisms Activation by Resve...

基于Malmquist-Luenberger指数西北五省绿色全要素生产率测算的研究

中国药理学会分析药理学专业委员会成立大会、第三届全国分析药理学学术大会暨贵州省药学会药学青年专业委员会成立大会

作者： Fei Xiang Minghang Li Lu Xu Xiaocui tian Hailin Liu Daohang Liu Qian Wang Yuchun Wang jiangyan Rao Zhi Dong Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology College of PharmacyChongqing Medical University School of Pharmacy Chongqing Medical and Pharmaceutical College

Damaged mitochondria is a key factor of cellular death in cerebral ischemia-reperfusion㈣***(Res),a activator of the silent information regulator 1(SIRTl),has the protective effects on mitochondrial founction for reli... 详细信息

关键词： Mitochondrial Quality Control Mechanisms Activation by Resveratrol Attenuates Mitochondrial Damage Induced by Cerebral Ischemia Reperfusion Injury

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上海节能 2020年第7期 640-648页

作者：田丰梁江艳新疆财经大学经济学院

基于分析西北五省的资源与环境状况,采用Malmquist-Luenberger指数测算2001-2017年中国西北五省绿色全要素生产率,并对其进行分解。结果显示,陕西的绿色全要素生产率均值为1.37,是西北五省中最高的省份,甘肃、新疆和宁夏三省分别为1.09... 详细信息

基于分析西北五省的资源与环境状况,采用Malmquist-Luenberger指数测算2001-2017年中国西北五省绿色全要素生产率,并对其进行分解。结果显示,陕西的绿色全要素生产率均值为1.37,是西北五省中最高的省份,甘肃、新疆和宁夏三省分别为1.09、1.07和1.06,处于居中水平,最低的青海为1.02;自2000-2017年间,西北五省绿色全要素生产率的年增长率由高到低分别为陕西6.18%、甘肃0.71%、宁夏0.42%、青海0.18%和新疆-0.02%。整体而言,除新疆外,其他省份的绿色全要素生产率保持稳定增长的趋势。在对西北五省中绿色全要素生产率的分解中,规模技术进步起到了主要拉动作用,规模效率变化起到一定抑制作用。根据结论,本研究从进一步推动节能减排、提高绿色技术水平、加强环境规制、优化要素配置四个方面提出对策建议,以期提高西北五省的绿色全要素生产率。

关键词：绿色全要素生产率 Malmquist-Luenberger 西北五省

斑岩型Au矿床的包裹体标志:以黑龙江金厂金矿矿床为例

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岩石学报 2008年第9期24卷 2011-2016页

作者：张文淮秦江艳张德会田璐王丽丽王永中国地质大学北京100083 中国科学院地质与地球物理研究所矿产资源研究重点实验室北京100029

通过对黑龙江金厂金矿床和河北蔡家营铅-锌-银矿床的对比研究,发现斑岩中包裹体的演化和成分特征反映了成矿流体的演化、成矿能力和矿床成因,对这类矿床的找矿评价也具有一定的参考价值。金厂金矿床中代表岩浆演化各个阶段的包裹体类型... 详细信息

通过对黑龙江金厂金矿床和河北蔡家营铅-锌-银矿床的对比研究,发现斑岩中包裹体的演化和成分特征反映了成矿流体的演化、成矿能力和矿床成因,对这类矿床的找矿评价也具有一定的参考价值。金厂金矿床中代表岩浆演化各个阶段的包裹体类型完全,且包裹体富含盐类、成矿物质和挥发组分,表明该区岩浆结晶分异作用完善、具有较强的成矿能力,能形成斑岩型矿床。而河北蔡家营铅-锌-银矿床,斑岩中只有硅酸盐玻璃包裹体和后期盐水溶液包裹体,反映该岩浆分异演化程度不高、分异作用极不完善。含盐度较高而且大量挥发组分的存在可能是后期热液活化萃取围岩成矿物质的重要因素。

关键词：包裹体岩浆演化结晶分异金厂

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基于全局时频注意力网络的语音伪造检测

计算机研究与发展 2021年第7期58卷 1466-1475页

作者：王成龙易江燕陶建华马浩鑫田正坤傅睿博中国科学技术大学信息科学技术学院合肥230027 模式识别国家重点实验室(中国科学院自动化研究所) 北京100080 中国科学院大学人工智能学院北京100049

语音伪造检测是近年的一个研究热点,受到了广泛关注.目前,卷积神经网及其变种的提出,使其在语音伪造检测任务中取得了不错进展.然而,目前仍存在2方面问题:1)当前工作假设送入卷积神经网络的特征图的每一维对结果的影响是相同的,忽视了... 详细信息

语音伪造检测是近年的一个研究热点,受到了广泛关注.目前,卷积神经网及其变种的提出,使其在语音伪造检测任务中取得了不错进展.然而,目前仍存在2方面问题:1)当前工作假设送入卷积神经网络的特征图的每一维对结果的影响是相同的,忽视了每一维上特征图的不同位置强调的信息是不一样的.2)此外,前人工作大多关注特征图的局部信息,没有利用全局视图中特征图之间的关系.为了解决以上挑战,引入全局时频注意力框架,分别对通道维度和时频维度做了注意力变换.具体而言,引入了2个并行的注意力模块:1)时频注意力模块;2)全局注意力模块.对于时频注意力模块,可以通过使用加权求和在所有时频特征图上聚合特征来进行更新.对于全局注意力模块,借鉴了SE-Net的思想,通过参数为每个特征通道生成权重.通过这种办法,可以得到特征通道上响应的全局分布.在ASVspoof2019 LA公开数据集上进行了一系列实验,结果显示所提的模型取得不错的效果,最佳模型的等错误率达到4.12%,刷新了单个模型的最好成绩.

关键词：语音鉴伪注意力机制语音伪造检测全局注意力时频注意力