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MOF-derived Cu embedded into N-doped mesoporous carbon as a robust support of PdAu nanocatalysts for ethanol electrooxidation

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Rare Metals 2024年第3期43卷 1083-1094页

作者： Yu-Fu huang Peng Wu Jun-Ping Tang Jian Yang Jing Li Shuai Chen Xue-Ling Zhao ChengChen Bin-Wei Zhang Yan-Yun Ma Wei-Heng Shi Dong-Hai Lin Shi-Gang Sun School of Energy and Materials Shanghai Engineering Research Center of Advanced Thermal Functional MaterialsShanghai Key Laboratory of Engineering Materials Application and EvaluationShanghai Polytechnic UniversityShanghai201209China State Key Laboratory of Physical Chemistry of Solid Surfaces Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China School of Chemistry and Chemical Engineering Chongqing UniversityChongqing401331China Center of Advanced Energy Technology and Electrochemistry Institute of Advanced Interdisciplinary StudiesChongqing UniversityChongqing400044China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou215123China department of Materials Science and Engineering Drexel UniversityPhiladelphiaPA19104USA

Metal-organic frameworks(MOFs)h ave attracted widespread attention due to their large surface area and porous *** designing the nanostructures of MOFs to promote their application in ethanol electrooxidation is still a ***,a novel Cu-NCNs(Cu-nitrogen-doped carbon nanotubes)support was synthesized by pyrolysis of melamine(MEL)and Cu-ZIF-8 together,and then,Pd-Au nanoalloys were loaded by sodium borohydride reduction method to prepare PdAu@Cu-NCNs *** generating mesoporous carbon with high specific surface area and favorable electron and mass transport can be used as a potential excellent carrier for PdAu *** addition,the balance of catalyst composition and surface structure was tuned by controlling the content of Pd and ***,the best-performed Pd_(2)Au_(2)@Cu-NCN-1000-2(where 1000 means the carrier calcination temperature,and 2 means the calcination constant temperature time)catalyst exhibits better long-term stability and electrochemical activity for ethanol oxidation in alkaline media(4.80 A·mg^(-1)),which is 5.05 times higher than that of commercial Pd/C(0.95 A·mg^(-1)).Therefore,this work is beneficial to further promoting the application of MOFs in direct ethanol fuel cells(DEFCs)and can be used as inspiration for the design of more efficient catalyst support structures.

关键词： Metal-organic frameworks(MOFs) N-doped Mesoporous carbon PdAu Ethanol electrooxidation

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Artificial Nucleic Acid Tractor-Directed Simultaneous Depletion of Oncogenic Membrane Proteins Without Hijacking Proteolysis-Specific Actuator

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CCS Chemistry 2024年第2期6卷 439-449页

作者： Zhen Zou Songlan Pan Qian Xue Ting Chen Ziyun huang Bei Qing Pengfei Liu Conghui Zhao Yunlin Sun Erhu Xiong Ronghua Yang Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research Ministry of EducationCollege of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081 School of Chemistry and Chemical Engineering Hunan Provincial Key Laboratory of CytochemistryChangsha University of Science and TechnologyChangsha 410114 The Second Xiangya Hospital Central South UniversityChangsha 410011

Targeted protein degradation(TPD)is an emerging tool for degrading proteins of interest,which affords an attractive modality for cancer ***,the present TPD technologies must engage a proteolysis-specific actuator to initiate degradation of targeted proteins in the proteasome or ***,we report an artificial tractor that can induce endocytosis-mediated protein depletion without hijacking a proteolysis-specific *** this design,bispecific aptamer chimeras(BSACs)are established,which can bridge human epidermal growth factor receptor 2(ErbB-2),an important biomarker in a common important biomarker in cancer,with membrane proteins of *** advantage of the property of aptamer-induced endocytosis and digestion of ErbB-2,another membrane protein is translocated into the lysosome in a hitchhike-like manner,resulting in lysosomal proteolysis along with *** strategy frees the TPD from the fundamental limitation of proteolysis-specific actuator and allows simultaneous regulation of the quantity and function of two oncogenic receptors in a cell-type-specific manner,expanding the application scope of TPD-based therapeutics.

关键词： targeted protein degradation aptamer epidermal growth factor receptor 2 lysosome membrane proteins cancer therapy

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NLRP3 activation in macrophages promotes acute intestinal injury in neonatal necrotizing enterocolitis

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World Journal of Pediatrics 2024年第2期20卷 153-164页

作者： Bo Shi Cheng-Jie Lyu Zhen-Kai Le Hao-Sen Ji Yi Xiao Yuan-Yuan Zhang Shou-Jiang huang Lin-Jun Yu Qiang Shu Jin-Fa Tou Deng-Ming Lai department of Neonatal Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China department of Pulmonology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China department of Thoracic and Cardiovascular Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China

Background Macrophages are involved in various immune inflammatory disease *** study aimed to investigate the role and mechanism of macrophages in regulating acute intestinal injury in neonatal necrotizing enterocolitis(NEC).Methods CD68,nucleotide-binding oligomerization domain,leucine-rich repeat,and pyrin domain-containing 3(NLRP3),cysteine aspartate-specific protease-1(caspase-1),and interleukin-1β(IL-1β)in paraffin sections of intestinal tissues from NEC and control patients were detected with immunohistochemistry,immunofluorescence,and western *** pet milk,hypoxia and cold stimulation were used to establish a mouse(wild type and Nlrp3^(-/-))model of *** mouse macrophage(RAW 264.7)and rat intestinal epithelial cell-6 lines were also cultured followed by various ***,intestinal epithelial cell injuries,and IL-1β release were *** Compared to the gut“healthy”patients,the intestinal lamina propria of NEC patients had high macrophage infiltration and high NLRP3,caspase-1,and IL-1β ***,in vivo,the survival rate of Nlrp3^(-/-)NEC mice was dramatically improved,the proportion of intestinal macrophages was reduced,and intestinal injury was decreased compared to those of wild-type NEC ***3,caspase-1,and IL-1β derived from macrophages or supernatant from cocultures of macrophages and intestinal epithelial cells also caused intestinal epithelial cell *** Macrophage activation may be essential for NEC ***3/caspase-1/IL-1β cellular signals derived from macrophages may be the underlying mechanism of NEC development,and all these may be therapeutic targets for developing treatments for NEC.

关键词： Caspase-1 Interleukin-1β Macrophage Necrotizing enterocolitis NLRP3

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基于神经网络优化算法的海洋动态缓波型立管设计

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海洋工程 2024年第3期42卷 83-94页

作者：黄松黄宇杰何杨烨中国石油大学(北京)安全与海洋工程学院北京102249 清华大学能源与动力工程系北京100084

柔性立管连接海上平台和水下生产系统,缓波型构型可以减轻其受到的顶部张力和疲劳损伤,触地点处系链对于固定水下立管起着重要作用,然而加装系链的缓波型立管系统设计更为复杂。通过缓波型基本理论计算出合理的立管初始状态,之后使用立... 详细信息

柔性立管连接海上平台和水下生产系统,缓波型构型可以减轻其受到的顶部张力和疲劳损伤,触地点处系链对于固定水下立管起着重要作用,然而加装系链的缓波型立管系统设计更为复杂。通过缓波型基本理论计算出合理的立管初始状态,之后使用立管分析软件OrcaFlex,在充分考虑环境因素、船体结构、立管材料和线型以及重力块、浮力块、系链等配置参数的情况下,建立缓波型立管系统有限元模型,通过静动态分析验证其满足设定的关于立管构型、张力、弯曲半径,系链张力和FPSO偏移量5个约束条件。结合神经网络优化算法和遗传算法制定出针对文中立管系统的优化算法并通过MATLAB编程将浮力块数量优化至最少,之后基于L-M算法构建神经网络模型,通过迭代训练提升精度,得到最终参数优化结果。通过对比优化前后静动态分析结果可知:优化后浮力块数量大幅减少,立管最大有效张力大幅减小,而悬挂段最低点深度有一定程度的增大,整体构型更趋向于合理的缓波型构型。

关键词：缓波型立管浮力块动态响应神经网络优化设计

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Carbon materials for enhanced photothermal conversion:Preparation and applications on steam generation

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Materials Reports(Energy) 2024年第2期4卷 34-44页

作者： Jiayi Zhu Liu huang Feng Bao Guanli Chen Kangjin Song Zheling Wang Hong Xia Jinping Gao Yibing Song Caizhen Zhu Fushen Lu Tingting Zheng Muwei Ji College of Chemistry and Chemical Engineering Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong ProvinceShantou UniversityShantou515063China School of Chemistry and Chemical Engineering Guangdong Pharmaceutical UniversityZhongshan528458China Institute of Low-Dimensional Materials Genome Initiative College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen518060China department of Pharmacy Shandong University of Traditional Chinese MedicineJinan250355China

Photothermal conversion attracted lots of attention in the past years and sorts of materials were explored to enhance photothermal *** the past years,solar-driven desalination by photothermal conversion was proposed to release the shortage of fresh water and then it was considered much more important to prepare photothermal materials on large scales with high performance and low *** this review,we summarized the works on carbon-based photothermal materials in the past years,including the preparation as well as their application in steam *** these works,we give an outlook on the difficulties and chances of how to design and prepare carbon-based photothermal materials.

关键词： Photothermal conversion Carbon Composites Solar energy Steam generation

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Atomically Precise design of PtSn Catalyst for the Understanding of the Role of Sn in Propane Dehydrogenation

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Precision Chemistry 2024年第6期2卷 245-255页

作者： Hui Ye Lina Cao Minghui Gu Han Nie Qingqing Gu Bing Yang Yunxing Bai Qinxue Nie Weixin huang Junling Lu Institute of Advanced Technology Key Laboratory of Precision and Intelligent ChemistryDepartment of Chemical PhysicsHefei National Research Center for Physical Sciences at the MicroscaleKey Laboratory of Surface and Interface Chemistry and Energy Catalysis of Anhui Higher Education InstitutesUniversity of Science and Technology of ChinaHefei 230026P.R.China CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical PhysicsThe Chinese Academy of SciencesDalian 116023P.R.China

Propane dehydrogenation(PDH),an atom-economic reaction to produce high-value-added propylene and hydrogen with high efficiency,has recently attracted extensive *** severe deactivation of Pt-based catalysts through sintering and coking remains a major challenge in this high-temperature *** introduction of Sn as a promoter has been widely applied to improve the stability and selectivity of the ***,the selectivity and stability of PtSn catalysts have been found to vary considerably with synthesis methods,and the role of Sn is still far from fully *** gain in-depth insights into this issue,we synthesized a series of PtSn/SiO_(2)and SnPt/SiO_(2)catalysts by varying the deposition sequence and Pt:Sn ratios using atomic layer deposition with precise *** found that PtSn/SiO_(2)catalysts fabricated by the deposition of SnO_(x)first and then Pt,exhibited much better propylene selectivity and stability than the SnPt/SiO_(2)catalysts synthesized the other way *** demonstrate that the presence of Sn species at the Pt-SiO_(2)interface is of essential importance for not only the stabilization of PtSn clusters against sintering under reaction conditions but also the promotion of charge transfers to Pt for high *** the above,the precise regulation of the Sn content is also pivotal for high performance,and the excess amount of Sn might generate additional acidic sites,which could decrease the propylene selectivity and lead to heavy coke *** findings provide deep insight into the design of highly selective and stable PDH catalysts.

关键词： Propane dehydrogenation PtSn catalysts sintering coke formation acidity

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压气机叶片几何气动性能优化设计方法综述

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推进技术 2024年第4期45卷 1-19页

作者：黄松王鹏汪洋冰中国航空工业集团公司金城南京机电液压工程研究中心二动力系统部江苏南京211106 中国航空工业集团公司航空机电系统综合航空科技重点实验室江苏南京211106

优化设计可有效减少对人工设计经验的依赖,改善压气机几何气动性能设计的难度,缩短压气机设计的周期。为克服压气机叶片几何气动性能优化设计中高维、耗时、黑箱三大难题,本文回顾近40年来在压气机气动外形参数化方法、数值计算技术、... 详细信息

优化设计可有效减少对人工设计经验的依赖,改善压气机几何气动性能设计的难度,缩短压气机设计的周期。为克服压气机叶片几何气动性能优化设计中高维、耗时、黑箱三大难题,本文回顾近40年来在压气机气动外形参数化方法、数值计算技术、优化算法三个方面的研究进展;总结了机器学习及数据挖掘、基于不确定性的鲁棒性优化设计理论的研究进展;指明优化设计可探索压气机几何形状最佳气动性能极限,并总结和展望了压气机叶片优化设计方法的发展方向。

关键词：压气机优化设计优化算法机器学习不确定性综述

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多级参数融合网络的驾驶场景目标检测方法研究

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机械工程学报 2024年第10期60卷 64-75页

作者：林晨何智成黄怡菲林智桂付广黄晋湖南大学整车先进设计制造技术全国重点实验室长沙410082 上汽通用五菱汽车股份有限公司技术中心柳州545007 澳门大学机电工程系中国澳门999078 清华大学车辆与运载学院北京100084

基于深度学习的目标检测方法在智能车载控制器应用时很难同时满足检测精度与速度的要求。因此,提出一种多级参数融合的驾驶场景目标检测方法,实现检测速度和精度的同步提升。首先,设计出一种多级分支结构用于构建模型,同时,为提高模型... 详细信息

基于深度学习的目标检测方法在智能车载控制器应用时很难同时满足检测精度与速度的要求。因此,提出一种多级参数融合的驾驶场景目标检测方法,实现检测速度和精度的同步提升。首先,设计出一种多级分支结构用于构建模型,同时,为提高模型的推理速度,引入一种多级参数融合的方法,即将多级结构层等效为单一的卷积-批标准化层,在保证模型泛化能力不变的条件下,大幅度减小模型的参数量。其次,为增加模型的检测精度,提出一种SSIoU(Soft scaledintersectionofunion)边界框损失计算方法以及一种联合半锚框的标签关联算法,提高模型对驾驶场景的适应能力。最后,开展基于DAIR-V2X-V数据集的试验验证,结果表明,所提出的多级参数融合模型,相比于目前先进的YOLO(You only look once)算法,检测精度(Mean average precision,mAP)提高了9.89%,推理速度(Frames per second,FPS)提高了51.89%。

关键词：智能汽车目标检测参数融合 SSIoU YOLO算法

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Multi-environment BSA-seq using large F3 populations is able to achieve reliable QTL mapping with high power and resolution: An experimental demonstration in rice

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The Crop Journal 2024年第2期12卷 549-557页

作者： Yan Zheng Ei Ei Khine Khin Mar Thi Ei Ei Nyein Likun huang Lihui Lin Xiaofang Xie Min Htay Wai Lin Khin Than Oo Myat Myat Moe San San Aye Weiren Wu College of Life Sciences Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Fujian Provincial Key Laboratory of Crop Breeding by design Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Key Laboratory of Genetics Breeding and Multiple Utilization of CropsMinistry of EducationFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina department of Botany Mawlamyine UniversityMon StateMawlamyineMyanmar department of Botany Dagon UniversityNorth DagonYangonMyanmar

Bulked-segregant analysis by deep sequencing(BSA-seq) is a widely used method for mapping QTL(quantitative trait loci) due to its simplicity, speed, cost-effectiveness, and efficiency. However, the ability of BSA-seq to detect QTL is often limited by inappropriate experimental designs, as evidenced by numerous practical studies. Most BSA-seq studies have utilized small to medium-sized populations, with F2populations being the most common choice. Nevertheless, theoretical studies have shown that using a large population with an appropriate pool size can significantly enhance the power and resolution of QTL detection in BSA-seq, with F_(3)populations offering notable advantages over F2populations. To provide an experimental demonstration, we tested the power of BSA-seq to identify QTL controlling days from sowing to heading(DTH) in a 7200-plant rice F_(3)population in two environments, with a pool size of approximately 500. Each experiment identified 34 QTL, an order of magnitude greater than reported in most BSA-seq experiments, of which 23 were detected in both experiments, with 17 of these located near41 previously reported QTL and eight cloned genes known to control DTH in rice. These results indicate that QTL mapping by BSA-seq in large F_(3)populations and multi-environment experiments can achieve high power, resolution, and reliability.

关键词： BSA-seq QTL mapping Large F3 population Multi-environment experiment Cross-validation

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Establishment of a humanized mouse model using steady-state peripheral blood-derived hematopoietic stem and progenitor cells facilitates screening of cancer-targeted T-cell repertoires

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Cancer Innovation 2024年第3期3卷 1-21页

作者： Yulin Xu Wei Shan Qian Luo Meng Zhang Dawei Huo Yijin Chen Honghu Li Yishan Ye Xiaohong Yu Yi Luo He huang Bone Marrow Transplantation Center The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Liangzhu Laboratory Zhejiang UniversityHangzhouChina Institute of Hematology Zhejiang UniversityHangzhouChina Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy HangzhouChina School of Medicine Zhejiang UniversityHangzhouChina

Background:Cancer-targeted T-cell receptor T(TCR-T)cells hold promise in treating cancers such as hematological malignancies and breast ***,approaches to obtain cancer-reactive TCR-T cells have been ***:Here,we developed a novel strategy to screen for cancer-targeted TCR-T cells using a special humanized mouse model with person-specific immune *** steady-state circulating hematopoietic stem and progenitor cells were expanded via three-dimensional culture of steady-state peripheral blood mononuclear cells,and then the expanded cells were applied to establish humanized *** human immune system was evaluated according to the kinetics of dendritic cells,monocytes,T-cell subsets,and *** fully stimulate the immune response and to obtain B-cell precursor NAML-6-and triple-negative breast cancer MDA-MB-231-targeted TCR-T cells,we used the inactivated cells above to treat humanized mice twice a day every 7 ***,human T cells were processed for TCRβ-chain(TRB)sequencing *** the repertoires had been constructed,features such as the fraction,diversity,and immune signature were ***:The results demonstrated an increase in diversity and clonality of T cells after *** preferential usage and features of TRBV,TRBJ,and the V–J combination were also *** stress also induced highly clonal Science and Technology,Grant/Award Number:2021C03010;Zhejiang Provincial Natural Science Foundation of China,Grant/Award Numbers:LTGY24H080003,LY21H080004 *** burden and survival analysis demonstrated that stress induction could significantly inhibit the growth of subsequently transfused live tumor cells and prolong the survival of the humanized ***:We constructed a personalized humanized mouse model to screen cancer-targeted TCR-T *** platform provides an effective source of cancer-targeted TCR-T cells and allows for the design of patient-specific engineered T cells.

关键词： cancer-targeted T-cell receptor T(TCR-T)cells circulating hematopoietic stem and progenitor cells(HSPCs) humanized mouse model steady-state peripheral blood T-cell receptorβ-chain(TRB) three-dimensional culture

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