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Novel OCRL1 gene mutations in six Chinese families with Lowe syndrome

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World Journal of Pediatrics 2016年第4期12卷 484-488页

作者： Yan Gao Fang jiang Zhi-Ying ou Guangzhou Women and Children's Medical Center GuangzhouChina

Background:Lowe syndrome,an X-linked,inheritable disease with clinical symptoms of congenital cataracts,incomplete Fanconi syndrome,and mental retardation,has an approximate incidence of 1 in *** 200 OCRL mutations related to Lowe syndrome have been found worldwide,with only ten mutations among the Chinese *** more mutations may exist in Chinese patients,we sequenced and analyzed the OCRL genes of six children with Lowe syndrome in a medical center in ***:Peripheral blood was collected from six children with Lowe syndrome and their relatives,and ten healthy *** DNA was extracted from the blood and applied to amplify the twenty-four exons and flanking introns of the OCRL *** mutations were identified by ***:Five mutations(c.1528C>T,c.2187insG,c.1366C>T,c.1499G>A,and c.2581G>A)of the OCRL gene were found in five families;c.2187insG and c.1366C>T were novel *** of the five mutations were detected in 20 normal *** mutation was found in the sixth ***:Two novel mutations of the OCRL gene,c.2187insG and c.1366C>T,were found in Chinese patients with Lowe syndrome,which will provide new clues for the etiology of Lowe syndrome and could be beneficial to genetic diagnosis of the condition.

关键词： Lowe syndrome mutation OCRL gene

Micro-Climate Evaluation System in Thermal Mines

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Journal of China University of Mining and Technology 2006年第1期16卷 1-4页

作者： yang Sheng-qiang ou Xiao-ying CHENG Jian-wei WANG Yi-jiang YU Bao-hai School of Mineral and Safety Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

A fuzzy evaluation method was used to evaluate the microclimate in thermal mines. A theoretical model of a microclimate evaluation system was designed and membership functions of the evaluation indices in the system were established. An analytical hierarchy process (AHP) was used to analyze the weight of the evalua- tion indices and their methods of calculation. Software for this evaluation system was developed and used for the evaluation of the microclimate of 714 sections in a mine. It is shown that the evaluation results correspond com- pletely with the actual situation. This evaluation system and the software can be applied in thermal mines.

关键词： membership grade weight fuzzy evaluation method thermal mine

Development and sensing performance study of a smart CFRP cable assembled by multi-group anchorage units

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International Journal of Smart and Nano Materials 2023年第3期14卷 286-302页

作者： Lian Shao Huanyu yang Jinping ou Zhi Zhou Faculty of Infrastructure Engineering Dalian University of TechnologyDalian 116024China School of Civil Engineering Harbin Institute of TechnologyHarbinChina School of Civil Engineering and Architecture Hainan UniversityHaikouChina

Carbon fiber reinforced polymer(CFRP)can be applied for bridge cables due to its excellent *** the important load-bearing structural component,real-time force monitoring of the CFRP cable is *** paper presents a new smart CFRP cable that combines the self-sensing rods with embedded sensors and the anchorage system using extrusion *** embedding optical fiber(OF)and coaxial cable Fabry-Perot interferometer(CCFPI)into CFRP rods respectively,two types of self-sensing rods(CFRP-OF rod and CFRP-CCFPI rod)were fabricated.A new anchorage unit using an extrusion process was proposed as a basic component of smart CFRP *** units holding a CFRP-OF rod and a CFRP-CCFPI rod were tested to obtain their sensing and mechanical *** ancho-rage units were assembled to form a smart CFRP cable with self-sensing functionality.A verification test was carried out to confirm the capabil-ity of monitoring the cable *** test results demonstrate that the smart CFRP cable composed of multiple anchorage units has good potential in bridge engineering.

关键词： Carbon fiber reinforced polymer smart cable sensor extrusion process bridge engineering

Shedding light on neurons:optical approaches for neuromodulation

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National Science Review 2022年第10期9卷 34-54页

作者： Shan jiang Xiang Wu Nicholas J.Rommelfanger Zihao ou Guosong Hong Department of Materials Science and Engineering Stanford University Wu Tsai Neurosciences Institute Stanford University Department of Applied Physics Stanford University

Today’ s optical neuromodulation techniques are rapidly evolving,benefiting from advances in photonics,genetics and materials *** this review,we provide an up-to-date overview of the latest optical approaches for *** begin with the physical principles and constraints underlying the interaction between light and neural *** then present advances in optical neurotechnologies in seven modules:conventional optical fibers,multifunctional fibers,optical waveguides,light-emitting diodes,upconversion nanoparticles,optical neuromodulation based on the secondary effects of light,and unconventional light sources facilitated by ultrasound and magnetic *** conclude our review with an outlo ok on new methods and mechanisms that afford optical neuromodulation with minimal invasiveness and footprint.

关键词： optical neuromodulation optogenetics neural interfaces

Long-term performance of packaged fiber Bragg grating sensors for strain monitoring inside creep medium

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International Journal of Smart and Nano Materials 2022年第1期13卷 42-63,I0003页

作者： Huanyu yang Ying Huang Zhi Zhou Jinping ou Faculty of Infrastructure Engineering Dalian University of TechnologyDalian116024Liaoning ProvinceChina Department of Civil and Environmental Engineering North Dakota State UniversityFargoNorth DakotaUSA Hainan University School of Civil and Architectural EngineeringHaikou570228Hainan ProvinceChina School of Civil and Environmental Engineering Harbin Institute of Technology(Shenzhen)ShenzhenGuangdong ProvinceChina

To investigate the long-term performance of the packaged fiber Bragg grating(FBG)sensors embedded in civil infrastructure for strain monitoring,in this paper,the influence of host matrix’s creep effect on the behavior of the FBG sensors was systematically studied through theoretical,numerical,and experimental analysis.A theoretical strain transfer analysis between the optic fiber,packaging layer,and host matrix to consider the creep effect of the host matrix was performed accordingly for long-term strain *** studies were carried out using numerical analysis for FBG sensors packaged with glass fiber reinforced plastic(GFRP),also known as FBG-GFRP sensors in concrete,as an *** results show that embedded in a creep medium,an acceptable long-term performance of packaged FBG sensors requires the packaging layer to have a minimum length and maximum thick*** long-term creep tests using epoxy resin and concrete as host matrix for FBG-GFRP sensors also clearly demonstrated that the influence of creep effect cannot be ignored for strain measurements if the host matrix has a creep potential and the developed correction model performed well to reduce measurement errors of such sensors in creep medium.

关键词： Fiber Bragg gratings(FBG)sensor strain transfer creep packaging layer epoxy resin concrete

EPIC 202843107:a close eclipsing binary containing a δ Scuti variable

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Research in Astronomy and Astrophysics 2019年第8期19卷 63-68页

作者： Jian-Wen ou Ming yang Ji-Lin Zhou School of Astronomy and Space Science & Key Laboratory of Modern Astronomy and Astrophysics in Ministry of Education Nanjing University

This paper reports on the discovery that an eclipsing binary system, EPIC 202843107, has aδ Scuti variable component. The phased light curve from the Kepler space telescope presents a detached configuration. The binary modeling indicates that the two component stars have almost the same radius and may have experienced orbital circularization. Frequency analyses are performed for the residual light curve after subtracting the binary variations. The frequency spectrum reveals that one component star is a δ Scuti variable. A large frequency separation is cross-identified with the corresponding histogram, the Fourier transform and the echelle diagram method. The mean density of the δ Scuti component is estimated to be 0.09 g cm-3 based on the large separation and density relation. Systems like EPIC 202843107 are helpful to study the stellar evolution and physical state of binary stars.

关键词： binaries:eclipsing-stars:individual:EPIC 202843107 stars:variables:δ Scuti stars:oscillations

Algebraic Approach to the Study of Quantum Integrability

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Chinese Physics Letters 1999年第1期16卷 6-8页

作者： XU Gong-ou yang Ya-tian Department of Physics Nanjing UniversityNanjing 210093 Department of Physics Fujian Normal UniversityFuzhou 350007

The basic problem of quantum integrability has been systematically studied with an algebraic *** the introduction of the dynamical symmetry algebra the difficulty in transferring the classical integrability condition into quantum mechanics is *** the superconvergent technique of Kolmogorov,it has been proved that systems with Hamiltonians expressed merely with elements of a definite dynamical symmetry algebra form an integrable class of systems corresponding to that dynamical symmetry.

关键词： dynamical algebra symmetry

Nanoconfinement-induced water molecules and hydrogen molecules transport behaviors in ball-in-ball structure photocatalysts to improve hydrogen evolution

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Nano Research 2024年第5期17卷 3752-3760页

作者： Ben Chong Baorong Xu He Li Honghui ou Guidong yang XJTU-Oxford Joint International Research Laboratory of Catalysis School of Chemical Engineering and TechnologyXi’an Jiaotong UniversityXi’an 710049China

The diffusion,adsorption/desorption behaviors of water molecules and hydrogen molecules are of great importance in heterogeneous photocatalytic hydrogen *** the study of structure-property-performance relationships,nanoconfined space provides an ideal platform to promote mass diffusion and transfer due to their extraordinary properties that are different from the bulk ***,we designed and prepared a nanoconfined CdS@SiO_(2)-NH_(2) nanoreactor,whose shell is composed of amino-functionalized silica nanochannels,and encapsulates spherical CdS as a photocatalyst *** and simulated results reveal that the amino-functionalized nanochannels promote water molecules’and hydrogen molecules’directional diffusion and *** molecules are enriched in the nanocavity between the core and the shell,and promote the interfacial photocatalytic *** a result,the maximized water enrichment and minimized hydrogen-occupied active sites enable photocatalyst with optimized mass transfer kinetics and localization electron distribution on the CdS surface,leading to superior hydrogen production performance with activity as high as 37.1 mmol·g^(-1)·h^(-1).

关键词： nanochannels photocatalytic hydrogen evolution mass transfer amino-functionalized CdS

Effective Model Compression via Stage-wise Pruning

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Machine Intelligence Research 2023年第6期20卷 937-951页

作者： Ming-yang Zhang Xin-Yi Yu Lin-Lin ou School of Information Engineering Zhejiang University of TechnologyHangzhou310000China

Automated machine learning(AutoML)pruning methods aim at searching for a pruning strategy automatically to reduce the computational complexity of deep convolutional neural networks(deep CNNs).However,some previous work found that the results of many Auto-ML pruning methods cannot even surpass the results of the uniformly pruning *** this paper,the ineffectiveness of Auto-ML pruning,which is caused by unfull and unfair training of the supernet,is shown.A deep supernet suffers from unfull training because it contains too many *** overcome the unfull training,a stage-wise pruning(SWP)method is proposed,which splits a deep supernet into several stage-wise supernets to reduce the candidate number and utilize inplace distillation to supervise the stage ***,a wide supernet is hit by unfair training since the sampling probability of each channel is ***,the fullnet and the tinynet are sampled in each training iteration to ensure that each channel can be ***,the proxy performance of the subnets trained with SWP is closer to the actual performance than that of most of the previous AutoML pruning ***,experiments show that SWP achieves the state-of-the-art in both CIFAR-10 and ImageNet under the mobile setting.

关键词： Automated machine learning(AutoML) channel pruning model compression distillation convolutional neural networks(CNN)