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基于改进凸包缺陷算法的扎带定位方法

纺织学报 2024年第9期45卷 212-219页

作者：周其洪陈唱任佳伟洪巍岑均豪东华大学机械工程学院上海201620 广州盛原成自动化科技有限公司广东广州511400

针对传统视觉在检测捆扎带时存在难检、漏检、定位扎带位置困难和速度慢等问题,提出一种基于改进凸包缺陷算法的扎带定位方法。采用自适应直方图均衡化图像增强算法,以增强编织袋区域与背景的对比度;利用快速凸包算法获得编织袋轮廓的凸... 详细信息

针对传统视觉在检测捆扎带时存在难检、漏检、定位扎带位置困难和速度慢等问题,提出一种基于改进凸包缺陷算法的扎带定位方法。采用自适应直方图均衡化图像增强算法,以增强编织袋区域与背景的对比度;利用快速凸包算法获得编织袋轮廓的凸包,减少获取凸包的时间;最后,通过改进凸包缺陷算法对编织袋轮廓凸包进行缺陷检测,根据检测结果中凸包缺陷点的位置和缺陷深度进行筛选得到扎带定位点。同时为验证该算法的准确性与鲁棒性,在具有复杂背景干扰的环境下进行实验,将传统凸包缺陷算法与改进后的凸包缺陷算法进行对比分析。实验结果表明:相比于传统凸包缺陷算法无法检测出编织袋轮廓的全部缺陷从而存在漏检,改进后的凸包缺陷算法漏检率为0,定位误差小于4 mm,可有效定位扎带位置并具有较高的鲁棒性。

关键词：扎带定位凸包算法缺陷检测图像增强直方图均衡化筒子纱包装

New Cassane Diterpenoids from the Seed Kernels of Caesalpinia cucullata, Exhibit Anti-inflammatory Effect in vitro by Inhibiting iNOS Enzymatic Activity

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Chinese Journal of Chemistry 2021年第6期39卷 1625-1634页

作者： Miao Wang Yi-ren Yang Yan Yin Kai-Ru Song Li-ping Long Xian-Zhe Li Bei Zhou Hui-Yuan Gao School of Traditional Chinese Moterio Medico Shenyang Pharmaceutical UniversityShenyangLiaoning 110016China Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of Education Shenyang Pharmoceuticol UniversityShenyangLiaoning 110016China

Inflammation is a complex biological response to *** cassane diterpenoids from Caesalpinia genus exhibit significant anti-inflammation *** new cassane diterpenoids(1-8)along with seven known ones(9-15)were obtained from the seed kernels of Caesalpinia cucullata *** is the first report on chemical investigation of the seed kernels of ***,and the cassane diterpenes were found in this plant for the first *** structures were elucidated based on the extensive spectroscopic analyses,and the absolute configurations were identified by ECD calculation and X-ray *** compounds were evaluated for their anti-inflammation activity by inhibiting NO production in LPS-induced RAW 264.7 *** 1-2 and 9-11 exhibited effective inhibitory activity with inhibition rate more than 50%.The iNOS enzyme activity and molecular docking experiments were performed to explore the preliminary ***,a potential anti-inflammatory mechanism revealed that the bioactive cassane inhibited overproduction of NO by targeting key residues in the iNOS active cavity to reduce iNOS enzymatic activation.

关键词： Caesalpinia cucullata Roxb. Cassane diterpenoids Structure elucidation Biological activity iNOS enzyme activity

Replication of hepatitis B virus in primary duck hepatocytes transfected with linear viral DNA

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World Journal of Gastroenterology 2005年第32期11卷 5019-5021页

作者： Yun-Qing Yao Ding-Feng Zhang Ni Tang Ai-Long Huang Xiao-Yi Zou jiang-Feng Xiao Yun Luo Da-Zhi Zhang Bo Wang Wei-ping Zhou Hong ren Qi Liu Shu-Hua Guo Department of Infectious Diseases of the First Affiliated Hospital Chongqing University of Medical Sciences Chongqing 400016 China Institute for Viral Hepatitis Chongqing University of Medical Sciences Chongqing 400010 China

AIM: To explore the expression and replication of hepatitis B virus (HBV) DNA in primary duck hepatocytes (PDHs).METHODS: Complete HBV genome was transfected into PDHs by electroporation (transfected group, 1.19×1012copies of linear HBV DNA/1×107 PDHs). After 1-5 d of transfection, HBsAg and HBeAg in the supernatant and lysate of PDHs were measured with the IMX ***, replicative intermediates of HBV DNA were analyzed by Southern blotting and Dot blotting. PDHs electroporated were used as control ***: HBsAg in the hepatocyte lysates of transfected group was 15.24 (1 d), 14.55 (3 d) and 5.13 (5 d; P/N values, positive≥2.1) respectively. HBeAg was negative (＜2.1). Both HBsAg and HBeAg were negative in the supernatant of transfected group. Dot blotting revealed that HBV DNA was strongly positive in the transfected group and negative in the control group. Southern blot analysis of intracellular total DNA indicated that there were relaxed circular (rc DNA), covalently closed circular (ccc DNA), and single-stranded (ss DNA) HBV DNA replicative intermediates in the transfected group, there was no integrated HBV DNA in the cellular genome. These parameters were negative in control ***: Expression and replication of HBV genes can occur in hepatocytes from non-mammalian *** replication has no critical species-specificity, and yet hepatic-specific regulating factors in hepatocytes may be essential for viral replication.

关键词： Hepatitis B virus Replication Expression Primary duck hepatocytes

结合加速时温数据和加权外推的橡胶老化寿命预测

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机械科学与技术 2024年第6期43卷 1072-1077页

作者：吕向飞任琪张博邓钦文重庆城市管理职业学院智能工程学院重庆401331 重庆大学机械传动国家重点实验室重庆400044

针对加速数据外推合理性瓶颈,在高温加速试验数据的基础上,提出加权外推的方法实现橡胶寿命的准确预测。首先,建立橡胶性能的非线性加速退化模型,并采用非线性最小二乘法实现对不同温度下的加速因子进行识别;其次,建立加速因子和加速温... 详细信息

针对加速数据外推合理性瓶颈,在高温加速试验数据的基础上,提出加权外推的方法实现橡胶寿命的准确预测。首先,建立橡胶性能的非线性加速退化模型,并采用非线性最小二乘法实现对不同温度下的加速因子进行识别;其次,建立加速因子和加速温度的阿累尼乌斯模型,根据误差特性进行活化能的加权推算;最后,由活化能推算出使用温度下的寿命,通过已有数据的建模验证了方法的有效性。研究可为提升橡胶零部件的加速寿命预测的准确性提供支撑,同时也可为其他机械零部件的可靠性评估提供参考。

关键词：橡胶老化寿命时温叠加加速退化加权外推

基层政府治理水平对农民奋斗价值观的影响研究

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西南大学学报（社会科学版） 2024年第2期50卷 131-142页

作者：金绍荣罗锐任赞杰刘柯潇西南大学经济管理学院重庆400715 中国农业大学经济管理学院北京100083 香港都会大学人文社会科学院中国香港999077

赓续艰苦奋斗精神,激发农民奋斗意志,是当前基层治理中农民思想建设的重要内容。基于2018年与2020年中国家庭追踪调查数据,利用有序Probit模型,实证分析基层政府治理水平对农民奋斗价值观的影响及作用机制。研究发现:第一,基层政府治理... 详细信息

赓续艰苦奋斗精神,激发农民奋斗意志,是当前基层治理中农民思想建设的重要内容。基于2018年与2020年中国家庭追踪调查数据,利用有序Probit模型,实证分析基层政府治理水平对农民奋斗价值观的影响及作用机制。研究发现:第一,基层政府治理水平与农民奋斗价值观呈正相关,即基层政府治理水平越高,农民越倾向于认为“努力工作能有回报”,越发增强“对未来的信心”;第二,基层政府治理水平对农民奋斗价值观的影响,主要通过提高该群体的生活满意度和工作满意度来实现;第三,高水平的基层政府治理正向促进了建档立卡农民和非建档立卡农民奋斗价值观的塑造,且这种促进作用在非建档立卡农民中更显著。

关键词：基层政府治理水平农民价值观有序Probit模型乡村振兴

Verification of Seasonal Prediction by the Upgraded China Multi-Model Ensemble Prediction System(CMMEv2.0)

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Journal of Meteorological Research 2024年第5期 880-900页

作者： Jie WU Hong-Li ren jianghua WAN Jingpeng LIU Jinqing ZUO Changzheng LIU Ying LIU Yu NIE Chongbo ZHAO Li GUO Bo LU Lijuan CHEN Qing BAO Jingzhi SU Lin WANG Jing-Jia LUO Xiaolong JIA Qingchen CHAO CMA Key Laboratory of Climate Prediction Studies National Climate Centre China Meteorological Administration (CMA) Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science & Technology State Key Laboratory of Severe Weather and Institute of Tibetan Plateau Meteorology Chinese Academy of Meteorological SciencesChina Meteorological Administration State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric Physics Chinese Academy of Sciences CMA Earth System Modeling and Prediction Centre China Meteorological Administration

Based on a combination of six Chinese climate models and three international operational models, the China multimodel ensemble (CMME) prediction system has been upgraded into its version 2 (CMMEv2.0) at the National Climate Centre (NCC) of the China Meteorological Administration (CMA) by including new model members and expanding prediction products. A comprehensive assessment of the performance of the upgraded CMME during its hindcast (1993–2016) and real-time prediction (2021–present) periods is conducted in this study. The results demonstrate that CMMEv2.0 outperforms all the individual models by capturing more realistic equatorial sea surface temperature (SST) variability. It exhibits better prediction skills for precipitation and 2-m temperature anomalies, and the improvements in prediction skill of CMMEv2.0 are significant over East Asia. The superiority of CMMEv2.0 can be attributed to its better projection of El Ni?o–Southern Oscillation (ENSO; with the temporal correlation coefficient score for Ni?o3.4 index reaching 0.87 at 6-month lead) and ENSO-related teleconnections. As for the real-time prediction in recent three years, CMMEv2.0 has also yielded relatively stable skills; it successfully predicted the primary rainbelt over northern China in summers of 2021–2023 and the warm conditions in winters of 2022/2023. Beyond that, ensemble sampling experiments indicate that the CMMEv2.0 skills become saturated after the ensemble model number increased to 5–6, indicating that selection of only an optimal subgroup of ensemble models could benefit the prediction performance, especially over the extratropics, yet the underlying reasons await future investigation.

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基于TGF-β1/Smads信号通路探讨鹿红益心颗粒对心力衰竭大鼠心肌纤维化的影响

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中国中药杂志 2024年第13期49卷 3583-3590页

作者：李晓静王丽蓉蒋兵任春贞吕欣芳吴雪赵会林赵信科李应东甘肃中医药大学中西医结合学院甘肃兰州730000 甘肃省中医药防治慢性病重点实验室甘肃兰州730000 甘肃中医药大学附属医院甘肃兰州730000 兰州大学第二医院心血管内科甘肃兰州730030 武威市中医医院心血管科甘肃兰州730000

旨在探讨鹿红益心颗粒对心力衰竭大鼠心肌纤维化的影响及可能的作用机制。将60只雄性Wistar大鼠随机分为对照组、模型组以及鹿红益心颗粒低、中、高剂量组,每组12只。除对照组外,其余各组大鼠通过腹腔注射阿霉素(DOX)诱导心力衰竭模型... 详细信息

旨在探讨鹿红益心颗粒对心力衰竭大鼠心肌纤维化的影响及可能的作用机制。将60只雄性Wistar大鼠随机分为对照组、模型组以及鹿红益心颗粒低、中、高剂量组,每组12只。除对照组外,其余各组大鼠通过腹腔注射阿霉素(DOX)诱导心力衰竭模型。将鹿红益心颗粒溶于等量生理盐水,分别予以低、中、高剂量(2.8、5.6、11.2 g·kg^(-1)·d^(-1))进行灌胃,对照组和模型组均给予等量生理盐水,持续灌胃40 d。给药结束后,超声心动图测量左心室射血分数(LVEF)和左心室缩短分数(LVFS);测量大鼠体质量和心脏体质量,计算心脏体质量比;酶联免疫吸附法测定血清中白细胞介素-6(IL-6)、白细胞介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)、转化生长因子-β1(TGF-β1)、生长刺激表达基因2蛋白(ST2)、N末端B型利钠肽原(NT-proBNP)、半乳糖凝集素-3(Gal-3)和肌酸激酶同工酶(CK-MB)水平;苏木素-伊红(HE)染色和Masson染色观察心肌组织病理形态;蛋白免疫印迹法和实时荧光定量聚合酶链式反应分别检测心肌组织中IL-6、IL-17、TNF-α、TGF-β1、Smad3、Smad7、α-平滑肌肌动蛋白(α-SMA)、Ⅰ型胶原(COL-Ⅰ)蛋白及其mRNA表达水平。结果显示,与对照组相比,模型组大鼠LVEF、LVFS、心脏体质量比值均显著下降(P<0.05),IL-6、IL-17、TNF-α、TGF-β1、ST2、NT-proBNP、Gal-3、CK-MB水平均显著上升(P<0.05);HE染色可见心肌组织炎性改变;Masson染色显示心脏横截面面积及室腔面积减小且出现不同程度的心肌纤维化(P<0.05);心肌组织中IL-6、IL-17、TNF-α、TGF-β1、Smad3、α-SMA、COL-Ⅰ蛋白及其mRNA表达均显著升高(P<0.05),Smad7蛋白及其mRNA表达显著降低(P<0.01)。与模型组相比,鹿红益心颗粒低、中、高剂量组大鼠LVEF、LVFS及心脏体质量比值均显著上升(P<0.05),IL-6、IL-17、TNF-α、TGF-β1、ST2、NT-proBNP、Gal-3、CK-MB水平均下显著下降(P<0.05);HE染色显示心肌组织炎性改变逐渐减轻;Masson染色显示心脏横截面面积及室腔面积增大,心肌纤维化面积减少(P<0.05);心肌组织中IL-6、IL-17、TNF-α、TGF-β1、Smad3、α-SMA、COL-Ⅰ蛋白及其mRNA表达均显著降低(P<0.05),Smad7蛋白及其mRNA表达均显著升高(P<0.05)。综上所述,鹿红益心颗粒可能通过调节TGF-β1/Smads信号通路,抑制炎症相关蛋白表达,减少细胞外基质的沉积,缓解心肌纤维化,对心力衰竭的治疗具有重要价值。

关键词：心力衰竭鹿红益心颗粒 TGF-β1/Smads信号通路心肌纤维化治疗

Laparoscopic resection of synchronous intraductal papillary mucinous neoplasms:A case report

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World Journal of Gastroenterology 2012年第44期18卷 6510-6514页

作者： Xiao-Wu Xu Rong-Hua Li Wei Zhou Jie Wang ren-Chao Zhang Ke Chen Yi-ping Mou Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang Uni- versity Hangzhou 310016 Zhejiang Province China

We describe herein a 68-year-old woman who was diagnosed with a quite rare entity of intraductal papillary mucinous neoplasms(IPMNs) occurring simultaneously in the left lateral lobe of liver and the tail of *** computed tomography and magnetic resonance cholangiopancreatography showed a cystic dilatation of the pancreatic duct in the pancreatic tail,which suggested an IPMN,and multiple intrahepatic duct stones in the left lateral *** patient underwent a laparoscopic left lateral hepatolobectomy and spleenpreserving distal ***-operative finding of massive mucin in the dilated bile duct implied an intraductal mucinous tumor in the *** diagnosis of synchronous IPMNs in the liver and pancreas was confirmed by pathological *** patient was followed up for 6 mo without signs of *** several cases of IPMN of liver without any pancreatic association have been reported,the simultaneous occurrence of IPMNs in the liver and pancreas is very *** the best of our knowledge,it is the first reported case treated by laparoscopic resection.

关键词： Laparoscopy Pancreas Liver Intraductalpapillary mucinous neoplasm Synchronous neoplasm

A Barbier type reaction promoted by in situ formed active metal bismuth from NaBH_4 and BiCl_3 in aqueous media

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Chinese Journal of Chemistry 1996年第5期14卷 462-466页

作者： ren,ping-Da PAN,Shi-Feng DONG,Ting-Wei WU,Shi-HuiDepartment of Chemistry,Pudan University,Shanghai 200433,China Department of Chemistry Fudan University Shanghai 200483 China

In the presence of active metal bismuth (Bi) which was prepared from the combination of bismuth trichloride and sodium borohydride,aldehydes have been found to react with allyl bromide in aqueous media,and the corresp... 详细信息

关键词： Barbier type reaction aqueous medium reaction active metal bismuth