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Dose,Plasma Level,and Treatment Outcome Among Methadone Patients in Shanghai,China

Neuroscience Bulletin 2016年第6期32卷 538-544页

作者： Haifeng jiang Maureen Hillhouse jiang Du Shujun Pan Ang Alfonso Jun Wang Zhirong zhou Weijun Yuan Walter Ling min Zhao Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai 200030 China Department of Psychiatry Integrated Substance Abuse Program University of California at Los AngelesLos Angeles CA 90025 USA Shanghai Yangpu District Mental Health Center Shanghai 200093 China Shanghai Xuhui District Mental Health Center Shanghai 200232 China Shanghai Hongkou District Mental Health Center Shanghai 200083 China

Abstract The purpose of this study was to investigate the blood levels of methadone in participants receiving methadone for the treatment of opioid dependence. After stabilization on methadone for four weeks, blood samples from 95 participants were collected between treatment weeks 4 and 12, before and after receiving doses of methadone, and its blood levels were measured. A multiple linear regression model was used to examine the associa- tion between methadone blood levels and the outcomes of methadone maintenance treatment （MMT）. Outcome dif- ferences between participants who had high （≥2） or low （〈2） peak-to-trough ratios were also compared using an independent sample t-test. The blood level of methadone was not correlated with the clinical outcome of MMT with the moderate range of doses given. However, the retention of patients who had a free peak-to-trough ratio 〉2 was significantly poorer than those whose ratio was 〈2. Thus, monitoring plasma methadone levels is unlikely to be effective for guiding dosing decisions in situations where compliance with MMT is already very high or when themethadone dose is no longer the dominant factor in determining the clinical outcome. However, monitoring plasma methadone levels is still helpful for guiding the dosage for patients with a rapid metabolism.

关键词： Methadone Plasma level Treatmentoutcome Metabolism

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A Method of Choosing the Optimal Number of Singular Values in the Inverse Laplace Transform for the Two-Dimensional NMR Distribution Function

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Chinese Physics Letters 2013年第1期30卷 1-4页

作者： jiang Zhi-min WANG Wei-min Institute of Quantum Electronics School of Electronic Engineering and Computer SciencePeking UniversityBeijing 100871

Two-dimensional(2D)nuclear magnetic resonance(NMR)distributions as functions of diffusion coefficient and relaxation time are powerful tools in the study of porous *** propose a practical method to perform proper truncation of singular value decomposition(TSVD)in Laplace inversion for obtaining 2D-NMR distributions from measured NMR *** analyzing basic algorithms for Laplace inversion,it is well known that proper TSVD does not affect the inversion result for an ill-posed problem with zero-order Tikhonov regularization,but can greatly increase the inversion *** this new method,the optimal number of singular values for data compression is applied to each dimension *** method also makes full use of the redundancy nature of the data with a finite signal-to-noise ratio and well balances the tradeoff between the speed and the *** method does not require the stochastic information of the estimated parameters when obtaining the optimal number of singular values.

关键词： NMR singular relaxation

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Ir(Ⅲ)-based Ratiometric Hypoxic Probe for Cell Imaging

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Chinese Journal of Polymer Science 2023年第5期41卷 794-801,I0011页

作者： Shi-Lu Ji Hua-min Lan Sen-Sen zhou Xiao-Ke Zhang Wei-Zhi Chen Xi-Qun jiang Department of Polymer Science&Engineering College of Chemistry&Chemical EngineeringNanjing UniversityNanjing 210093China College of Science Nanjing Forestry UniversityNanjing 210037China

Two new ratiometric hypoxia probes(Ir-C343 and Ir-GFP)are synthesized by covalently incorporating florescent internal standard molecules coumarin 343(C343)and green fluorescent protein(GFP)into bis[1-(9,9-dimethyl-9H-fluoren-2-yl)-isoquinoline](succinylacetone)Ir(Ⅲ)(Ir-fliq),*** connecting with internal standard molecules,the Ir-fliq moiety still exhibits high sensitivity to oxygen concentration,while the fluorescence intensity of the internal standard remains relatively constant under different oxygen *** a result,a ratiometric response is realized that is only related to oxygen *** addition,Ir-GFP shows more promising applications in the ratiometric hypoxia imaging of cells due to its long excitation wavelength,good water solubility,high biocompatibility,and low relative fluorescence intensity compared with the phosphorescent emitter Ir-fliq.

关键词： Hypoxia probe Ratiometric probe Hypoxic response Cell imaging

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Study of parametric roll in oblique waves using a three-dimensional hybrid panel method

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Journal of Hydrodynamics 2020年第1期32卷 126-138页

作者： min Gu Shu-xia Bu jiang Lu jiangsu Key Laboralory of Green Ship Technology China Ship Scientific Research CenterWiuxi 214082.China

A reliable numerical tool for the prediction of the parametric roll is important in the development of the second generation intact stability *** main difficulty of the prediction of the parametric roll comes from the significant coupling of the roll with other motions,especially the heave and pitch *** this paper,the numerical method for determining the parametric roll is studied and the results are benchmarked against the model test ***,a 3 degrees-of-freedom(DOF)time domain hybrid panel method is validated by experimental data in regular oblique waves and irregular head ***,the verified 3D O F method is extended to a fully coupled 6 DOF method with the course ***,taking the C11 containership as the test case,the parametric roll in oblique waves is computed,and the effects of the surge,sway and yaw motions on the parametric roll are evaluated with the developed mathematical *** results show that the effects of the surge and sway motions on the parametric roll is insignificant,while the effects of the yaw motion are more *** results of the roll amplitudes and the standard deviation of the roll angles show that the model based on 3 DOF gives relatively conservative results,and can be directly used for the stability assessment of the parametric roll.

关键词： 6DOF mathematical model irregular oblique waves second generation intact stability in IMO

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Water Evaporation Triggered Self-Assembly of MXene on Non-Carbonized Wood with Well-Aligned Channels as Size-Customizable Free-Standing Electrode for Supercapacitors

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Energy & Environmental Materials 2023年第5期6卷 347-354页

作者： Weimin Chen Zhao Li Feng jiang min Luo Kai Yang Daotong Zhang Wangwang Xu Chaozheng Liu Xiaoyan zhou Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry University International Innovation Center for Forest Chemicals and Materials jiangsu Engineering Research Center of Fast-growing Trees and Agri-fiber Materials Nanjing 210037China Sustainable Functional Biomaterials Laboratory Department of Wood ScienceThe University of British ColumbiaVancouver BC V6T 1Z4Canada School of Renewable Natural Resources Louisiana State University Agricultural CenterBaton Rouge LA 70803USA

Herein,non-carbonized wood-based electrodes and separators with well-aligned channels and excellent mechanical properties are developed for *** enhance the conductivity and boost the capacitance,Ti_(3)C_(2)(MXene)nanosheets with high electrical conductivity and excellent electrochemical activity are loaded into the wood cells via self-assembly triggered by fast evaporating water in Ti_(3)C_(2)*** the assistance of positive charged polydopamine microspheres with large surface area,the self-restacking of Ti_(3)C_(2)nanosheets can be avoided and the high mass loading(50 wt%)can be achieved due to the extra driving force for Ti_(3)C_(2)*** from the conductive Ti_(3)C_(2)nanosheets with massive active sites and the multiple well-aligned channels in wood with efficient transportation pathways for charge carriers,the as-designed free-standing electrode shows a large areal capacitance of 1060 mF cm^(-2)at 0.5 mA cm^(-2)and high capacitance retention of 67%at 10 mA cm^(-2).Also,this electrode is highly size-customizable,showing a good ability to be industrially processed into various shapes and ***,an all-wood based supercapacitor with Ti_(3)C_(2)/wood composites as two layers of electrodes and a wood slice as the separator is fabricated,presenting a high energy density of 10.5μW h cm^(-2)at 389.9μW cm^(-2).

关键词： free-standing electrode MXene nanosheets polydopamine microspheres supercapacitor wood slice with well-aligned channels

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Structural insights into the regulatory mechanism of the Pseudomonas aeruginosa YfiBNR system

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Protein & Cell 2016年第6期7卷 403-416页

作者： min Xu Xuan Yang Xiu-An Yang Lei zhou Tie-Zheng Liu Zusen Fan Tao jiang National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Chinese Academy of Sciences Key Laboratory of Infection and Immunity Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China

YfiBNR is a recently identified bis-（3＇-5＇）-cyclic dimeric GMP （c-di-GMP） signaling system in opportunistic pathogens. It is a key regulator of biofilm formation, which is correlated with prolonged persistence of infection and antibiotic drug resistance. In response to cell stress, YfiB in the outer membrane can sequester the pariplasmic protein YfiR, releasing its inhibition of YfiN on the inner membrane and thus provoking the diguanylate cyclase activity of YfiN to induce c-di-GMP production. However, the detailed regulatory mechanism remains elusive. Here, we report the crystal struc- tures of YfiB alone and of an active mutant YfiB^L43P complexed with YfiR with 2：2 stoichiometry. Structural analyses revealed that in contrast to the compact conformation of the dimeric YfiB alone, YfiB^L43P adopts a stretched conformation allowing activated YfiB to penebate the peptidoglycan （PG） layer and access YfiR. YfiBL43P shows a more compact PG-binding pocket and much higher PG binding affinity than wild-type YflB, suggesting a tight correlation between PG binding and YfiB activation. In addition, our crystallographic analyses revealed that YflR binds Vitamin B6 （VB6） or L-Trp at a YfiB-binding site and that both VB6 and L-Trp are able to reduce YfiBL43P-induced biofilm formation. Based on the structural and biochemical data, we propose an updated regulatory model of the YfiBNR system.

关键词： the YfiBNR system c-di-GMP Vitamin B6,L-Trp peptidoglycan layer bioflim formation

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A cascade of in situ conversion of bicarbonate to CO_(2) and CO_(2) electroreduction in a flow cell with a Ni-N-S catalyst

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Journal of Energy Chemistry 2024年第1期88卷 183-193,I0005页

作者： Linghui Kong min Wang Yongxiao Tuo Shanshan zhou Jinxiu Wang Guangbo Liu Xuejing Cui Jiali Wang Luhua jiang Nanomaterials and Electrocatalysis Laboratory College of Materials Science and EngineeringQingdao University of Science and TechnologyQingdao 266042ShandongChina State Key Laboratory of Heavy Oil Processing College of New EnergyChina University of Petroleum(East China)Qingdao 266580ShandongChina

Combination of CO_(2) capture using inorganic alkali with subsequently electrochemical conversion of the resultant HCO_(3)^(-)to high-value chemicals is a promising route of low cost and high *** electrochemical reduction of HCO_(3)^(-)is challenging due to the inaccessible of negatively charged molecular groups to the electrode ***,we adopt a comprehensive strategy to tackle this challenge,i.e.,cascade of in situ chemical conversion of HCO_(3)^(-)to CO_(2) and CO_(2) electrochemical reduction in a flow *** a tailored Ni-N-S single atom catalyst(SACs),where sulfur(S)atoms located in the second shell of Ni center,the CO_(2)electroreduction(CO_(2)ER)to CO is *** experimental results and density functional theory(DFT)calculations reveal that the introduction of S increases the p electron density of N atoms near Ni atom,thereby stabilizing^(*)H over N and boosting the first proton coupled electron transfer process of CO_(2)ER,i.e.,^(*)+e^(-)+^(*)H+^(*)CO_(2)→^(*)*** a result,the obtained catalyst exhibits a high faradaic efficiency(FE_(CO)~98%)and a low overpotential of 425 mV for CO production as well as a superior turnover frequency(TOF)of 47397 h^(-1),outcompeting most of the reported Ni *** importantly,an extremely high FECOof 90%is achieved at 50 mA cm^(-2)in the designed membrane electrode assembly(MEA)cascade electrolyzer fed with liquid *** work not only highlights the significant role of the second coordination on the first coordination shell of the central metal for CO_(2)ER,but also provides an alternative and feasible strategy to realize the electrochemical conversion of HCO_(3)^(-)to high-value chemicals.

关键词： S doped Ni-N-C single atom catalysts CO_(2)electrochemical reduction DFT calculations Membrane electrode assembly Reduction of bicarbonate

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Improving solar control of magnetism in ternary organic photovoltaic system with enhanced photo-induced electrons doping

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Nano Research 2022年第3期15卷 2626-2633页

作者： Yujing Du Shiping Wang Lei Wang Shengye Jin Yifan Zhao Tai min Zhuangde jiang Ziyao zhou ming Liu Electronic Materials Research Laboratory Key Laboratory of the Ministry of Education&International Center for Dielectric ResearchSchool of Electronic Science and Engineeringthe International Joint Laboratory for Micro/Nano Manufacturing and Measurement TechnologyXi'an Jiaotong UniversityXi'an 710049China State Key Laboratory of Molecular Reaction Dynamics and Collaborative Innovation Center of Chemistry for Energy Materials(iChEM) Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Center for Spintronics and Quantum Systems State Key Laboratory for Mechanical Behavior of MaterialsXi'an Jiaotong UniversityXi'an 710049China State Key Laboratory for Manufacturing Systems Engineering Collaborative Innovation Center of High-End Manufacturing Equipmentthe International Joint Laboratory for Micro/Nano Manufacturing and Measurement TechnologyXi'an Jiaotong UniversityXi'an 710049China

§The growing demand for storage space has promoted in-depth research on magnetic performance regulation in an energy-saving ***,we developed a solar control of magnetism,allowing the magnetic moment to be manipulated by sunlight instead of the magnetic field,current,or ***,binary and ternary photoactive systems with different photon-to-electron conversions are *** photovoltaic/magnetic heterostructures with a ternary system induce larger magnetic changes due to higher short current density(J SC)(20.92 mA·cm^(−2))compared with the binary system(11.94 mA·cm^(−2)).During the sunlight illumination,ferromagnetic resonance(FMR)shift increases by 80%(from 169.52 to 305.48 Oe)attributed to enhanced photo-induced electrons doping,and the variation of saturation magnetization(M S)is also amplified by 14%(from 9.9%to 11.3%).Furthermore,photovoltaic performance analysis and the transient absorption(TA)spectra indicate that the current density plays a major role in visible light manipulating *** findings clarify the laws of sunlight control of magnetism and lay the foundation for the next generation solar-driven magneto-optical memory applications.

关键词： multiferroic heterostructure magnetoelectric coupling ferromagnetic resonance magnetic anisotropy interface charge doping

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Hierarchical Dispatch Method for Integrated Heat and Power Systems Based on a Feasible Region of Boundary Variables

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CSEE Journal of Power and Energy Systems 2020年第3期6卷 543-553页

作者： Tuo jiang Yong min Weichun Ge Lei Chen Qun Chen Fei Xu Huanhuan Luo Guiping zhou State Key Laboratory of Control and Simulation of Power System and Generation Equipment Department of Electrical EngineeringTsinghua UniversityBeijing 100084China State Grid Liaoning Electric Power Supply Co.Ltd. Shenyang 110000China Department of Engineering Mechanics Tsinghua UniversityBeijing 100084China

Fully utilizing the flexibility provided by a district heating system(DHS)can promote wind power accommodation for an electric power system(EPS).However,for privacy or communication reasons,existing power and heat dispatch methods are not suitable for practical *** this paper,a general math formulation of the hierarchical dispatch method is proposed to coordinate EPS and DHS operators based on the feasible region of boundary variables(FRBV),and a method based on the simplicial approximation approach is proposed to obtain a conservative FRBV approximation of a DHS.A simulation based on a real 41-node DHS is constructed to determine the factors that may impact the boundaries of the FRBV,and then the performance of the simplicial approximation approach is displayed by visualizing the approximation process for the FRBV,and finally three dispatch methods are compared to show the advantages of the proposed hierarchical dispatch method.

关键词： District heating system feasible region hierarchical dispatch method integrated heat and power system simplicial approximation approach

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Programmable DNA-responsive microchip for the capture and release of circulating tumor cells by nucleic acid hybridization

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Nano Research 2018年第5期11卷 2592-2604页

作者： Shan Guo Haiyan Huang Xujing Deng Yuqi Chen Zhuoran jiang min Xie Songmei Liu Weihua Huang Xiang zhou College of Chemistry and Molecular Sciences the Institute for Advanced Studies of Wuhan University Hubei Province Key Laboratory of Allergy and Immunology Wuhan University Wuhan 430072 China Zhongnon Hospital Wuhan University Wuhan 430072 China Key Laboratory of Analytical Chemistry for Biology and Medicine (ministry of Education) College of Chemistry and Molecular Sciences Wuhan University Wuhan 430072 China

The detection and analysis of circulating tumor cells （CTCs） from patients＇ blood is important to assess tumor status; however, it remains a challenge. In the present study, we developed a programmable DNA-responsive microchip for the highly efficient capture and nondestructive release of CTCs via nucleic acid hybridization. Transparent and patternable substrates with hierarchical architectures were integrated into the microchip with herringbone grooves, resulting in greatly enhanced cell-surface interaction via herringbone micromixers, more binding sites, and better matched topographical interactions. In combination with a high-affinity aptamer, target cancer cells were specifically and efficiently captured on the chip. Captured cancer cells were gently released from the chip under physiological conditions using toehold-mediated strand displacement, without any destructive factors for cells or substrates. More importantly, aptamercontaining DNA sequences on the surface of the retrieved cancer cells could be further amplified by polymerase chain reaction （PCR）, facilitating the detection of cell surface biomarkers and characterization of the CTCs. Furthermore, this system was extensively applied to the capture and release of CTCs from patients＇ blood samples, demonstrating a promising high-performance platform for CTC enrichment, release, and characterization.

关键词： DNA-responsive microchip hierarchical architecture circulating tumor cells(CTCs) aptamer capture release nucleic acid hybridization

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