检索结果-南通市图书馆

The CXCR4-CXCL12 axis promotes T cell reconstitution via efficient hematopoietic immigration

Journal of Genetics and Genomics 2022年第12期49卷 1138-1150页

作者： Fangying Zhao Yafang Lu Zhifan Li jiangyong he Nianfei Cui Lingfei Luo Li Li Institute of Developmental Biology and Regenerative Medicine Key Laboratory of Freshwater Fish Reproduction and DevelopmentMinistry of EducationSouthwest UniversityChongqing 400715China Research Center of.Stem Cells and Ageing Chongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing 400714China

T cells play a critical role in immunity to protect against pathogens and malignant cells.T cell immunodeficiency is detrimental,especially when T cell perturbation occurs during severe infection,irradiation,chemotherapy,and age-related thymic ***,strategies that enhance T cell reconstitution provide considerable benefit and warrant intensive ***,we report the construction of a T cell ablation model in Tg(coro1a:Den NTR)zebrafish via metronidazole *** nascent T cells are mainly derived from the hematopoietic cells migrated from the kidney,the functional homolog of bone marrow and the complete recovery time is 6.5 days *** cxcr4b gene is upregulated in the responsive hematopoietic *** interference of CXCR4 via both genetic and chemical manipulations does not greatly affect T lymphopoiesis,but delays T cell regeneration by disrupting hematopoietic *** contrast,cxcr4b accelerates the replenishment of hematopoietic cells in the ***,Cxcl12b,a ligand of Cxcr4,is increased in the thymic epithelial cells of the injured *** or increased expression of Cxcl12b results in compromised or accelerated T cell recovery,respectively,similar to those observed with *** together,our study reveals a role of CXCR4-CXCL12 signaling in promoting T cell recovery and provides a promising target for the treatment of immunodeficiency due to T cell injury.

关键词： T cell reconstitution Immigration Cxcr4b Cxcl12b Zebrafish

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Land surface temperature retrieval for arid regions based on Landsat-8 TIRS data:a case study in Shihezi,Northwest China

引用

Journal of Arid Land 2014年第6期6卷 704-716页

作者： Lei YANG YunGang CAO XiaoHua ZHU Shenghe ZENG GuoJiang YANG jiangyong he XiuChun YANG Department of Remote Sensing and Geographic Information Engineering Faculty of Geosciences and Environmental EngineeringSouthwest Jiaotong University Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Institute of Farmland Water Conservancy and Soil-fertilizer Xinjiang Academy of Agricultural and Reclamation Science Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences College of Environment and Planning Shangqiu Normal University

Scientific interest in geophysical information about land surface temperature （LST） is ever increasing, as such information provides a base for a large number of applications, including environmental and agricultural monitoring. Therefore, the research of LST retrieval has become a hot topic. Recent availability of Landsat-8 satel- lite imagery provides a new data source for LST retrieval. hence, exploring an adaptive method with reliable ac- curacy seems to be essential. In this study, basing on features of Landsat-8 TIRS thermal infrared channels, we re-calculated parameters in the atmospheric transmittance empirical models of the existing split-window algorithm, and estimated the ground emissivity with the help of the land cover classification map of the study area. Further- more, a split-window algorithm was rebuilt by virtual of the estimation model of the updated atmospheric transmit- tance and the ground emissivity, and then a remote sensing retrieval for the LST of Shihezi city in Xinjiang Uygur autonomous region of Northwest China was conducted on the basis of this modified algorithm. Finally, precision validation of the new model was implemented by using the MODIS LST products. The results showed that the LST retrieval from Landsat-8 TIRS data based on our algorithm has a higher credibility, and the retrieved LST is more consistent with the MODIS LST products. This indicated that the modified algorithm is suitable for retrieving LST with competitive accuracy. With higher resolutions, Landsat-8 TIRS data may provide more accurate observation for LST retrieval.

关键词： thermal infrared remote sensing land surface temperature retrieval split-window algorithm Landsat-8 TIRS

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tunable and narrow linewidth multi-wavelength Brillouin-erbium fiber laser using dual-wavelength pumping

引用

Optoelectronics Letters 2022年第6期18卷 349-353页

作者： ZHU Kaiyan he jiangyong CHANG Kun XING Dengke LIU Yange WANG Zhi Tianjin Key Laboratory of Optoelectronic Sensor and Sensing Network Technology Institute of Modern OpticsNankai UniversityTianjin 300350China

We demonstrate a multi-wavelength Brillouin-erbium fiber laser(BEFL)with narrow linewidth and tunable wavelength interval using dual-wavelength Brillouin *** generation of multi-wavelength output in BEFL is based on the combination of stimulated Brillouin scattering(SBS)and four-wave mixing(FWM)effect in a fiber *** tunable wavelength interval is determined by the artificially controlled wavelength interval of the pumping *** BEFL could compress a 1 MHz pump laser to a 340 Hz Brillouin Stokes laser,which proves the BEFL has excellent capability of linewidth *** erbium-doped fiber pumped by 980 nm laser is inserted into the cavity to further amplify the Brillouin *** wideband multi-wavelength BEFL covering over 50 nm is successfully generated when the 980 nm pump power is 400 *** features of multi-wavelength BEFL provide an effective method for optical communication systems and optical fiber sensing.

关键词： pumping fiber laser

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Alterations in immune cell heterogeneities in the brain of aged zebrafish using single-cell resolution

引用

Science China(Life Sciences) 2023年第6期66卷 1358-1378页

作者： jiangyong he Fangying Zhao Bingyue Chen Nianfei Cui Zhifan Li Jie Qin Lingfei Luo Congjian Zhao Li Li Institute of Developmental Biology and Regenerative Medicine Key Laboratory of Freshwater Fish Reproduction and DevelopmentMinistry of EducationSouthwest UniversityChongqing400715China Research Center of Stem cells and Aging Chongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing400714China Chongqing Engineering Research Center of Medical Electronics and Information Technology School of BioinformaticsChongqing University of Posts and TelecommunicationsChongqing400065China

Immunocytes,including the microglia,are crucial in the neurodegenerative process in old ***,the understanding regarding microglia heterogeneity and other involved immunocytes remains *** analyzed 26,456 immunocytes from 12-and 26-month-old zebrafish brains at single-cell *** and T lymphocytes were detected in the brain at both time *** types of microglia were annotated,namely,ac+microglia and xr+microglia,which were clustered into subsets 1,2,3,4,5,and subsets 6,7,8,9,*** microglia predominated the adult brains and cooperated with T cells to perform the functions of immune response and neuronal *** validated the specific microglia *** novel transgenic lines,Tg(lgals3bpb:e GFP)and Tg(apoc1:e GFP),were created,which faithfully labeled ac+microglia and served as valuable labeling ***,the microglia population reduced while T cells of six subtypes intriguingly increased to serve as the primary immune cells in aged *** in 12-month-old brains,T cells,together with microglia,exhibited a coordinated signature of inflammation in the 26-month-old *** findings revealed the immunocytes atlas in aged zebrafish *** implied the involvement of microglia and T cells in the progression of neurodegeneration in aging.

关键词： aging scRNA-seq microglia T lymphocyte inflammation zebrafish

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sub-terahertz-repetition-rate frequency comb generated by filter-induced instabilities in passive driven fiber resonators

引用

Photonics Research 2022年第2期10卷 465-474页

作者： Pan Wang jiangyong he Xiaosheng Xiao Zhi Wang Yange Liu Institute of Modern Optics Nankai UniversityTianjin Key Laboratory of Micro-scale Optical Information Science and TechnologyTianjin 300350China School of Electronic Engineering State Key Laboratory of Information Photonics and Optical CommunicationsBeijing University of Posts and TelecommunicationsBeijing 100876China

Ultrahigh-repetition-rate frequency comb generation exhibits great potential in applications of optical waveform synthesis, direct comb spectroscopy, and high capacity telecommunications. here we present the theoretical investigations of a filter-induced instability mechanism in passive driven fiber resonators with a wide range of cavity dispersion regimes. In this novel concept of modulation instability, coherent frequency combs are demonstrated numerically with rates up to sub-terahertz level. Floquet stability analysis based on the Ikeda map is utilized to understand the physical origin of the filter-induced instability. Comparison with the well-known Benjamin–Feir instability and parametric instability is performed, revealing the intrinsic distinction in the family of modulation instabilities. Our investigations might benefit the development of ultrahigh-repetition-rate frequency comb generation, providing an alternative method for the microresonators.

关键词： passive fiber repetition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

阿托品对提高多巴酚丁胺负荷超声心动图诊断价值的研究

引用

中国超声医学杂志 1999年第9期15卷 26-28页

作者：王霏贺江勇吴芳石家庄市白求恩国际和平医院特诊科

目的⑶研究阿托品对提高多巴酚丁胺负荷超声心动图诊断的价值⒚方法⑶对２７１例临床可疑或确诊的冠心病患者行多巴酚丁胺负荷超声心动图 ⒉ ＤＳＥ⒕检查⒙其中６９例不能达到预估心率且未诱发心肌缺血者加用阿托品⒚２７１例中... 详细信息

目的⑶研究阿托品对提高多巴酚丁胺负荷超声心动图诊断的价值⒚方法⑶对２７１例临床可疑或确诊的冠心病患者行多巴酚丁胺负荷超声心动图 ⒉ ＤＳＥ⒕检查⒙其中６９例不能达到预估心率且未诱发心肌缺血者加用阿托品⒚２７１例中５８例于ＤＳＥ检查前 ⒉后⒕２周内行冠脉造影⒚结果⑶单纯使用多巴酚丁胺达预估心率者１３７例 ⒉５１％ ⒕⒙检出心肌缺血１２１例⒛加用阿托品后⒙达预估心率者共１８９例 ⒉６９％ ⒕⒙检出心肌缺血共１４３例⒚与冠脉造影结果相对照⒙ ＤＳＥ检查中加用阿托品较单纯使用多巴酚丁胺敏感性由７８％升至８９％ ⒉ Ｐ＜００１⒕⒙特异性无明显变化⒚结论⑶在ＤＳＥ试验中加用阿托品⒙提高了ＤＳＥ的诊断价值⒚

关键词：多巴酚丁胺负荷试验阿托品心肌缺血

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

学案导学,让线上教育更高率

引用

当代家庭教育 2020年第36期 44-45页

作者：何江勇广东省广州市黄埔区东荟花园小学

今年3月,各省市根据教育部的工作部署,以不同的方式开展了线上教育工作。我校根据上级从"教的设计"转向"学的设计"的教学资源设计和开发精神,创新使用了导学案配合线上教育的教学模式,注重对学生进行教师指导下的自主学习能力培养,取得... 详细信息

今年3月,各省市根据教育部的工作部署,以不同的方式开展了线上教育工作。我校根据上级从"教的设计"转向"学的设计"的教学资源设计和开发精神,创新使用了导学案配合线上教育的教学模式,注重对学生进行教师指导下的自主学习能力培养,取得了较好的教育效果。本文以数学导学案为例,对导学案不同环节的设计与实施要点进行了介绍与分享。

关键词：导学案设计线上教育

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

热解气氛对所得半焦燃烧污染气体释放的影响

引用

煤炭转化 2019年第1期42卷 31-39页

作者：王昱邹冲赵俊学马成何江永西安建筑科技大学冶金工程学院西安硕士生710055

采用热质联用技术,考察了不同热解气氛下制备的半焦在燃烧过程中污染气体的释放特征。结果表明:加入氢气、甲烷和一氧化碳的热解气氛与纯氮气气氛下热解制备半焦相比,SO_2,NO_2和CO的释放强度均有显著降低,这反映出还原性气体能促进含... 详细信息

采用热质联用技术,考察了不同热解气氛下制备的半焦在燃烧过程中污染气体的释放特征。结果表明:加入氢气、甲烷和一氧化碳的热解气氛与纯氮气气氛下热解制备半焦相比,SO_2,NO_2和CO的释放强度均有显著降低,这反映出还原性气体能促进含硫有机官能团、含氮有机官能团和部分含氧羧基官能团的断裂与释放;在还原气氛下制备的半焦在燃烧过程中污染气体的释放温度区间也有明显缩短,进一步说明了还原性热解气氛有助于降低半焦燃烧过程中污染气体的释放;此外,还原性气体还显著提高了半焦的放热量。因此,提高热解气氛中还原性气体比例,是实现半焦清洁燃烧的有效方法。

关键词：低温热解半焦燃烧热解气氛污染气体放热量

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

低温干馏煤气/富氧大当量比燃烧实验及数值模拟研究

引用

煤炭转化 2021年第2期44卷 25-34页

作者：任萌萌马成赵俊学邹冲何江永西安建筑科技大学冶金工程学院西安710055

在内热式低温煤干馏中,引入富氧燃烧,同时提高煤气当量比,是在维持炉内温度分布基本不变的前提下提高煤气质量的有效途径。通过不同富氧比及不同尺寸烧嘴下的大当量比煤气/富氧燃烧实验结合数值模拟分析,探究了富氧低温干馏中的内热火... 详细信息

在内热式低温煤干馏中,引入富氧燃烧,同时提高煤气当量比,是在维持炉内温度分布基本不变的前提下提高煤气质量的有效途径。通过不同富氧比及不同尺寸烧嘴下的大当量比煤气/富氧燃烧实验结合数值模拟分析,探究了富氧低温干馏中的内热火焰温度分布特性及其受工艺条件和烧嘴尺寸的影响。结果表明:增大富氧比的同时增大燃料当量比可以维持平均火焰温度与空气助燃工况基本一致,但火焰锋面温度受局部当量比及流动条件影响;减小燃料及氧化剂射流的初始速度差,可以减缓组分混合、延长火焰并降低火焰锋面温度;煤气中三种气体按参与反应的速率快慢排序依次为氢气、一氧化碳、甲烷,随着燃烧反应进入湍流混合速率控制模式,组分间的选择性燃烧特征相对减弱。

关键词：煤低温干馏大当量比富氧燃烧温度场计算流体动力学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

低温干馏煤气/富氧大当量比燃烧热力学分析

引用

煤炭转化 2021年第4期44卷 13-19页

作者：任萌萌赵俊学邹冲何江永张红西安建筑科技大学冶金工程学院西安710055

为明确煤气/富氧大当量比燃烧过程中煤气各可燃组分间氧化剂竞争机制及其对内热火焰温度和干馏介质成分的影响,对该反应体系进行了热力学分析。结果表明:各组分的燃烧优先度随反应温度而变化,低温(1143 K)下CH_(4)优先燃烧;除选择性燃烧... 详细信息

为明确煤气/富氧大当量比燃烧过程中煤气各可燃组分间氧化剂竞争机制及其对内热火焰温度和干馏介质成分的影响,对该反应体系进行了热力学分析。结果表明:各组分的燃烧优先度随反应温度而变化,低温(1143 K)下CH_(4)优先燃烧;除选择性燃烧外,甲烷化和甲烷重整反应在800 K~1000 K发生转变、水煤气反应平衡等因素共同决定了反应体系平衡组分中的xCH_(4)随温度升高而降低,xCO和xH_(2)随温度升高而升高且CO和H_(2)相互共存;各燃料组分的选择性燃烧及不完全燃烧产物间相互转化的热效应,导致绝热火焰温度差值高达550 K以上;CO_(2)稀释对平衡温度的降低作用大于H_(2)O稀释对平衡温度的降低作用,但H_(2)O稀释条件下平衡组分中的xH_(2)更高;当量比大于6时,当量比对平衡温度的影响减弱。实际工艺参数设计中可以适当降低当量比以提高干馏介质中的氢气含量,有助于加氢热解。

关键词：低温煤干馏热力学分析选择性燃烧大当量比富氧燃烧

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：