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Revealing the specific role of sulfide and nano-alumina in composite solid-state electrolytes for performance-reinforced ether-nitrile copolymers

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Journal of Energy Chemistry 2024年第4期91卷 628-636页

作者： Haoyang Yuan Changhao Tian Mengyuan Song Wenjun Lin Tao huang Aishui Yu department of Chemistry Collaborative Innovation Center of Chemistry for Energy MaterialsShanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsInstitute of New EnergyFudan UniversityShanghai 200438China Laboratory of Advanced Materials Fudan UniversityShanghai 200438China

Composite solid-state electrolytes represent a critical pathway that balances the interface compatibility and lithium-ion conductivity in all-solid-state *** quest for stable and highly ion-conductive combinations between polymers and fillers is vital,but blind attempts are often made due to a lack of understanding of the mechanisms involved in the interaction between polymers and ***,we employ in-situ polymerization to prepare a polymer based on an ether-nitrile copolymer with high cathode stability as the foundation and discuss the performance enhancement mechanisms of argyrodite and *** 1%content of sulfide interacting with the polymer at the two-phase interface,the local enhancement of lithium-ion migration capability can be achieved,avoiding the reduction in capacity due to the low ion conductivity of the passivation layer during *** capacity retention after 50cycles at 0.5 C increases from 83.5%to 94.4%.Nano-alumina,through anchoring the anions and interface inhibition functions,eventually poses an initial discharge capacity of 136.8 m A h g^(-1)at 0.5 C and extends the cycling time to 1000 h without short-circuiting in lithium metal *** the combined action of dual fillers on the composite solid-state electrolyte,promising insights are provided for future material design.

关键词： Composite solid-state electrolytes Lithium metal anode Dual fillers Interfacial ionic conduction Inert nano-alumina

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Bubble dynamics properties of B-particles in a quasi-2D gas-solid fluidized bed:Computational particle fluid dynamics numerical simulation and post-processed by digital image analysis technique

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Particuology 2024年第3期86卷 223-238页

作者： Zemin Yuan Zhong huang Guotao Qin Guanjia Zhao Suxia Ma Hairui Yang Guangxi Yue Key Laboratory of Clean and Efficient Combustion and Utilization in the Circulating Fluidized Bed Taiyuan University ofTechnologyTaiyuan030024China department of Energy and Power Engineering Tsinghua UniversityBeijing100084.China

Bubble dynamics properties play a crucial and significant role in the design and optimization of gas-solid fluidized *** this study,the bubble dynamics properties of four B-particles were investigated in a quasi-two-dimensional(quasi-2D)fluidized bed,including bubble equivalent diameter,bubble size distribution,average bubble density,bubble aspect ratio,bubble hold-up,bed expansion ratio,bubble radial position,and bubble *** studies were performed by computational particle fluid dynamics(CPFD)numerical simulation and post-processed with digital image analysis(DIA)technique,at superficial gas velocities ranging from 2u_(mf) to 7u_(mf).The simulated results shown that the CPFD simulation combining with DIA technique post-processing could be used as a reliable method for simulating bubble dynamics properties in quasi-2D gas-solid fluidized ***,it seemed not desirable for the simulation of bubble motion near the air distributor at higher superficial gas velocity from the simulated average bubble density *** superficial gas velocity significantly affected the bubble equivalent diameter and evolution,while it had little influence on bubble size distribution and bubble aspect ratio distribution for the same *** time-averaged bubble hold-up and bed expansion ratio increased with the increase of superficial gas *** core-annular flow structures could be found in the fluidized bed for all *** average bubble rising velocity increased with the increasing bubble equivalent *** bubble lateral movement,the smaller bubbles might be more susceptible,and superficial gas velocity had a little influence on the absolute lateral velocity of *** simulated results presented a valuable and novel approach for studying bubble dynamics *** comprehensive understanding of bubble dynamics behaviors in quasi-2D gas-solid fluidized beds would provide support in the design,operation,and optimization of gas-solid

关键词： Bubble dynamics properties CPFD simulation Quasi-2D gas-solid fluidized bed Digital image analysis

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Directly targeting BAX for drug discovery:Therapeutic opportunities and challenges

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2378-2401页

作者： Zhenwei Zhang Linghui Hou Dan Liu Shenglin Luan Min huang Linxiang Zhao Key Laboratory of Structure-Based Drugs design&Discovery of Ministry of Education Shenyang Pharmaceutical UniversityShenyang 110016China China Resources Sanjiu Medical&Pharmaceutical Co. Ltd.Shenzhen 518000China

For over two decades,the development of B-cell lymphoma-2(Bcl-2)family therapeutics has primarily focused on anti-apoptotic proteins,resulting in the first-in-class drugs called BH3 mimetics,especially for Bcl-2 inhibitor *** pro-apoptotic protein Bcl-2-associated X protein(BAX)plays a crucial role as the executioner protein of the mitochondrial regulated cell death,contributing to organismal development,tissue homeostasis,and *** dysregulation of BAX is closely associated with the onset and progression of diseases characterized by pathologic cell survival or death,such as cancer,neurodegeneration,and heart *** addition to conducting thorough investigations into the physiological modulation of BAX,research on the regulatory mechanisms of small molecules identified through biochemical screening approaches has prompted the identification of functional and potentially druggable binding sites on BAX,as well as diverse all-molecule BAX *** review presents recent advancements in elucidating the physiological and pharmacological modulation of BAX and in identifying potentially druggable binding sites on ***,it highlights the structural and mechanistic insights into small-molecule modulators targeting diverse binding surfaces or conformations of BAX,offering a promising avenue for developing next-generation apoptosis modulators to treat a wide range of diseases associated with dysregulated cell death by directly targeting BAX.

关键词： Apoptosis Pro-apoptotic protein BAX Dynamic conformational activation Small-molecule apoptosis modulators

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Indole derivatives as agrochemicals:An overview

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Chinese Chemical Letters 2024年第7期35卷 66-72页

作者： Ping Sun Yuanqin huang Shunhong Chen Xining Ma Zhaokai Yang Jian Wu National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China

Indole is a biologically active compound formed by the fusion of benzene and pyrrole,and it is widely found in natural products and *** to the unique structure and properties of indole,its derivatives often exhibit distinctive physiological activities,which has led to widespread attention in the field of pesticide *** the design strategies and structure-activity relationships(SARs)of compounds is a crucial step in developing novel *** review mainly summarizes indole compounds with plant growth regulating,antiviral,fungicidal,herbicidal,and insecticidal activities,with the aim of providing new insights into the discovery and mechanism of action of novel indole-based pesticides.

关键词： Indole compounds Agrochemicals Biological activity Structure-activity relationship Mechanism of action

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Drainage of paddy terraces impacts structures and soil properties in the globally important agricultural heritage of Hani Paddy Terraces,China

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International Soil and Water Conservation Research 2024年第1期12卷 64-76页

作者： Ming Wang Li Rong Yanbo Li Jiangcheng huang Yuanmei Jiao Xiaoyan Wei Institute of International Rivers and Eco-Security Kunming650500China Yunnan Key Laboratory of International Rivers and Transboundary Eco-Security Kunming650500China Power China Kunming Engineering Corporation Limited Kunming650051China department of Geography Yunnan Normal UniversityKunming650500China Yunnan Provincial Archives of Surveying and Mapping(Yunnan Provincial Geomatics Centre) Kunming650032China

Marginalization and abandonment of paddy terraces are widespread,but their effects on the sustainability of subsequent agricultural production are still *** Paddy Terraces,included in Globally Important Agriculture Heritage Systems,are threatened by paddy fields ***,changes in terrace structure,the productivity of topsoil(0-20 cm),and soil water holding capacity at 0-70 cm depth were determined in a case study of Hani Paddy Terraces in Amengkong River Basin in Yuanyang County in Southwestern China,which had been converted into dryland terraces for 2-14 *** results showed that:(1)The degree of terrace structures degradation exhibited a U-shaped curve with increasing time since draining,with those drained for 5-9 years having the best structure;(2)Soil productivity index decreased first and then increased with time after conversion;(3)Maximum water holding capacity at 0-70 cm soil depth dramatically decreased after conversion and such trend became increasingly obvious with increasing time since *** study revealed that drainage of paddy terraces along with associated changes in crop and field management led to an increase in soil productivity,but degradation of terrace structures and a decrease in water holding capacity will inhibit restoration to paddy *** findings enhance the understanding of the biophysical changes due to marginalization in paddy terraces.

关键词： Hani paddy terraces Terraces marginalization Terrace structure degradation Soil productivity Water holding capacity

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Impact of surface-reflected seismic waves on the seismic isolation performance of circular tunnel isolation layers

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Journal of Mountain Science 2024年第3期21卷 901-917页

作者： LU Jiahui LUO Junjie huang Xiangyun HONG Junliang HE YanXin ZHOU Fulin department of Civil Engineering Xi’an University of Architecture and Technology(XAUAT)Xi’an 710055China Earthquake Engineering Research and Test Centre Guangzhou UniversityGuangzhou 510623China Guangdong Provincial Key Laboratory of Earthquake Engineering and Applied Technology Guangzhou UniversityGuangzhou 510623China Key Laboratory of Earthquake Resistance Earthquake Mitigation and Structural SafetyMinistry of EducationGuangzhou UniversityGuangzhou 510623China

Seismic isolation is an effective strategy to mitigate the risk of seismic damage in ***,the impact of surface-reflected seismic waves on the effectiveness of tunnel isolation layers remains under *** this study,we employ the wave function expansion method to provide analytical solutions for the dynamic responses of linings in an elastic half-space and an infinite elastic *** comparing the results of the two models,we investigate the seismic isolation effect of tunnel isolation layers induced by reflected seismic *** findings reveal significant differences in the dynamic responses of the lining in the elastic half-space and the infinitely elastic ***,the dynamic stress concentration factor(DSCF)of the lining in the elastic half-space exhibits periodic fluctuations,influenced by the incident wave frequency and tunnel depth,while the DSCF in the infinitely elastic space remain ***,the seismic isolation application of the tunnel isolation layer is found to be less affected by surface-reflected seismic *** results provide valuable insights for the design and assessment of the seismic isolation effect of tunnel isolation layers.

关键词： Circular tunnel seismic isolation Surface reflection Response of liners Wave-function expansion method

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Metabolomics signature of blood pressure salt sensitivity and its link to cardiovascular disease:A dietary salt-intervention trial

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Science China(Life Sciences) 2024年第8期67卷 1666-1675页

作者： Zhennan Lin Jianxin Li Fangchao Liu Jie Cao Shufeng Chen Jichun Chen Keyong huang Yaqin Wang Hongfan Li Yan Wang Jianfeng huang Dongfeng Gu Xiangfeng Lu Key Laboratory of Cardiovascular Epidemiology Department of EpidemiologyFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical College/National Center for Cardiovascular DiseasesBeijing 100037China Medical School Southern University of Science and TechnologyShenzhen 518055China

Individuals with a high degree of salt sensitivity(SS)have a greater risk of cardiovascular disease(CVD),but whether SS fosters CVD by influencing metabolomics homeostasis remains *** study aimed to reveal the role of the SS-related metabolomics signature in the development of CVDs,based on the MetaSalt study,which was a dietary salt-intervention trial conducted at four centers in China in 2019.A total of 528 participants were recruited and underwent 3 days of baseline observations,a 10-day low-salt intervention,and a 10-day highsalt *** untargeted metabolomics,lipidomics,and BP measurements were scheduled at each *** were grouped into extreme SS,moderate SS,and salt-resistant(SR)individuals according to their BP responses to *** mixed models were used to identify SS-related metabolites and determine the relationship between the SS-related metabolomics signature and arterial *** randomization(MR)analyses were applied to establish the causal pathways among the SS-related metabolites,BP,and *** the 713 metabolites,467 were significantly changed after the high-salt *** them,the changes in 30 metabolites from the low-salt to the high-salt intervention differed among the SS *** the remaining nonsalt-related metabolites,the baseline levels of 11 metabolites were related to *** 41 metabolites explained 23%of the variance in ***,SS and its metabolomics signature were positively correlated with arterial *** analyses demonstrated that the SS-related metabolites may affect CVD risk by altering BP,indicating that the increase in BP was the consequence of the changes in SS-related metabolites rather than the *** study revealed that the metabolomics signature of SS individuals differs from that of SR individuals and that the changes in SS-related metabolites may increase arterial stiffness and foster *** study provides insight into understanding the biolog

关键词： salt sensitivity dietary salt intake metabolomics Mendelian randomization cardiovascular disease

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Sampling-efficient path planning and improved actor-critic-based obstacle avoidance for autonomous robots

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Science China(Information Sciences) 2024年第5期67卷 197-214页

作者： Yefeng YANG Tao huang Tianqi WANG Wenyu YANG Han CHEN Boyang LI Chih-yung WEN department of Aeronautical and Aviation Engineering The Hong Kong Polytechnic University Center for Control Theory and Guidance Technology Harbin Institute of Technology School of Engineering The University of Newcastle Research Center for Unmanned Autonomous Systems The Hong Kong Polytechnic University

Autonomous robots have garnered extensive utilization in diverse fields. Among the critical concerns for autonomous systems, path planning holds paramount importance. Notwithstanding considerable efforts in its development over the years, path planning for autonomous systems continues to grapple with challenges related to low planning efficiency and inadequate obstacle avoidance response in a timely *** study proposes a novel and systematic solution to the path planning problem within intricate office buildings. The solution consists of a global planner and a local planner. To handle the global planning aspect, an adaptive clustering-based dynamic programming rapidly exploring random tree(ACDP-RRT) algorithm is proposed. ACDP-RRT effectively identifies obstacles on the map by leveraging geometric *** obstacles are then represented as a collection of sequentially arranged convex polygons, optimizing the sampling region and significantly enhancing sampling efficiency. For local planning, a network decoupling actor-critic(ND-AC) algorithm is employed. The proposed ND-AC simplifies the local planner design process by integrating planning and control loops into a neural network(NN) trained via an end-to-end model-free deep reinforcement learning(DRL) framework. Moreover, the adoption of network decoupling(ND) techniques leads to an improved obstacle avoidance success rate when compared to conventional actor-critic(AC)-based methods. Extensive simulations and experiments are conducted to demonstrate the effectiveness and robustness of the proposed approach.

关键词： rapidly exploring random tree (RRT) adaptive clustering network decoupling actor critic (AC) path planning

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Review of the Tuned Mass Damper Inerter(TMDI)in Energy Harvesting and Vibration Control:designs,Analysis and Applications

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2361-2398页

作者： Xiaofang Kang Qiwen huang Zongqin Wu Jianjun Tang Xueqin Jiang Shancheng Lei School of Civil Engineering Anhui Jianzhu UniversityHefei230601China Key Laboratory of Intelligent Underground Detection Technology Anhui Jianzhu UniversityHefei230601China Chengnan College Changsha University of Science and TechnologyChangsha410015China

Tuned mass damper inerter(TMDI)is a device that couples traditional tuned mass dampers(TMD)with an inertial *** inertial device produces resistance proportional to the relative acceleration at its two ends through its“inertial”*** to its unique mechanical properties,TMDI has received widespread attention and application in the past twenty *** different configurations are required in different practical situations,TMDI is still active in the research on vibration control and energy harvesting in *** paper provides a comprehensive review of the research status of *** work first examines the generation and important vibration control characteristics of ***,the energy harvesting performance of electromagnetic tuned mass damper inerter(EM-TMDI)is *** work emphasizes the formation of a passive dynamic vibration absorber by coupling traditional TMD with inertial *** paper also summarizes the design and implementation of optimal vibration control and energy harvesting for ***,this paper details the applications of TMDI in the fields of bridges and building ***,this paper summarizes the necessity of research on tuned mass-damper-inertia,the challenges faced currently,and future research directions,such as control of parameters in electromagnetic energy harvesting TMDI systems and low-cost TMDI.

关键词： TMDI EM-TMDI energy harvesting vibration control inertial device

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Transcriptomic and epigenomic landscapes of muscle growth during the postnatal period of broilers

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1851-1865页

作者： Shuang Gu Qiang huang Yuchen Jie Congjiao Sun Chaoliang Wen Ning Yang State Key Laboratory of Animal Biotech Breeding and Frontier Science Center for Molecular design Breeding China Agricultural UniversityBeijing 100193China National Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics Breeding and ReproductionMinistry of Agriculture and Rural AffairsDepartment of Animal Genetics and BreedingCollege of Animal Science and Technology China Agricultural UniversityBeijing 100193China. Sanya Institute of China Agricultural University Hainan 572025China

Background Broilers stand out as one of the fastest-growing livestock globally,making a substantial contribution to animal meat ***,the molecular and epigenetic mechanisms underlying the rapid growth and development of broiler chickens are still *** study aims to explore muscle development patterns and regulatory networks during the postnatal rapid growth phase of fast-growing *** measured the growth performance of Cornish(CC)and White Plymouth Rock(RR)over a 42-d *** muscle samples from both CC and RR were randomly collected at day 21 after hatching(D21)and D42 for RNA-seq and ATAC-seq library *** The consistent increase in body weight and pectoral muscle weight across both breeds was observed as they matured,with CC outpacing RR in terms of weight at each stage of *** expression analysis identified 398 and 1,129 genes in the two dimensions of breeds and ages,respectively.A total of 75,149 ATAC-seq peaks were annotated in promoter,exon,intron and intergenic regions,with a higher number of peaks in the promoter and intronic *** age-biased genes and breed-biased genes of RNA-seq were combined with the ATAC-seq data for subsequent *** results spotlighted the upregulation of ACTC1 and FDPS at D21,which were primarily associated with muscle structure development by gene cluster ***,a noteworthy upregulation of MUSTN1,FOS and TGFB3 was spotted in broiler chickens at D42,which were involved in cell differentiation and muscle regeneration after injury,suggesting a regulatory role of muscle growth and *** This work provided a regulatory network of postnatal broiler chickens and revealed ACTC1 and MUSTN1 as the key responsible for muscle development and *** findings highlight that rapid growth in broiler chickens triggers ongoing muscle damage and subsequent *** findings provide a foundation for future research to i

关键词： ATAC-seq Broiler Pectoral muscle development Rapid growth RNA-seq

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