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Optimized Combinatorial Properties of an AlMgSi(Cu) Alloy Achieved by a Mechanical-Thermal Combinatorial Process

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Acta Metallurgica Sinica(English Letters) 2020年第5期33卷 751-758页

作者： Li-Mei Liu Yu-Xiang Lai Chun-Hui Liu jiang-hua chen Center for High-Resolution Electron Microscopy College of Materials Science&EngineeringHunan UniversityChangsha 410082China Hunan Province Key Laboratory for Spray Deposition Technology and Application Hunan UniversityChangsha 410082China

Enhancing combinatorial properties,such as excellent corrosion resistance,high strength and good ductility combined,is an important issue for manufacturing high-quality AlMgSi(Cu)***,we show that this can be achieved by optimizing a combinatorial process consisting of pre-ageing,cold-rolling and post-ageing to tailor the hierarchical microstructures of the *** electron microscopy analysis reveals that the enhanced combinatorial properties of corrosion resistance,strength and ductility are owing to modification of grain boundary microstructure in good association with changes of precipitate microstructures and a more homogenous distribution of solute atoms,as compared with the microstructures of the alloy processed by thermal ageing only.

关键词： Al alloy Corrosion resistance Mechanical property Ageing Deformation

Kidney disease models:tools to identify mechanisms and potential therapeutic targets

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Zoological Research 2018年第2期39卷 72-86页

作者： Yin-Wu Bao Yuan Yuan jiang-hua chen Wei-Qiang Lin Kidney Disease Center First Affiliated Hospital School of Medicine Zhejiang University Institute of Translational Medicine School of Medicine Zhejiang University

Acute kidney injury （AKI） and chronic kidney disease （CKD） are worldwide public health problems affecting millions of people and have rapidly increased in prevalence in recent years. Due to the multiple causes of renal failure, many animal models have been developed to advance our understanding of human nephropathy. Among these experimental models, rodents have been extensively used to enable mechanistic understanding of kidney disease induction and progression, as well as to identify potential targets for therapy. In this review, we discuss AKI models induced by surgical operation and drugs or toxins, as well as a variety of CKD models （mainly genetically modified mouse models）. Results from recent and ongoing clinical trials and conceptual advances derived from animal models are also explored.

关键词： Acute kidney injury Chronic kidneydisease Mouse models Transgenic mice

Complex Precipitation Sequences of Al-Cu-Li-(Mg)Alloys Characterized in Relation to Thermal Ageing Processes

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Acta Metallurgica Sinica(English Letters) 2016年第1期29卷 94-103页

作者： Zhen Gao jiang-hua chen Shi-Yun Duan Xiu-Bo Yang Cui-Lan Wu Center for High-Resolution Electron Microscopy College of Materials Science and EngineeringHunan University

The A1-Cu-Li-（Mg） alloy is a high-performance lightweight material strengthened by complex coexisting precipitates that form in the alloy upon thermal ageing. Using high-resolution （scanning） transmission electron microscopy in association with first-principles energy calculations, we systematically studied the complex coexisting precipitates in the alloys and correlated their precipitation sequences with thermal ageing processes applied. The principal results are the following：（1） eight types of precipitates can be observed in the alloy; （2） of these precipitates, the Tl-phase is most stable. The S-phase precipitates with segregated Li atoms at their interfacial edges are unexpectedly more stable than the a-phase; （3） the Tl-phase has a characteristic precursor that plays the key role in its nucleation and growth.

关键词： AI-Cu-Li alloy Electron microscopy Ageing Precipitation Strength

Quantitative Electron Tomography for Accurate Measurement of Precipitates Microstructure Parameters in Al–Cu–Li Alloys

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Acta Metallurgica Sinica(English Letters) 2022年第11期35卷 1882-1894页

作者： Shi-Yong Li Ruo-Han Shen Yu-Tao He Cui-Lan Wu jiang-hua chen Centre for High Resolution Electron Microscopy College of Materials Science and EngineeringHunan UniversityChangsha 410082China College of Materials Science and Engineering Hainan UniversityHaikou 570228China

Mechanical theories show that properties of alloys are strongly dependent on the morphological parameters oftheir strengthening ***,accurate measurement of precipitates microstructure parameters is still a challenging *** this article,we develop a quantitative electron tomography method by combining computer vision technology to accurately characterize the three-dimensional microstructure parameters,such as volume fractions,sizes and distributions,of the T_(1) and δ’/θ’/δ’ precipitates in Al-Cu-Li(-Mg) *** they have extremely large aspect-ratios in shape and large numbers in density upon formation in the Al matrix,these thin plate-like precipitates are difficult to be characterized quantitatively without the assistance of computer vision *** is shown that the property difference between two peak-aged states of the alloy can be well explained with the quantitative precipitate parameters correctly *** these correct precipitate data,we also tested the validity of current mechanical models for projecting the contribution of precipitates to the strengths of the alloy,demonstrating that quantitative relations between strength and micro structure parameters still need to be refined.

关键词： Al–Cu–Li–Mg alloy T1 precipitate δ′/θ′/δ′composite precipitate Morphological parameters Electron tomography Computer vision

Extra-pulmonary tuberculosis infection in the dialysis patients with end stage renal diseases:case reports and literature review

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第1期14卷 76-82页

作者： Wen-fang YANG Fei HAN Xiao-hui ZHANG Ping ZHANG jiang-hua chen Kidney Disease Center the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

The diagnosis of extra-pulmonary tuberculosis(TB) seems relatively difficult due to the absence of specific symptoms and signs in patients on peritoneal dialysis or *** report four cases of extra-pulmonary tuberculosis on dialysis,with two cases on peritoneal dialysis and two cases on *** presentations,therapy,and outcomes of TB infection in these patients were ***,the English literature published in the PubMed database associating extra-pulmonary tuberculosis on dialysis over the last three decades is reviewed.A total of 61 studies containing 70 cases were *** most common primary disease was diabetic nephropathy(22.86%,16/70).The peritoneum(31.42%,22/70),bone(21.42%,15/70),and lymph node(20%,14/70) were the most frequently *** organ infection was common(90%,63/70).Fever(58.57%,41/70),pain(35.71%,25/70),and enlarged lymph node(20%,14/70) were the most common ***(67.14%,47/70) and culture(40%,28/70) provided most reliable methods for clear diagnosis of *** combined treatment of isoniazid,rifampicin,pyrazinamide,and ethambutol(44.29%,31/70) was the most common *** majority of patients improved(82.86%,58/70);however,12 cases got worse(17.14%),with 10 of them dying(14.29%).Physicians should be aware of the non-specific symptoms and location of infection,and consider tuberculosis in their differential diagnoses in dialysis patients presenting with symptoms such as fever,pain,and weight loss.

关键词： Extra-pulmonary tuberculosis End stage renal disease Dialysis

Double-Shelled L1_(2) Nano-structures in Quaternary Al–Er–Sc–Zr Alloys: Origin and Critical Significance

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Acta Metallurgica Sinica(English Letters) 2021年第9期34卷 1277-1284页

作者： Chao-Min Zhang Pan Xie Yong jiang Sheng Zhan Wen-Quan Ming jiang-hua chen Ke-Xing Song Hao Zhang School of Materials Science and Engineering Henan Key Laboratory of Non-Ferrous Materials Science&Processing TechnologyHenan University of Science and TechnologyLuoyang 471023China School of Materials Science and Engineering Central South UniversityChangsha 410083China College of Materials Science and Engineering Hunan UniversityChangsha 410082China jiangsu Haoran Spray Forming Alloy Co. LtdZhenjiang 212132China

The formation of highly coherent double-shelled L1_(2) nano-precipitates in dilute Al–Er–Sc–Zr alloys was investigated with the combined use of Cs-corrected transmission electron microscopy characterization and first-principles energetics calculations. The double-shelled nano-precipitates are primarily featured with an Er-rich core surrounded by a Sc-rich inner shell and a Zr-rich outer shell. First-principles energetics analyses based on the classic homogenous nucleation theory suggested that once forms, this double-shell structure can be thermally stable. The predominant formation of this double-shell structure has thus both profound kinetic and thermodynamic origins. Its formation and stability preference to all other possible L1_(2) nano-structures would become more pronounced as its size increases, no matter what the solute ratio and aging temperature of interest.

关键词： Al alloys Core–shell L12 nano-phase First-principles

Synergistic Effect of Alloying Atoms on Intrinsic Stacking-Fault Energy in Austenitic Steels

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Acta Metallurgica Sinica(English Letters) 2017年第3期30卷 272-279页

作者： Ling-Hong Liu Tou-Wen Fan Cui-Lan Wu Pan Xie Ding-Wang Yuan jiang-hua chen Center for High-Resolution Electron Microscopy College of Materials Science and Engineering Hunan UniversityChangsha 410082 China College of Science Central South University of Forestry and Technology Changsha 410004 China Hunan Province Key Laboratory for Spray Deposition Technology and Application Hunan University Changsha 410082 China

Intrinsic stacking-fault energy is a critical parameter influencing the various mechanical performances of aus- tenitic steels with high Mn concentrations. However, quantitative calculations of the stacking-fault energy （SFE） of the face-centered cubic （fcc） Fe, including the changes in concentrations and geometrical distribution of alloying atoms, cannot be obtained by using previous computation models. On the basis of the interaction energy model, we evaluated the effects of a single alloying atom （i.e., Mn, A1, Si, C and N）, as well as its aggregates, including the Mn-X dimer and Mn2-X trimer （X = A1, Si, C and N） on the SFE of the fcc Fe via first-principle calculations. Given low concentrations （〈10 wt%） of alloying atoms, dimers and trimers, theoretical calculations reveal the following：（1） Alloying atom Mn causes a decrease in the SFE, whereas A1, Si, C and N significantly increase the SFE; （2） combination with other alloying atoms to form the Mn-X dimer （X = A1, Si, C and N） exerts an effect on SFE that, to a certain extent, is close to that of the corresponding single X atom; （3） the interaction between Mnz-X and the stacking fault is stronger than that of the corresponding single X atom, inducing a significant increase in the SFE of fcc Fe. The theoretical results we obtained demonstrate that the increase in SFE in high-Mn steel originates from the synergistic effect of Mn and other trace alloy atoms.

关键词： Stacking-fault energy Synergism First-principle calculation Austenitic steel Alloying effect

Can sacubitril/valsartan become the promising drug to delay the progression of chronic kidney disease?

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Journal of Geriatric Cardiology 2020年第12期17卷 782-786页

作者： Yang chen Lu-Ying GUO Ling-Fei ZHAO Yan-Hong MA Xue-Ling ZHU Ying XU jiang-hua chen Kidney Disease Center The First Affiliated HospitalZhejiang University School of MedicineZhejiangChina The Third Grade Laboratory under the National State Administration of Traditional Chinese MedicineZhejiangChina Key Laboratory of Kidney Disease Prevention and Control Technology ZhejiangChina National Key Clinical Department of Kidney Diseases Institute of NephrologyZhejiang UniversityZhejiangChina State Key Laboratory for Diagnosis and Treatment of Infectious Diseases ZhejiangChina National Clinical Research Center for Infectious Diseases the First Affiliated HospitalZhejiang University School of MedicineZhejiangChina Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases the First Affiliated HospitalZhejiang University School of MedicineZhejiangChina

1 Introduction Chronic kidney disease(CKD)often coexists with or is a complication of cardiovascular *** studies have shown that CKD increases the risk of cardiovascular death and all-cause death and was considered to be a risk equivalent of coronary heart disease.[1,2]Adjusted for confounders,decreased glomerular filtration rate(GFR)and increased albuminuria are both independent risk factors for cardiovascular events.[3,4]The risk for cardiovascular death linearly increases with the decline of GFR in a certain range(<70 mL/min per 1.73 m^2)and the increase of albuminuria without a threshold effect[3].

关键词： Cardiovascular disease Chronic kidney disease Kidney function Sacubitril/valsartan

PI-3 kinase pathway can mediate the effect of TGF-β1 in inducing the expression of SHARP-2 in LLC-PK1 cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第9期10卷 702-706页

作者： Zhang-fei SHOU Qin ZHOU Jie-ru CAI jiang-hua chen Kazuya YAMADA Kaoru MIYAMOTO Kidney Disease Center the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Key Laboratory of Multi-organ Combined Transplantation Ministry of Health Hangzhou 310003 China Department of Biochemistry Faculty of Medical Sciences University of Fukui Eiheiji-cho Fukui 910-1193 Japan

We aim to investigate the effect of transforming growth factor （TGF）-β1 on the expression of enhancer of split- and hairy-related protein-2 （SHARP-2） messenger RNA （mRNA） and its signaling pathway. In this study, several cell lines including LLC-PK1 （a porcine kidney tubular epithelial cell line）, MDCK （Madin-Darby canine kidney） and CTLL-2 （cytotoxic T-lymphocyte line） were treated with recombinant human TGF-131, and a series of experiments were carried out, involving Northern blot analysis of total RNA from these cells. Further, several specific chemical inhibitors were applied before TGF-β1 treatment to probe the signaling pathway. The results showed that TGF-β1 can significadtly up-regulate SHARP-2 mRNA expression in the LLC-PK1 cell line. The peak level of induction was found 2 h after TGF-β1 stimulation. While one phospho- inositide 3-kinases （PI-3） kinase inhibitor, LY294002, completely blocked the effect of TGF-131 on SHARP-2 mRNA expression in LLC-PK1 cells at a low concentration, other inhibitors, including PD98059, staurosporine, AG490, wortmannin, okadaic acid and rapamycin, had no effect. The effect of LY294002 was dose-dependent. We conclude that, in LLC-PK1 cells at least, TGF-β1 can effectively induce the SHARP-2 mRNA expression and that the PI-3 kinase pathway can mediate this effect.

关键词： Transforming growth factor (TGF)-β1 Split- and hairy-related protein-2 (SHARP-2) Phosphoinositide 3-kinases (PI-3)kinase pathway LY294002