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Mechanism of Immune Hyporesponsiveness Induced by Recipient-derived Immature Dendritic Cells in Liver Transplantation Rat

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Chinese Medical Sciences Journal 2011年第1期26卷 28-35页

作者： Li Li Sheng-ning Zhang jiang-hua ran Jing Liu Zhu Li Lai-bang Li Department of Hepatobiliary Pancreatic Surgery First People＇s Hospital of Kunming Kunming Medical College Liver Transplantation Center of Organ Transplantation Institute of Yunnan Province Kunming 650011 China

Objective To investigate the mechanism of immune hyporesponsiveness induced by donor-antigen- unloaded recipient-derived immature dendritic cell （imDC） of liver grafts in rats. Methods Forty Sprague-Dawley rats （donor） and forty male Wistar rats （recipient） were randomly divided into 4 groups： control, cyclosporine A （CsA）, mature DC （mDC）, and imDC groups respectively, with 10 donor rats and 10 recipient rats in each group. Recipient rats in CsA group were treated with 10 mg-kg-~＇d-I CsA starting day 2 after the transplantation. Recipients in the mDC or imDC groups were given Wistar rat derived mDCs （1 × 10^6/rat） or imDCs （1 × 10^6/rat） via dorsal vein of the penis respectively 1 day before the transplantation. In each group, 5 recipients were kept for determination of survival time and the other 5 rats were executed at day 10 after transplantation. Blood samples were collected for the measurement of serum alanine aminotransferase （ALT）, total bilirubin （TBIL）, interleukin 2 （IL-2）, interferon gamma （IFN-γ）, IL-4, and IL-10 levels. Liver tissue was harvested for HE staining and acute rejection evaluation. Expression levels of Fas-L/Fas in the grafts were detected by immunohistochemical staining; andWestern blot was used to detect the expression level of Scurfm. Results The survival time of CsA and imDC groups was significantly longer than that of control and mDC groups （all P〈0.05）. The levels of serum ALT and TBIL in the control group （2072.20±217.93 IU/L and 147.42±22.02pmol/L） and mDC group （2117.00±285.13 IU/L and 141.58±20.82 pmol/L） were significantly higher than those in the CsA group （59.68±13.48 IU/L and 15.40±2.13 pmol/L） or imDC group （50.80±9.63 IU/L and 14.44±3.49 pmol/L）（all P〈0.05）. In the CsA and imDC groups, the levels of IL-2 （22.52±3.75 pg/mL and 22.12±3.90 pg/mL） and IFN-γ （309.20±25.19 pg/mL and 321.00±21.64 pg/mL） were significantly lower, but the levels of IL-4 （297.60±25.07 pg/mL and 277.00±22.47 pg/mL） and IL-10 （1226.00±140.49 pg/mL an

关键词： rat liver transplantation rejection immature dendritic cell immunehyporesponsiveness

Advanced Functional Electromagnetic Shielding Materials:A Review Based on Micro‑Nano Structure Interface Control of Biomass Cell Walls

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Nano-Micro Letters 2025年第1期17卷 98-134页

作者： Yang Shi Mingjun Wu Shengbo Ge Jianzhang Li Anoud Saud Alshammari Jing Luo Mohammed A.Amin hua Qiu Jinxuan jiang Yazeed M.Asiri Runzhou huang hua Hou Zeinhom M.El‑Bahy Zhanhu Guo Chong Jia Kaimeng Xu Xiangmeng Chen Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037People’s Republic of China State Key Laboratory of Efficient Production of Forest Resourced Beijing Forestry UniversityQinghua East Road 35Haidian DistrictBeijing 100083People’s Republic of China Department of Physics Faculty of Sciences‑ArarNorthern Border UniversityArar 91431Saudi Arabia Department of Chemistry College of ScienceTaif UniversityP.O.Box 1109921944 TaifSaudi Arabia Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Integrated Composites Lab Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024People’s Republic of China Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr CityCairo 11884Egypt Yunnan Provincial Key Laboratory of Wood Adhesives and Glued Products International Joint Research Center for Biomass MaterialsSouthwest Forestry UniversityKunming 650224People’s Republic of China School of Science Henan Agricultural UniversityZhengzhou 450002People’s Republic of China

Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass *** materials offer numerous advantages such as being lightweight,porous,and *** to their porous nature,interfacial compatibility,and electrical conductivity,biomass materials hold significant potential as EMI shielding *** concerted efforts on the EMI shielding of biomass materials have been reported,this research area is still relatively new compared to traditional EMI shielding *** particular,a more comprehensive study and summary of the factors influencing biomass EMI shielding materials including the pore structure adjustment,preparation process,and micro-control would be *** preparation methods and characteristics of wood,bamboo,cellulose and lignin in EMI shielding field are critically discussed in this paper,and similar biomass EMI materials are summarized and *** composite methods and fillers of various biomass materials were *** paper also highlights the mechanism of EMI shielding as well as existing prospects and challenges for development trends in this field.

关键词： Biomass materials Electromagnetic interference shielding Micro-nano structure interface control Conductivity

Bioactive materials from berberine-treated human bone marrow mesenchymal stem cells accelerate tooth extraction socket healing through the jaw vascular unit

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Science China Life Sciences 2025年

作者： Ruyu Wang Tianxiao Wang Ziyu Chen Jiandong jiang Yifei Du hua Yuan Yongchu Pan Yuli Wang Department of Oral and Maxillofacial Surgery The Affiliated Stomatological Hospital of Nanjing Medical University State Key Laboratory Cultivation Base of Research Prevention and Treatment for Oral Diseases Jiangsu Province Engineering Research Centre of Stomatological Translational Medicine Nanjing Medical University Department of Stomatology Chongzhou People's Hospital Medical Basic Research Innovation Centre for Cardiovascular and Cerebrovascular Diseases Ministry of Education International Joint Laboratory for Drug Target of Critical Illnesses School of PharmacyNanjing Medical University Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences & Peking Union Medical College Department of Orthodontic The Affiliated Stomatological Hospital of Nanjing Medical University State Key Laboratory Cultivation Base of Research Prevention and Treatment for Oral Diseases Jiangsu Province Engineering Research Centre of Stomatological Translational Medicine Nanjing Medical University

Delayed tooth extraction socket(TES) healing can cause failure of subsequent oral implantation and increase socioeconomic burden on patients. Excessive amounts of M1 macrophages, apoptotic neutrophils(ANs), and neutrophil extracellular traps(NETs) impair alveolar bone regeneration during TES healing. In the present study, we first discovered that conditioned medium(CM) collected from berberine-treated human bone marrow mesenchymal stem cells(BBR-HB-CM) accelerated TES healing. BBR-HB-CM contained bioactive materials that promoted the polarization of macrophages from M1 to M2, impeded the formation of ANs and NETs, and modulated M2 macrophage efferocytosis in vivo and in vitro. Mechanistically, BBR-HB-CM promoted bone formation by inhibiting macrophage-myofibroblast transition and reprogrammed macrophage polarization through p85/AKT/mTOR pathway-dependent autophagy. The 3-methyladenine abolished the therapeutic effects of BBR-HB-CM. Further studies revealed that BBR-HB-CM accelerated TES healing in rats with type 2 diabetes mellitus. Overall, our results demonstrated that BBR-HB-CM had high potential to promote rapid TES healing.

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2型糖尿病患者非糖尿病一级亲属的胰岛素抵抗出现先于β细胞功能缺陷

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中华内分泌代谢杂志 2009年第5期25卷 498-500页

作者：刘玉辉李玲高杰清石英厉平姜冉华刘聪中国医科大学附属盛京医院内分泌科第一作者现在沈阳军区总医院干二科沈阳110004

目的研究2型糖尿病患者非糖尿病一级亲属的胰岛素抵抗和胰岛β细胞功能的变化。方法选取2型糖尿病患者一级亲属23名，其中糖耐量正常者10名（NGT组），糖耐量受损者13名（IGT组）。以无糖尿病家族史的糖耐量正常者9名（NC组）为对照。... 详细信息

目的研究2型糖尿病患者非糖尿病一级亲属的胰岛素抵抗和胰岛β细胞功能的变化。方法选取2型糖尿病患者一级亲属23名，其中糖耐量正常者10名（NGT组），糖耐量受损者13名（IGT组）。以无糖尿病家族史的糖耐量正常者9名（NC组）为对照。应用高胰岛素-正葡萄糖钳夹技术和静脉葡萄糖耐量试验评估胰岛素抵抗和胰岛β细胞功能。结果NGT组和IGT组的葡萄糖输注率（mg·kg^-1·min^-1）分别为（7．04±0．62）和（6．16±0．73），与NC组（10．22±0．93）相比明显降低（均P〈0．05）。NGT组的第一时相胰岛素分泌量（对数转换）高于IGT组（3．87±0．24vs3．03±0．28，P〈0．05），NC组为（3．37±0．30）。NGT组（1．43±0．22）与NC组（1．18＋0．41）的葡萄糖处置指数（对数转换）明显高于IGT组（0．32±0．20，P〈0．01或P〈0．05），NC组与NGT组之间差异无统计学意义。结论2型糖尿病患者非糖尿病一级亲属已经存在胰岛素抵抗，当胰岛素分泌不能代偿抵抗时开始出现糖耐量减退。

关键词：糖尿病 2型一级亲属胰岛素抵抗胰岛β细胞功能葡萄糖钳夹技术

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沉井施工中常见问题及解决方法

施工技术 2005年第S1期34卷 354-356页

作者：何江华冉纪海桑宝岩陈太林徐州空军学院江苏徐州221000

主要介绍了沉井施工过程中常见的问题,并提出了预防和解决措施。

关键词：沉井施工流砂

Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

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World Journal of Clinical Cases 2025年第2期13卷 24-32页

作者： Xiao-Yi Wang Yao Hao Zi-Jian Wang Xiu-Liang Xu jiang-hua Yang Department of Infectious Diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(P<0.001).The distribution of pathological types of appendicitis was different between the two groups(P<0.001).The incidence of acute suppurative appendicitis in non-schistosomal appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(CI):0.349-0.728;P<0.001].The proportion of acute attack of chronic appendicitis in schistosomal appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%CI:1.815-3.763;P<0.001).The proportion of schistosomal appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%CI:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

Foreign body granuloma in the tongue differentiated from tongue cancer:A case report

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World Journal of Clinical Cases 2022年第18期10卷 6247-6253页

作者： Zhen-hua jiang ran Xv Li Xia Department of Otolaryngology-Head and Neck Surgery Mianyang Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaMianyang 621000Sichuan ProvinceChina

BACKGROUND Embedded foreign bodies in the tongue are rarely seen in clinical *** untreated foreign body can cause a granuloma which often presents as an enlarged tongue ***,if foreign body ingestion status is unknown,physical examination and magnetic resonance imaging(MRI)tend to lead to suspicion of tongue cancer,especially in older ***,differential diagnosis of an enlarged tongue mass is important,especially because it is closely related to the choice of treatment *** SUMMARY A 61-year-old woman was admitted to the hospital with pain and noticeable swelling in the tongue that had persisted for over 1 *** had no previous medical *** revealed abnormal signal intensities that were indicative of a ***,the oral surgeon and radiologist arrived at a primary diagnosis of tongue *** patient visited the Ear Nose and Throat Department for further consultation and underwent an ultrasound examination of the *** ultrasonography was consistent with a linear hyperechoic foreign body which was indicative of an embedded foreign body(bone)in the tongue,even though the patient denied any history of foreign body *** surgical enucleation of the lesion was *** mass which included a fish bone was completely *** post-operative pathological examination confirmed that the mass was a granuloma containing collagen fibers,macrophages and chronic inflammatory *** patient recovered without complications over a 2 mo follow-up *** We report a rare case of foreign body granuloma in the tongue that was primarily diagnosed as tongue *** MRI and ultrasound examinations revealed a piece of bone in the left lateral aspect of the *** granuloma,which contained a fish bone,was completely removed via surgery and confirmed via *** diagnosis of the enlarged tongue mass was critical to the selection of treatment method.

关键词： Tongue Foreign body Granuloma Cancer Differential diagnosis Case report

Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui jiang Hui-Li Kang Yi jiang hua-Wei Zhang Xiao-Mei Song Yu-Ze Li Wen-Li huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

HCV亚基因组复制子细胞培养上清外泌体HCV RNA的分离及其与胞内病毒水平的相关性

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中国病毒病杂志 2016年第1期6卷 17-21页

作者：王江华费然王雪艳张海莹魏来北京大学人民医院北京大学肝病研究所丙型肝炎和肝病免疫治疗北京市重点实验室北京100044

目的检测丙型肝炎病毒（HCV）复制子细胞培养上清中外泌体HCV RNA的稳定性和表达水平,并研究干扰素α抑制HCV复制过程中,外泌体HCV RNA水平与胞内病毒复制水平的相关性。方法建立G418筛选稳定表达的HCV复制子细胞模型HCV-Con I-Rep,比... 详细信息

目的检测丙型肝炎病毒（HCV）复制子细胞培养上清中外泌体HCV RNA的稳定性和表达水平,并研究干扰素α抑制HCV复制过程中,外泌体HCV RNA水平与胞内病毒复制水平的相关性。方法建立G418筛选稳定表达的HCV复制子细胞模型HCV-Con I-Rep,比较超速离心和沉淀法对HCV RNA阳性外泌体的分离效果;实时定量PCR法检测培养上清的HCV RNA水平并评价其对表面活性剂NP-40和RNase A的敏感性;不同剂量干扰素α（0、0.4、2、10、50、250IU/ml）处理72h或100IU/ml干扰素α处理不同时间（0、6、12、24、48、72h）,分别检测上清和胞内HCV RNA水平,并评价两者的相关性。结果成功构建了稳定表达的HCV复制子细胞模型;PEG沉淀较超速离心法能够更高效地分离外泌体;HCV复制子细胞培养上清外泌体中含有较高水平（~106 IU/ml）的HCV RNA,但在表面活性剂的存在下,可因外泌体脂质膜破坏而被RNase A降解;干扰素α处理过程中,胞内HCV RNA和上清中外泌体HCV RNA水平均显著降低;Spearman相关性分析提示,胞内HCV RNA和上清中外泌体HCV RNA在不同剂量干扰素处理组和不同处理时间组的水平均具有显著相关性（r=0.9690,P〈0.01和r=0.7069,P=0.001）。结论 HCV亚基因组复制子细胞培养上清外泌体HCV RNA水平可作为更方便检测的指标,反映胞内病毒复制水平的变化。

关键词：丙型肝炎病毒复制子外泌体干扰素α