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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： shan Ping Yu Emily Choi Michael Qjiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

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Bifunctional bridging capping layer enables 24.5% efficiency of perovskite solar cells with polymer-based hole transport materials

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Science China Chemistry 2025年第1期68卷 350-359页

作者： Can Zhu Yiyang Wang Lei Meng Beibei Qiu Jing Li Shucheng Qin Ke Hu Xin jiang Wenbin lai Minchao Liu Zhe Liu Chenxing Lu Jinyuan Zhang Yongfang Li Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences School of Chemical Science University of Chinese Academy of Sciences Key Laboratory of Solid State Optoelectronic Devices of Zhejiang Province College of Physics and Electronic Information Engineering Zhejiang Normal University Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of Sciences Laboratory of Advanced Optoelectronic Materials College of Chemistry Chemical Engineering and Materials ScienceSoochow University

Developing a bridge capping layer between perovskite and hole transport layer materials（HTMs） in the n-i-p perovskite solar cells（pero-SCs） is an effective approach to modify the morphology of HTMs and passivate the perovskite ***, we select the quinoxaline-based bifunctional passivation agent, quinoxalin-6-yl-methylamine hydrochloride（Qx MACl）,as the bridging layer, and a D-A copolymer PBQ12 containing the same quinoxaline unit as an HTM for the n-i-p pero-SCs. Due to the π-π stacking among the common quinoxaline units in the bridge layer and HTM, Qx MACl induces the π-π stacking of the PBQ12 film and improves the film morphology of HTMs with better conductivity. Additionally, Qx MACl can effectively passivate the perovskite surface, and PBQ12 possesses appropriate energy levels and high hole mobility. The pero-SCs based on FAPbI3with PBQ12/Qx MACl treatment showed a higher power conversion efficiency（PCE） of 24.05% and outstanding stability, maintaining 95.4% and 92.1% of its initial PCE after 750 h of storage and after over 800 h of thermal annealing at 85 °C, respectively. To further enhance the PCE of the PBQ12/Qx MACl-based devices, we developed a non-metal ion dopant for the PBQ12 HTM. Through trace doping of PBQ12 HTM by the non-metal ion dopant, the PCE of the PBQ12/Qx MACl-based devices reached 25.24%（the calibrated PCE of 24.55% by the National Institute of Metrology, China）.

关键词： D-A copolymer, hole transport materials, bifunctional bridge capping layer, passivation perovskite solar cells

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Towards a scientific rationale for traditional properties of Chinese medicinal plants: “natures” and “flavors”

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Chinese Herbal Medicines 2019年第3期11卷 258-266页

作者： Li-ping Li Ben-gang Zhang Zhao Zhang Xiao-jin Li Guo-ping Wang Hai-long Song Cong-zhao Fan Yang-ming jiang Tuo Wang Hui-hui Zhao Wei-hong Cui jiang-shan lai Xiu-lian Chi Xue-ping Wei Chong-ming Wu Yao-dong Qi Hai-tao Liu Pei-gen Xiao Eimear Nic Lughadha Christine J.Leon Institute of Remote Sensing and Digital Earth Chinese Academy of SciencesBeijing100101China Institute of Medicinal Plant Development Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing100193China Xinjiang Institute of Chinese and Ethnic Medicine Urumqi830002China State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing100093China National Resource Center for Chinese Materia Medica China Academy of Chinese Medical SciencesState Key Laboratory Breeding Base of Dao-di HerbsBeijing100700China Conservation Science Department Royal Botanic GardensKewRichmondSurreyTW93AEUK Collections Department Royal Botanic GardensKewRichmondSurreyTW93AEUK

Objective: According to theory of Chinese medicine property, the ecological environment shapes properties(natures and flavors) of Chinese materia medica(CMM) and there are close relationships between certain natures and flavors. However, to date these observations have not been validated scientifically in the context of the whole flora of a region. The present study aims to address this ***: We collected geographical distributions of 3637 vascular plant species native to the Xinjiang region of northwest China, of which around 812 are medicinal plants. The CMM property characters of these medicinal plants were also collected. All medicinal plants were then analyzed in the occurrence of their natures(cold, cool, neutral, warm, and hot) and flavors(sweet, bitter, sour, salty, and pungent). Possible correlations between these properties and environmental factors, notably climate, as well as correlations with plant species richness of the wider native flora of Xinjiang were then investigated using permutation test and ***: Cold species(38.5%) were more numerous than warm(21.0%) and neutral(22.3%), while bitter species(43.3%) were more numerous than pungent(25.6%), sweet(22.4%) and sour(6.7%) ones. Species with bitter flavor were most commonly also cold(48.6%) in nature, sour flavor usually coincided with cold(44.2%) or cool nature(26.0%), whereas pungent or sweet species tended to be warm(34.4%, 28.4%) or neutral(27.8%, 28.4%). The percentages of species of cold/cool nature, bitter flavor were higher in mountainous regions, and the percentages of warm/neutral and pungent/sweet/sour were higher in basins. The percentages of species of cold/cool, bitter were positively correlated with actual evapotranspiration(AET),and also plant species richness but had a bell-shaped relationship with potential evapotranspiration(PET),whereas the inverse situation was shown for warm/neutral and pungent/sweet/sour ***: Analysis of the data in Xinjiang

关键词： flavor nature Chinese materia medica theory of Chinese medicine property Xinjiang region

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组织工程技术修复颞下颌关节:问题与挑战

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中国组织工程研究 2025年第22期29卷 4804-4812页

作者：赖鹏宇梁冉沈山暨南大学口腔医学院广东省广州市510632

背景:颞下颌关节疾病的传统疗法受限于疾病严重程度和个体差异。相比之下,组织工程作为一种新兴治疗方法,可以根据患者具体情况定制个性化治疗方案,减少手术过程中的不确定性,提高治疗效果。目的:综述组织工程修复颞下颌关节的最新研究... 详细信息

背景:颞下颌关节疾病的传统疗法受限于疾病严重程度和个体差异。相比之下,组织工程作为一种新兴治疗方法,可以根据患者具体情况定制个性化治疗方案,减少手术过程中的不确定性,提高治疗效果。目的:综述组织工程修复颞下颌关节的最新研究成果和进展。方法:以“颞下颌关节,组织工程,种子细胞,支架,生长因子,动物模型”为中文检索词,以“temporomandibular joint,tissue engineering,seed cell,scaffold,growth factor,animal model”为英文检索词,分别在PubMed数据库和中国知网进行文献检索,检索时限为各数据库建库时间至2024年3月。通过分析和阅读文献进行筛选,按照排除筛选标准纳入文献,最终纳入57篇文献进行综述。结果与结论:(1)随着生物学、材料学与工程学等技术的发展,颞下颌关节组织工程己取得较大进展,例如种子细胞的筛选、新型支架的开发、生长因子作用机制的探索、多种动物模型的构建等,目前大多数研究尚处于体外实验阶段,动物实验等体内研究尚未大规模开展,组织工程修复颞下颌关节的临床应用还需更多证据支持。(2)尽管颞下颌关节组织工程研究仍存在许多问题和挑战等待解决,依然展现出广阔的临床应用前景,有望在将来成为颞下颌关节疾病出色高效的治疗方式。

关键词：组织工程颞下颌关节软骨缺损种子细胞支架水凝胶脱细胞外基质生长因子外泌体动物模型

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Surface micro-arrays enhancing electromagnetic interference shielding of polydimethylsiloxane/multiwalled carbon nanotubes nanocomposites

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Nano Research 2025年第1期18卷 508-519页

作者： Ke jiang Zhi Chen Ji Yu Chen Zheng shan Huang Ming Wang Chongqing Key Laboratory of Soft-Matter Material Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China School of Mechanics Civil Engineering and ArchitecturesNorthwestern Polytechnical UniversityXi’an 710072China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Herein,the electromagnetic shielding performance of surface concave-convex(SC)and zig-zag micro-arrays was studied by using a simulation prediction and a three-dimensional(3D)printing custom ***,surface stripe concaveconvex(SSC)and surface cylindrical concave-convex(SCC)micro-arrays with or without zig-zag micro-arrays are designed,and their shielding performance is simulated in multi-bands(C-,X-band).The multiwalled carbon nanotubes/polydimethylsiloxane composites(MWCNT/PDMS)with different SC structures and different electrical conductivity are molded in acrylonitrile-butadiene-styrene copolymer(ABS)molds which are printed by a 3D *** results show that the electromagnetic interference shielding effectiveness(EMI SE)of the samples can be enhanced by constructing the SC micro-arrays with zig-zag micro-arrays,and improving with the increase of conductivity and *** addition,the shielding mechanism of the SC-MWCNT/PDMS composites is investigated and discussed by an electromagnetic simulation.

关键词： surface micro-arrays electrical properties electromagnetic interference(EMI)shielding three-dimensional(3D)printing

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Analytical solutions for elastic binary nanotubes of arbitrary chirality

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Acta Mechanica Sinica 2016年第6期32卷 1046-1057页

作者： lai jiang Wanlin Guo State Key Laboratory of Mechanics and Control for Mechanical Structures and Key Laboratory for Intelligent Nano Materials and Devices (MOE) Nanjing University of Aeronautics and Astronautics

Analytical solutions for the elastic properties of a variety of binary nanotubes with arbitrary chirality are obtained through the study of systematic molecular mechanics. This molecular mechanics model is first extended to chiral binary nanotubes by introducing an additional out-of-plane inversion term into the so-called stick-spiral model, which results from the polar bonds and the buckling of binary graphitic crystals. The closed-form expressions for the longitudinal and circumferential Young's modulus and Poisson's ratio of chiral binary nanotubes are derived as functions of the tube diameter. The obtained inversion force constants are negative for all types of binary nanotubes, and the predicted tube stiffness is lower than that by the former stick-spiral model without consideration of the inversion term, reflecting the softening effect of the buckling on the elastic properties of binary nanotubes. The obtained properties are shown to be comparable to available density functional theory calculated results and to be chirality and size sensitive. The developed model and explicit solutions provide a systematic understanding of the mechanical performance of binary nanotubes consisting of III-V and II-VI group elements.

关键词： Binary nanotubes Elastic properties Molecular mechanics Chirality Analytical solutions

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A New Series of Mo-free 21.5Cr-3.5Ni-xW-0.2N Economical Duplex Stainless Steels

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Journal of Iron and Steel Research International 2014年第1期21卷 69-75页

作者： Zi-xing ZHANG Qing-xuan RAN Yu-lai XU Xiao-jiang YU Da-wei jiang Xue-shan XIAO Laboratory for Microstructures Institute of MaterialsShanghai University

A new series of economical Mo-free duplex stainless steels 21.5Cr-3.5Ni-xW-0. 2N （x = 1.8 -- 3. 0, mass%） have been developed. The effects of W on mechanical properties and corrosion resistance were investigated, and the microstructures were analyzed by optical microscopy, X-ray diffraction, transmission electron microscopy and electron backscatter diffraction. The designed steels have a balanced ferrite-austenite relation and are free of sigma phase after solution treatment at 750--1 300 ~C for 30 min followed by water-quenching, whereas a small number of Cr23 C~ precipitates were found after solution treatment at 750 ~C. After solution treatment at 1050 ℃, the steel with 1.8~ （mass percent） W exhibits the highest room temperature tensile strength due to the strongest work hardening effect, while the steel with 3.0% （mass percent） W exhibits the highest fracture elongation owing to the transformation-in- duced plasticity （TRIP） effect. The ductile-brittle transition （DBT） and martensite transformation are respectively found in the ferrite and austenite, which deteriorates the impact properties of the steels with the increase of W con- tent. The corrosion resistance of the designed steels is improved with the increase of W content. The pitting resistance of austenite is obviously better than that of ferrite for the designed alloys. Among the designed steels, the steel with 1.8% （mass percent） W is found to be an optimum steel with excellent comprehensive properties and lowest production cost.

关键词： economical duplex stainless steel tungsten mechanical property pitting corrosion resistance

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Application of Online SVR on the Dynamic Liquid Level Soft Sensing

Application of Online SVR on the Dynamic Liquid Level Soft S...

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第25届中国控制与决策会议

作者： Bai shan jiang Zijian Wang Tong lai Haozhe School of Electrical Engineering Shenyang University of Technology

ISBN: (纸本)9781467355339

There exist different kinds of drawbacks and security risks in the measurement methods of dynamic liquid level in oilfield, consequently ,each of them can’t provide reliable protection to the oilfield for its high efficiency production operations and easily to cause significant economic losses .In order to solve the problems above , soft sensing technology is found as a new way to measure the dynamic liquid level of the oilfield instead of original hardware technology. ANN is a kind of soft sensing technology which is earlier to be used as the way to measure the dynamic liquid level ,but there are some problems restricted its use of areas, such as easy to fall into local minimization, slow convergence speed and poor generalization *** to the oilfield data’s characteristics ,Online SVR algorithm is proposed to be a solution to measure the dynamic liquid level in this paper. As a kind of soft sensing technology ,Online SVR not only has the same performance of ANN, but also can update the forcast model by online .In addition, it also solve the problems of ANN .Online SVR algorithm is verified by the experiment in this paper and the result of this experiment shows that Online SVR has higher precision than ANN .The experimental results also show the Online SVR can be used in measuring the dynamic liquid level in oilfield.

关键词： Dynamic Liquid Level Soft Sensing Online SVR Artificial Neural Networks

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A Scoping Review of Global Guidelines for the Disclosure of Secondary Genomic Findings to Inform the Establishment of Guidelines in China

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China CDC weekly 2022年第32期4卷 697-705页

作者： shan jiang School of Population and Public Health the University of British ColumbiaVancouverBCCanada

The detection and disclosure of secondary findings(SFs)is a preventive strategy for medically-actionable hereditary health *** countries have guidelines on management and disclosure of SFs,while others avoid detection and disclosure of *** study is a review of clinical guidelines from six countries and the European Union to identify similarities and differences among SF *** from this review supports harmonization of guidelines across countries to promote broad international collaborations on genomics and to benefit precision *** study can serve as a reference for development of SF management guidelines in China by contributing evidence from other countries to the ethical and methodological challenges under debate.

关键词： finding hereditary Secondary

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Experimental study of solid-liquid origami composite structures with improved impact resistance

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Theoretical & Applied Mechanics Letters 2024年第2期14卷 118-123页

作者： Shuheng Wang Zhanyu Wang Bei Wang Zhi Liu Yunzhu Ni Wuxing lai shan jiang Yong An Huang AML Department of Engineering MechanicsLaboratory of Flexible Electronics TechnologyTsinghua UniversityBeijing 100084China Institute of Advanced Structure Technology Beijing Key Laboratory of Lightweight Multi-functional Composite Materials and StructuresBeijing Institute of TechnologyBeijing 100081China Hangzhou Institute of Technology Xidian UniversityHangzhou 311200China Nanjing Research Institude of Electronics Technology Nanjing 210039China The Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China

In this paper,a liquid-solid origami composite design is proposed for the improvement of impact *** this design strategy,Kresling origami composite structures with different fillings were designed and fabricated,namely air,water,and shear thickening fluid(STF).Quasi-static compression and drop-weight impact experiments were carried out to compare and reveal the static and dynamic mechanical behavior of these *** results from drop-weight impact experiments demonstrated that the solid-liquid Kresling origami composite structures exhibited superior yield strength and reduced peak force when compared to their empty ***,the Kresling origami structures filled with STF exhibited significantly heightened yield strength and reduced peak *** example,at an impact velocity of 3 m/s,the yield strength of single-layer STF-filled Kresling origami structures increased by 772.7%and the peak force decreased by 68.6%.This liquid-solid origami composite design holds the potential to advance the application of origami structures in critical areas such as aerospace,intelligent protection and other important *** demonstrated improvements in impact resistance underscore the practical viability of this approach in enhancing structural performance for a range of applications.

关键词： Solid-liquid design Origami structure Impact resistance Shear thickening fluid

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