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A novel protein domain is important for photosystem Ⅱ complex assembly and photoautotrophic growth in angiosperms

Molecular Plant 2023年第2期16卷 374-392页

作者： Wei Li jiangfan guo Xue Han Xiaowen Da Kai Wang Hongfei Zhao Shi-Tang Huange Bosheng Li Hang He Ruirui Jiang Shichen Zhou Peng Yan Tao Chen Yi He Jiming Xu Yu Liu Yunrong Wu Huixia Shou Zhongchang Wu Chuanzao Mao Xiaorong Mo State Key Laboratory of Plant Environmental Resilience College of Life ScienceZhejang UniversityHangzhou 310058PR China College of Life Science Shaanxi Normal UniversityXi'anShaanxi Province 710062PR China School of Advanced Agricultural Sciences and School of Life Sciences State Key Laboratory of Protein and Plant Gene ResearchPeking UniversityBeijing 100871China Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agricultural Sciences at WeifangWeifangShandong 261000China College of Urban Construction Zhejiang Shuren UniversityHangzhou 310015PR China School of Life Sciences Peking UniversityBeijing 100871PR China State Key Laboratory of Subtropical Silviculture Zhejiang A&F UniversityLin'anHangzhou 311300PR China

Photosystem Ⅱ(PSⅡ)is a multi-subunit protein complex of the photosynthetic electron transport chain that is vital to *** the structure,composition,and function of PSⅡ have been extensively studied,its biogenesis mechanism remains less *** rhodanese-like(TROL)provides an anchor for leaf-type ferredoxin:NADP^(+)***,we report the chacterizaton of a second type of TROL protein,TROL2,encoded by seed plant genomes whose function has not previously been *** show that TROL2 is a PSⅡ assembly cofactor with essential roles in the establishment of ***2 contains a 45-amino-acid domain,termed the chlorotic lethal seedling(CLS)domain,that is both necessary and sufficient for TROL2 function in PSⅡ assembly and photoautotrophic *** analyses suggest that TROL2 may have arisen from ancestral TROL1 via gene duplication before the emergence of seed plants and acquired the CLS domain via evolution of the sequence encoding its N-terminal *** further reveal that TROL2(or CLS)forms an assembly cofactor complex with the intrinsic thylakoid membrane protein LOW PSⅡ ACCUMULATION2 and interacts with small PSⅡ subunits to facilitate PSⅡ complex ***,our study not only shows that TROL2(CLS)is essential for photoautotrophy in angiosperms but also reveals its mechanistic role in PSⅡ complex assembly,shedding light on the molecular and evolutionary mechanisms of photosynthetic complex assemblyin angiosperms.

关键词： PSⅡassembly TROL2 assembly factors angiosperms evolution

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新型含噪数据流集成分类的算法

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计算机应用 2018年第6期38卷 1591-1595页

作者：袁泉郭江帆重庆邮电大学通信新技术应用研究中心重庆400065 重庆信科设计有限公司重庆401121

针对数据流中概念漂移和噪声问题,提出一种新型的增量式学习的数据流集成分类算法。首先,引入噪声过滤机制过滤噪声;然后,引入假设检验方法对概念漂移进行检测,以增量式C4.5决策树为基分类器构建加权集成模型;最后,实现增量式学习实例... 详细信息

针对数据流中概念漂移和噪声问题,提出一种新型的增量式学习的数据流集成分类算法。首先,引入噪声过滤机制过滤噪声;然后,引入假设检验方法对概念漂移进行检测,以增量式C4.5决策树为基分类器构建加权集成模型;最后,实现增量式学习实例并随之动态更新分类模型。实验结果表明,该集成分类器对概念漂移的检测精度达到95%~97%,对数据流抗噪性保持在90%以上。该算法分类精度较高,且在检测概念漂移的准确性和抗噪性方面有较好的表现。

关键词：数据流噪声概念漂移分类算法分类精度

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正念减压疗法对新冠疫情期间医务人员主观压力及焦虑抑郁的影响

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国际精神病学杂志 2022年第2期49卷 235-238页

作者：王晟过江帆魏丹张乐群余斌江西省精神病院南昌330029

目的新冠肺炎具有传染性强、传播速度快、人群普遍易感等特点。医务人员在高风险、高压力的环境下工作,极易出现焦虑和抑郁等心理问题,亟待有效的心理干预。方法研究共招募到510名一线抗疫医务人员,有44名最终完成研究,其中干预组20名,... 详细信息

目的新冠肺炎具有传染性强、传播速度快、人群普遍易感等特点。医务人员在高风险、高压力的环境下工作,极易出现焦虑和抑郁等心理问题,亟待有效的心理干预。方法研究共招募到510名一线抗疫医务人员,有44名最终完成研究,其中干预组20名,对照组24名。对干预组进行8周的线上正念减压训练(Mindfulness-Based Stress Reduction,MBSR),对照组予以心理支持。采用焦虑自评量表(Self-rating Anxiety Scale,SAS)、抑郁自评量表(Self-rating Depression Scale,SDS)、和压力知觉量表(Chinese Perceived Stress Scale,CPSS)对参与者进行测评,评估干预效果。结果两组医务人员的SDS、SAS、CPSS评分均显著下降(P值<0.001);干预组下降较对照组更明显(P值<0.001)。结论正念减压疗法能有效降低新冠疫情期间医务人员焦虑、抑郁和压力水平。

关键词：新冠肺炎医务人员焦虑抑郁正念减压疗法

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Guaranteeing the response deadline for general aggregation trees

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Frontiers of Computer Science 2020年第6期14卷 97-110页

作者： jiangfan LI Chendie YAO Junxu XIA Deke guo Science and Technology on Information Systems Engineering Laboratory National University of Defense TechnologyChangsha 410073China

It is essential to provide responses to queries within time deadlines,even if not exact and *** reduce the query latency,systems usually partition large-scale data computations as a series of tasks over many processes and aggregate them to reduce the response time by using aggregation *** obstacle is that the involved processes of a query usually differ in their speeds,thus not all processes can complete their tasks in *** would directly degrade the response quality(the number of outputs received by the root of an aggregation tree).In this paper,we propose a general aggregation tree model,Tarot,to maximize the response quality by systematically addressing the following challenging issues:(1)fine-grained partition of the query deadline along the multi-level aggregation tree;(2)learning the distribution of durations at each level in the aggregation tree to optimize the wait durations at aggregators;(3)adaptively reassigning tasks over processes according to their status;(4)performing periodic aggregation of received outputs from the low level to avoid missing the *** prior model does not consider the four aspects *** evaluations indicate that Tarot can adapt to multi-level trees and considerably improve the response quality compared to prior work while guaranteeing the query deadline.

关键词： aggregation query performance variations tasks reassignment

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中药基于NF-κB信号通路干预改善糖尿病肾病的研究进展

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中国实验方剂学杂志 2024年第20期30卷 241-251页

作者：郭江凡王晓萌张秋娥李晓晨刘铜华吴丽丽秦灵灵李青松陕西中医药大学第一临床医学院陕西咸阳712046 北京中医药大学教育部中医养生学重点实验室北京100029

糖尿病肾病(DN)是糖尿病患者的慢性微血管并发症,也是终末期肾病(ESRD)的主要原因。研究表明核转录因子-κB(NF-κB)通过激活炎症、氧化应激、纤维化、凋亡、自噬、焦亡等病理机制参与了DN的病理进程。因此,阻断NF-κB信号通路的转导有... 详细信息

糖尿病肾病(DN)是糖尿病患者的慢性微血管并发症,也是终末期肾病(ESRD)的主要原因。研究表明核转录因子-κB(NF-κB)通过激活炎症、氧化应激、纤维化、凋亡、自噬、焦亡等病理机制参与了DN的病理进程。因此,阻断NF-κB信号通路的转导有助于防治DN。目前,西医治疗包括降糖、降压、降脂等策略,以及使用内皮素受体拮抗剂、盐皮质激素受体拮抗剂、醛固酮合酶抑制剂等药物,但仍无法阻断DN的病理进程。中医药具有标本兼治、简便价廉等优势,近年来其在干预DN进程中取得了显著进展,其中NF-κB作为关键因子在中药防治DN中发挥了重要作用。该文总结了近五年来中药基于NF-κB信号通路治疗DN的研究成果,阐述了多种中药提取物,如多糖类、萜类、酚类、黄酮类、皂苷类和生物碱类,以及中药复方如槐杞黄颗粒、黄芪三七复方、丹蛭降糖胶囊等,通过调控NF-κB信号通路及其上下游因子,阻断DN的病理进程,从而抑制DN引起的肾脏病理损伤并减缓肾功能恶化,旨在为研发防治DN的药物提供新的思路和参考依据。

关键词：中药糖尿病肾病核转录因子-κB(NF-κB) 信号通路病理机制

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城市封锁对疫情初期的疾病防控影响分析

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福建电脑 2021年第9期37卷 5-8页

作者：何超李建敦黄琨郭江帆李志鹏陈思垚上海电机学院电子信息学院上海201200

新冠病毒的无症状感染者是疾病流行的重要传染源。为了解城市封闭对有效遏制病毒的蔓延的作用,本文构建了一种改进的SEIR模型来估计人群中隐形感染者的数量。通过对模型的参数估计,分析影响疫情初期病毒传播的重要因子,用数据验证了城... 详细信息

新冠病毒的无症状感染者是疾病流行的重要传染源。为了解城市封闭对有效遏制病毒的蔓延的作用,本文构建了一种改进的SEIR模型来估计人群中隐形感染者的数量。通过对模型的参数估计,分析影响疫情初期病毒传播的重要因子,用数据验证了城市封锁对疫情传播的重要作用。

关键词：新冠冠状病毒防疫措施 SEIR模型无症状感染者

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Chromatin accessibility and translational Iandscapes of tea plants under chilling stress

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Horticulture Research 2021年第1期8卷 1458-1472页

作者： Pengjie Wang Shan Jin Xuejin Chen Liangyu Wu Yucheng Zheng Chuan Yue Yongchun guo Xingtan Zhang jiangfan Yang Naixing Ye College of Horticulture Fujian Agriculture and Forestry University/Key Laboratory of Tea Science in Universities of Fujian ProvinceFuzhou 350002China Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China

Plants have evolved regulatory mechanisms at multiple levels to regulate gene expression in order to improve their cold ***,limited information is available regarding the stress response at the chromatin and translational ***,we characterize the chromatin accessibility,transcriptional,and translational landscapes of tea plants in vivo under chilling stress for the first *** stress signi ficantly affected both the transcription and translation levels as well as the translation efficiency of tea plants.A total of 3010 genes that underwent rapid and independent translation under chilling stress were observed,and they were signi ficantly enriched in the photosynthesis-antenna protein and phenylpropanoid biosynthesis pathways.A set of genes that were signi ficantly responsive to cold at the transcription and translation levels,including four(+)-neomenthol dehydrogenases(MNDs)and two(E)-nerolidol synthases(NESs)arranged in tandem on the chromosomes,were also *** detected potential upstream open reading frames(uORFs)on 3082 genes and found that tea plants may inhibit the overall expression of genes by enhancing the translation of uORFs under chilling *** addition,we identi fied distal transposase hypersensitive sites(THSs)and proximal THSs and constructed a transcriptional regulatory network for tea plants under chilling *** also identi fied 13 high-con fidence transcription factors(TFs)that may play a crucial role in cold *** results provide valuable information regarding the potential transcriptional regulatory network in plants and help to clarify how plants exhibit flexible responses to chilling stress.

关键词： stress chilling landscape

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Genetic basis of high aroma and stress toleranee in the oolong tea cultivar genome

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Horticulture Research 2021年第1期8卷 1256-1270页

作者： Pengjie Wang Jiaxin Yu Shan Jin Shuai Chen Chuan Yue Wenling Wang Shuilian Gao Hongli Cao Yucheng Zheng Mengya Gu Xuejin Chen Yun Sun Yuqiong guo jiangfan Yang Xingtan Zhang Naixing Ye College of Horticulture Fujian Agriculture and Forestry University/Key Laboratory of Tea Science in Universities of Fujian Province350002 FuzhouChina Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural Sciences518120 ShenzhenChina Center for Genomics and Biotechnology Fujian Provincial Key Laboratory of Haixia Applied Plant Systems BiologyKey Laboratory of GeneticsFujian Agriculture and Forestry University350002 FuzhouChina

Tea plants(Camellia sinensis)are commercially cultivated in>60 countries,and their fresh leaves are processed into tea,which is the most widely consumed beverage in the *** several chromosome-level tea plant genomes have been published,they collapsed the two haplotypes and ignored a large number of allelic variations that may underlie important biological functions in this ***,we present a phased chromosome-scale assembly for an elite oolong tea cultivar,"Huangdan",that is well known for its high levels of *** on the two sets of haplotype genome data,we identi fi ed numerous genetic variations and a substantial proportion of allelic imbalance related to important traits,including aroma-and stress-related *** genomics revealed extensive structural variations as well as expansion of some gene families,such as terpene synthases(TPSs),that likely contribute to the high-aroma characteristics of the backbone parent,underlying the molecular basis for the biosynthesis of aroma-related chemicals in oolong *** results uncovered the genetic basis of special features of this oolong tea cultivar,providing fundamental genomic resources to study evolution and domestication for the economically important tea crop.

关键词： sinensis cultivar elite

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基于有监督对比学习的遥感图像场景分类

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光子学报 2021年第7期50卷 79-90页

作者：郭东恩夏英罗小波丰江帆重庆邮电大学重庆市空间大数据智能技术工程研究中心重庆400065 南阳理工学院计算机与软件学院河南南阳473000

针对遥感场景图像中复杂背景以及类内多样性和类间相似性影响场景分类性能的问题,提出一种基于有监督对比学习的遥感场景分类方法。该方法包含判别性特征学习和线性分类两个阶段。在判别性特征学习阶段,引入有监督对比损失以拉近同类场... 详细信息

针对遥感场景图像中复杂背景以及类内多样性和类间相似性影响场景分类性能的问题,提出一种基于有监督对比学习的遥感场景分类方法。该方法包含判别性特征学习和线性分类两个阶段。在判别性特征学习阶段,引入有监督对比损失以拉近同类场景间的距离并增大不同类场景间的距离,提高类内多样性和类间相似性场景的判别能力;然后引入门控自注意模块对无用的背景信息进行过滤且聚焦关键场景区域,提高复杂背景的场景识别;最后引入一个预训练的Inception V3语义分支,把语义分支和原始模型提取的特征进行融合增强特征判别能力,以提高场景分类的整体性能。线性分类阶段通过对特征学习阶段训练的模型进行微调获得分类结果。在AID和NWPU-RESISC45数据集上的综合实验证明了所提方法的有效性。

关键词：有监督对比学习特征融合遥感场景分类门控机制自注意机制遥感图像预训练模型

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Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to hypothalamus and habenula

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中国药理学与毒理学杂志 2023年第7期37卷 547-548页

作者： WANG Muran LI Peijun LI Zewen Beatriz S.da SILVA ZHENG Wu XIANG Zhenghua HE Yan XU Tao Cristina CORDEIRO DENG Lu DAI Yuwei YE Mengqian LIN Zhiqing ZHOU Jianhong ZHOU Xuzhao YE Fenfen Rodrigo A CUNHA CHEN jiangfan guo Wei Wenzhou Medical University University of Coimbra NavalMedicalUniversity

Depressive disorder ranks as a major burden of disease worldwide, yet the current antidepressant medications are limited by frequent non-responsiveness and significant side effects. The lateral septum(LS) is thought to control of depression, however, the cellular and circuit substrates are largely unknown. Here, we identified a subpopulation of LS GABAergic adenosine A2A receptors(A2AR)-positive neurons mediating depressive symptoms via direct projects to the lateral habenula(LHb) and the dorsomedial hypothalamus(DMH). Activation of A2AR in the LS augmented the spiking frequency of A2AR-positive neurons leading to a decreased activation of surrounding neurons and the bi-directional manipulation of LS-A2AR activity demonstrated that LS-A2ARs are necessary and sufficient to trigger depressive phenotypes. Thus, the optogenetic modulation(stimulation or inhibition) of LS-A2AR-positive neuronal activity or LSA2AR-positive neurons projection terminals to the LHb or DMH, phenocopied depressive behaviors. Moreover,A2AR are upregulated in the LS in two male mouse models of repeated stress-induced depression. This identification that aberrantly increased A2AR signaling in the LS is a critical upstream regulator of repeated stress-induced depressive-like behaviors provides a neurophysiological and circuit-based justification of the antidepressant potential of A2AR antagonists, prompting their clinical translation.

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