检索结果-南通市图书馆

Journal of Clinical and Nursing Research 2024年第4期8卷 231-236页

作者： Jia Meng jianglin zang Tianyu Gao Boyang Wu Xiaoyang Guo Wei Liu Radiation Therapy Department Affiliated Hospital of Hebei UniversityBaoding 071000China

Objective: To explore the effect of bundled nursing intervention on lung cancer patients with a high risk of PICC-related thrombosis. Methods: Eighty-six PICC patients were selected and randomly divided into a control group and an observation group of 43 patients each. The control group received general nursing care and the observation group received bundled nursing intervention based on the control group. The occurrence of venous thrombosis, quality of life score, Zung self-rating depression scale (SDS) score, self-rating anxiety (SAS) score, and nursing satisfaction after treatment were compared between the two groups. Results: The incidence rate of PICC-related venous thrombosis in the observation group (2/4.652%) was lower than that of the control group (13/30.231%) after nursing intervention (P < 0.05). After the intervention, the quality-of-life scores of the observation group were higher than those of the control group (P < 0.001). After the intervention, the SDS and SAS scores of the observation group were lower than those of the control group (P < 0.001). The nursing satisfaction rate of the observation group (41/ 4.652%) was higher than that of the control group (35/18.604%) (P < 0.05). The difference is statistically significant. Conclusion: In the care of lung cancer patients with a high risk of PICC-related thrombosis, bundled nursing care achieved better results.

关键词： Care bundle Lung cancer PICC Thrombosis

Research on Anti-Fluctuation Control of Winding Tension System Based on Feedforward Compensation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2024年第5期139卷 1239-1261页

作者： Yujie Duan Jianguo Liang jianglin Liu Haifeng Gao Yinhui Li Jinzhu Zhang Xinyu Wen College of Mechanical and Vehicle Engineering Taiyuan University of TechnologyTaiyuan030024China College of Electronic Information and Optical Engineering Taiyuan University of TechnologyTaiyuan030024China School of Electronic Information Engineering Taiyuan University of Science and TechnologyTaiyuan030000China

In the fiber winding process,strong disturbance,uncertainty,strong coupling,and fiber friction complicate the winding constant tension *** order to effectively reduce the influence of these problems on the tension output,this paper proposed a tension fluctuation rejection strategy based on feedforward *** addition to the bias harmonic curve of the unknown state,the tension fluctuation also contains the influence of bounded noise.A tension fluctuation observer(TFO)is designed to cancel the uncertain periodic signal,in which the frequency generator is used to estimate the critical parameter ***,the fluctuation signal is reconstructed by a third-order auxiliary *** estimated signal feedforward compensates for the actual tension ***,a time-varying parameters fractional-order PID controller(TPFOPID)is realized to attenuate the bounded noise in the ***,TPFOPID is enhanced by TFO and applied to control a tension control system considering multi-source *** stability of the method is analyzed by using the Lyapunov ***,numerical simulations verify that the proposed scheme improves the tracking ability and robustness of the system in response to tension fluctuations.

关键词： Constant tension control anti-fluctuation strategy tension fluctuation observer time-varying parameters fractional-order PID controller feedforward compensate

The influence of proxy selection on global annual mean temperature reconstructions during the Common Era

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年第8期67卷 2522-2534页

作者： Bao YANG Xia LI Minhui HE Feng WANG Yesi ZHAO Peng ZHANG jianglin WANG Frontiers Science Center for Critical Earth Material Cycling School of Geography and Ocean ScienceNanjing UniversityNanjing 210023China Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Centre Eau Terre Environnement Institut National de la Recherche ScientifiqueQuébecQCG1K 9A9Canada GEOTOP Research Centre in the Dynamics of the Earth System MontréalQC H2X 3Y7Canada

The reconstruction of global annual mean temperatures made by the PAGES 2k Consortium in 2019 represents one of the most influential sequences of global climate variability over the Common ***,it is still not clear how the reconstruction can be influenced by the selection of reconstruction methods and the selection of proxy records with different temporal resolutions over different *** adopt a widely used Composite-Plus-Scale method to elucidate the effects of the selection of the proxy records on temperature *** ensure the uniformity of data,different types of proxy records spanning the past~2000 years from the PAGES 2k proxy network were used to investigate the potential effects of proxy selection in hemispheric and global temperature reconstructions during the past two *** long-term trends,spectral characteristics,and volcanic responses of the annual temperatures were studied based on the *** results reveal a significant cooling trend in the global annual mean temperature using both tree-ring and non-tree-ring records during the 1–1850CE period,and show that the cooling exhibits a stronger trend in the Southern Hemisphere(SH)than that in the Northern Hemisphere(NH).Yet,the long-term trends vary according to different combinations of proxy *** reconstructions based on different types of proxies also exhibit different features in terms of volcanic responses and spectral ***-ring-based temperature reconstructions show stronger cooling responses to tropical volcanic eruptions,while non-tree-ring-based reconstructions suggest less robust volcanic responses,which may be related to dating uncertainties and low temporal resolution of the ***-ring width records tend to preserve a substantial proportion of high-frequency(200 years)*** are needed to reduce uncertainti

关键词： Millennial cooling trend Global climate change Proxy records Volcanic eruptions Spectral properties Common Era

同方期刊数据库

5-Aminolaevulinic acid-based photodynamic therapy for actinic keratosis in Chinese patients: A prospective multicenter study

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第12期137卷 1510-1512页

作者： Menglong Ran Wenyu Wu Yang Tang Liang Zhang Miaojian Wan Siliang Xue jianglin Zhang Hang Li Department of Dermatology and Venerology Peking University First HospitalNational Clinical Research Center for Skin and Immune DiseasesBeijing Key Laboratory of Molecular Diagnosis on DermatosesBeijing 100034China Department of Dermatology Huashan HospitalFudan UniversityShanghai 200040China The First Affiliated Hospital of Kunming Medical University KunmingYunnan 650032China Department of Dermatology Wuhan No.1 HospitalWuhanHubei 430022China Department of Dermatology The 3rd Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China Department of Dermatology Sichuan University West China HospitalChengduSichuan 610044China Shenzhen People’s Hospital(The Second Clinical Medical College Jinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)ShenzhenGuangdong 518020China

To the Editor:Actinic keratosis(AK)is a precancerous skin condition caused by chronic exposure to ultraviolet *** mainly occurs on sun-exposed areas like the head and face,leading to cosmetic concerns and an increased risk of progressing to primary squamous cell carcinoma(with a 0.60%risk at 1 year and 2.57%risk at 4 years).[1]Photodynamic therapy(PDT)is a targeted,non-invasive therapy that has been approved in Europe for the treatment of AK,squamous cell carcinoma in situ,and basal cell carcinomas.5-Aminolaevulinic acid(ALA)-based PDT,which utilizes the photosensitizer ALA,has shown high cure rates,low recurrence rates,and favorable cosmetic outcomes as arst-line treatment for AK.[1]However,due to variations in skin color,ethnicity,and lifestyle habits,the incidence of AK is lower among Asians compared to Caucasians.[1]There are limited clinical studies on PDT for AK in Asia—particularly lacking large-scale multicenter *** knowledge gap hinders the establishment of treatment standards specically tailored for Asian patients with AK undergoing ***,as the aging population increases in Asia,the incidence of AK demand for medical intervention among Asians is also rising *** conducted this multicenter study aiming to comprehensively investigate the efcacy and safety of ALA-PDT in Chinese patients with AK.

关键词： patients treatment utilize

CMKLR1 senses chemerin/resolvin E1 to control adipose thermogenesis and modulate metabolic homeostasis

在线全文

学校读者我要写书评

暂无评论

Fundamental Research 2024年第3期4卷 575-588页

作者： Zewei Zhao Siqi Liu Bingxiu Qian Lin Zhou jianglin Shi Junxi Liu Lin Xu Zhonghan Yang Department of Biochemistry Molecular Cancer Research CenterSchool of MedicineSun Yat-sen UniversityShenzhenGuangdong 518107China Department of Biochemistry Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510080China School of Public Health Sun Yat-sen UniversityGuangzhouGuangdong 510080China

Induction of beige fat for thermogenesis is a potential therapy to improve homeostasis against obesity.β3-adrenoceptor(β3-AR),a type of G protein-coupled receptor(GPCR),is believed to mediate the thermogenesis of brown fat in ***,β3-AR has low expression in human adipose tissue,precluding its activation as a standalone clinical *** study aimed at identifying a potential GPCR target to induce beige *** found that chemerin chemokine-like receptor 1(CMKLR1),one of the novel GPCRs,mediated the development of beige fat via its two ligands,chemerin and resolvin E1(RvE1).The RvE1 levels were decreased in the obese mice,and RvE1 treatment led to a substantial improvement in obese features and augmented beige fat ***,despite sharing the same receptor as RvE1,the chemerin levels were increased in obesogenic conditions,and chemerin treatment led to an augmented obese phenotype and a decline of beige fat ***,RvE1 and chemerin induced or restrained the development of beige fat,respectively,via the mechanistic target of rapamycin complex 1(mTORC1)signaling *** further showed that RvE1 and chemerin regulated mTORC1 signaling differentially by forming hydrogen bonds with different binding sites of *** conclusion,our study showed that RvE1 and chemerin affected metabolic homeostasis differentially,suggesting that selectively modulating CMKLR1 may be a potential therapeutic target for restoring metabolic homeostasis.

关键词： Obesity Insulin resistance Thermogenesis CMKLR1 Resolvin E1 Chemerin

Research on the Reform of"Separation of Three Rights"for Rural Homesteads in Juancheng County,Shandong Province

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Agricultural Research 2024年第7期16卷 12-18页

作者： jianglin MU Shiqin YANG Institute of Land Resources and Sustainable Development Yunnan University of Finance and EconomicsKunming 650221China

In order to realize rural revitalization in an all-round way and promote the sustainable and healthy development of the economy and society,China is committed to deepening the pace of building a new countryside with Chinese *** reform of the"Separation of Three Rights"of rural homesteads is a key measure,which aims to activate rural resources,enhance the vitality of rural economic development,and then promote the overall process of rural *** study selects Juancheng County,Heze City,Shandong Province as a typical *** an in-depth analysis of the relevant policy orientation of the national homestead reform and the specific practice of local promotion work,it systematically sorts out the registration of homestead rights,transfer of use rights and relevant policy measures adopted in paid use,qualification conversion,policy publicity and system *** in-depth research on the system reform practice of the"Separation of Three Rights"of homesteads in Juancheng County,this paper reveals the main problems existing in the current reform,including the lack of clear policy support for the mechanism of paid use of homesteads,difficulties in the process of identifying qualification rights and challenges,the imperfection of the transfer mechanism of use rights,and the lack or lag of relevant policies.A series of problem-oriented policy suggestions are put forward,including establishing and improving the system of paid use of rural homesteads,improving the income distribution mechanism,promoting the innovation of the mortgage guarantee system for the right to use homesteads,and optimizing the homestead qualification certification *** suggestions aim to provide a useful reference for the Juancheng County Government in promoting the reform of"Separation of Three Rights"of homesteads,and then promote the rational allocation and efficient utilization of rural homestead resources.

关键词： Rural homesteads "Separation of Three Rights" Rural revitalization Juancheng County

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

铁路工程建设环水保风险演化研究

铁道工程学报 2024年第5期41卷 94-99,117页

作者：郭峰吴彦林古江林中南大学长沙410075

研究目的:随着绿色发展理念的提出,对铁路工程建设环境保护和水土保持提出了更高的要求。为顺利完成工程建设环水保目标,识别铁路工程建设环水保风险因素,建立环水保风险演化的系统动力学模型,并以H铁路工程项目为例进行仿真分析,了解... 详细信息

研究目的:随着绿色发展理念的提出,对铁路工程建设环境保护和水土保持提出了更高的要求。为顺利完成工程建设环水保目标,识别铁路工程建设环水保风险因素,建立环水保风险演化的系统动力学模型,并以H铁路工程项目为例进行仿真分析,了解风险演化过程,明确风险防控的重点任务。研究结论:(1)在建设过程中环水保风险呈现先增加后稳定的总体趋势,其中开工建设前期为环水保风险的集中涌现阶段;(2)风险因素取值的变化将对环水保风险产生不同程度的影响,其中环水保专项资金不足改变对环水保风险系统影响最大,人员专业能力不足和环境本底调查不全面次之,施工机械污染大变动对系统影响较小;(3)工程项目引入风险预警机制有利于控制环水保风险,预警值的大小将影响风险防控效果;(4)本研究结果可为工程项目防控环水保风险提供借鉴与参考。

关键词：铁路工程建设环水保风险风险演化系统动力学

教育、科技、人才一体化发展的历史镜鉴和时代回应

在线全文

学校读者我要写书评

暂无评论

国家教育行政学院学报 2024年第3期315卷 6-10页

作者：周江林上海市教育科学研究院上海200032

党的二十大报告提出,“教育、科技、人才是全面建设社会主义现代化国家的基础性、战略性支撑”。这是党中央在新时代为教育、科技、人才作出的价值定性,并且首次在党代会报告里将这三者进行统筹安排和一体化部署,以开辟发展新领域新赛道... 详细信息

党的二十大报告提出,“教育、科技、人才是全面建设社会主义现代化国家的基础性、战略性支撑”。这是党中央在新时代为教育、科技、人才作出的价值定性,并且首次在党代会报告里将这三者进行统筹安排和一体化部署,以开辟发展新领域新赛道,不断塑造发展新动能新优势。党中央作出的这个重大战略安排,体现了中国共产党对教育、科技、人才发展历史的充分尊重、对发展现状的精准掌控和对发展规律的熟谙运用。推进教育、科技、人才一体化发展既需要具备一定的基础条件。

关键词：时代回应党代会报告人才一体化统筹安排现代化科技

“双一流”高校数字化转型的价值、偏差与路向

在线全文

学校读者我要写书评

暂无评论

研究生教育研究 2024年第3期 27-33页

作者：周江林上海市教育科学研究院教育大数据与教育决策实验室上海200032

数字化转型是一种颠覆式的技术变革。“双一流”高校数字化转型是顺应数字化发展潮流的客观要求,对于丰富发展全球教育数字化转型的多样化实践、助力加速我国社会转型的时代步伐和促进落实高质量发展的根本性要求都有独特的当代价值。... 详细信息

数字化转型是一种颠覆式的技术变革。“双一流”高校数字化转型是顺应数字化发展潮流的客观要求,对于丰富发展全球教育数字化转型的多样化实践、助力加速我国社会转型的时代步伐和促进落实高质量发展的根本性要求都有独特的当代价值。当前“双一流”高校数字化转型在观念认识、顶层设计、数据技术应用以及制度创新等方面还存在诸多不适应之处。为有效推进“双一流”高校数字化转型,需要在强化政府的引导作用、鼓励企业积极参与、重构新型内部组织、培育数据文化氛围以及加强数据基础设施建设等方面采取应对措施。

关键词： “双一流”高校数字化转型改革路向

维普期刊数据库博看期刊

多模态合一鸡尾酒疗法在晚期恶性肿瘤治疗中的应用

在线全文

学校读者我要写书评

暂无评论

中华放射肿瘤学杂志 2024年第7期33卷 673-677页

作者：陈江林吴稚冰浙江中医药大学第二临床医学院杭州310053 浙江大学医学院附属浙江医院肿瘤科杭州310030

晚期恶性肿瘤的治疗方式通常包括化疗、放疗、免疫治疗、靶向治疗等。然而,单一的治疗手段常常面临耐药性、不良反应大等问题,因此,亟需寻求新的治疗模式及方法。2015年,Siwen Hu-Lieskovan首次提出了“肿瘤鸡尾酒疗法”。鸡尾酒疗法是... 详细信息

晚期恶性肿瘤的治疗方式通常包括化疗、放疗、免疫治疗、靶向治疗等。然而,单一的治疗手段常常面临耐药性、不良反应大等问题,因此,亟需寻求新的治疗模式及方法。2015年,Siwen Hu-Lieskovan首次提出了“肿瘤鸡尾酒疗法”。鸡尾酒疗法是将三种及以上不同的治疗手段有机整合,从而发挥协同抗肿瘤作用。近年来,许多研究者也将鸡尾酒疗法应用于基础和临床研究,包括:联合化疗药、靶向药以及免疫药等,使药物之间优势互补;联合热疗、化疗与免疫治疗,通过热疗改善肿瘤免疫抑制微环境,激发宿主免疫应答,再联合抗程序性死亡受体1(aPD-1)药物等产生协同作用。研究结果都显示鸡尾酒疗法可提升中晚期恶性肿瘤的疗效,改善患者的预后。本文对鸡尾酒疗法这种全新的治疗模式的作用和影响进行综述,以便为更深入探索新组合方案治疗中晚期恶性肿瘤提供参考。

关键词：肿瘤,恶性晚期热疗法多模态治疗鸡尾酒疗法免疫检查点抑制剂