检索结果-南通市图书馆

Journal of Mountain Science 2024年第9期21卷 3201-3214页

作者： fu jiangtao ZHOU Zhe GUO Hong ZHAO Jimei YU Dongmei WU Jie HU Xiasong School of Civil Engineering and Architecture Shaanxi University of TechnologyHanzhong 723000China Crop Science postdoctoral research station Qinghai UniversityXining 810016China School of Geological Engineering Qinghai UniversityXining 810016China Qinghai institute of Salt Lakes Chinese Academy of SciencesXining 810008China Department of Geographical Science Shaanxi University of TechnologyHanzhong 723000China

Gauge length influences the biomechanical properties of herbaceous roots such as tensile resistance,tensile strength and Young’s ***,the extent to which and how these biomechanical properties of herbaceous roots are influenced remain *** better understand the behavior of roots in tension under different conditions and to illustrate these behaviors,uniaxial tensile tests were conducted on the Poa araratica roots as the gauge length increased from 20 mm to 80 ***,ANOVA was used to test the impact of the significant influences of gauge length on the biomechanical properties,nonlinear regression was applied to establish the variation in the biomechanical properties with gauge length to answer the question of the extent to which the biomechanical properties are influenced,and Weibull models were subsequently introduced to illustrate how the biomechanical properties are influenced by gauge *** results reveal that(1)the variation in biomechanical properties with root diameter depends on both the gauge length and the properties themselves;(2)the gauge length significantly impacts most of the biomechanical properties;(3)the tensile resistance,tensile strength,and tensile strain at cracks decrease as the gauge length increases,with values decreasing by 20%-300%,while Young’s modulus exhibits the opposite trend,with a corresponding increase of 30%;and(4)the Weibull distribution is suitable for describing the probability distribution of these biomechanical properties;the Weibull modulus for both tensile resistance and tensile strain at cracks linearly decrease with gauge length,whereas those for tensile strength and Young’s modulus exhibit the opposite *** tensile resistance,tensile strength,and tensile strain at the cracks linearly decrease with increasing gauge length,while the tensile strength and Young’s modulus linearly increase with increasing gauge length.

关键词： Biomechanical properties of roots Weibull distribution ANOVA Uniaxial tensile test Linear regression

A combined nanotherapeutic approach targeting farnesoid X receptor,ferroptosis,and fibrosis for nonalcoholic steatohepatitis treatment

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第5期14卷 2228-2246页

作者： jiangtao fu Pingping Zhang Zhiguo Sun Guodong Lu Qi Cao Yiting Chen Wenbin Wu Jiabao Zhang Chunlin Zhuang Chunquan Sheng Jiajun Xu Ying Lu Pei Wang The Center for Basic Research and Innovation of Medicine and Pharmacy(MOE) School of PharmacyNaval Medical UniversityShanghai 200433China National Demonstration Center for Experimental Pharmaceutical Education Naval Medical University/Second Military Medical UniversityShanghai 200433China Department of Diving and Hyperbaric Medicine Naval Special Medical CenterNaval Medical UniversityShanghai 200433China

Obeticholic acid(OCA),a farnesoid X receptor(FXR)agonist with favorable effects on fatty and glucose metabolism,has been considered the leading candidate drug for nonalcoholic steatohepatitis(NASH)***,its limited effectiveness in resolving liver fibrosis and lipotoxicity-induced cell death remains a major ***,a newly recognized form of cell death characterized by uncontrolled lipid peroxidation,is involved in the progression of *** oxide(NO)is a versatile biological molecule that can degrade extracellular *** this study,we developed a PEGylated thiolated hollow mesoporous silica nanoparticles(MSN)loaded with OCA,as well as a ferroptosis inhibitor liproxsatin-1 and a NO donor S-nitrosothiol(ONL@MSN).Biochemical analyses,histology,multiplexed flow cytometry,bulk-tissue RNA sequencing,and fecal 16S ribosomal RNA sequencing were utilized to evaluate the effects of the combined nanoparticle(ONL@MSN)in a mouse NASH *** with the OCA-loaded nanoparticles(O@MSN),ONL@MSN not only protected against hepatic steatosis but also greatly ameliorated fibrosis and ***@MSN also displayed enhanced therapeutic actions on the maintenance of intrahepatic macrophages/monocytes homeostasis,inhibition of immune response/lipid peroxidation,and correction of microbiota *** findings present a promising synergistic nanotherapeutic strategy for the treatment of NASH by simultaneously targeting FXR,ferroptosis,and fibrosis.

关键词： Nonalcoholic steatohepatitis Nanotherapy Farnesoid X receptor Ferroptosis Fibrosis Obeticholic acid S-Nitrosothiol Liproxstatin-1

Antibiotherapy removal of an ingested fish bone with inflammation and mild abscess:a case report

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Antibiotherapy removal of an ingested fish bone with inflamm...

2019年浙江省医学会耳鼻咽喉头颈外科学学术大会

作者： Jueting Wu jiangtao fu The People’s Hospital of Lishui

Background:Although most of the foreign body,such as a fish bone can be inadvertently dislodged,severious complications range from mild inflammatory changes to abscess formation and viscus perforation can occurs for the delayed visiting time and unaware of the ingestion *** such cases,surgery treatment is inevitable.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

机场周围飞机噪声测量的影响因素分析

中国环境监测 2016年第4期32卷 126-129页

作者：符江涛厦门市环境监测中心站福建厦门361021

简要回顾了机场周围飞机噪声的测量方法、评价指标;针对测量过程中存在的问题,从测量周期、飞行架次分布、机型的代表性、环境背景噪声等几个方面考察了对测量数据的影响,对机场周围飞机噪声测量的影响因素进行了分析;论证了缩短测量周... 详细信息

简要回顾了机场周围飞机噪声的测量方法、评价指标;针对测量过程中存在的问题,从测量周期、飞行架次分布、机型的代表性、环境背景噪声等几个方面考察了对测量数据的影响,对机场周围飞机噪声测量的影响因素进行了分析;论证了缩短测量周期的可行性,当每天的飞行架次在200架左右时,以3 d取代7 d的做法较为可行;对于飞机噪声测量过程中存在的问题,提出了个人看法和建议。

关键词：机场周围飞机噪声测量影响因素

利用阈值浮动技术实现机场周围飞机噪声的自动测量

在线全文

学校读者我要写书评

暂无评论

中国环境监测 2017年第1期33卷 127-130页

作者：符江涛厦门市环境监测中心站福建厦门361021

介绍一种自动、高效测量机场周围飞机噪声的技术方法"阈值浮动技术",即噪声测量仪的运行阈值随环境背景噪声的高低而自主浮动的技术。利用该技术,当被测飞机噪声声级高于运行阈值时,噪声测量仪启动"记录、分析、录音"等程序的运行;当被... 详细信息

介绍一种自动、高效测量机场周围飞机噪声的技术方法"阈值浮动技术",即噪声测量仪的运行阈值随环境背景噪声的高低而自主浮动的技术。利用该技术,当被测飞机噪声声级高于运行阈值时,噪声测量仪启动"记录、分析、录音"等程序的运行;当被测飞机噪声声级低于运行阈值时,停止相关程序的运行。由于运行阈值是浮动的,因而实现了机场周围飞机噪声的自动、高效和准确测量。给出了实现"阈值浮动技术"的计算机算法,并列举了测量实例对该项技术加以验证,证明了该技术方法行之有效。

关键词：机场周围飞机噪声自动测量阈值浮动技术

Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2022年第9期12卷 3650-3666页

作者： Jie Tong Dongjie Li Hongbo Meng Diyang Sun Xiuting Lan Min Ni Jiawei Ma Feiyan Zeng Sijia Sun jiangtao fu Guoqiang Li Qingxin Ji Guoyan Zhang Qirui Shen Yuanyuan Wang Jiahui Zhu Yi Zhao Xujie Wang Yi Liu Shenxi Ouyang Chunquan Sheng fuming Shen Pei Wang Department of Pharmacy Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China Department of Pharmacology School of PharmacyNaval Medical University/Second Military Medical UniversityShanghai 200433China Department of General Surgery Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China Department of Pharmacy Shanghai Fourth People’s HospitalTongji University School of MedicineShanghai 200081China Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Chemical Biology Research Center School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhou 325000China Department of Medicinal Chemistry School of PharmacyNaval Medical University/Second Military Medical UniversityShanghai 200433China Institute of Nuclear Medicine Tongji University School of MedicineShanghai 200072China

Metabolic-associated fatty liver disease(MAFLD),which is previously known as non-alcoholic fatty liver disease(NAFLD),represents a major health concern worldwide with limited ***,we provide evidence that ferroptosis,a novel form of regulated cell death characterized by iron-driven lipid peroxidation,was comprehensively activated in liver tissues from MAFLD *** canonical-GPX4(cGPX4),which is the most important negative controller of ferroptosis,is downregulated at protein but not mRNA ***,a non-canonical GPX4 transcript-variant is induced(inducible-GPX4,iGPX4)in MAFLD *** high fat-fructose/sucrose diet(HFFD)and methionine/choline-deficient diet(MCD)-induced MAFLD pathologies,including hepatocellular ballooning,steatohepatitis andﬁbrosis,were attenuated and aggravated,respectively,in cGPX4-and iGPX4-knockin ***4 and iGPX4 isoforms also displayed opposing effects on oxidative stress and ferroptosis in *** of iGPX4 by siRNA alleviated lipid stress,ferroptosis and cell ***,the triggered iGPX4 interacts with cGPX4 to facilitate the transformation of cGPX4 from enzymatic-active monomer to enzymatic-inactive oligomers upon lipid stress,and thus promotes ***-immunoprecipitation and nano LC–MS/MS analyses confirmed the interaction between iGPX4 and *** results reveal a detrimental role of non-canonical GPX4 isoform in ferroptosis,and indicate selectively targeting iGPX4 may be a promising therapeutic strategy for MAFLD.

关键词： Ferroptosis GPX4 Alternative isoform Fatty liver Oligomerization Methionine/choline-deficient diet High fat-fructose/sucrose diet Protein interaction

在线全文

学校读者我要写书评

暂无评论

垂穗披碱草根系力学特性统计分析

山地学报 2020年第6期38卷 894-903页

作者：付江涛李晓康陕西理工大学土木工程与建筑学院陕西理工大学数学与计算机科学学院

垂穗披碱草作为一种适应性强、分布广泛的优良水土保持植物,广泛应用于各类山区生态恢复/修复工程。为合理评估垂穗披碱草在水土保持工程中的力学作用,本文对生长于青海省河南县的多年野生垂穗披碱草(Elymus nutans Griseb.)根系进行单... 详细信息

垂穗披碱草作为一种适应性强、分布广泛的优良水土保持植物,广泛应用于各类山区生态恢复/修复工程。为合理评估垂穗披碱草在水土保持工程中的力学作用,本文对生长于青海省河南县的多年野生垂穗披碱草(Elymus nutans Griseb.)根系进行单根拉伸试验,测定其单根根径、抗拉力、抗拉强度、拉伸率和拉伸模量等五项力学指标;通过数理统计模型(正态分布、瑞利分布、伽马分布和威布尔分布)对五项力学指标分布特性进行统计分析;采用卡方检验(χ~2检验)和柯尔莫哥洛夫-斯米洛夫检验(K-S检验)对五项指标在不同分布函数中的显著性进行了检验;对比了两种检验方法的优劣,确定各指标的最优分布函数。研究结果表明:垂穗披碱草根系力学五项指标表现出巨大的变异性,变异系数为37.01%～76.00%;四种分布函数均可定性描述根系各指标的分布特征,但不同指标在不同分布函数下表现出一定程度的差异;相较于χ~2检验,K-S检验由于其更适用于小样本数据,其检验结果更具有可信性;五项指标中,根径和拉伸率最优分布函数均为伽马分布,抗拉力和抗拉强度最优分布函数均为威布尔分布,拉伸模量最优分布函数为正态分布。该研究结果对于深入认识垂穗披碱草根系力学特性,揭示垂穗披碱草在水土保持工程中的力学机制具有重要的理论价值。

关键词：植被护坡根系力学指标分布函数

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

汉中地区农村房屋抗震性能调查分析研究

世界地震工程 2020年第3期36卷 93-99页

作者：郭光玲郭瑞付江涛陕西理工大学土木工程与建筑学院汉中723000

整理并分析汉中地区的地震背景、地震动参数和地质灾害,调查区域内地震动参数有差异的9类样本行政镇的931栋典型农村房屋,研究典型农村房屋的结构类型、抗震概念设计和建造场地等因素对房屋抗震性能的影响。结果表明:汉中地区地质构造复... 详细信息

整理并分析汉中地区的地震背景、地震动参数和地质灾害,调查区域内地震动参数有差异的9类样本行政镇的931栋典型农村房屋,研究典型农村房屋的结构类型、抗震概念设计和建造场地等因素对房屋抗震性能的影响。结果表明:汉中地区地质构造复杂,深大断裂发育,94.7%的区域为灾害易发区,存在4个地震烈度异常区;农村既有房屋结构类型有土木结构、砖木结构、砖混结构和框架结构,其中砖木结构和砖混结构是主要的抗震结构类型,框架结构是新型抗震结构类型;区域内农村房屋的建造场地条件危险性大并且抗震概念设计不足,房屋震害严重,村民的工程地质和地震地质等相关知识匮乏。该研究可为村镇房屋的防震减灾工作提供参考。

关键词：农村房屋抗震性能调查研究地震背景地震动参数

在线全文

学校读者我要写书评

暂无评论

双膜法处理印染废水及其回用的工程应用

工业水处理 2010年第1期30卷 86-89页

作者：付江涛汪荣王国强浙江欧美环境工程有限公司浙江湖州313000

采用双膜法工艺处理某印染厂印染废水并回用,结果表明,系统运行良好,对COD的去除率达到了99%以上,对浊度、色度的去除率均接近100%,反渗透对盐分的去除率在98%以上。产水水质及水量稳定,满足回用印染要求,工程投资回报率高,经济和环境... 详细信息

采用双膜法工艺处理某印染厂印染废水并回用,结果表明,系统运行良好,对COD的去除率达到了99%以上,对浊度、色度的去除率均接近100%,反渗透对盐分的去除率在98%以上。产水水质及水量稳定,满足回用印染要求,工程投资回报率高,经济和环境效益显著。

关键词：印染废水超滤反渗透跨膜压差回用