检索结果-南通市图书馆

Frontiers of Medicine 2016年第2期10卷 204-211页

作者： jiangnan liu Bin Yi Zhe Zhang Yi Cao Laboratory of Molecular and Experimental Pathology Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China Kunming College of Life Science University of Chinese Academy of Sciences Kunming 650223 China

CD176 （Thomsen-Friedenreich antigen） is a tumor-associated carbohydrate epitope （glycotope） functionally involved in blood spread and fiver metastasis of cancer cells by mediating the adhesion of cancer cells to endothelial cells and hepatocytes, respectively. CD176 could be a promising target for antitumor immunotherapy. We applied B lymphocytes obtained from mice immunized with CD176 antigen and constructed a phage display library. A positive clone of CD176 single-chain variable antibody fragment （scFv） was successfully screened from this library. The CD176 scFv was expressed in Escherichia coli and purified. The purified scFv can bind to the natural CD176 expressed on the surface of cancer cells. Furthermore, the CD176 scFv inhibits the adhesion of CD176＋ cancer cells to endothelial cells and hepatocytes. This CD176 scFv provides a basis for future development of recombinant CD176-specific antibodies that can be used in therapeutic application.

关键词： CD 176 Thomsen-Friedenreich antigen scFv cancer therapy adhesion metastasis

Evidence fusion theory in healthcare

在线全文

学校读者我要写书评

暂无评论

Journal of Management Analytics 2018年第4期5卷 276-286页

作者： jiangnan liu Nan Kang Yi Man Alliance Manchester Business School The University of ManchesterManchesterUK Antai College of Economics and Management Shanghai Jiaotong UniversityShanghaiPeople’s Republic of China

In the context of popularized healthcare,cloud computing centers are used to collect medical data from the cloud and diagnose *** means a technical framework that can be applied to the medical diagnostic process in popularized healthcare is needed in order to provide technical *** on the evidence fusion theory,this study established a multi-modality image evidence fusion method,which can simulate the doctor’s diagnostic process and use multiple modalities of medical images to diagnose *** study used the evidence fusion method to fuse two different modalities of medical *** accuracy of the diagnosis after fusion was higher than that of diagnosis through two modalities *** fusion method has achieved great results in the process of multi-modality image fusion.

关键词： popularized healthcare artificial intelligence evidence reasoning brain tumor detection

PHASE-FIELD SIMULATION FOR MICROSTRUCTURAL DEVELOPMENT OF TEXTURED CERAMICS PREPARED BY REACTION TEMPLATED GRAIN GROWTH

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Advanced Dielectrics 2012年第1期2卷 98-106页

作者： LIANGLIANG liu FENG GAO GUOXIN HU jiangnan liu State Key Laboratory of Solidification Processing College of Material Science and Engineering Northwestern Polytechnical University Xi'an 710072 P.R.China Xi'an Polytechnic University Xi'an 710048 China

A modified model using phase-field method in order to describe the microstructural development for the reaction templated grain growth process was *** current model well expressed anisotropic enlargement of the template *** initial parameters such as the matrix particles size,the template particles size,fraction,aspect ratio of the template particles and porosity were *** simulation results show that the fraction of oriented grains increases with decreasing the matrix particles size and porosity,and increasing the fraction of the initial template *** increase for the aspect ratio of template particles gives rise to the anisotropic microstructure *** study suggests that the simulation results would give a guiding principle in terms of the initial preparation conditions for the textured ceramics having both a large fraction of oriented grains and anisotropic microstructure.

关键词： Phase-field simulation templated grain growth anisotropic functional ceramics

InGaN micro-light-emitting diodes monolithically grown on Si:achieving ultra-stable operation through polarization and strain engineering

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2022年第10期11卷 2540-2548页

作者： Yuanpeng Wu Yixin Xiao Ishtiaque Navid Kai Sun Yakshita Malhotra Ping Wang Ding Wang Yuanxiang Xu Ayush Pandey Maddaka Reddeppa Walter Shin jiangnan liu Jungwook Min Zetian Mi Department of Electrical Engineering and Computer Science University of MichiganAnn ArborMI 48109USA Department of Materials Science and Engineering University of MichiganAnn ArborMI 48109USA

Micro or submicron scale light-emitting diodes(μLEDs)have been extensively studied recently as the next-generation display *** is desired that μLEDs exhibit high stability and efficiency,submicron pixel size,and potential monolithic integration with Si-based complementary metal-oxide-semiconductor(CMOS)*** such uLEDs,however,has remained a daunting *** polar nature of Ill-nitrides causes severe wavelength/color instability with varying carrier concentrations in the active *** etching-induced surface damages and poor material quality of high indium composition InGaN quantum wells(QWs)severely deteriorate the performance of uLEDs,particularly those emitting in the green/red *** we report,for the first time,μLEDs grown directly on Si with submicron lateral *** μLEDs feature ultra-stable,bright green emission with negligible quantum-confined Stark effect(QCSE).Detailed elemental mapping and numerical calculations show that the QCSE is screened by introducing polarization doping in the active region,which consists of InGaN/AlGaN QWs surrounded by an AlGaN/GaN shell with a negative Al composition gradient along the *** comparison with conventional GaN barriers,AlGaN barriers are shown to effectively compensate for the tensile strain within the active region,which significantly reduces the strain distribution and results in enhanced indium incorporation without compromising the material *** study provides new insights and a viable path for the design,fabrication,and integration of high-performance μLEDs on Si for a broad range of applications in on-chip optical communication and emerging augmented reality/mixed reality devices,and so on.

关键词： polarization diodes strain

Nicotine gum or patch treatment for smoking cessation and smoking reduction： a multi-centre study in Chinese physicians

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Medicine 2014年第1期8卷 84-90页

作者： Dan Xiao Nanshan Zhong Chunxue Bai Qingyu Xiu Canmao Xie Dayi Hu Yun Mao Roland Perfekt Elisabeth Kruse Qing Li John jiangnan liu Chen Wang Beijing Chao-Yang Hospital Capital Medical University WHO Collaborating Center for Tobacco or Health Beijing 100020 China Beijing Institute of Respiratory Medicine Beij'ing 100020 China Department of Respiratory Capital Medical University Beijing 100069 China Guangzhou Institute of Respiratory Disease 1st Affiliated Hospital Guangzhou Medical College Guangzhou 520120 China Zhongshan Hospital Fudan University Shanghai 200032 China Changzheng Hospital 2nd Military Medical University Shanghai 200003 China 1st Affiliated Hospital Sun Yat-sen University Guangzhou 510080 China people's Hospital Peking University Beijing 100044 China Shanghai Johnson & Johnson Pharmaceuticals Shanghai 200245 China McNeil AB Helsingborg Sweden Johnson & Johnson New Jersey USA Research Centre of Respiratory Medicine in Beijing Hospital Ministry of Health of the People 1's Republic of China Beijing 100730 China

In China, around 23% of physicians （41% male, 3% female） currently smoke. Pharmacotherapy for tobacco dependence is available, but is not widely used in China. The purpose of this study was to estimate the effectiveness and the safety on smoking cessation of nicotine gum and nicotine patch in Chinese healthcare professionals. Three hundred regular smokers motivated to quit were recruited from six hospitals in China. All subjects were accepted nicotine replacement therapy, and they could choose nicotine gum （2 mg or 4 mg, depending on baseline smoking level） or nicotine patch （15 mg/16 h） for 12 weeks, with a 12-week follow-up. Limited behavioural support was provided. At Week 24, the 2-24 weeks continuous abstinence rate （verified by expired carbon monoxide） was 17%, the point prevalence abstinence rate （no smoking since the previous visit） was 35%, and 38% of subjects had continuously reduced their daily cigarette consumption by at least 50% versus baseline. Compliance with treatment was good, particularly with patch. No serious adverse event was reported, and most adverse events were mild or moderate. The most common treatment-related adverse events were gastro- intestinal （both gum and patch） and local irritation symptoms. Nicotine patch and gum were well tolerated in Chinese smokers. Abstinence rates were comparable to those previously reported with nicotine replacement therapy, and many smokers who did not quit substantially reduced their cigarette consumption.

关键词： nicotine replacement therapy smoking cessation Chinese physicians

在线全文

学校读者我要写书评

暂无评论

基于约束函数的变胞机构变胞方程

机械工程学报 2012年第9期48卷 1-9页

作者：刘江南于德介湖南大学汽车车身先进设计制造国家重点实验室长沙410082

变胞机构拥有多个变换的稳态和变胞态,其拓扑构态描述与分析是变胞机构结构学的难点。采用数学分析方法,探索全面、简便而准确地描述和分析变胞机构构态拓扑结构的问题。根据运动副约束的特征,定义反映运动副类型、级别、自由度、方位... 详细信息

变胞机构拥有多个变换的稳态和变胞态,其拓扑构态描述与分析是变胞机构结构学的难点。采用数学分析方法,探索全面、简便而准确地描述和分析变胞机构构态拓扑结构的问题。根据运动副约束的特征,定义反映运动副类型、级别、自由度、方位、性质及其随时间变化情况等诸多特征信息的参数——运动副约束函数,采用矩阵法构建以约束函数为元素的机构变胞源运动链邻接矩阵。针对合并构件、分离构件、改变构件性质、新增运动副、消除运动副及改变运动副性质等六类机构变胞方式,分别定义相应的机构变胞函数和变胞矩阵,建立相邻稳态之间变胞态的机构变胞方程。应用实例表明,所定义的运动副约束函数、运动链邻接矩阵、变胞矩阵和变胞函数等概念能简便、广泛地描述变胞机构的构态特征,基于约束函数的机构变胞方程能准确地描述和分析机构相邻稳态之间变胞态的变换过程,为变胞机构的结构分析提供一种新的途径和方法,并为进一步的变胞机构运动学和动力学分析以及机构综合研究提供理论基础。

关键词：变胞机构约束函数变胞方程变胞函数变胞矩阵

基于转化邻接矩阵的含复铰运动链描述与同构识别

在线全文

学校读者我要写书评

暂无评论

机械工程学报 2012年第5期48卷 15-21页

作者：刘江南于德介湖南大学汽车车身先进设计制造国家重点实验室长沙410082

针对机构分析与综合中复合铰链难以处理和含复铰运动链同构识别困难的问题,分析复合铰链的内部结构,提出引入Pin构件将复合铰链转化为多个并联单铰链的新方法,从而将含复铰运动链转化为只含单铰的简单运动链。定义运动链转换邻接矩阵,... 详细信息

针对机构分析与综合中复合铰链难以处理和含复铰运动链同构识别困难的问题,分析复合铰链的内部结构,提出引入Pin构件将复合铰链转化为多个并联单铰链的新方法,从而将含复铰运动链转化为只含单铰的简单运动链。定义运动链转换邻接矩阵,用于描述含复铰运动链,通过分析发现该矩阵的内涵性质丰富,方便运动链的分析。提出运用转换邻接矩阵的阶数、对角线元素矢量、矩阵特征值和特征矢量等参数识别判断含复铰运动链同构关系的方法,这些特征参数是含复铰运动链的不变量。实例证明,利用转化邻接矩阵可简单、方便、直观地描述含复铰运动链,其特征值和特征矢量用于识别含复铰运动链的同构关系,具有准确、高效和简便的特点。定义的转化邻接矩阵及其运用方法为复合铰链的处理以及含复铰运动链的识别提供了新的途径。

关键词：复合铰链转化邻接矩阵运动链同构识别

在线全文

学校读者我要写书评

暂无评论

领域特色创新方法优选决策模型

湖南大学学报（自然科学版） 2023年第4期50卷 105-113页

作者：刘江南杜文轩湖南大学汽车车身先进设计制造国家重点实验室湖南长沙410082

面向领域特色创新方法的推广应用,为了解决对众多创新方法进行优选时的决策困难,通过分析和评价不同方法对实际应用情境的适应度,提出一种领域特色创新方法优选决策模型.以轨道交通装备领域为例,通过企业实际应用情境分析,建立了包含产... 详细信息

面向领域特色创新方法的推广应用,为了解决对众多创新方法进行优选时的决策困难,通过分析和评价不同方法对实际应用情境的适应度,提出一种领域特色创新方法优选决策模型.以轨道交通装备领域为例,通过企业实际应用情境分析,建立了包含产品类型、创新对象、创新链环节、创新类别和创新程序的五维应用情境空间;根据空间维度及其层次关系,构建了应用情境适用度评价指标体系,同时为了减少人为评价的主观影响,提出模糊层次分析法和熵值法相结合的组合赋权法;结合逼近理想值排序法,建立多种领域特色创新方法的FE-T优选决策模型.通过模型求解各方法的总适用度分值,基于规则排序确定多方法优选序列.将该决策模型用于指导某企业转向架创新项目中的方法选择,得到了适用于该项目应用情境的领域特色创新方法优选序列,为领域特色创新方法的优选提供参考.

关键词：领域知识优选决策创新方法模糊层次分析法熵值法逼近理想值排序法

维普期刊数据库博看期刊

在线全文

学校读者我要写书评

暂无评论

变拓扑机构可变运动副设计目录研究

湖南大学学报（自然科学版） 2017年第10期44卷 33-40页

作者：刘江南张文博湖南大学汽车车身先进设计制造国家重点实验室湖南长沙410082

可变运动副作为变拓扑机构改变拓扑结构的关键所在,其结构设计是变拓扑机构构型综合的难点.基于可变运动副拓扑变化方式的研究,构建可变运动副设计目录,用于可变运动副的结构设计.分别针对可变运动副的改变轴线方位、改变数目和改变类... 详细信息

可变运动副作为变拓扑机构改变拓扑结构的关键所在,其结构设计是变拓扑机构构型综合的难点.基于可变运动副拓扑变化方式的研究,构建可变运动副设计目录,用于可变运动副的结构设计.分别针对可变运动副的改变轴线方位、改变数目和改变类型等三类拓扑变化过程,分析可变运动副的约束变化特征,并采用运动副约束函数的算术运算进行描述.在归纳设计可变运动副结构形式的基础上,对可变运动副拓扑变化方式、约束变化特征和对应结构等设计信息进行分类和汇编,构建可变运动副设计目录.应用实例表明,采用可变运动副设计目录,能快速有效地设计可变运动副结构,为含可变运动副的变拓扑机构构型综合提供了方便.

关键词：变拓扑机构运动副约束变化特征设计目录

Nicotine gum or patch treatment for smoking cessation and smoking reduction:a multi-centre study in Chinese physicians

在线全文

学校读者我要写书评

暂无评论

Nicotine gum or patch treatment for smoking cessation and sm...