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Fibromatosis-like metaplastic carcinoma of the breast:Two case reports

World Journal of Clinical Cases 2023年第18期11卷 4384-4391页

作者： Wei-Yu Bao jiang-hong zhou Yan Luo Yun Lu Department of Breast Surgery Ⅰ Gansu Provincial Cancer HospitalLanzhou 730050Gansu ProvinceChina Department of Nursing Gansu Provincial Cancer HospitalLanzhou 730050Gansu ProvinceChina Department of Pathology Gansu Provincial Cancer HospitalLanzhou 730050Gansu ProvinceChina Functional Department Gansu Provincial Cancer HospitalLanzhou 730050Gansu ProvinceChina

BACKGROUND Fibromatosis-like metaplastic carcinoma is classified as a rare type of metaplastic carcinoma of the breast by the 2012 WHO pathological and genetic classification criteria for breast tumors,which takes hyperplastic spindle cells as the main component and is often misdiagnosed as benign stromal proliferative lesions or benign mesenchymal tumors of the breast because of its mild ***,we collected the clinical data of 2 cases of fibromatosis-like metaplastic carcinoma of the breast and performed pathomorphological observation and immunohistochemical staining of the surgically resected *** to the clinical features,imaging features,immunophenotype,diagnosis and differential diagnosis of 2 cases of fibromatosis-like metaplastic carcinoma of the breast,it was further *** SUMMARY Case 1:A 56-year-old postmenopausal female was admitted due to"right breast mass for over 1 year and local ulceration for over 1 mo".Physical examination showed a mass with a diameter of 4.5 cm×5.5 cm palpable at 2.5 cm from the nipple at 1 o'clock in the right *** skin on the surface of the mass ruptured about 3 cm,with a small amount of exudation and bleeding,less clear boundary,hard texture,fair activity,without obvious *** obvious abnormality was palpable in the left *** enlarged lymph nodes were palpable in the bilateral axillae and bilateral supraclavicular *** removing the mass tissue,it was promptly sent to the pathology department for *** 2:Female,52-years-old,premenopausal,admitted due to"right breast mass for more than 3 mo".Physical examination showed a 4.0 cm×4.0 cm diameter mass palpable at 2.0 cm of the nipple in the lower outer 7 o'clock direction of the right breast,with less clear boundary,hard texture,fair activity,no significant tenderness,no palpable significant abnormalities in the left breast,and no palpable enlarged lymph nodes in the bilateral axillae and bilateral supraclavi

关键词： Breast cancer Fibromatosis-like metaplastic carcinoma Metaplastic carcinoma Spindle cell lesion Pathology

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Efficacy of Solitaire AB stent-release angioplasty in acute middle cerebral artery atherosclerosis obliterative cerebral infarction

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World Journal of Clinical Cases 2021年第19期9卷 5028-5036页

作者： Xi-Feng Wang Ming Wang Gang Li Xue-Yu Xu Wei Shen Jing Liu Shuang-Shuang Xiao jiang-hong zhou Department of Neurology Puai HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430033Hubei ProvinceChina

BACKGROUND In both national and international studies,the safety and effectiveness of treatment with the Solitaire stent in patients with ischemic stroke caused by acute large vessel occlusion were good,and the disability rate was significantly ***,there are currently only a few reports on the differences in endovascular treatment for different etiological classifications,especially in the anterior cranial circulation,aorta atherosclerotic stenosis,and acute *** To investigate the efficacy of Solitaire AB stent-release angioplasty in patients with acute middle cerebral artery atherosclerosis obliterative cerebral *** Twenty-five patients with acute middle cerebral atherosclerosis obliterative cerebral infarction were retrospectively enrolled in this study from January 2017 to December *** Solitaire AB stent was used to improve anterior blood flow to maintain modified cerebral infarction thrombolysis[modified thrombolysis in cerebral infarction(mTICI)]at the 2b/3 level or above,the stent was then unfolded and *** All 25 patients underwent successful surgery,with an average recanalization time of 23 *** patient died of cerebral hemorrhage and cerebral herniation after the *** National Institutes of Health Stroke Scale(NIHSS)scores immediately after surgery(7.5±5.6),at 24 h(5.5±5.6)and at 1 wk(3.6±6.7)compared with the preoperative NIHSS score(15.9±4.4),were significantly different(P<0.01).One case of restenosis was observed 3 mo after surgery(the stenosis rate was 50%without clinical symptoms),the modified Rankin scale scores were 0 points in 14 cases(56%),1 point in 4 cases(16%),2 points in 2 cases(8%),3 points in 3 cases(12%),4 points in 1 case(4%),and 6 points in 1 case(4%).CONCLUSION In acute middle cerebral artery atherosclerosis obliterative cerebral infarction,when the Solitaire AB stent is unfolded and the forward blood flow is maintained at mTICI level 2b/3 or higher,stent release may be a

关键词： Stent angioplasty Atherosclerosis obliterative Acute cerebral infarction

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Voriconazole in an infant with cryptococcal meningitis

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Chinese Medical Journal 2008年第3期121卷 286-288页

作者： SHEN Yin-zhong WANG jiang-rong LU hong-zhou Department of Infectious Diseases Shanghai Public HealthClinical Center Fudan University Shanghai 201508 China

Cryptococcus neoformans （C. neoformans） is the most common cause of fungal meningitis worldwide.1 Cryptococcal meningitis is an opportunistic infection commonly found in immunocompromised hosts, especially HIV-infected adults. It also occurs in apparently immunocompetent individuals. Rarely has it been reported in children, and it is almost nonexistent in infants. Voriconazole is a member of a second generation of antifungal triazoles with broad spectrum antifungal activity, oral and parenteral bioavailability and a favorable safety profile in adults.3 This patient shows improved in vitro activity against C. neoformans when compared to fluconazole and it has been used successfully in about half the patients with refractory cryptococcosis.4 However, the efficacy and safety of voriconazole as a antifungal agent in children with cryptococcal meningitis have not been well assessed, This report described cryptococcal meningitis in a 13-day-old premature neonate who recovered without overt toxicity after voriconazole was added to an antifungal regimen that included amphotericin B and flucytosine. We focused on the response of this child with cryptococcal meningitis to voriconazole.

关键词： voriconazole cryptococcal meningitis child

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Mitigated calcification of glutaraldehyde-fixed bovine pericardium by tannic acid in rats

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Chinese Medical Journal 2008年第17期121卷 1675-1679页

作者： WANG De jiang hong LI Jun zhou Jian-ye HU Sheng-shou Research Center for Cardiovascular Regenerative Medicine Ministry of Health Cardiovascular Institute and Fuwai Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100037 China

Background Bioprosthetic heart valves derived from glutaraldehyde （Glut）-fixed xenografts have been widely used to replace diseased cardiac valves. However, calcification and degeneration are common following their implantation. Inflammation is closely associated with calcification of Glut-fixed xenografts via macrophage infiltration. Tannic acid （TA） possesses anti-inflammatory effects. This study was designed to investigate the anti-calcification of TA treatment on the Glut-fixed bovine pericardium （BP） in a rat subdermal model. Methods Fresh BP was divided into two groups （10 in each group） and separately subjected to different fixation procedures as follows：（1） Glut group： fixation with 0.6% Glut alone; （2） Glut/TA group： fixation with 0.6% Glut and subsequent 0.3% TA. Then the BP samples were subdermally implanted in juvenile male Sprague-Dawley rats and explanted 21 days after implantation. Each explanted BP sample was divided into three parts for calcium content analysis von Kossa＇s staining and immunohistochemical staining, and reverse transcription-polymerase chain reaction study. Results The data from quantitative calcium analysis and von Kossa＇s staining showed that Glut-fixed BP developed significantly more calcification than Glut/TA-fixed BP （（90.3＋32.5） mg/g dry weight vs （6.4_＋1.3） mg/g dry tissue, P 〈0.01）. Immunostaining demonstrated lower matrix metalloproteinase-9 and tenascin-C expression as well as macrophage infiltration into Glut/TA-fixed BP than in its Glut-fixed counterpart （P 〈0.01 for all）. Additionally, the reverse transcription-polymerase chain reaction study showed that higher levels of expression of matrix metalloproteinase-9 and tenascin-C mRNA occurred within Glut-fixed BP than within the Glut/TA-fixed ones （P 〈0.01 for all）. Conclusion TA exerts excellent anti-calcification effects on Glut-fixed BP via inhibiting macrophage infiltration and expression of matrix metalloproteinase-9 and tenascin-C.

关键词： tannic acid calcification macrophage pericardium bioprosthesis xenograft

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Predicting the Coupling Specificity of G-protein Coupled Receptors to G-proteins by Support Vector Machines

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Genomics, Proteomics & Bioinformatics 2005年第4期3卷 247-251页

作者： Cui-Ping Guan Zhen-Ran jiang Yan-hong zhou Hubei Bioinformatics and Molecular Imaging Key Laboratory Huazhong University of Science and Technology Wuhan 430074 China.

G-protein coupled receptors （GPCRs） represent one of the most important classes of drug targets for pharmaceutical industry and play important roles in cellular signal transduction. Predicting the coupling specificity of GPCRs to G-proteins is vital for further understanding the mechanism of signal transduction and the function of the receptors within a cell, which can provide new clues for pharmaceutical research and development. In this study, the features of amino acid compositions and physiochemical properties of the full-length GPCR sequences have been analyzed and extracted. Based on these features, classifiers have been developed to predict the coupling specificity of GPCRs to G-protelns using support vector machines. The testing results show that this method could obtain better prediction accuracy.

关键词： GPCR G-protein SVM coupling specificity

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Tailoring Light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

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Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao Li hong zhou Zhihao Ren Cheng Xu Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas Light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

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In Vitro Construction of Effective M1GS Ribozymes Targeting HCMV UL54 RNA Segments

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Acta Biochimica et Biophysica Sinica 2005年第3期37卷 210-214页

作者： Yun-Zhen SU hong-Jian LI Yue-Qin LI Hao-Jun CHEN Dong-Sheng TANG Xin ZHANG hong jiang Tian-hong zhou College of Life Science and Technology,Jinan University,Guangzhou 510632,China CollegeofLifeScienceandTechnology JinanUniversityGuangzhou510632China

Seven sequence-specific ribozymes(M1GS RNAs)derived in vitro from the catalytic RNAsubunit of Escherichia coli RNase P and targeting the mRNAs transcribed by the UL54 gene encoding theDNA polymerase of human cytomegalovirus were screened from 11 ribozymes that were designed based onfour rules:(1)the NCCA-3′ terminal must be unpaired with the substrate;(2)the guide sequence(GS)mustbe at least 12 nt in length;(3)the eighth nucleotide must be U,counting from the site-1;and(4)around thecleavage site,the sites-1/+1/+2 must be U/G/C or C/G/*** investigation of the factors affecting thecleavage effect and the optimal ratio for M1GS/substrate was carried *** was determined that the optimalratio for M1GS/substrate was 2:1 and too much M1GS 1ed to substrate *** indicated *** M1GS that cleaved HCMV UL54 RNA segments in vitro were successfully designed and *** studies support the use of ribozyme M1GS as antisense molecules to silence HCMV mRNA in vitro,andusing the selection procedure as a general approach for the engineering of RNase P ribozymes.

关键词： ribonuclease P (RNase P) guide sequence HCMV DNA polymerase

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骤冷区内熟料内部温度分布的模拟探究

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武汉理工大学学报 2012年第4期34卷 24-26页

作者：姜洪舟陈平方周建武汉理工大学材料科学与工程学院武汉430070 武汉理工大学材料复合新技术国家重点实验室武汉430070

运用ANSYS 12.0有限元分析软件包作为计算平台,针对实际尺寸范围内的熟料颗粒和实际风速范围内某些典型情况,对篦冷机骤冷区熟料内部的温度分布进行模拟表征。按照数值模拟计算数据,可显示出以下的结果:在骤冷过程中,熟料颗粒的表面温... 详细信息

运用ANSYS 12.0有限元分析软件包作为计算平台,针对实际尺寸范围内的熟料颗粒和实际风速范围内某些典型情况,对篦冷机骤冷区熟料内部的温度分布进行模拟表征。按照数值模拟计算数据,可显示出以下的结果:在骤冷过程中,熟料颗粒的表面温度首先降低,并且下降得比料球内部温度要快得多。在150s内,若风速相同,料径越大,料球内部的温度下降趋势越平缓;若料径相同,风速越大,料球内部的温度下降趋势越陡。模拟计算结果将为骤冷区内熟料的冷却控制提供有益的参考。

关键词：水泥熟料骤冷区温度场数值模拟

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一种基于SimMechanics CAD转换器生成虚拟样机的方法

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系统仿真学报 2007年第20期19卷 4699-4703页

作者：张镭丛大成姜洪洲李洪人哈尔滨工业大学电液伺服仿真及实验系统研究所哈尔滨150001

SimMechanics CAD转换器是一座沟通机械系统CAD装配图、MATLAB下SimMechanics动力学模型和虚拟现实环境的桥梁。利用此转换器可以方便的将机电产品虚拟样机的仿真模型统一于MATLAB下,并由此模型驱动虚拟现实环境。介绍了SimMechanics CA... 详细信息

SimMechanics CAD转换器是一座沟通机械系统CAD装配图、MATLAB下SimMechanics动力学模型和虚拟现实环境的桥梁。利用此转换器可以方便的将机电产品虚拟样机的仿真模型统一于MATLAB下,并由此模型驱动虚拟现实环境。介绍了SimMechanics CAD转换器的原理以及利用它生成虚拟样机的方法,并通过两个实例说明基于此方法开发虚拟样机的优越性。

关键词：虚拟样机 SimMechanics CAD转换器虚拟现实 Stewart平台飞行模拟器

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摆动推进鱼类鱼体波复模态分解及其特性分析

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水下无人系统学报 2020年第2期28卷 119-125页

作者：崔祚姜洪州贵州理工学院航空航天工程学院贵州贵阳550003 哈尔滨工业大学机电工程学院黑龙江哈尔滨710077

在自然界中,大多数鱼类通过身体和尾鳍的复合波动形成独特的鱼体波曲线,以获得其快速高效的游动性能。文中以鱼体波为研究对象,采用复模态正交分解(COD)方法来研究鱼体的复合波动模式。从振动模态的角度看,鱼类的游动是粘弹性鱼体在流... 详细信息

在自然界中,大多数鱼类通过身体和尾鳍的复合波动形成独特的鱼体波曲线,以获得其快速高效的游动性能。文中以鱼体波为研究对象,采用复模态正交分解(COD)方法来研究鱼体的复合波动模式。从振动模态的角度看,鱼类的游动是粘弹性鱼体在流体中的强迫振动,鱼体波对应的是复模态振型。根据COD方法,将鱼体波分解为纯行波和纯驻波两部分,并利用复模态振型实部和虚部的相关系数来定义鱼体波的行波系数。通过分析鳗鲡科乐锦鳚鱼和亚鲹科虹鳟鱼的鱼体波数据,得到对应鱼体波的行波系数分别为0.793和0.604。结果表明,乐锦鳚鱼的鱼体波中含有较大的行波成分,而虹鳟鱼鱼体波则含有较多的驻波成分。该结论从生物学上验证了鱼体波的复模态特性,该特性与鱼体动力学特性以及游动模式有着密切关系。

关键词：鱼类游动模式鱼体波曲线复模态分解行波系数

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