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L.reuteri ZJ617 inhibits inflammatory and autophagy signaling pathways in gut-liver axis in piglet induced by lipopolysaccharide

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Journal of Animal Science and Biotechnology 2022年第2期13卷 551-566页

作者： Tao Zhu jiangdi mao Yifan Zhong Congxiang Huang Zhaoxi Deng Yanjun Cui Jianxin Liu Haifeng Wang The Key Laboratory of Molecular Animal Nutrition Ministry of EducationCollege of Animal ScienceZhejiang UniversityHangzhou 310058China Xixi Hospital of Hangzhou Hangzhou 310023China

Background:This study investigated the protective effects of L.reuteri ZJ617 on intestinal and liver injury and the underlying mechanisms in modulating inflammatory,autophagy,and apoptosis signaling pathways in a piglet challenged with lipopolysaccharide(LPS).Methods:Duroc×Landrace×Large White piglets were assigned to 3 groups(n=6/group):control(CON)and LPS groups received oral phosphate-buffered saline for 2 weeks before intraperitoneal injection(i.p.)of physiological saline or LPS(25μg/kg body weight),respectively,while the ZJ617+LPS group was orally inoculated with ZJ617 for 2 weeks before i.***.of LPS.Piglets were sacrificed 4 h after LPS injection to determine intestinal integrity,serum biochemical parameters,inflammatory signaling involved in molecular and liver injury pathways.Results:Compared with controls,LPS stimulation significantly increased intestinal phosphorylated-p38 MAPK,phosphorylated-ERK and JNK protein levels and decreased IκBαprotein expression,while serum LPS,TNF-α,and IL-6 concentrations(P<0.05)increased.ZJ617 pretreatment significantly countered the effects induced by LPS alone,with the exception of p-JNK protein levels.Compared with controls,LPS stimulation significantly increased LC3,Atg5,and Beclin-1 protein expression(P<0.05)but decreased ZO-1,claudin-3,and occludin protein expression(P<0.05)and increased serum DAO and D-xylose levels,effects that were all countered by ZJ617 pretreatment.LPS induced significantly higher hepatic LC3,Atg5,Beclin-1,SOD-2,and Bax protein expression(P<0.05)and lower hepatic total bile acid(TBA)levels(P<0.05)compared with controls.ZJ617 pretreatment significantly decreased hepatic Beclin-1,SOD2,and Bax protein expression(P<0.05)and showed a tendency to decrease hepatic TBA(P=0.0743)induced by LPS treatment.Pretreatment of ZJ617 before LPS injection induced the production of 5 significant metabolites in the intestinal contents:capric acid,isoleucine 1TMS,glycerol-1-phosphate byproduct,linoleic acid,alanine-alanine(P<0.05).Conclusions:These results demonstrated

关键词： Gut-liver axis Hepatic injury Intestinal barrier Lactobacillus Piglet Signaling pathways

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Proof of Two Supercongruences of Truncated Hypergeometric Series_(4)F_(3)

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Acta Mathematica Sinica,English Series 2024年第4期40卷 1015-1028页

作者： Guo Shuai mao Department of Mathematics Nanjing University of Information Science and TechnologyNanjing 210044P.R.China

In this paper,we prove two supercongruences conjectured by Z.-W.Sun via the Wilf-Zeilberger method.One of them is,for any prime p>3,4F3[7/6 1/2 1/2 1/2 1/6 1 1]-1/8]-1/2≡p(-2/p)+p^(3)/4(2/p)Ep-3 (mod p^(4))where(·/p... 详细信息

关键词： Supercongruence truncated hypergeometric series Wilf–Zeilberger method Euler numbers Legendre symbol

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Amorphous oxide semiconductor for monolithic 3D DRAM: an enabler or passer-by?

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National Science Review 2024年第3期11卷 19-20页

作者： Shujuan mao Guilei Wang Chao Zhao Beijing Superstring Academy of Memory Technology

Since dynamic random-access memory(DRAM) was invented in 1968 and put to market in the 1970s, 1 transistor plus 1 capacitor(1T1C)(Fig. 1a) cells have been used to take advantage of their structural simplicity and ease...

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Advances in mesenchymal stem cells therapy for tendinopathies

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Chinese Journal of Traumatology 2024年第1期27卷 11-17页

作者： Xu-Feng mao Xi-Qian Zhang Zhe-Yu Yao Hai-Jiao mao Department of Orthopaedic Surgery The First Affiliated Hospital of Ningbo UniversityNingbo315010Zhejiang provinceChina

Tendinopathies are chronic diseases of an unknown etiology and associated with inflammation.Mesenchymal stem cells(MSCs)have emerged as a viable therapeutic option to combat the pathological progression of tendinopathies,not only because of their potential for multidirectional differentiation and self-renewal,but also their excellent immunomodulatory properties.The immunomodulatory effects of MSCs are increasingly being recognized as playing a crucial role in the treatment of tendinopathies,with MSCs being pivotal in regulating the inflammatory microenvironment by modulating the immune response,ultimately contributing to improved tissue repair.This review will discuss the current knowledge regarding the application of MSCs in tendinopathy treatments through the modulation of the immune response.

关键词： Mesenchymal stem cells Tendinopathy Immunomodulation Treatment Review

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Autotomy does not affect the locomotor performance of a scorpion

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Integrative Zoology 2024年第2期19卷 336-338页

作者： Aijia mao Shichang ZHANG Centre for Behavioral Ecology and Evolution State Key Laboratory of Biocatalysis and Enzyme EngineeringSchool of Life SciencesHubei UniversityWuhanChina

Autotomy,the self-induced loss of a body part,is one of the most extreme forms of defense against predation.It occurs in a variety of animal taxa,including both vertebrates and invertebrates(Fleming et al.2007).The most commonly seen examples are spiders,lizards,and crustaceans(Emberts et al.2019)(Fig.1).By performing the autotomy behavior,animals can effectively survive predation or non-predatory entrapment,or reduce the cost of injury(Emberts et al.2019;Wuthrich et al.2022).

关键词： scorpion extreme performance

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Emerging materials and transistors for integrated circuits

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National Science Review 2024年第3期11卷 7-8页

作者： Ming Liu Lian-mao Peng Lab of Nanofabrication and Novel Device Integration Institute of Microelectronics Chinese Academy of Sciences Key Laboratory for the Physics and Chemistry of Nanodevices and Center for Carbon-based Electronics School of Electronics Peking University

The device technology for integrated circuits(ICs) has received a great deal of attention in the past decade since the mainstream silicon-based complementary metal-oxide-semiconductor(CMOS) field-effect transistor(FET) for modern ICs had been encountering development bottlenecks due to the combination of power constraints, physics, cost and fabrication processes.

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菜籽粕混合发酵饲料替代豆粕对生长猪生长性能、养分表观消化率以及血清生化和抗氧化指标的影响

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动物营养学报 2024年第1期36卷 162-173页

作者：毛江笛倪志翔汪海峰浙江大学动物科学学院杭州310058

本试验旨在研究菜籽粕混合发酵饲料替代豆粕对生长猪生长性能、养分表观消化率以及血清生化和抗氧化指标的影响。试验选用70%菜籽粕、15%玉米皮和15%麸皮混合作为发酵原料,筛选菌种后选择添加酵母菌、罗伊氏乳杆菌(Lactobacillus reute... 详细信息

本试验旨在研究菜籽粕混合发酵饲料替代豆粕对生长猪生长性能、养分表观消化率以及血清生化和抗氧化指标的影响。试验选用70%菜籽粕、15%玉米皮和15%麸皮混合作为发酵原料,筛选菌种后选择添加酵母菌、罗伊氏乳杆菌(Lactobacillus reuteri)和中性蛋白酶进行发酵。优化发酵条件后将条件控制为含水量55%、发酵温度30℃、发酵时间60 h,干燥制得发酵饲料。在饲喂试验中,选取平均体重为(39.3±5.3)kg的“杜×长×大”三元杂交生长猪72头,随机分为3组,每组3个重复,每个重复8头猪(公母各占1/2)。对照组(CON组)饲喂基础饲粮,未发酵组(RMD组)饲喂用15%未发酵菜籽粕混合饲料替代基础饲粮中豆粕、玉米和麸皮的饲粮,发酵组(FRMD组)饲喂用15%菜籽粕混合发酵饲料替代基础饲粮中豆粕、玉米和麸皮的饲粮。试验期28 d。结果表明:1)混合发酵显著提高了菜籽粕混合饲料的粗蛋白质(CP)和三氯乙酸酸溶蛋白(TCA-N)含量(P0.05);FRMD组总磷表观消化率要显著高于RMD组(P0.05),而FRMD组血清UN含量无显著差异(P>0.05);与RMD组相比,FRMD组血清谷胱甘肽过氧化物酶(GSH-Px)活性显著降低(P<0.05)。由此可见,混合发酵可提高菜籽粕的营养价值,并且菜籽粕在混合发酵后可部分替代生长猪饲粮中的豆粕。

关键词：菜籽粕固态发酵豆粕替代生长性能生长猪

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Heat Storage Performance of PCM in a Novel Vertical Pointer-Shaped Finned Latent Heat Tank

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Journal of Thermal Science 2024年第2期33卷 422-434页

作者： mao Qianjun ZHU Yuanyuan LI Tao School of Urban Construction Wuhan University of Science and TechnologyWuhan430065China

The heat storage performance of latent heat storage systems is not good due to the poor thermal conductivity of phase change materials.In this paper,a new type of pointer-shaped fins combining rectangular and triangular fins has been employed to numerically simulate the melting process in the heat storage tank,and the fin geometry parameter effects on heat storage performance have been studied.The results indicate that compared with the bare tube and the rectangular finned tank,the melting time of the phase change material in the pointer-shaped finned tank is reduced by 64.2%and 15.1%,respectively.The closer the tip of the triangular fin is to the hot wall,the better the heat transfer efficiency.The optimal height of the triangular fin is about 8 mm.Increasing the number of fins from 4 to 6 and from 6 to 8 reduces the melting time by 16.0%and 16.7%respectively.However,increasing the number of fins from 8 to 10 only reduces the melting time by 8.4%.When the fin dimensionless length is increased from 0.3 to 0.5 and from 0.5 to 0.7,the melting time is shortened by 17.5%and 13.0%.But the melting time is only reduced by 2.9%when the dimensionless fin length is increased from 0.7 to 0.9.For optimising the design of the thermal storage system,the results can provide a reference value.

关键词： thermal energy storage phase change material pointer-shaped fins heat storage performance

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Equilibrium Strategy of the Pursuit-Evasion Game in Three-Dimensional Space

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 446-458页

作者： Nuo Chen Linjing Li Wenji mao School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049 Institute of Automation Chinese Academy of SciencesBeijing 100190China

The pursuit-evasion game models the strategic interaction among players, attracting attention in many realistic scenarios, such as missile guidance, unmanned aerial vehicles, and target defense. Existing studies mainly concentrate on the cooperative pursuit of multiple players in two-dimensional pursuit-evasion games. However, these approaches can hardly be applied to practical situations where players usually move in three-dimensional space with a three-degree-of-freedom control. In this paper,we make the first attempt to investigate the equilibrium strategy of the realistic pursuit-evasion game, in which the pursuer follows a three-degree-of-freedom control, and the evader moves freely. First, we describe the pursuer's three-degree-of-freedom control and the evader's relative coordinate. We then rigorously derive the equilibrium strategy by solving the retrogressive path equation according to the Hamilton-Jacobi-Bellman-Isaacs(HJBI) method, which divides the pursuit-evasion process into the navigation and acceleration phases. Besides, we analyze the maximum allowable speed for the pursuer to capture the evader successfully and provide the strategy with which the evader can escape when the pursuer's speed exceeds the threshold. We further conduct comparison tests with various unilateral deviations to verify that the proposed strategy forms a Nash equilibrium.

关键词： Differential game equilibrium strategy pursuit-evasion game threedegree-of-freedom control

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First Passage Density of Brownian Motion with Two-sided Piecewise Linear Boundaries

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1505-1520页

作者： Zhen YU mao Zai TIAN Center for Applied Statistics School of StatisticsRenmin University of ChinaBeijing 100872P.R.China School of Mathematics and Data Science Changji UniversityChangji 831100P.R.China

The first passage time has many applications in fields like finance,econometrics,statistics,and biology.However,explicit formulas for the first passage density have only been obtained for a few cases.This paper derives an explicit formula for the first passage density of Brownian motion with twosided piecewise continuous boundaries which may have some points of discontinuity.Approximations are used to obtain a simplified formula for estimating the first passage density.Moreover,the results are also generalized to the case of two-sided general nonlinear boundaries.Simulations can be easily carried out with Monte Carlo method and it is demonstrated for several typical two-sided boundaries that the proposed approximation method offers a highly accurate approximation of first passage density.

关键词： Boundary non-crossing probability first density passage density two-sided piecewise continuous boundaries Brownian motion

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