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In Situ-Constructed LixMoS2 with Highly Exposed Interface Boosting High-Loading and Long-Life Cathode for All-Solid-State Li-S Batteries

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Energy & Environmental Materials 2024年第4期7卷 163-174页

作者： Hao Li Rui Wang jiangping song Dan Liu Hongyang Gao Yimin Chao Haolin Tang A State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Department of Chemistry Chemical Engineering and Life Science Wuhan University of Technology Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory School of Chemistry University of East Anglia

As the persistent concerns regarding sluggish reaction kinetics and insufficient conductivities of sulfur cathodes in all-solid-state Li-S batteries(ASSLSBs),numerous carbon additives and solid-state electrolytes (SSEs) have been incorporated into the cathode to facilitate ion/electron pathways around ***,this has resulted in a reduced capacity and decomposition of SSEs.

关键词： all-solid-state lithium–sulfur batteries conversion/intercalation high-loading and long-life low carbon content mixed ionic/electronic conductivities

A Heterozygous Phospholamban Variant(p.R14del)Leads to Left Ventricular Involvement and Heart Failure Phenotypes in Arrhythmogenic Right Ventricular Cardiomyopathy

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Phenomics 2024年第1期4卷 13-23页

作者： Han Mo Xiumeng Hua Mengni Bao Zhe Sun Xiao Chen Mengda Xu jiangping song Shenzhen Key Laboratory of Cardiovascular Disease Fuwai Hospital Chinese Academy of Medical SciencesShenzhen 518057China State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College167A Beilishi RoadXi Cheng DistrictBeijing 100037China Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovascular Implant Materials Animal Experimental CentreFuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

This study aimed to determine the prevalence and clinical features of Arrhythmogenic Right Ventricular Cardiomyopathy(ARVC)caused by pathogenic mutations in the Phospholamban(PLN)*** study included 170 patients who had a confrmed diagnosis of ARVC and underwent PLN genetic screening using next-generation *** fndings of this study provide valuable insights into the association between PLN mutations and ARVC,which can aid in the development of more efective diagnostic and treatment strategies for ARVC *** of the patients evaluated,six had a rare pathogenic mutation in PLN with the same p.R14del *** screening revealed that heterozygous carriers of p.R14del exhibited a defnite ARVC *** clinical studies,individuals with the p.R14del mutation experienced a similar rate of malignant arrhythmia events as those with classic desmosome *** adjusting for covariates,individuals with PLN mutations had a two point one seven times greater likelihood of experiencing transplant-related risks compared to those who did not possess PLN mutations(95%CI 1.08–6.82,p=0.035).The accumulation of left ventricular fat and fbers is a pathological marker for ARVC patients with p.R14del *** a cohort of 170 Chinese ARVC patients,three point fve percent of probands had the PLN pathogenic variant(p.R14del)and all were *** data shows that PLN-related ARVC patients are at high risk for ventricular arrhythmias and heart failure,which requires clinical diferentiation from classic ***,carrying the p.R14del mutation can be an independent prognostic risk factor in ARVC patients.

关键词： Arrhythmogenic right ventricular cardiomyopathy Phospholamban Left ventricular involvement Heart failure Risk stratifcation

PBX/Knotted 1 homeobox-2(PKNOX2)is a novel regulator of myocardial fibrosis

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2231-2249页

作者： Liang Chen Haotong Li Xiaorui Liu Ningning Zhang Kui Wang Anteng Shi Hang Gao Deniz Akdis Ardan MSaguner Xinjie Xu Elena Osto Willem Van de Veen Guangyu Li Antoni Bayés-Genís Firat Duru jiangping song Xiangjie Li Shengshou Hu State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China School of Statistics and Data Science Nankai UniversityTianjinChina Department of Cardiology University Heart CenterUniversity Hospital Zurich and University of ZurichZurichSwitzerland Institute for Clinical Chemistry University Hospital Zurich and University of ZürichZurichSwitzerland Swiss Institute of Allergy and Asthma Research(SIAF) University of ZurichDavosSwitzerland Heart Institute Hospital Universitari Germans Trias i PujolBadalonaCIBERCVSpain

Much effort has been made to uncover the cellular heterogeneities of human hearts by single-nucleus RNA ***,the cardiac transcriptional regulation networks have not been systematically described because of the limitations in detecting transcription *** this study,we optimized a pipeline for isolating nuclei and conducting single-nucleus RNA sequencing targeted to detect a higher number of cell signal genes and an optimal number of transcription *** this unbiased protocol,we characterized the cellular composition of healthy human hearts and investigated the transcriptional regulation networks involved in determining the cellular identities and functions of the main cardiac cell *** in fibroblasts,a novel regulator,PKNOX2,was identified as being associated with physiological fibroblast activation in healthy *** validate the roles of these transcription factors in maintaining homeostasis,we used single-nucleus RNA-sequencing analysis of transplanted failing hearts focusing on fibroblast *** trajectory analysis suggested that PKNOX2 was abnormally decreased from fibroblast activation to pathological myofibroblast *** gain-and loss-of-function in vitro experiments demonstrated the inhibitory role of PKNOX2 in pathological fibrosis ***,fibroblast-specific overexpression and knockout of PKNOX2 in a heart failure mouse model induced by transverse aortic constriction surgery significantly improved and aggravated myocardial fibrosis,*** summary,this study established a high-quality pipeline for single-nucleus RNA-sequencing analysis of heart *** this optimized protocol,we described the transcriptional regulation networks of the main cardiac cell subtypes and identified PKNOX2 as a novel regulator in suppressing fibrosis and a potential therapeutic target for future translational studies.

关键词： NOX2 homeostasis fibrosis

Vegetable Genetic Resources in China

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Horticultural Plant Journal 2018年第2期4卷 83-88页

作者： WANG Haiping LI Xixiang song jiangping Institute of Vegetables and Flowers Chinese Academy of Agricultural Sciences/Beijing Research Station of Vegetable Crop Gene Resources and Germplasm Enhancement Ministry of Agriculture

China is recognized as an important region for plant biodiversity based on its vast and historical collection of vegetable germplasm. The aim of this review is to describe the exploration status of vegetable genetic resources in China, including their collection, preservation, evaluation, and utilization. China has established a number of national-level vegetable genetic resources preservation units, including the National Mid-term Genebank for Vegetable Germplasm Resources, the National Germplasm Repository for Vegetatively-Propagated Vegetables, and the National Germplasm Repository for Aquatic Vegetables. In 2015, at least 36 000 accessions were collected and preserved in these units. In the past decade, 44 descriptors and data standards for different species have been published, and most accessions have been evaluated for screening the germplasms for specific important traits such as morphological characteristics, disease resistance, pest resistance, and stress ***, the genetic diversity and evolution of some vegetable germplasms have been evaluated at the molecular level. Recently, more than 1 000 accessions were distributed to researchers and breeders each year by various means for vegetable research and production. However,additional wild-relative and abroad germplasms from other regions need to be collected and preserved in the units to expand genetic ***, there is a need to utilize advanced techniques to better understand the background and genetic diversity of a wide range of vegetable genetic resources. This review will provide agricultural scientists' insights into the genetic diversity in China and provide information on the distribution and potential utilization of these valuable genetic resources.

关键词： vegetable genetic resource preservation evaluation utilization

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Metal-nitrogen-doped hybrid ionic/electronic conduction triple-phase interfaces for high-performance all-solid-state lithium-sulfur batteries

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Nano Research 2023年第8期16卷 10956-10965页

作者： Hao Li jiangping song Fanglin Wu Rui Wang Dan Liu Haolin Tang A State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Department of Chemistry School of ChemistryChemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070China

The point-to-point contact mechanism in all-solid-state Li-S batteries(ASSLSBs)is not as efficient as a liquid electrolyte which has superior mobility in the electrode,resulting in a slower reaction kinetics and inadequate ionic/electronic conduction network between the S(or Li_(2)S),conductive carbon,and solid-state electrolytes(SSEs)for achieving a swift(dis)charge ***,a series of hybrid ionic/electronic conduction triple-phase interfaces with transition metal and nitrogen co-doping were *** graphitic ordered mesoporous carbon frameworks(TM-N-OMCs;TM=Fe,Co,Ni,and Cu)serve as hosts for Li_(2)S and Li_(6)PS_(5)Cl(LPSC)and provide abundant reaction sites on the triple *** from both experimental and computational research display that the combination of Cu-N co-dopants can promote the Li-ion diffusion for rapid transformation of Li_(2)S with adequate ionic(6.73×10^(−4)S·cm^(−1))/electronic conductivities(1.77×10^(−2)S·cm^(−1))at 25℃.The as-acquired Li_(2)S/Cu-N-OMC/LPSC electrode exhibits a high reversible capacity(1147.7 mAh·g^(−1))at 0.1 C,excellent capacity retention(99.5%)after 500 cycles at 0.5 C,and high areal capacity(7.08 mAh·cm^(−2)).

关键词： all-solid-state lithium-sulfur batteries triple-phase interfaces ordered mesoporous carbons mixed ion/electron conductivities Li_(6)PS_(5)Cl solid electrolyte

Phenotypes of Cardiovascular Diseases:Current Status and Future Perspectives

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Phenomics 2021年第5期1卷 229-241页

作者： Hang Zhang Xiumeng Hua jiangping song The Cardiomyopathy Research Group State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College167A Beilishi RoadXi Cheng DistrictBeijing 100037China

Cardiovascular diseases(CVDs)are a large group of diseases and have become the leading cause of morbidity and mortality *** considerable progresses have been made in the diagnosis,treatment and prognosis of CVD,commu-nication barriers between clinicians and researchers still exist because the phenotypes of CVD are complex and diverse in clinical practice and lack of ***,it is particularly important to establish a standardized and unified terminology to describe *** recent years,there have been several studies,such as the Human Phenotype Ontology,attempting to provide a standardized description of the disease *** the present article,we outline recent advances in the classification of the major types of CVD to retrospectively review the current progresses of phenotypic studies in the cardiovascular field and provide a reference for future cardiovascular research.

关键词： Cardiovascular disease Phenotype Classification Therapy

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基于SSR标记的百合资源遗传背景分析

生物工程学报 2024年第4期40卷 1211-1224页

作者：韩嘉琪王海平宋江萍贾会霞张晓辉李森徐楚李芝洁阳文龙山西农业大学园艺学院山西晋中030801 中国农业科学院蔬菜花卉研究所蔬菜生物育种全国重点实验室北京100081

为研究百合(Lilium spp.)种质资源的遗传背景,精准评价和筛选优异种质用于百合的遗传改良,本研究采用简单序列重复(simple sequence repeat,SSR)分子标记技术对来自我国11个省份的62份百合种质资源进行了遗传背景分析。结果表明,83对百... 详细信息

为研究百合(Lilium spp.)种质资源的遗传背景,精准评价和筛选优异种质用于百合的遗传改良,本研究采用简单序列重复(simple sequence repeat,SSR)分子标记技术对来自我国11个省份的62份百合种质资源进行了遗传背景分析。结果表明,83对百合SSR引物中有15对引物具有多态性,共扩增出157个等位基因位点,每个位点的等位基因数为5−19个,平均每个位点有效等位基因数(number of effective alleles,Ne)为4.1628,平均观测杂合度(observed heterozygosity,Ho)和平均期望杂合度(expected heterozygosity,He)分别为0.2282和0.6941,平均多态性信息含量(polymorphism information content,PIC)为0.6788,平均Nei’s多样性指数(Nei’s diversity index,H)和平均Shannon信息指数(Shannon’s information index,I)分别为0.6941和1.5949,说明供试百合种质遗传多样性丰富。利用非加权配对算术平均法(unweighted pair group method with arithmetic mean,UPGMA)进行聚类分析,可将62份种质分为5大类,主成分分析将材料分为3个类群,结合两种分析发现各类群存在一定地理相关性,绝大数来源相同的百合种质可聚为一类。群体结构分析将百合群体划分为4个类群和1个混合类群。上述研究结果为百合种质资源的精准鉴定和育种利用提供了一定的理论依据和基因资源。

关键词：百合种质资源遗传背景简单序列重复(SSR)

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On-site conversion reaction enables ion-conducting surface on red phosphorus/carbon anode for durable and fast sodium-ion batteries

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Journal of Energy Chemistry 2023年第5期80卷 381-391,I0009页

作者： jiangping song Xin Peng Dan Liu Hao Li Mengjun Wu Kan Fang Xinxin Zhu Xinyuan Xiang Haolin Tang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070HubeiChina Department of Chemistry School of ChemistryChemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070HubeiChina Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Xianhu Hydrogen ValleyFoshan 528200.GuangdongChina

The practical applications of high-capacity alloy-type anode materials in sodium-ion batteries(SIBs)are challenged by their vast volume effects and resulting unstable electrode-electrolyte interphases during discharge-charge *** red phosphorus(P)/carbon anode material as an example,we report an on-site conversion reaction to intentionally eliminate the volume effect-dominated surface P and yield an ionically conducting layer of Na3PS4solid-state electrolyte on the *** a surface reconstruction can significantly suppress the electrode swelling and simultaneously enable the activation energy of interfacial Na+transfer as low as 36.7 k J mol^(-1),resulting in excellent electrode stability and ultrafast reaction ***,excellent cycling performance(510 mA h g^(-1)at 5 A g^(-1)after 1000 cycles with a tiny capacity fading rate of 0.016%per cycle)and outstanding rate capability(484 mA h g^(-1)at 10 A g^(-1)are achieved in half *** coupled with Na_(3)V_(2)(PO4)3cathode,the full cells exhibit 100%capacity retention over 200 cycles at 5C with an average Coulombic efficiency of 99.93%and a high energy density of 125.5 W h kg^(-1)at a power density of 8215.6 W kg^(-1)(charge or discharge within~49 s).Remarkably,the full cell can steadily operate at a high areal capacity of 1.9 mA h cm^(-2),the highest level among red P-based full SIBs ever reported.

关键词： Sodium-ion batteries Red phosphorus P_(4)S_(n) Na_(3)PS_(4) Solid electrolyte interphase

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A case of big substernal goiter resection

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Frontiers of Medicine 2008年第4期2卷 410-413页

作者： jiangping song Hongying LIAO Chao YU Jian ZHANG Yun LI Lijia GU Department of Cardiothoracic Surgery the Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 521000China

Substernal goiter is considered to be a dia-gnostic differential for all anterosuperior mediastinal *** a substernal goiter,surgical removal is sug-gested when it is large in size,with a possibility for malig-nancy or has local compression of adjacent *** can be performed through the neck or by the addition of a partial or complete sternotomy if necessary.A 58-year-old Chinese man from Guangdong Province had had dry cough for a year.A subsequent CT scan in our hospital suggested‘‘ectopic intrathoracic thyroid’’.Fine needle percutaneous mass biopsy also suggested‘‘ectopic intrathoracic thyroid’’.We performed a standard median sternotomy to remove the *** measured 13 cm 68 cm 66 cm in size,and weighed 2.8 *** patho-logical diagnosis confirmed a benign thyroid *** patient had no hoarseness,dyspnea or hypocalcemia and was quickly extubated in the operating ***,we encountered a big substernal goiter and had performed successful resection,which is reported here for reference.

关键词： goiter substernal resection