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Protein lipidation in health and disease:molecular basis,physiological function and pathological implication

Signal Transduction and Targeted Therapy 2024年第4期9卷 1423-1465页

作者： Yuan Yuan Peiyuan li jianghui li Qiu Zhao Ying Chang Xingxing He Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhanChina Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases WuhanChina

Posttranslational modifications increase the complexity and functional diversity of proteins in response to complex external stimuli and internal *** these,protein lipidations which refer to lipid attachment to proteins are prominent,which primarily encompassing five types including S-palmitoylation,N-myristoylation,S-prenylation,glycosylphosphatidylinositol(GPl)anchor and *** attachment to proteins plays an essential role in the regulation of protein trafficking,localisation,stability,conformation,interactions and signal transduction by enhancing *** evidence from genetic,structural,and biomedical studies has consistently shown that protein lipidation is pivotal in the regulation of broad physiological functions and is inextricably linked to a variety of *** of dedicated research have driven the development of a wide range of drugs targeting protein lipidation,and several agents have been developed and tested in preclinical and clinical studies,some of which,such as asciminib and lonafarnib are FDA-approved for therapeutic use,indicating that targeting protein lipidations represents a promising therapeutic ***,we comprehensively review the known regulatory enzymes and catalytic mechanisms of various protein lipidation types,outline the impact of protein lipidations on physiology and disease,and highlight potential therapeutic targets and clinical research progress,aiming to provide a comprehensive reference for future protein lipidation research.

关键词： lipid ation primarily

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Offshore Carbon Capture, Utilization, and Storage

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哈尔滨工程大学学报（英文版） 2024年第3期23卷 525-528页

作者： jianghui li State Key Laboratory of Marine Environmental Science College of Ocean and Earth SciencesXiamen UniversityXiamen 361102China

Climate change, resulting from human-caused CO_(2) and other greenhouse gas emissions, is an urgent problem that demands immediate action from everyone. The need to decrease emissions has sparked a renewed emphasis on developing and utilizing offshore Carbon Capture,Utilization,and Storage(CCUS) *** these technologies offer potential solutions to mitigate greenhouse gas emissions,many challenges must be addressed to ensure successful implementation.

关键词： Capture Storage Carbon

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Promising interlayer sensitization strategy for the construction of high-performance blue hyperfluorescence OLEDs

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light(Science & Applications) 2024年第7期13卷 1372-1382页

作者： jianghui Wang Peng Zou Letian Chen Zhentao bai Hao liu Wen-Cheng Chen Yanping Huo ben Zhong Tang Zujin Zhao State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular AggregatesSouth China University of TechnologyGuangzhou 510640China. School of Chemical Engineering and light Industry Guangdong University of TechnologyGuangzhou 510006China. School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenGuangdong 518172China

Multi-resonance thermally activated delayed fluorescence(MR-TADF)materials are promising candidates for organic light-emitting diodes(OLEDs)with narrow electroluminescence(EL)*** researches focus on fabricating hyperfluorescence OLEDs to improve EL efficiencies of MR-TADF emitters by co-doping them with TADF sensitizers in a single host ***,in many cases,the polarity of the single host could be not suitable for both blue MRTADF emitters and blue TADF sensitizers,resulting in broadened EL spectra in high-polar hosts or decreased EL efficiencies in low-polar ***,we wish to report an efficient sensitization strategy for blue MR-TADF emitters by constructing an interlayer-sensitizing configuration,in which the blue TADF sensitizers and blue MR-TADF emitters are separated into two closely aligned host layers with high polarity and low polarity,*** on this strategy,efficient blue hyperfluorescence OLEDs are realized and verified by employing various TADF sensitizers and different MR-TADF emitters,furnishing outstanding external quantum efficiencies of up to 38.8%and narrow EL *** results validate the feasibility and universality of this interlayer sensitization strategy,which provides an effective alternative to high-performance blue hyperfluorescence OLEDs.

关键词： OLEDs interlayer sensitization

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The Clausena lansium genome provides new insights into alkaloid diversity and the evolution of the methyltransferase family

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Journal of Integrative Agriculture 2024年第10期23卷 3537-3553页

作者： Yongzan Wei Yi Wang Fuchu Hu Wei Wang Changbin Wei bingqiang Xu liqin liu Huayang li Can Wang Hongna Zhang Zhenchang liang jianghui Xie State Key Laboratory of biological breeding of Tropical Crops Institute of Tropical Bioscience and BiotechnologyChineseAcademy of Tropical Agricultural SciencesHaikou 571101China Key Laboratory of Genetic Resources Evaluation and Utilization of Tropical Fruits and Vegetables(Co-construction by Ministryand Province) Ministry of Agriculture and Rural Affairs/Institute of Tropical Fruit TreesHainan Academy of Agricultural SciencesHaikou 571100China beijing Key Laboratory of Grape Sciences and Enology CAS Key Laboratory of Plant ResourcesInstitute of BotanyChineseAcademy of SciencesBeijing 100093China Key Laboratory of Tropical Fruit biology(Ministry of Agriculture and Rural Affairs) South Subtropical Crops Research InstituteChinese Academy of Tropical Agricultural SciencesZhanjiang 524091China Haikou Experimental Station Chinese Academy of Tropical Agricultural SciencesHaikou 571101China Sanya Institute of breeding and Multiplication/School of Tropical Agriculture and Forestry Hainan UniversityHaikou 570228China Sanya Research Academy Chinese Academy of Tropical Agricultural SciencesSanya 572019China

Wampee(Clausena lansium)is an important evergreen fruit tree native to southern China that has a long history of use for medicinal ***,a chromosome-level genome of *** was constructed with a genome size of 282.9 Mb and scaffold N50 of 30.75 *** assembled genome contains 48.70%repetitive elements and 24,381 protein-coding *** genomic analysis showed that *** diverged from Aurantioideae 15.91-24.95 million years ***,some expansive and specific gene families related to methyltransferase activity and S-adenosylmethionine-dependent methyltransferase activity were also *** analysis indicated that N-methyltransferase(NMT)is mainly involved in alkaloid biosynthesis and O-methyltransferase(OMT)participates in the regulation of coumarin accumulation in *** suggested that wampee's richness in alkaloids and coumarins might be due to the gene expansions of NMT and *** tandem repeat event was one of the major reasons for the NMT ***,the reference genome of *** will facilitate the identification of some useful medicinal compounds from wampee resources and reveal their biosynthetic pathways.

关键词： Clausena lansium genome evolution methyltransferase activity alkaloid biosynthesis coumarin accumulation

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Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： biao Xiao Chaoyang Chu Zhicheng lin Tianyuan Fang Yuyu Zhou Chuxia Zhang jianghui Shan Shiyu Chen liping li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

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一种基于ModelSim的红外图像仿真方法与系统

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红外技术 2024年第7期46卷 802-806页

作者：李江辉上海热芯视觉科技有限公司上海200331

在红外热成像的图像处理算法过程中,传统的算法仿真需要借助Matlab等图形处理工具软件先进行仿真再转化成FPGA处理器中可以运行的算法代码,而Matlab上的运行的语言、实现方式与FPGA硬件上运行的硬件描述语言和实现方式完全不同。导致转... 详细信息

在红外热成像的图像处理算法过程中,传统的算法仿真需要借助Matlab等图形处理工具软件先进行仿真再转化成FPGA处理器中可以运行的算法代码,而Matlab上的运行的语言、实现方式与FPGA硬件上运行的硬件描述语言和实现方式完全不同。导致转化过程复杂、转化精度损失、开发周期长等。本文提出了一种基于ModelSim仿真工具的红外图像仿真方法与系统,与Matlab等图形处理工具一样,编程写好代码,导入图像仿真后,立即输出图像显示,并能查看中间处理过程中的数据变化情况。并且ModelSim仿真运行的仿真代码可以直接拿到FPGA编译工具中运行,最终部署在硬件板卡上。在工程应用中,转化过程简单,开发效率大大提升。

关键词： FPGA ModelSim 红外热成像仿真方法图像处理算法硬件描述语言硬件加速

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Self-assembled monolayers(SAMs)in inverted perovskite solar cells and their tandem photovoltaics application

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Interdisciplinary Materials 2024年第2期3卷 203-244页

作者： Zijun Yi Xin li Yuchen Xiong Guibin Shen Wenguang Zhang Yihuai Huang Qinghui Jiang Xin Ren Ng Yubo Luo jianghui Zheng Wei lin Leong Fan Fu Tongle bu Junyou Yang State Key Laboratory of Material Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhanChina China‐Eu Institute for Clean and Renewable Energy Huazhong University of Science and TechnologyWuhanChina School of Electrical and Electronic Engineering Nanyang Technological UniversitySingaporeSingapore Department of Chemistry National University of SingaporeSingaporeSingapore School of Physics The University of SydneySydneyNew South WalesAustralia Laboratory for Thin Films and Photovoltaics Empa‐Swiss Federal Laboratories for Materials Science and TechnologyDübendorfSwitzerland State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhanChina

Self-assembled monolayers(SAMs)employed in inverted perovskite solar cells(PSCs)have achieved groundbreaking progress in device efficiency and stability for both single-junction and tandem configurations,owing to their distinctive and versatile ability to manipulate chemical and physical interface *** this regard,we present a comprehensive review of recent research advancements concerning SAMs in inverted perovskite singlejunction and tandem solar cells,where the prevailing challenges and future development prospects in the applications of SAMs are *** thoroughly examine the mechanistic roles of diverse SAMs in energy-level regulation,interface modification,defect passivation,and charge *** is achieved by understanding how interfacial molecular interactions can be finely tuned to mitigate charge recombination losses in inverted *** this comprehensive review,we aim to provide valuable insights and references for further investigation and utilization of SAMs in inverted perovskite single‐junction and tandem solar cells.

关键词： inverted perovskite solar cells power conversion efficiency self-assembled monolayers tandem

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Data error propagation in stacked bioclimatic envelope models

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Integrative Zoology 2024年第2期19卷 262-276页

作者： Xueyan li babak NAIMI Peng GONG Miguel b.ARAÚJO Guangdong Provincial Key Laboratory of Remote Sensing and Geographical Information System Guangdong Open Laboratory of Geospatial Information Technology and ApplicationGuangzhou Institute of GeographyGuangdong Academy of ScienceGuangzhouChina ‘Rui Nabeiro’biodiversity Chair CHANGE-MED InstituteUniversity ofÉvoraÉvoraPortugal Department of Geography and Department of Earth Sciences University of Hong KongHong KongChina Department of biogeography and Global Change National Museum of Natural SciencesCSICMadridSpain

Stacking is the process of overlaying inferred species potential distributions for multiple species based on outputs of bioclimatic envelope models(bEMs).The approach can be used to investigate patterns and processes of species *** data limitations on individual species distributions are inevitable,but how do they affect inferences of patterns and processes of species richness?We investigate the influence of different data sources on estimated species richness gradients in *** fitted bEMs using species distributions data for 334 bird species obtained from(1)global range maps,(2)regional checklists,(3)museum records and surveys,and(4)citizen science data using presence-only(Mahalanobis distance),presence-background(MAXENT),and presence–absence(GAM and bRT)*** species predictions were stacked to generate species richness ***,we show that different data sources and bEMs can generate spatially varying gradients of species *** environmental predictors that best explained species distributions also differed between data *** using citizen-based data had the highest accuracy,whereas those using range data had the lowest *** richness patterns estimated by GAM and bRT models were robust to data *** multiple data sets exist for the same region and taxa,we advise that explicit treatments of uncertainty,such as sensitivity analyses of the input data,should be conducted during the process of modeling.

关键词： richness patterns species distribution stacked bioclimatic envelope models uncertainty

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Underwater Gas Leakage Flow Detection and Classification based on Multibeam Forward-Looking Sonar

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哈尔滨工程大学学报（英文版） 2024年第3期23卷 674-687页

作者： Yuanju Cao Chao Xu jianghui li Tian Zhou Longyue lin baowei Chen Southampton Ocean Engineering Joint Institute Harbin Engineering UniversityHarbin 150001China College of Underwater Acoustic Engineering Harbin Engineering UniversityHarbin 150001China National Key Laboratory of Underwater Acoustic Technology Harbin Engineering UniversityHarbin 150001China Key Laboratory of Marine Information Acquisition and Security(Harbin Engineering University) Ministry of Industry and Information TechnologyHarbin 150001China State Key Laboratory of Marine Environmental Science College of Ocean and Earth SciencesXiamen UniversityXiamen 361102China

The risk of gas leakage due to geological flaws in offshore carbon capture, utilization, and storage, as well as leakage from underwater oil or gas pipelines, highlights the need for underwater gas leakage monitoring technology. Remotely operated vehicles(ROVs) and autonomous underwater vehicles(AUVs) are equipped with high-resolution imaging sonar systems that have broad application potential in underwater gas and target detection tasks. However, some bubble clusters are relatively weak scatterers, so detecting and distinguishing them against the seabed reverberation in forward-looking sonar images are challenging. This study uses the dual-tree complex wavelet transform to extract the image features of multibeam forward-looking sonar. Underwater gas leakages with different flows are classified by combining deep learning theory. A pool experiment is designed to simulate gas leakage, where sonar images are obtained for further processing. Results demonstrate that this method can detect and classify underwater gas leakage streams with high classification accuracy. This performance indicates that the method can detect gas leakage from multibeam forward-looking sonar images and has the potential to predict gas leakage flow.

关键词： Carbon capture utilization and storage(CCUS) Gas leakage Forward-looking sonar Dual-tree complex wavelet transform(DT-CWT) Deep learning

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A Stable Red Emission in Polymer light-Emitting Diodes based on Phenothiazine Derivative

A Stable Red Emission in Polymer Light-Emitting Diodes based...

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2007亚洲光电子会议LED材料与器件分会场

作者： Huayu Cao a Zhijian Chen a Yingliang liu a jianghui li b Shaokui Cao b lixin Xiao a Shengang Xu b Qihuang Gong a a State Key Laboratory for Artificial Microstructures & Mesoscopic Physics Department of Physics Peking University beijing 100871 PR China b School of Materials Science & Engineering Zhengzhou University Zhengzhou 450052 PR China

A novel soluble phenothiazine-based derivative, poly（3, 7-divinylene-N-octyl-phenothiazine 2, 3-diethylquinoxaline-5,8-diyl）（PQDN）, is synthesized for application in red light-emitting diodes. PQDN was characterized by the measurements of cyclic voltammetry （CV）, absorption and photoluminescence （PL） spectra. The band gap （Eg） was determined to be 1.89 eV. The smaller band gap suggested that the polymer is a good candidate for red electroluminescent materials. Polymer light-emitting diodes （PLEDs） with double-layer configuration of indium tin oxide （ITO） / （poly-ethylenedioxythiophene）:poly（styrene sulfonate）（PEDOT:PSS） / PQDN: poly（N-vinylcarbazole）（PVK）（100:0, 80:20, 60:40, and 20:80 wt.%） / Mg:Ag were fabricated. The electroluminescent （EL） property was studied in details. In order to improve the EL performance further, the devices were thermally annealed at 100oC for one hour under the protection of nitrogen. Luminance is increased obviously. EL peak wavelength and the Commision International de L’Eclairage （CIE） coordinates are unaltered and located in red region with the increase of the operating voltages,.

关键词： Phenothiazine red emission electroluminescence

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