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Success rate of current human-derived gastric cancer organoids establishment and influencing factors:A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1626-1646页

作者： Kai-Lin jiang Xiang-Xiang Wang Xue-Jiao Liu Li-Kun Guo Yong-Qi Chen Qing-ling Jia Ke-Ming Yang jiang-hong ling Department of Gastroenterology Shuguang HospitalShanghai 200021China Department of Pathology Shuguang HospitalShanghai 200021China

BACKGROUND Human-derived gastric cancer organoids(GCOs)are widely used in gastric cancer research;however,the culture success rate is generally *** To explore the potential influencing factors,and the literature on successful culture rates of GCOs was reviewed using *** PubMed,Web of Science,and EMBASE were searched for *** trained researchers selected the studies and extracted *** 17.0 software was used for meta-analysis of the incidence of each outcome *** adjusted Methodological Index for Non-Randomized Studies scale was used to assess the quality of the included *** plots and Egger’s test were used to detect publication *** analyses were conducted for sex,tissue source,histo-logical classification,and the pathological tumor-node-metastasis(pTNM)cancer staging *** Eight studies with a pooled success rate of 66.6%were *** derived from women and men had success rates of 67%and 46.7%,*** from surgery or biopsy/endoscopic submucosal dissection showed success rates of 70.9%and 53.7%,*** of poorly-differentiated,moderately-differentiated and signet-ring cell cancer showed success rates of 64.6%,31%,and 32.7%,*** with pTNM stages I-II and III-IV showed success rates of 38.3%and 65.2%,respectively.Y-27632 and non-Y-27632 use showed success rates of 58.2%and 70%,*** generated with collagenase were more successful than those constructed with Liberase TH and TrypLE(72.1%vs 71%,respectively).EDTA digestion showed a 50%lower success rate than other methods(P=0.04).CONCLUSION GCO establishment rate is low and varies by sex,tissue source,histological type,and pTNM *** Y-27632,and using Liberase TH,TrypLE,or collagenase yields greater success than EDTA.

关键词： Gastric cancer organoids Human-derived organoids Gastric cancer Cell lines In vitro research models

Bibliometrics analysis based on the Web of Science:Current trends and perspective of gastric organoid during 2010-2023

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World Journal of Gastroenterology 2024年第8期30卷 969-983页

作者： Kai-Lin jiang Yue-Bo Jia Xue-Jiao Liu Qing-ling Jia Li-Kun Guo Xiang-Xiang Wang Ke-Ming Yang Chen-Heng Wu Bei-Bei Liang jiang-hong ling Department of Gastroenterology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200021China Laboratory of Cancer Biology University of OxfordOxford OX37DQUnited Kingdom School of Traditional Chinese Medicine Shanghai University of Chinese MedicineShanghai 200021China Shanghai Key Laboratory of Molecular Imaging Shanghai University of Medicine and Health SciencesShanghai 201318China

BACKGROUND Three-dimensional organoid culture systems have been established as a robust tool for elucidating mechanisms and performing drug efficacy *** use of gastric organoid models holds significant promise for advancing personalized medicine ***,a comprehensive bibliometric review of this burgeoning field has not yet been *** To analyze and understand the development,impact,and direction of gastric organoid research using bibliometric methods using data from the Web of Science Core Collection(WoSCC)*** This analysis encompassed literature pertaining to gastric organoids published between 2010 and 2023,as indexed in the *** and VOSviewer were used to depict network maps illustrating collaborations among authors,institutions and keywords related to gastric ***,co-citation,and burst analysis methodologies were applied to assess the impact and progress of *** A total of 656 relevant studies were *** majority of research was published in gastroenterology-focused ***,Yana Zavros,Hans Clevers,James M Wells,Sina Bartfeld,and Chen Zheng were the 5 most productive authors,while Hans Clevers,Huch Meritxell,Johan H van Es,Marc Van de Wetering,and Sato Toshiro were the foremost influential scientists in this *** from the University Medical Center Utrecht,Netherlands Institute for Developmental Biology(Utrecht),and University of Cincinnati(Cincinnati,OH,United States)made the most significant ***,gastric organoids are used mainly in studies investigating gastric cancer(GC),Helicobacter pylori-infective gastritis,with a focus on the mechanisms of GC,and drug screening *** Key focus areas of research using gastric organoids include unraveling disease mechanisms and enhancing drug screening *** contributions from renowned academic institutions highlight this field’s dynamic growth.

关键词： Gastric organoid Gastric disease Bibliometrics analysis Gastric cancer Gastritis

Fertility-preserving treatment and pregnancy outcomes in the early stage of endometrial carcinoma

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Chinese Medical Journal 2013年第15期126卷 2965-2971页

作者： TONG Xiao-mei LIN Xiao-na jiang hong-fei jiang ling-ying ZHANG Song-ying LIANG Feng-bing Zhejiang Univ Dept Obstet & Gynecol Sir Run Run Shaw Hosp Sch Med Hangzhou 310016 Zhejiang Peoples R China

Objective This study aimed to review the available literature on fertility-preserving treatment and pregnancy outcomes in patients with early-stage endometrial carcinoma who desired to preserve their fertility. Data sources The PubMed database （1992-2012） was searched for the words ＂conservative ＂OR＂ fertility sparing ＂OR＂ fertility preserving＂ AND ＂endometrial neoplasms＂（MESH）. All relevant articles in English and the relevant references were collected. Study selection Data from published articles about fertility-preserving treatment of endometrial cancer, including the response and recurrence rate of conservative treatment, strategies of infertility treatment, pregnancy, and obstetric outcomes, were selected. Data were mainly extracted from 41 studies, which are listed in the reference section of this review. Results Hormone therapy was the most common method used for early-stage endometrial carcinoma in patients who wished to preserve fertility. Sixty percent of the patients became pregnant after remission of the carcinoma. The percentage of patients who conceived in the assisted reproductive technology group was higher than that of the natural pregnancy group （80.0% vs. 43.2%, P〈0.01）. A higher rate of preterm labor and multiple pregnancies was observed in the assisted reproductive technology group than that in the natural pregnancy group. The majority of pregnancies （71.4%） in the assisted reproductive technology group were achieved by in vitro fertilization-embryo transfer. The clinical pregnancy rate of transfer cycles in patients with endometrial carcinoma was 34.1%. Conclusions Assisted reproductive technology is a good option in well-selected patients with early-stage endometrial carcinoma who have completed conservative treatment. In vitro fertilization-embryo transfer offers an opportunity to achieve an immediate pregnancy.

关键词： endometrial carcinoma assisted reproductive technology in vitro fertilization fertility

双零色散光子晶体光纤结构参数的变化对其性能的影响

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物理学报 2010年第2期59卷 1095-1100页

作者：姜凌红侯蓝田燕山大学红外光纤与传感研究所亚稳材料制备技术与科学重点实验室秦皇岛066004

应用多极法,研究了正六边形结构光子晶体光纤的结构参数改变时,波长范围在0.8—1.8μm之间的双零色散光子晶体光纤的色散特性和非线系数随波长的变化规律.对具有相同结构参数的正六边形结构和正八边形结构进行比较,得到正六边形结构的... 详细信息

应用多极法,研究了正六边形结构光子晶体光纤的结构参数改变时,波长范围在0.8—1.8μm之间的双零色散光子晶体光纤的色散特性和非线系数随波长的变化规律.对具有相同结构参数的正六边形结构和正八边形结构进行比较,得到正六边形结构的双零色散光子晶体光纤的色散更加平坦,非线性系数有明显增大的结果.因此,正六边形结构更容易获得色散平坦的高非线性双零色散光子晶体光纤.最终设计了在800nm附近具有平坦色散和高非线性的正六边形双零色散光子晶体光纤.

关键词：光子晶体光纤双零色散非线性系数多极法

LC-MS determination and pharmacokinetic study of salidroside in rat plasma after oral administration of suspensions of traditional Chinese medicine Erzhi Wan and Fructus Ligustri lucidi

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Journal of Pharmaceutical Analysis 2011年第1期1卷 8-12页

作者： Ze-Yun Li Qing Li jiang Lu Jun-hong ling Xi-Hua Yu Xiao-Hui Chen Kai-Shun Bi School of Pharmacy Shenyang Pharmaceutical University Shenyang 110016 China.

A simple,rapid and sensitive liquid chromatography-mass spectrometry（LC-MS）method was developed for the determination of salidroside in rat plasma and study of its pharmacokinetics after oral administration of suspension of Erzhi Wan and Fructus Ligustri lucidi into Wistar *** sample of 200 μL was extracted with acetic ether-isopropanol（2∶1）and the extraction was performed on a Kromasil C18 column（150 mm×4.6 mm,5 μm）with the mobile phase of methanol-water（41∶59,v/v）within a run time of 6.0 *** analyte was monitored with positive electrospray ionization（ESI）by selected ion monitoring（SIM）*** target ions were m/z 323.05 for salidroside and m/z 411.05 for internal standard（IS）geniposide.A good linear relationship was obtained over the range of 5.0-500.0 ng/mL and the lower limit of quantification was 5.0 ng/*** validated method was successfully applied to the pharmacokinetic study of salidroside in rat plasma after oral administration of suspension of Erzhi Wan and Fructus Ligustri lucidi.

关键词： liquid chromatography-mass spectrometry(LC-MS) pharmacokinetics salidroside Erzhi Wan Fructus Ligustri lucidi

基于DIIS理论方法的国防科技智库研究体系建设

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中国电子科学研究院学报 2020年第8期15卷 750-755页

作者：江红玲中国电子科学研究院北京100041 中国电子科技集团有限公司发展战略研究中心北京100041

国防科技智库的研究,对我国国防和军队现代化建设具有举足轻重的作用,是保障我国国家安全的重要基石。本文以DIIS理论方法为核心,结合国防科技发展面临的新形势以及国防科技问题的特殊性、专业性,从数据收集、数据分析、信息提取、信息... 详细信息

国防科技智库的研究,对我国国防和军队现代化建设具有举足轻重的作用,是保障我国国家安全的重要基石。本文以DIIS理论方法为核心,结合国防科技发展面临的新形势以及国防科技问题的特殊性、专业性,从数据收集、数据分析、信息提取、信息研判、形成方案、产生报告等环节出发,给出国防科技问题研究的技术路线、步骤和方法工具,建立基于DIIS理论方法的国防科技智库研究体系,为我国国防科技智库的建设和研究提供新的思路和新的方法,提升我国国防科技研究水平。

关键词：国防科技智库研究 DIIS理论问题导向

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基于大数据的国防科技情报知识管理体系

中国电子科学研究院学报 2016年第3期11卷 245-249页

作者：江红玲中国电子科学研究院北京100041

随着知识经济和大数据时代的到来,国防科技情报的分析和管理呈现出多样化、个性化、智能化等特点,具有单一领域转向全领域、新兴数据源蓬勃发展、多数据源综合利用、情报分析智能化和严谨化的发展趋势。本文以知识管理为核心,综合大数... 详细信息

随着知识经济和大数据时代的到来,国防科技情报的分析和管理呈现出多样化、个性化、智能化等特点,具有单一领域转向全领域、新兴数据源蓬勃发展、多数据源综合利用、情报分析智能化和严谨化的发展趋势。本文以知识管理为核心,综合大数据相关技术,构建大数据环境下的国防科技情报知识管理体系,针对国防科技情报知识的获取和挖掘、知识存储、知识扩散、知识利用和创新,分别构建了国防科技情报知识挖掘系统、知识存储系统、知识扩散系统、知识利用和创新系统,以期实现国防科技情报知识的高效管理和利用。

关键词：大数据知识管理国防科技情报知识创新

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液芯高双折射率光子晶体光纤的特性研究

光子学报 2014年第9期43卷 21-26页

作者：姜凌红郑义郑凯彭继迎北京交通大学理学院激光所北京100044

设计了一种纤芯区域由中心椭圆缺陷孔和其横排的上下两侧椭圆孔组成的高双折射率光子晶体光纤，并在其纤芯中心椭圆缺陷孔中填充高折射率液体物质二硫化碳．利用有限元法分析了该光子晶体光纤的双折射率、功率限制因子、模场分布及色散... 详细信息

设计了一种纤芯区域由中心椭圆缺陷孔和其横排的上下两侧椭圆孔组成的高双折射率光子晶体光纤，并在其纤芯中心椭圆缺陷孔中填充高折射率液体物质二硫化碳．利用有限元法分析了该光子晶体光纤的双折射率、功率限制因子、模场分布及色散系数特性．研究结果表明：液芯光纤具有较高的纤芯功率限制因子，在波长0．6～1．6μm范围内实现了宽带大负色散系数，在波长1．55μm处光纤双折射率达到了6．8×10^2，即该结构液芯光子晶体光纤同时实现了宽带大负色散和高双折射率特性．通过结构参量容差性分析得到该光纤具有较好的偏振稳定性．

关键词：高双折射率功率限制因子色散系数有限元光子晶体光纤

串行流化床生物质气化费托(FT)合成的模拟

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合肥工业大学学报（自然科学版） 2015年第10期38卷 1396-1403页

作者：江宏玲肖军安徽省.水利部淮河水利委员会水利科学研究院安徽合肥230088 东南大学热能工程研究所江苏南京210096

文章以生物质稻秸为研究对象，利用AspenPlus软件建立了串行流化床生物质合成气费托（Fischer-Tropsch，FT）合成的模型，研究了不同反应条件包括气化温度、气化压力、气化过程水蒸气与生物质的比率（m（S）／m（B））、合成气中n（H2）... 详细信息

文章以生物质稻秸为研究对象，利用AspenPlus软件建立了串行流化床生物质合成气费托（Fischer-Tropsch，FT）合成的模型，研究了不同反应条件包括气化温度、气化压力、气化过程水蒸气与生物质的比率（m（S）／m（B））、合成气中n（H2）／n（CO）、合成温度以及合成压力对合成工艺的影响。结果表明．采用蛋壳型钻基催化剂，对于制费托合成油为目的的串行流化床生物质气化系统，用于费托合成的适宜工况条件为：建议气化温度850℃左右，气化压力0．1MPa．m（S）／m（B）约为0．4，合成气中n（H2）／n（CO）保持在2．0～2．1之间．合成反应温度取220℃为佳，反应压力选取2．0MPa左右。在此工况下．每kg稻秸可以获得约为0．54mol的费托合成油。

关键词：串行流化床生物质气化费托合成油流程模拟 Aspen Plus软件