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Journal of Geriatric Cardiology 2022年第8期19卷 618-621页

作者： Cheng-Duo ZhanG li-Jie SUN Bao-Xia CHEN jiang-li han Shao-Min CHEN Xin-Yu WANG Yuan-Yuan FAN Dan li Xin-Ye XU Department of Cardiology Peking University Third HospitalNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesBeijingChina

Acute obstruction of the right coronary ar-tery(RCA)can lead to right ventricular myocardial infarction(MI),which rarely lead to cardiogenic shock(CS).Hemodynamic sta-bility could be restored through fluid resuscitation and vasoactive drugs in most circumstances.Here,we present a highly representative case of refractory CS caused by massive right ventricular MI with api-cal aneurysm formation,who was successfully treated with extracorporeal membrane oxygenation(ECMO)post severe complication of acute right coronal dis-section.

关键词： ventricular aneurysm drugs

Correlation between serum free fatty acids levels and Gensini score in elderly patients with coronary heart disease

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Journal of Geriatric Cardiology 2014年第1期11卷 57-62页

作者： li-Yun HE Jun-Feng ZHAO jiang-li han Shan-Shan SHEN Xu-Jiao CHEN Department of Cardiology Peking University Third Hospital and Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Ministry ofHealth Beijing 100191 China Department of Emergency the Third Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310005 Zhejiang Province China Department of Geriatrics Zhejiang Hospital Hangzhou 310013 Zhejiang Province China

ObjectivesTo 调查在浆液之间的关系免费的丰满的酸(船边交货)层次和在有冠的心疾病( CAD )的老病人的冠的动脉损害的严厉经历了冠的 angiography 的 172 个老病人全部的 .MethodsA 被划分成 CAD 组( n = 128 )并且非CAD 组( n = 44 )... 详细信息

ObjectivesTo 调查在浆液之间的关系免费的丰满的酸(船边交货)层次和在有冠的心疾病( CAD )的老病人的冠的动脉损害的严厉经历了冠的 angiography 的 172 个老病人全部的 .MethodsA 被划分成 CAD 组( n = 128 )并且非CAD 组( n = 44 )根据冠的 angiography 的结果。浆液船边交货和类脂化合物层次被测量， Gensini 分数是 calculated.ResultsNo 物质年龄，性和 statins 的用法之间的差别，在船边交货层次没有统计意义(P >；0.05 ) 。以 Gensini 分数，它比在病人 60-69 岁在 70-79 年的病人是更高的[15.00 (5.00， 34.00 ) 对 10.00 (2.00， 24.00 ) ， P <；0.05 ] ，在男人更高比女人[14.00 (4.00， 34.00 ) 对 7.00 (2.50， 19.75 ) ， P <；0.05 ] ，并且在 statins 上的病人更高[13.50 (4.25， 33.50 ) 对 6.50 (2.00， 18.00 ) ， P <；0.05 ] 。浆液船边交货层次[449.50 (299.00， 624.75 ) mEq/L 对 388.00 (258.50， 495.25 ) mEq/L， P <；0.05 ] 并且 Gensini 分数[17.50 (8.00， 41.75 ) 对 1.00 (0， 5.00 ) ， P <；0.05 ] 比在非 CAD 组在 CAD 组是更高的。在 CAD 组，在在有 diseased 的不同数字的病人之中的船边交货层次没有统计意义冠的容器(P >；0.05 ) 。而且，船边交货层次断然与 Gensini 分数被相关(r = 0.394， P = 0.005 ) 。回归分析证明船边交货层次在调整因为另外的风险 factors.ConclusionsThe 浆液船边交货层次与 CAD 在老病人与 Gensini 分数被联系以后独立地与 Gensini 分数有关。它可能作为预言冠的动脉损害的严厉的 biomarker 显示船边交货。

关键词：冠状动脉造影游离脂肪酸心脏疾病患者酸水血清老年评分

Altered serum level of cartilage oligomeric matrix protein and its association with coronary calcification in patients with coronary heart disease

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Journal of Geriatric Cardiology 2017年第2期14卷 87-92页

作者： Fang-Fang WANG Lahati HA Hai-Yi YU lin MI jiang-li han Wei GAO Department of Cardiology Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Ministry of Health Peking University Third Hos-pital Beijing China

BackgroundCartilage oligomeric 矩阵蛋白质(COMP ) 主要在骨胳的系统和脉管的光滑的肌肉房间被发现。最近的研究证明它在血容器上有保护的功能并且能也禁止脉管的石灰化。我们在冠的心疾病( CHD )调查了浆液 COMP 病人，并且在浆液 CO... 详细信息

BackgroundCartilage oligomeric 矩阵蛋白质(COMP ) 主要在骨胳的系统和脉管的光滑的肌肉房间被发现。最近的研究证明它在血容器上有保护的功能并且能也禁止脉管的石灰化。我们在冠的心疾病( CHD )调查了浆液 COMP 病人，并且在浆液 COMP 和首先经历了多片跟随的冠的 angiography 的 233 个连续的胸疼痛病人全部的冠的 artery.MethodsA 的石灰化之间的关系在六个月以内计算了断层摄影术( MSCT )被招募并且根据缩小百分比的冠的 angiography 钠直径划分了成二个组：CHD 组(缩小 50% 的直径， n = 194 ) 并且控制组(直径变窄 liSA.ResultsThe 层次被决定比在控制组在 CHD 组是显著地更高的 155.7 (124.5-194.5 ) ng/mL 对 128.4 (113.0-159.9 ) ng/mL， P = 0.019。在 COMP， Gensini 分数，句法分数，冠的狭窄的严厉和有狭窄的冠的动脉的数字之间没有关联 >50% 。浆液 COMP 与年龄被相关(r = 0.294， P < 0.001 ) ， fasting 葡萄糖(r = 0.163， P = 0.015 ) ， HbA1c (r = 0.194， P = 0.015 ) 并且 CAC (r = 0.137， P = 0.037 ) 。逐步的线性回归分析显示出那 COMP 水平，年龄是在 CHD 病人的 CAC 的独立预言者(= 0.402， t = 2.612， P = 0.015；= 0.472， t = 3.077， P = 0.005 ) 。为预言 CHD 的 COMP 的性能在曲线(AUC ) 下面作为区域被显示出：0.632， 95% CI：0.549-0.715 和上面的 tertile CAC 是 AUC：0.602， 95% CI：在操作冠的动脉的特征(巨鸟) 曲线 analysis.ConclusionCalcification 的接收装置的 0.526-0.678 是浆液 COMP 的一个独立预言者。

关键词：冠状动脉造影蛋白水平基质蛋白冠心病钙化患者软骨血管平滑肌细胞

A case of applying left bundle branch pacing combined with atrioventricular node ablation to treat atrial fibrillation-induced heart failure

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Journal of Geriatric Cardiology 2021年第6期18卷 492-497页

作者： Lahati HA li-Yun HE Lei li jiang-li han Shu-Wang liU Yuan ZhanG Wei XU Wei GAO Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesKey Laboratory of Molecular Cardiovascular ScienceMinistry of EducationBeijing Key Laboratory of Cardiovascular Receptors ResearchBeijingChina

The core treatment of rapid arrhythmiainduced heart failure(HF)is to control the ventricular rate to an optimized lower level,which is usually achieved with various anti-arrhythmic drugs.However,arrhythmias may not respond well to pharmaceutical treatment for various reasons.Iatrogenic atrioventricular(AV)node ablation needs to be performed under these extreme conditions to lower the patient’s heart rate.

关键词： drugs fibrillation ventricular

Low density lipoprotein cholesterol level inversely correlated with coronary flow velocity reserve in patients with Type 2 diabetes

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Journal of Geriatric Cardiology 2013年第2期10卷 159-164页

作者： Jie Yu jiang-li han li-Yun He Xin-Heng Feng Wei-Hong li Jie-Ming Mao Wei Gao Guang Wang Department of Cardiology Peking University Third Hospital Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education Beijing 100191 China Department of Endocrinology Beijing Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020 China

Objectives To evaluate the association of coronary artery endothelial function and plasma levels of low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) in patients with Type 2 Diabetes Mellitus (DM). Methods We investigated 90 participants from our institution between October 2007 to March 2010: non-DM(n = 60) and DM(n = 30). As an indicator of coronary endothelial dysfunction, we used non-invasive Doppler echocardiography to quantify coronary flow velocity reserve (CFVR) in the distal part of the left descending artery after rest and after intravenous adenosine administration. Results Plasma level of LDL-C was significantly higher in patients with DM than in non-DM (3.21 ±0.64 vs. 2.86 ±0.72 mmo/L, P han non-diabetics (2.45 ±0.62 vs. 2.98 ±0.68, P lium. Increased LDL-C level may adversely impair coronary endothelial function in DM. HDL-C may lose its endothelial-protective effects, in part as a result of pathological conditions, especially under abnormal glucose metabolism.

关键词： Coronary flow velocity reserve Diabetes mellitus Endothelial function High-density lipoprotein cholesterol Low-density lipoprotein cholesterol

Prognostic value of coronary artery calcium score in patients with stable an-gina pectoris after percutaneous coronary intervention

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Journal of Geriatric Cardiology 2014年第2期11卷 113-119页

作者： Fang-Fang WANG jiang-li han Rong HE Xiang-Zhu ZENG Fu-Chun ZhanG li-Jun GUO Wei GAO Department of Cardiology Peking University Third Hospital Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptide Ministry of Health Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education Beijing 100191 China Department of Radiology Peking University Third Hospital Beijing 100191 China

ObjectivesTo 评估冠的动脉钙( CAC )的预示的值在经历了经皮的冠的干预(一种总线标准)的有稳定的心绞痛(树液)的病人的分数与经历了第一一种总线标准后面的多片计算机断层摄影术( MSCT )的树液一起的 334 个连续病人的 .MethodsA 总数... 详细信息

ObjectivesTo 评估冠的动脉钙( CAC )的预示的值在经历了经皮的冠的干预(一种总线标准)的有稳定的心绞痛(树液)的病人的分数与经历了第一一种总线标准后面的多片计算机断层摄影术( MSCT )的树液一起的 334 个连续病人的 .MethodsA 总数从我们的机构被注册在之间2007年1月和2012年6月。CAC 分数根据标准 Agatston 钙得分算法被计算。复杂一种总线标准被定义为高压力汽球的使用，吻汽球或 rotablator。过程相关的复杂并发症包括了解剖，吸藏，穿孔，不 / 慢流动和紧急情况冠的动脉绕过 grafting。主要不利心脏的事件(向) 与 CAC 分数 > 为心脏的 ischemic events.ResultsPatients 被定义为死亡，非致命的心肌的梗塞，目标损害 revascularization 和再进医院的一个联合结束点；300 (n = 145 ) 有的显著地更高的一种总线标准复杂性(13.1% 对 5.8% ， P = 0.017 ) 并且过程相关的复杂并发症的率(17.2% 对 7.4% ， P = 0.005 ) 与有 CAC 的病人获得 ≤ 比；300 (n = 189 ) 。在 22.5 个月(4-72 月) 的中部的后续以后，有 CAC 的病人获得 ≤；300 比有 CAC 的那些病人获得 > 的极大地不同；300 在累积大事宣传而结果并未举办的事幸存评价(88.9 对 79.0% ，木头等级 4.577， P = 0.032 ) 。在为另外的因素调整了以后，向的风险显著地更高[危险比率(HR ) ：4.3， 95% 信心间隔(95% CI ) ：2.4-8.2， P = 0.038 ] 在有一个 CAC 分数的病人 >；300 与有一个更低的 CAC score.ConclusionsThe CAC 分数的病人相比是为在经历了一种总线标准的树液病人的向的一个独立预言者并且显示一种总线标准和过程相关的复杂并发症的复杂性。

关键词：冠状动脉心绞痛稳定型患者钙化价值预后计算机断层扫描

Recurrent vital thrombotic events in a young man with FVIII gene duplication

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Chinese Medical Journal 2021年第8期134卷 996-998页

作者： ling-li Wang Dan liu Na Feng Mu-Ye Ping jiang-li han Wei Gao Fang-Fang Wang Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesKey Laboratory of Molecular Cardiovascular ScienceMinistry of EducationBeijing Key Laboratory of Cardiovascular Receptors ResearchBeijing 100191China Department of Laboratory Medicine Peking University Third HospitalBeijing 100191China

To the Editor:The coagulation system is a complex regulatory system in the human body.In this case,the young patient had various vital thrombosis,including cerebral venous sinus thrombosis(CVST),coronary thrombosis,and left ventricular thrombus.However,the patient had neither hypercoagulable-related diseases nor risks nor coagulative or fibrinolytic protein deficiency.[1] Further genetic testing did not show the usual gene mutations relevant to coagulation dysfunction.W e report such a patient with a slight elevation in coagulation FVIII activity and a rare FVIII gene duplication.

关键词： diseases cerebral coronary

Association between serum cartilage oligomeric matrix protein and coronary artery calcification in maintenance hemodialysis patients

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Journal of Geriatric Cardiology 2020年第2期17卷 67-73页

作者： Lahati HA Jun-Bao SHI Hai-Yi YU Kun YANG Hai-Ning WANG Fang-Fang WANG jiang-li han Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesKey Laboratory of Molecular Cardiovascular ScienceMinistry of EducationBeijing Key Laboratory of Cardiovascular Receptors ResearchBeijingChina Department of Nephrology Peking University Third HospitalBeijingChina Department of Endocrinology Peking University Third HospitalBeijingChina

Background Coronary artery calcification(CAC)is common in end-stage renal disease(ESRD)patients,and the extent of CAC is closely related to cardiovascular outcomes in ESRD patients.Cartilage oligomeric matrix protein(COMP),as a component of the vascular matrix,has been found to be an inhibitor of arterial calcification in basic studies.However,there is no clinical research on the correlation between COMP and CAC in maintenance hemodialysis(MHD)patients.The aim of this study was to explore the relationship between serum COMP levels and CAC and cardiovascular events in MHD patients.Methods Serum COMP levels were compared between 54 MHD patients and 66 healthy people.MHD patients were then divided into three groups according to the tertiles of the concentration of COMP level and were followed up for major adverse cardiac events(MACEs),which were defined as a combined end point of new onset angina pectoris,nonfatal myocardial infarction,heart failure,coronary artery revascularization,hospitalization due to angina pectoris and all-cause deaths.The CAC score was calculated based on computed tomography scans.Results The serum COMP level in MHD patients was significantly higher than that in the general population[984.23(248.43-1902.61)ng/mL vs.219.01(97.26-821.92)ng/mL,Plinear regression suggested that after adjusting for age,fasting blood glucose(Glu)and glycosylated hemoglobin(HbAlc),CAC score was an independent predictor in the final model for COMP level(β=0.424,t=3.130,P<0.01).The receiver operating characteristic(ROC)curve showed that COMP≥994 mg/mL had 68.0%sensitivity and 72.4%specificity for the prediction of severe CAC[area under the curve(AUC):0.674,P=0.030,95%CI:0.526-0.882].After a median follow-up of 16 months(8-24 months),there was no difference in the incidence rate of MACEs between the upper,middle and lower serum COMP groups.Conclusions Our study found that MHD patien

关键词： Biomarker Cartilage oligomeric matrix protein Coronary artery calcification Maintenance hemodialysis

Optimization of manganese-rich slag extraction from low-manganese ore smelting by response surface methodology

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Journal of Iron and Steel Research(International) 2022年第10期29卷 1573-1582页

作者： Shuang-ping Yang jiang-han li Wen-bing Gao Hai-jin liu College of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina

Manganese-rich slag is a raw material for smelting silicon–manganese alloys using an electric furnace.The blast furnace method is the main method for smelting manganese-rich slag.This method has the problems of a long process,large coke consumption,and easy volatilization of metals such as lead and zinc,which affects smelting safety.A new technology for smelting manganese-rich slag with low-manganese high-iron ore by smelting reduction optimization was proposed.This technology has the advantages of a short process,low energy consumption,low carbon emissions,and comprehensive recycling of lead,zinc,and other metals.According to the chemical composition,X-ray diffraction analysis,and particle size analysis of Cote d’Ivoire low-manganese ore,an experiment was carried out on manganese-rich slag by reduction–smelting separation.Combined with the design scheme of the Box–Behnken principle,three experimental factors(temperature,basicity,and carbon content)were selected as the influences to study.The influence that each factor has on the recovery rate of manganese was studied by response surface methodology,and the experimental factors were optimized.The results show that under the conditions of a reduction-smelting temperature of 1402℃,basicity of R=0.10,and carbon content of 10 mass%,the recovery rate of manganese is 97%.A verification experiment was carried out under the optimal conditions,and the error was only 1.24%;this proves that the response surface method prediction model is reliable and accurate.This is of great significance for the comprehensive utilization of lean-manganese ore resources.

关键词： Low-manganese high-iron ore Manganese-rich slag Response surface methodology Manganese recovery

Large animal models for Huntington's disease research

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Zoological Research 2024年第2期45卷 275-283页

作者： Bofeng han Weien liang Xiao-jiang li Shihua li Sen Yan Zhuchi Tu Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan University Key Laboratory of CNS Regeneration(Jinan University)-Ministry of EducationGuangdong Key Laboratory of Non-Human Primate ResearchGuangzhouGuangdong 510632China Department of Pathophysiology School of MedicineJinan UniversityGuangzhouGuangdong 510632China

Huntington'sdisease(HD)isahereditary neurodegenerative disorder for which there is currently no effectivetreatmentavailable.Consequently,the development of appropriate disease models is critical to thoroughly investigate disease progression.The genetic basis of HD involves the abnormal expansion of CAG repeats in the huntingtin(HTT)gene,leading to the expansion of a polyglutamine repeat in the HTT protein.Mutant HTT carrying the expanded polyglutamine repeat undergoes misfolding and forms aggregates in the brain,which precipitate selective neuronal loss in specific brain regions.Animal models play an important role in elucidating the pathogenesis of neurodegenerative disorders such as HD and in identifying potential therapeutic targets.Due to the marked species differences between rodents and larger animals,substantial efforts have been directed toward establishing large animal models for HD research.These models are pivotal for advancing the discovery of novel therapeutic targets,enhancing effective drug delivery methods,and improving treatment outcomes.We have explored the advantages of utilizing large animal models,particularly pigs,in previous reviews.Since then,however,significant progress has been made in developing more sophisticated animal models that faithfully replicate the typical pathology of HD.In the current review,we provide a comprehensive overview of large animal models of HD,incorporating recent findings regarding the establishment of HD knock-in(KI)pigs and their genetic therapy.We also explore the utilization of large animal models in HD research,with a focus on sheep,non-human primates(NHPs),and pigs.Our objective is to provide valuable insights into the application of these large animal models for the investigation and treatment of neurodegenerative disorders.

关键词： Huntington's disease Large animal models Sheep Non-human primates Transgenic pigs