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Cladding of aluminum alloy 6061-T6 to mild steel by an electromagnetic tube bulging process: finite element modeling

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Advances in Manufacturing 2019年第1期7卷 73-83页

作者： Zhi-Song Fan Su-Ting huang jiang-hua deng School of Mechanical Engineering and Automation Fuzhou University Fuzhou 350116 People's Republic of China

Bimetal tubes have useful applications in various industries where service conditions demand more different requirements in the tube core than its outside surface. The recent use of electromagnetic forces to deform or join metallic workpieces at high speeds has undergone rapid growth for materials processing. However, to date, no sufficient systematic understanding of the underlying principles of a subsequent high-speed electromagnetic tube bulging process to manufacture bimetal tubes has been gained. In this work, magnetic pulse cladding of Al/Fe clad bimetal tubes was analyzed by finite element modeling (FEM) using ANSYS software. The validity of FEM analyses was first confirmed by experiments in terms of the deformed shape. Second, the effect of cladding parameters (such as axial feeding being the dominant factor in the multi-step process) on the bulging and thinning behavior of the Al clad tube was presented in detail. Both the numerical simulation and experimental results show that no more than 70% of the bulging-coil length is an appropriate amount for the feeding length to prevent defects from being introduced by non-uniform deformation in the transition zone of the Al clad tube. The distributions of the magnetic flux line, magnetic force, and plastic strain in different cladding steps were then analyzed. It was concluded that during the multi-step cladding process, there was an uneven distribution of the magnetic field force along the transition zone. Consequently, inharmonious plastic deformation behavior occurs, which results in a limited acceleration of the transition zone to a certain impact velocity.

关键词： Bimetal tubes Magnetic pulse cladding Finite element (FE) simulation Axial feeding

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Influence of die geometry on self-piercing riveting of aluminum alloy AA6061-T6 to mild steel SPFC340 sheets

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Advances in Manufacturing 2019年第2期7卷 209-220页

作者： jiang-hua deng Feng Lyu Ru-Ming Chen Zhi-Song Fan School of Mechanical Engineering and Automation Fuzhou University Fuzhou 350116 People's Republic of China

The self-piercing riveting (SPR) process was used to join 2.0-mm-thick aluminum alloy 6061-T6 and 1.2-mm-thick mild steel SPFC340 sheets. SPR joints produced with a conventional flat-bottom die and conicalsection dies were investigated both experimentally and numerically. Lap shear tests were conducted under quasistatic conditions to evaluate the load-carrying capability of these SPR joints. The effect of variation in die geometry (such as variation in the die groove shape, cone height, and die radius) on the main mechanical response of the joints, namely the peak load and energy absorption, was discussed. The results showed that SPR joints produced with the conical-section dies exhibited a failure mode similar to those produced with a conventional die. All the joints failed by tearing of the top steel sheet. Cracks that occurred in the bottom aluminum alloy 6061-T6 sheet around the rivet leg were a result of tangential tensile stress. The cone height of a conical-section die is the most important parameter affecting the surface quality of Al/steel SPR joints. Conical-section dies with a moderate convex can ensure a good surface quality during the SPR process. In addition, SPR joints with single conical-section die allow higher tensile strength and energy absorption compared to those with double conical-section die.

关键词： Self-piercing riveting (SPR) Aluminum/steel dissimilar sheet Conical-section die Lap shear test

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交变电场作用下细胞膜离子通道电流的趋肤效应

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天津大学学报（自然科学与工程技术版） 2004年第9期37卷 792-796页

作者：王江张骅邓斌天津大学电气与自动化工程学院天津300072

自然状态下细胞跨膜通道开放后,离子在化学梯度力和膜电场力作用下运动,形成离子电流,维持细胞正常的电生理特性.在外电场作用下,离子通道暴露于感应电磁环境中.作为电生理活动基础的各种离子,在电磁力作用下,其运动状态受到影响,直接... 详细信息

自然状态下细胞跨膜通道开放后,离子在化学梯度力和膜电场力作用下运动,形成离子电流,维持细胞正常的电生理特性.在外电场作用下,离子通道暴露于感应电磁环境中.作为电生理活动基础的各种离子,在电磁力作用下,其运动状态受到影响,直接导致离子电流值的改变.为量化分析这一作用机理,可根据离子通道的物理性质将其等效为圆柱导体,建立通道的电学模型并推导离子电流密度的分布函数.分析可知,在外加交变电场作用下,细胞膜离子通道电流的径向密度分布发生了变化,越靠近通道壁,离子电流密度越大,即产生趋肤效应,进而影响跨膜通道对离子的通透性.

关键词：离子通道离子电流电磁场趋肤效应

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平面连杆机构的提升形态及稳定性分析

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土木工程学报 2010年第1期43卷 13-21页

作者：蒋本卫邓华伍晓顺浙江大学浙江杭州310058

将"机构法"施工的柱面网壳简化为平面连杆机构,分析体系在提升过程中的运动形态。以吊索长度作为运动驱动的控制参数,将体系的提升过程看作为由一系列随控制参数变化的平衡构型组成。采用动力松弛法求解各吊索长度离散点所对应的连杆机... 详细信息

将"机构法"施工的柱面网壳简化为平面连杆机构,分析体系在提升过程中的运动形态。以吊索长度作为运动驱动的控制参数,将体系的提升过程看作为由一系列随控制参数变化的平衡构型组成。采用动力松弛法求解各吊索长度离散点所对应的连杆机构平衡构型,从而实现提升过程的模拟。根据系统切线刚度矩阵的正定性条件,通过跟踪切线刚度矩阵最小特征值的变化来分析运动形态的稳定性。通过一个柱面网壳算例,考察了文中形态分析方法的计算精度和收敛性,分析了不同分段、不同吊索布置情况下体系的提升形态特征,并对影响运动形态稳定性的因素进行了讨论。

关键词：平面连杆机构运动形态施工分析稳定性

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Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin Lin Zhu Teng jiang Junshan Zhou Fuling Yan Qiwen deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui jiang Hui-Li Kang Yi jiang hua-Wei Zhang Xiao-Mei Song Yu-Ze Li Wen-Li huang Dong-Dong Zhang Chong deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway:a potential therapeutic approach for neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3095-3112页

作者： Fengcheng deng Dan Yang Lingxi Qing Yifei Chen Jilian Zou Meiling Jia Qian Wang Runda jiang Lihua huang College of Pharmacy Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina

The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhances communication along the gut–brain *** gut microbiota influences the cAMP-PKA signaling pathway through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine ***,alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota,creating a dynamic network of microbial-host *** reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus playing a role in the modulation of neurological *** coordinated activity of the gut microbiota and the cAMP-PKA signaling pathway regulates processes such as amyloid-β protein aggregation,mitochondrial dysfunction,abnormal energy metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively influence the onset and progression of neurological *** study explores the complex interplay between the gut microbiota and cAMP-PKA signaling pathway,along with its implications for potential therapeutic interventions in neurological *** pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway may improve outcomes in neurodegenerative diseases and emotional *** can be achieved through various methods such as dietary modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage *** findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway may provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases.

关键词： cyclic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway strategy therapies

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Global trend of review articles focused on cardiopulmonary bypass:Perspectives from bibliometrics

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World Journal of Methodology 2025年第2期15卷 166-173页

作者： Lei deng Rui Zhou Xian-Jie Zhang Yan-hua Peng Department of Gastroenterology Deyang People’s HospitalDeyang 618000Sichuan ProvinceChina Department of Anesthesiology and Perioperative Medicine Shanghai Fourth People's HospitalSchool of MedicineTongji UniversityShanghai 200434China Department of Anesthesiology Deyang People’s HospitalDeyang 618000Sichuan ProvinceChina

BACKGROUND Cardiopulmonary bypass(CPB)is a life-support technology widely used in *** articles reflect research advances in a certain topic or field within a certain period of *** To perform a bibliometric analysis of the review articles that focused on CPB for cardiovascular *** This study was based on a bibliometric *** were acquired from the Web of Science and basic bibliometric parameters were analyzed and visualized using VOSviewer and *** We identified 141 review articles on ***,the number of publications increased,and most of them were published in the 2010s(n=57,40.4%)and the 2020s(n=45,31.9%).There were 113(80.1%)narrative review articles,21(14.9%)meta-analysis studies and 7(5.0%)systematic review *** United States(n=25,17.7%)and China(n=21,14.9%)were the leading countries in terms of publication *** articles were published in 98 different *** Journal of Cardiothoracic and Vascular Anesthesia(n=14,10.0%)and Perfusion-United Kingdom(n=11,7.8%)were preferred by the *** high-frequency keywords included inflammatory response,children,acute kidney injury,meta-analysis and off-pump,except for CPB and cardiac *** response had the closest relationship with CPB during cardiac *** complications of CPB,including inflammatory response,kidney injury and ischemia,caught lots of *** The rapid increase of review papers shows that the research on CPB in cardiac surgery is increasingly being emphasized by scholars and clinical staff ***-analysis has been widely conducted to analyze clinical controversies and further guide clinical *** to improving the outcomes of patients undergoing cardiac surgery with CPB are the hot spots in this field.

关键词： Cardiopulmonary bypass Review article Bibliometric analysis Cardiac surgery Hot spots

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兵团第四师妇女子宫颈癌筛查结果分析

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农垦医学 2014年第3期36卷 253-256页

作者：黄霞张红蒋登华新疆生产建设兵团第四师医院妇科新疆伊宁835000

目的:探讨人类乳头瘤病毒(HPV)感染与宫颈癌及癌前病变的关系,并提出相应的干预措施.方法:2013年1～12月选取兵团四师妇女为研究对象,对30 ～ 60岁妇女进行HPV检测及阴道镜检查筛查宫颈癌及癌前病变(子宫颈上皮内瘤变,CIN).结果:筛查兵... 详细信息

目的:探讨人类乳头瘤病毒(HPV)感染与宫颈癌及癌前病变的关系,并提出相应的干预措施.方法:2013年1～12月选取兵团四师妇女为研究对象,对30 ～ 60岁妇女进行HPV检测及阴道镜检查筛查宫颈癌及癌前病变(子宫颈上皮内瘤变,CIN).结果:筛查兵团四师女性20 107例,HPV阳性者3 862例(19.21％),宫颈癌及癌前病变27例(0.13％).HPV阳性者中宫颈癌及癌前病变病变检出率明显高于HPV阴性者;以病理组织学诊断为金标准,评价HPV检测对预测宫颈癌及癌前病变的临床价值,其敏感度为81.48％,特异度为80.87％,阳性预测值为19.10％,阴性预测值为99.43％.结论:HPV感染与宫颈癌及癌前病变有着密切的相关性,把HPV感染者作为高危人群进行长期定期检查对预防和控制宫颈癌及癌前病变有着积极有效的作用;健康人群的普查对宫颈癌及癌前病变的早发现、早治疗起着至关重要的作用,应加强健康教育,促进健康人群自觉参与宫颈癌筛查.

关键词：子宫颈癌 HPV CIN

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虚拟产品开发关键技术的应用

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上海交通大学学报 2003年第1期37卷 21-25页

作者：潘军蒋祖华马登哲严隽琪上海交通大学机械与动力工程学院CIM研究所上海200030

在总结虚拟产品开发内涵的基础上 ,定义了与虚拟产品开发技术相关的基本概念 ,提出了支持虚拟产品开发的全息建模方法 .将产品定义数据、环境定义数据及两者之间的作用规律建立在统一的仿真模型结构之上 ,能够有效地支持虚拟产品开发 .

关键词：虚拟产品开发全息建模方法仿真模型 VPD 产品定义数据环境定义数据斜盘式压缩机

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