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Mechanism of Immune Hyporesponsiveness Induced by Recipient-derived Immature Dendritic Cells in Liver Transplantation Rat

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Chinese Medical Sciences Journal 2011年第1期26卷 28-35页

作者： Li Li Sheng-ning Zhang jiang-hua Ran Jing Liu Zhu Li lai-bang Li Department of Hepatobiliary Pancreatic Surgery First People＇s Hospital of Kunming Kunming Medical College Liver Transplantation Center of Organ Transplantation Institute of Yunnan Province Kunming 650011 China

Objective To investigate the mechanism of immune hyporesponsiveness induced by donor-antigen- unloaded recipient-derived immature dendritic cell （imDC） of liver grafts in rats. Methods Forty Sprague-Dawley rats （donor） and forty male Wistar rats （recipient） were randomly divided into 4 groups： control, cyclosporine A （CsA）, mature DC （mDC）, and imDC groups respectively, with 10 donor rats and 10 recipient rats in each group. Recipient rats in CsA group were treated with 10 mg-kg-~＇d-I CsA starting day 2 after the transplantation. Recipients in the mDC or imDC groups were given Wistar rat derived mDCs （1 × 10^6/rat） or imDCs （1 × 10^6/rat） via dorsal vein of the penis respectively 1 day before the transplantation. In each group, 5 recipients were kept for determination of survival time and the other 5 rats were executed at day 10 after transplantation. Blood samples were collected for the measurement of serum alanine aminotransferase （ALT）, total bilirubin （TBIL）, interleukin 2 （IL-2）, interferon gamma （IFN-γ）, IL-4, and IL-10 levels. Liver tissue was harvested for HE staining and acute rejection evaluation. Expression levels of Fas-L/Fas in the grafts were detected by immunohistochemical staining; andWestern blot was used to detect the expression level of Scurfm. Results The survival time of CsA and imDC groups was significantly longer than that of control and mDC groups （all P〈0.05）. The levels of serum ALT and TBIL in the control group （2072.20±217.93 IU/L and 147.42±22.02pmol/L） and mDC group （2117.00±285.13 IU/L and 141.58±20.82 pmol/L） were significantly higher than those in the CsA group （59.68±13.48 IU/L and 15.40±2.13 pmol/L） or imDC group （50.80±9.63 IU/L and 14.44±3.49 pmol/L）（all P〈0.05）. In the CsA and imDC groups, the levels of IL-2 （22.52±3.75 pg/mL and 22.12±3.90 pg/mL） and IFN-γ （309.20±25.19 pg/mL and 321.00±21.64 pg/mL） were significantly lower, but the levels of IL-4 （297.60±25.07 pg/mL and 277.00±22.47 pg/mL） and IL-10 （1226.00±140.49 pg/mL an

关键词： rat liver transplantation rejection immature dendritic cell immunehyporesponsiveness

Evaluation of monthly turbulent heat fluxes from WHOI analysis and NCEP reanalysis in the tropical Atlantic

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Acta Oceanologica Sinica 2005年第5期24卷 14-26页

作者： jiang hua WANG Hui WU Dexing Institute of Climate System Chinese Academy of Meteorological Sciences Beijing 100081 China Chinese Academy of Meteorological Sciences Beijing 100081 China Institute of Physical Oceanography Ocean University of China Qingdao 266003 China

The biases and their sources in monthly turbulent heat fluxes from the Woods Hole Oceanographic Institution （WHOI） analysis, and the National Centers for Environmental Prediction-National Center for Atmospheric Research reanalyses 1 and 2 （NCEPI and NCEP2） are checked in the climatically representative regions in the tropical Atlantic using the fluxes from the Southampton Oceanographic Centre （SOC） and the pilot research moored array in the tropical Atlantic （PIRATA） as references. For the WHOI analysis, the biases in turbulent heat fluxes mainly exist in equatorial regions which are due to the overestimated sea surface temperature and the underestimated 2 m air humidity. For the NCEP2 reanalysis, the maximum biases, about （40±5） W/m^2, exist in southeast and northeast trade wind regions, which are mainly caused by the flux algorithm used because the biases in wind speed and air-sea humidity difference are relatively small. In the equatorial regions, the flux biases in the NCEP2 derived from both flux-related basic variables and algorithm are equally large. Although the estimations of time series trends and air-sea humidity difference of the NCEPI are improved greatly in the NCEP2, the biases of latent heat flux in the NCEP2 are about 20 W/m^2 greater than those from the NCEP1 in the trade wind regions. The result shows that the climatologies and monthly variabilities of the turbulent heat fluxes from the WHOI are more accurate than those from the NCEP1 and NCEP2 in the tropical Atlantic, especially on outside of the equatorial regions.

关键词： turbulent heat fluxes evaluation the tropical Atlantic

Mechanobiology in vascular remodeling

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National Science Review 2018年第6期5卷 933-946页

作者： Yue Han Kai huang Qing-Ping Yao Zong-lai jiang Institute of Mechanobiology & Medical Engineering School of Life Sciences & BiotechnologyShanghai Jiao Tong University School of Biological Science & Medical Engineering Beijing Advanced Innovation Center for Biomedical Engineering Beihang University

Vascular remodeling is a common pathological process in cardiovascular diseases and includes changes in cell proliferation, apoptosis and differentiation as well as vascular homeostasis. Mechanical stresses, such as shear stress and cyclic stretch, play an important role in vascular remodeling. Vascular cells can sense the mechanical factors through cell membrane proteins, cytoskeletons and nuclear envelope proteins to initiate mechanotransduction, which involves intercellular signaling, gene expression, and protein expression to result in functional regulations. Non-coding RNAs, including micro RNAs and long non-coding RNAs, are involved in the regulation of vascular remodeling processes. Mechanotransduction triggers a cascade reaction process through a complicated signaling network in cells. High-throughput technologies in combination with functional studies targeting some key hubs and bridging nodes of the network can enable the prioritization of potential targets for subsequent investigations of clinical translation. Vascular mechanobiology, as a new frontier field of biomechanics, searches for principles of stress-growth in vasculature to elucidate how mechanical factors induce biological effects that lead to vascular remodeling,with the goal of understanding the mechanical basis of the pathological mechanism of cardiovascular diseases at the cellular and molecular levels. Vascular mechanobiology will play a unique role in solving the key scientific problems of human physiology and disease, as well as generating important theoretical and clinical results.

关键词： mechanobiology vascular remodeling cardiovascular disease mechanotransduction endothelial cell vascular smooth muscle cell nuclear envelope microRNA

Singularity analysis of Jeffcott rotor-magnetic bearing with time delays

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Applied Mathematics(A Journal of Chinese Universities) 2012年第4期27卷 419-427页

作者： XU Xiu-yan jiang Wei-hua Department of Mathematics Heilongjiang Institute of Science and TechnologyHarbin 150027China Department of Mathematics Harbin Institute of TechnologyHarbin 150001China

A Jeffcott rotor-magnetic bearing with time delays is investigated in this paper. Firstly, it is found that the characteristic equation of the system satisfies the conditions of the singularity. Secondly, the center manifold reduction and normal form are employed to study the bifurcation from simple zero and zero-purely imaginary singularities. The results of this paper will help to understand the influence of the time delays in feedback loop on the dynamics of rotor-magnetic bearing system.

关键词： Jeffcott rotor-magnetic bearing time delay singularity normal form.

Remarks on One-Dimensional Compressible Navier-Stokes Equations with Density-Dependent Viscosity and Vacuum

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Acta Mathematica Sinica,English Series 2010年第10期26卷 2015-2030页

作者： Zhen hua GUO Chang jiang ZHU Center for Nonlinear Studies and Department of Mathematics Northwest University Xi'an 710069 P. R. China Laboratory of Nonlinear Analysis Department of Mathematics Central China Normal University Wuhan 4300794 P. R. China

The Navier-Stokes system for one-dimensional compressible fluids with density-dependent viscosities when the initial density connects to vacuum continuously is considered in the present paper. When the viscosity coefficient u is proportional to pθ with 0 〈 θ 〈 1, the global existence and the uniqueness of weak solutions are proved which improves the previous results in [Vong, S. W., Yang, T., Zhu, C. J.： Compressible Navier-Stokes equations with degenerate viscosity coefficient and vacuum II. J. Differential Equations, 192（2）, 475-501 （2003）]. Here p is the density. Moreover, a stabilization rate estimate for the density as t → ＋∞ for any θ 〉 0 is also given.

关键词： Compressible Navier-Stokes equations density-dependent viscosity vacuum asymptotic behavior

Seasonal variability of turbulent heat fluxes in the tropical Atlantic Ocean based on WHOI flux product

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Acta Oceanologica Sinica 2007年第5期26卷 1-11页

作者： jiang hua WANG Hui WU Dexing Institute of Climate System Chinese Academy of Meteorological Sciences Beijing 100081 China Institute of Physical Oceanography Ocean University of China Qingdao 266003 China

The mean seasonal variability of turbulent heat fluxes in the tropical Atlantic Ocean is examined using the Woods Hole Oceanographic Institution （WHOI） flux product. The most turbulent heat fluxes occur during winter seasons in the two hemispheres, whose centers are located at 10° -20°N and 5° 15°S respectively. In climatological ITCZ, the turbulent heat fluxes are the greatest from June to August, and in equatorial cold tongue the turbulent heat fluxes are the greatest from March to May. Seasonal variability of sensible heat flux is smaller than that of latent heat flux and mainly is dominated by the variations of air-sea temperature difference. In the region with larger climatological mean wind speed （air-sea humidity difference）, the variations of air-sea humidity difference （wind speed） dominate the variability of latent heat flux. The characteristics of turbulent heat flux yielded from theory analysis and WHOI dataset is consistent in physics which turns out that WHOI＇ s flux data are pretty reliable in the tropical Atlantic Ocean.

关键词： turbulent heat fluxes seasonal variation tropical Atlantic

Self-synchronization theory of dual motor driven vibration system with two-stage vibration isolation frame

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Applied Mathematics and Mechanics(English Edition) 2015年第2期36卷 265-278页

作者： He LI Dan LIU lai jiang Chunyu ZHAO Bangchun WEN School of Mechanical Engineering and Automation Northeastern University

This paper studies self-synchronization and stability of a dual-motor driven vibration system with a two-stage vibration isolation frame. Oscillation amplitude of the material box large enough can be ensured on the vibration system in order to screen materials. Reduction of the dynamic load transmitted to the foundation can also be achieved for the vibration system. A Lagrange equation is used to set up the motion differential equations of the system, and a dimensionless coupled equation of the eccentric rotors is obtained using a method of modified average small parameter. According to the existence condition of zero solution in the dimensionless coupled equation of the eccentric rotors, the precondition for commencing self-synchronization motion is *** stability condition of self-synchronization is obtained based on the Routh-Hurwitz criterion. The theoretical analysis is validated by simulations and experiments.

关键词： self-synchronization vibration system stability vibration isolation

Method for Improving Transverse Wall Thickness Precision of Seamless Steel Tube Based on Tube Rotation

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Journal of Iron and Steel Research International 2015年第10期22卷 924-930页

作者： Yong-zheng jiang hua-ping TANG State Key Laboratory of High Performance Complex Manufacturing Central South University

The tube rotation method （TRM） refers to the rotational movement of steel tube about its axis as well as translation in rolling direction in stretch reducing rolling process. The influence of the TRM on transverse wall thickness precision of seamless steel tube was studied. Thickness distribution of the TRM was obtained by superimposing the thickened amount of single pass rolling. Results show that the TRM can effectively improve the evenness of thickness distribution. In order to analyze the influence mechanism of the TRM, the finite element method was adopted to simulate the thickness distribution in stretch reduction process. Results show that the TRM changes the roundtrip flow between two fix places of conventional stretch reducing and inhibits the directional accumulation of metal. In addition, the TRM has a correction effect on thickness cusp. All these advantages of the TRM help to improve the transverse wall thickness precision of seamless steel tube.

关键词： seamless tube stretch reducing transverse unevenness tube rotation method

Thermodynamic Calculation of Inclusion Formation in Mg-Al-Si-O System of 430 Stainless Steel Melts

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Journal of Iron and Steel Research International 2011年第2期18卷 14-17页

作者： jiang Zhou-hua LI Shuang-jiang LI Yang School of Materials and Metallurgy Northeastern University Shenyang 110004 Liaoning China

A phase diagram was drawn through thermodynamic calculation to understand the equilibrium conditions of 2MgO · SiO2 , MgO · Al2O3 , 3Al2O3 · 2SIO2, and 2MgO·2Al2O3 · 5SiO2 formation in Mg-AI-Si-O system of 430 stainless steel melts at 1873 K. Further, the thermodynamic formation and transformation conditions of MgO · Al2O3 inclusion were discussed. The following results are obtained when ws, =0.26% and wo = 1.0 × 10^-5 in molten steel. The uniphase cordierite inclusion is difficult to exist stably; MgO· At203 inclusion cannot he formed in case of wAl being less than 1× 10^- 6 ; 3Al2O3 · 2SiO2 would change to MgO· Al2O3 and 2MgO · SiO2 in turn with increasing the Mg content when wAl is above 1.7× 10^- 6 ; with the formation of MgO · Al2O3 inclusion, A1 content increases with increasing Mg content when wMg is over 1. 7 × 10^- 9. For equilibrium condition and calculated steel composition, 2MgO·SiO2 inclusion would be formed ultimately and MgO · Al2O3 is almost inexistent.

关键词： phase diagram thermodynamic calculation MgO · Al2O3 inclusion 430 stainless steel