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热轧变形对纯钴显微组织和力学性能的影响

中国有色金属学报 2024年第6期34卷 2019-2029页

作者：徐仰涛魏江龙南宏强兰州理工大学省部共建有色金属先进加工与再利用国家重点实验室兰州730050 兰州理工大学材料科学与工程学院兰州730050 金川集团股份有限公司镍钴资源综合利用国家重点实验室金昌737100

为研究不同热轧变形量对纯钴的显微组织和力学性能的影响,对高纯钴(99.95%)进行500℃下的热轧处理,将试样水冷后进行XRD、EBSD表征。结果表明:初始态试样中HCP相、FCC相两相共存,且以HCP相为主;随轧制进行,最大晶粒尺寸从28.08μm细化到... 详细信息

为研究不同热轧变形量对纯钴的显微组织和力学性能的影响,对高纯钴(99.95%)进行500℃下的热轧处理,将试样水冷后进行XRD、EBSD表征。结果表明:初始态试样中HCP相、FCC相两相共存,且以HCP相为主;随轧制进行,最大晶粒尺寸从28.08μm细化到12.35μm,∑3退火孪晶和相变孪晶的含量降低,残余应变增加,两相含量发生改变,FCC相含量上升,HCP相含量降低;不同相中大小角度晶界呈现相同的变化趋势,小角度晶界(LAGB)含量上升,大角度晶界(HAGB)含量降低;压下量27%的试样性能最好,其屈服强度、抗拉强度、硬度和伸长率(657.18 MPa、964.05 MPa、298.2HV_(0.5)和42.87%)相较于初始态(408.34 MPa、862.53 MPa、214.4HV_(0.5)和38.07%)均有提升;塑性随强度的增加不降反升,主要是由FCC相含量上升、大尺寸片层状HCP相晶粒发生细化和均匀化所致。

关键词：纯钴热轧显微组织力学性能

氧化锌/儿茶酚甲醛树脂微球抗菌粘胶纤维的制备及其性能

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纺织学报 2024年第2期45卷 21-27页

作者：史玉磊曲连艺刘江龙徐英俊青岛大学功能纺织品与先进材料研究院山东青岛266071 青岛大学纺织服装学院山东青岛266071

为制备高效抗菌和力学性能优良的粘胶纤维,由一步水热反应制备氧化锌/儿茶酚甲醛树脂(ZnO/CFR)微球,将之以不同比例与粘胶纺丝液共混,通过湿法纺丝制得一系列抗菌粘胶纤维。借助扫描电子显微镜、透射电子显微镜、X射线光电子能谱仪、多... 详细信息

为制备高效抗菌和力学性能优良的粘胶纤维,由一步水热反应制备氧化锌/儿茶酚甲醛树脂(ZnO/CFR)微球,将之以不同比例与粘胶纺丝液共混,通过湿法纺丝制得一系列抗菌粘胶纤维。借助扫描电子显微镜、透射电子显微镜、X射线光电子能谱仪、多重光散射仪等研究了ZnO/CFR微球的微观形貌、化学组成及其在粘胶纺丝液中的分散性和稳定性,分析了粘胶纤维的颜色、形态、抗菌性能及力学性能等。结果表明:ZnO/CFR微球形状规则,粒径为0.9~2.5μm,微球内随机分布有若干纳米ZnO,可在粘胶纺丝液中分散均匀,长期保持稳定,纺丝过程中无明显损失;所得抗菌粘胶纤维呈棕黑色,锌含量达0.85~2.08 mg/g,对大肠杆菌和金黄色葡萄球菌具有高效的非溶出型广谱抗菌作用,抑菌率达99.9%以上,且力学性能保持优良。

关键词：氧化锌抗菌性能粘胶纤维儿茶酚微球水热反应

Omics-based integrated analysis identified ATRX as a biomarker associated with glioma diagnosis and prognosis

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Cancer Biology & Medicine 2019年第4期16卷 784-796页

作者： Yingbin Xie Yanli Tan Chao Yang xuehao Zhang Can xu Xiaoxia Qiao jianglong xu Shaohui Tian Chuan Fang Chunsheng Kang Department of Neurosurgery Affiliated Hospital of Hebei UniversityBaoding 071000China Department of Neurosurgery Hebei University Medical CollegeBaoding 071000China Department of Pathology Hebei University Medical CollegeBaoding 071000China Department of Pathology Affiliated Hospital of Hebei UniversityBaoding 071000China Lab of Neuro-oncology Tianjin Neurological InstituteKey Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous SystemTianjin Medical University General HospitalTianji n 300052China Department of Oncology Affiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhou 510095China

Objective:ATRX is a multifunctional protein that is tightly regulated by and implicated in transcriptional regulation and chromatin remodeling.Numerous studies have shown that genetic alterations in ATRX play a significant role in gliomas.This study aims to further determine the relationship between ATRX and glioma prognosis and identify possible mechanisms for exploring the biological significance of ATRX using large data sets.Methods:We used The Cancer Genome Atlas(TCGA)database and 130 immunohistochemical results to confirm the difference in ATRX mutations in high-and low-grade gliomas.An online analysis of the TCGA glioma datasets using the cBioPortal platform was performed to study the relationship between ATRX mutations and IDH1,TP53,CDKN2 A and CDKN2 B mutations in the corresponding TCGA glioma dataset.In combination with clinical pathology data,the biological significance of the relationships were analyzed.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analyses and annotations of all adjacent genes in the network were performedin the Database for Annotation,Visualization and Integrated Discovery(DAVID)and R language.A protein-protein interaction(PPI)network was constructed,and the interactions of all adjacent nodes were analyzed by the String database and using Cytoscape software.Results:In the selected TCGA glioma datasets,a total of 2,228 patients were queried,21%of whom had ATRX alterations,which co-occurred frequently with TP53 and IDH1 mutations.ATRX alterations are associated with multiple critical molecular events,which results in a significantly improved overall survival(OS)rate.In low-grade gliomas,ATRX mutations are significantly associated with multiple important molecular events,such as ZNF274 and FDXR at mRNA and protein levels.A functional cluster analysis revealed that these genes played a role in chromatin binding and P53,and a link was observed between ATRX and IDH1 and TP53 in the interaction network.ATRX and TP53 are important nodes in the network and have pot

关键词： ATRX mutation copy number variation glioma biomarkers

IDH 野生型胶质母细胞瘤的组织病理特征及分子病理特征分析

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神经疾病与精神卫生 2024年第5期24卷 328-333页

作者：刘国鸣肖梦麟徐灿徐江龙田少辉方川河北大学附属医院神经外科河北大学临床医学院保定071000 河北省脑胶质瘤精准诊断与治疗重点实验室保定071000

目的研究异柠檬酸脱氢酶(IDH)野生型胶质母细胞瘤(GBM)的组织病理及分子病理特征。方法选取2021年9月—2023年8月于河北大学附属医院神经外科接受手术治疗的74例GBM患者为研究对象,采用苏木精-伊红染色观察组织病理学特点;采用免疫组织... 详细信息

目的研究异柠檬酸脱氢酶(IDH)野生型胶质母细胞瘤(GBM)的组织病理及分子病理特征。方法选取2021年9月—2023年8月于河北大学附属医院神经外科接受手术治疗的74例GBM患者为研究对象,采用苏木精-伊红染色观察组织病理学特点;采用免疫组织化学染色及二代测序方法研究分子病理学特征;采用Kaplan-Meier法绘制生存分析曲线,分析患者生存期与IDH1突变之间的关系。结果74例GBM患者中男性占60.81%(45/74),患者年龄为(55.23±4.58)岁。58例为额叶肿瘤,16例为颞叶肿瘤。苏木精-伊红染色组织形态学结果显示,82.43%(61/74)的肿瘤组织可见典型的栅栏状坏死、血管增生、肿瘤异型性显著,符合典型GBM组织形态特点,其余肿瘤组织形态学符合2级或3级星形细胞瘤的形态特征。免疫组织化学染色结果显示,所有肿瘤IDH1 R132H染色均为阴性,Ki-67染色示平均阳性率为38%。二代测序分子病理结果显示,所有组织IDH1/2均为阴性,表皮生长因子受体(EGFR)扩增阳性占74.32%(55/74),端粒酶逆转录酶(TERT)启动子区域突变占59.46%(44/74)。细胞周期素依赖性激酶抑制因子2A/B(CDKN2A/B)发生纯合性缺失的比例为33.78%(25/74)。O6-甲基鸟嘌呤-DNA甲基转移酶(MGMT)启动子区甲基化水平高表达占47.30%(35/74)。结论GBM具有IDH野生型的分子特征,部分病例伴有EGFR扩增、TERT启动子区突变、CDKN2A/B纯和缺失、MGMT启动子区高甲基化的分子改变。

关键词：胶质母细胞瘤病理学 IDH野生型组织病理学分子病理学

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西番莲种质资源花粉活力鉴定方法探究

福建农业学报 2024年第3期39卷 302-309页

作者：项艳艳黄伟杰赖江龙汤礼梅林挺兴李亮魏秀清许家辉福建农林大学园艺学院福建福州350002 福建省农业科学院果树研究所福建福州350013 宁德市蕉城区柑橘无检疫性病虫母本园种苗繁育场福建宁德352000

【目的】明确西番莲属植物花粉最佳离体培养基、离体培养最适观测时间、花粉的最适染色法和花粉贮藏条件,快速精准鉴定西番莲属种质资源的花粉活力,为其种质资源利用与新品种选育提供科学依据。【方法】以6份西番莲属种质资源的花粉为... 详细信息

【目的】明确西番莲属植物花粉最佳离体培养基、离体培养最适观测时间、花粉的最适染色法和花粉贮藏条件,快速精准鉴定西番莲属种质资源的花粉活力,为其种质资源利用与新品种选育提供科学依据。【方法】以6份西番莲属种质资源的花粉为试验材料,设计正交试验,探究不同浓度的蔗糖、H3BO3、Ca(NO3)2和聚乙二醇-4000(PEG-4000)对花粉离体萌发率的影响;利用最佳花粉离体培养基,筛选花粉离体培养最适观测时间;采用I2-KI染色法、TTC染色法与亚历山大染色法,探究最适的西番莲花粉染色法;通过不同贮藏温度与时间处理,筛选花粉的最佳贮藏条件。【结果】正交试验筛选出最佳培养基配方为100 g·L^(-1)蔗糖+0.04 g·L^(-1)H3BO3+0.01 g·L^(-1)Ca(NO3)2+150 g·L^(-1)PEG-4000+200 mg·L^(-1)MgSO_(4)·7H2O+100 mg·L^(-1)KNO3,pH值5.5;花粉离体培养1 h为最适观测时间;TTC染色法染色效果好且结果与离体萌发率无显著差异,可有效检测西番莲花粉活力;花粉贮藏24 h以内,25℃与4℃的贮藏温度下花粉活力分别为30.48%、26.69%,花粉贮藏时间在1~7 d,4℃下花粉活力仍保持在26.54%~27.05%。【结论】筛选出西番莲属植物花粉离体萌发的最佳培养基组合、离体培养最适观测时间、花粉最适染色法与花粉贮藏最佳条件,为西番莲属植物花粉活力的快速筛选和品种改良提供理论依据。

关键词：西番莲花粉活力花粉培养基花粉离体萌发染色法花粉贮藏

First-principles calculations of Ni–(Co)–Mn–Cu–Ti all-d-metal Heusler alloy on martensitic transformation,mechanical and magnetic properties

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International Journal of Minerals,Metallurgy and Materials 2023年第5期30卷 930-938页

作者： Huaxin Qi Jing Bai Miao Jin Jiaxin xu Xin Liu Ziqi Guan jianglong Gu Daoyong Cong Xiang Zhao Liang Zuo Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Material Science and EngineeringNortheastern UniversityShenyang 110819China Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province School of Resources and MaterialsNortheastern University at QinhuangdaoQinhuangdao 066004China State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004China Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing 100083China

The martensitic transformation,mechanical,and magnetic properties of the Ni_(2)Mn_(1.5-x)Cu_(x)Ti_(0.5) (x=0.125,0.25,0.375,0.5) and Ni_(2-y)Co_(y)Mn_(1.5-x)Cu_(x)Ti_(0.5)[(x=0.125,y=0.125,0.25,0.375,0.5) and (x=0.125,0.25,0.375,y=0.625)]alloys were systematically studied by the first-principles calculations.For the formation energy,the martensite is smaller than the austenite,the Ni–(Co)–Mn–Cu–Ti alloys studied in this work can undergo martensitic transformation.The austenite and non-modulated (NM) martensite always present antiferromagnetic state in the Ni_(2)Mn_(1.5-x)Cu_(x)Ti_(0.5) and Ni_(2-y)Co_(y)Mn_(1.5-x)Cu_(x)Ti_(0.5) (y<0.625) alloys.When y=0.625 in the Ni_(2-y)Co_(y)Mn_(1.5-x)Cu_(x)Ti_(0.5) series,the austenite presents ferromagnetic state while the NM martensite shows antiferromagnetic state.Cu doping can decrease the thermal hysteresis and anisotropy of the Ni–(Co)–Mn–Ti alloy.Increasing Mn and decreasing Ti content can improve the shear resistance and normal stress resistance,but reduce the toughness in the Ni–Mn–Cu–Ti alloy.And the ductility of the Co–Cu co-doping alloy is inferior to that of the Ni–Mn–Cu–Ti and Ni–Co–Mn–Ti alloys.The electronic density of states was studied to reveal the essence of the mechanical and magnetic properties.

关键词： Ni–Mn–Ti-based all-d-metal Heusler alloys first-principles calculations mechanical properties martensitic transformation magnetic properties

Effects of surface vortex on the drawdown and dispersion of floating particles in stirred tanks

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Particuology 2020年第2期18卷 159-168页

作者： Wentao xu Yangbo Tan Meng Li jianglong Sun De Xie Zeng Liu School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China School of Naval Architecture and Ocean Engineering Huazhong University of Science and TechnologyWuhan 430074China Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration Shanghai 200240China Hubei Key Laboratory of Naval Architecture and Ocean Engineering Hydrodynamics Wuhan 430074China Ocean Engineering.Huazhong University of Science and Technology Wuhan 430074.China

The effects of surface vortex on the drawdown and dispersion of floating particles in stirred tanks were investigated.Particle distribution and power consumption were analyzed by experiments and numerical simulations in both baffled and unbaffled tanks agitated by a Rushton impeller.In unbaffled tanks,a non-aggregation rule was applied and the average dispersion index was found to serve as a reasonable prediction of the full drawdown of floating particles.The critical impeller speeds in an unbaffled tank were higher than those in a tank with vertical baffles.At each immersion depth in a baffled tank,particles distributed more uniformly and more power was consumed.Comparison of snapshots of the baffled and unbaffled tanks shows that the surface vortex increases the drawdown speed while it decreases the particle distribution uniformity and power consumption.Therefore,the use of baffles to suppress the surface vortex provides for a more uniform particle distribution in stirred tanks.

关键词： Stirred tank Surface vortex Solids drawdown Complete dispersion

机器人辅助单孔加一孔腹腔镜肾盂成形术在儿童UPJO中的疗效分析

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中华泌尿外科杂志 2023年第7期44卷 524-528页

作者：徐新茹陈江龙林珊何玉峰徐迪福建省立医院小儿外科福州350001 福建医科大学福州350001

目的探讨达芬奇机器人辅助单孔加一孔腹腔镜肾盂成形术在儿童肾盂输尿管连接处梗阻(UPJO)中的疗效。方法回顾性分析2021年9月至2022年8月福建省立医院诊断为UPJO并行机器人辅助单孔加一孔腹腔镜肾盂成形术的13例儿童患者的临床资料。患... 详细信息

目的探讨达芬奇机器人辅助单孔加一孔腹腔镜肾盂成形术在儿童肾盂输尿管连接处梗阻(UPJO)中的疗效。方法回顾性分析2021年9月至2022年8月福建省立医院诊断为UPJO并行机器人辅助单孔加一孔腹腔镜肾盂成形术的13例儿童患者的临床资料。患儿年龄为60.0(1.3,108.0)个月;左侧10例,右侧3例。临床表现为腹痛3例,合并泌尿系感染2例,无症状10例。术前同位素肾图提示患肾功能(28.32±1.82)%,双侧分肾功能相差>10%者7例;机械性梗阻5例;术前超声检查提示患侧肾皮质厚度为(1.98±0.23)cm。术中于脐置入单孔多通道套管并置入机器人系统,于脐上6 cm处置入8 mm套管为加一孔;探查腹膜下扩张的肾盂,经腹壁悬吊牵引肾盂,暴露视野,切开、扩张肾盂,裁剪扩张的肾盂,置入输尿管支架,并吻合肾盂输尿管。结果13例手术均顺利完成,无中转开放手术。手术时间180.0(165.0,190.2)min;术中出血量<5 ml;术后住院时间7.0(7.0,7.0)d,住院费用5.63(5.21,5.65)万元。术后2个月拔除输尿管支架,未出现尿路感染及腰痛等明显并发症。术后随访时间6~18个月,中位值12(8,13)个月。复查泌尿系超声提示肾皮质厚度(4.95±0.57)cm,同位素肾图提示分肾功能(38.02±1.76)%,5例机械性梗阻全部转变为不全性梗阻。结论达芬奇机器人辅助单孔加一孔腹腔镜肾盂成形术手术操作较为精细,在更好的伤口愈合及美容效果基础上,患肾功能得到恢复,并发症少。

关键词：儿童肾盂成形术机器人手术单孔加一孔肾积水

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仿贻贝型耐久抗菌织物的制备及其性能

纺织学报 2023年第2期44卷 176-183页

作者：曲连艺刘江龙徐英俊王玉忠青岛大学功能纺织品与先进材料研究院山东青岛266071 四川大学化学学院四川成都610064

为获取高效耐久的抗菌织物,以儿茶酚、乌托品和氯化锌等为前驱物,通过简便快捷的一步水热反应,在棉、锦纶及锦纶/棉等织物表面原位构筑纳米氧化锌/儿茶酚甲醛树脂结构,制得仿贻贝型耐久抗菌织物。借助扫描电子显微镜、X射线光电子能谱... 详细信息

为获取高效耐久的抗菌织物,以儿茶酚、乌托品和氯化锌等为前驱物,通过简便快捷的一步水热反应,在棉、锦纶及锦纶/棉等织物表面原位构筑纳米氧化锌/儿茶酚甲醛树脂结构,制得仿贻贝型耐久抗菌织物。借助扫描电子显微镜、X射线光电子能谱仪等对织物的形貌与化学构成进行测试与表征,分析了织物的抗菌、力学、手感、细胞毒性等性能及甲醛残留量。结果表明:纳米氧化锌被儿茶酚甲醛树脂固着在织物上,所得织物对革兰氏阳性菌、革兰氏阴性菌和真菌均具有高效的非溶出型抗菌作用,且耐水洗效果突出,在循环洗涤50次后的抑菌率仍高达99.99%;抗菌织物的断裂强力未明显下降,手感评分与原织物相近,细胞毒性较低,未检出甲醛残留。

关键词：棉织物锦纶织物锦纶/棉织物抗菌织物纳米氧化锌儿茶酚耐水洗性水热反应