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A novel chronic nerve compression model in the rat

Neural Regeneration Research 2018年第8期13卷 1477-1485页

作者： Zhen-Yu Liu Zhen-Bing chen jiang-hai chen Department of Hand Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology

Current animal models of chronic peripheral nerve compression are mainly silicone tube models. However, the cross section of the rat sciatic nerve is not a perfect circle, and there are differences in the diameter of the sciatic nerve due to individual differences. The use of a silicone tube with a uniform internal diameter may not provide a reliable and consistent model. We have established a chronic sciatic nerve compression model that can induce demyelination of the sciatic nerve and lead to atrophy of skeletal muscle. In 3-week-old pups and adult rats, the sciatic nerve of the right hind limb was exposed, and a piece of surgical latex glove was gently placed under the nerve. N-butyl-cyanoacrylate was then placed over the nerve, and after it had set, another piece of glove latex was placed on top of the target area and allowed to adhere to the first piece to form a sandwich-like complex. Thus, a chronic sciatic nerve compression model was produced. Control pups with latex or N-butyl-cyanoacrylate were also prepared. Functional changes to nerves were assessed using the hot plate test and electromyography. Immunofluorescence and electron microscopy analyses of the nerves were performed to quantify the degree of neuropathological change. Masson staining was conducted to assess the degree of fibrosis in the gastrocnemius and intrinsic paw muscles. The pup group rats subjected to nerve compression displayed thermal hypoesthesia and a gradual decrease in nerve conduction velocity at 2 weeks after surgery. Neuropathological studies demonstrated that the model caused nerve demyelination and axonal irregularities and triggered collagen deposition in the epineurium and perineurium of the affected nerve at 8 weeks after surgery. The degree of fibrosis in the gastrocnemius and intrinsic paw muscles was significantly increased at 20 weeks after surgery. In conclusion, our novel model can reproduce the functional and histological changes of chronic nerve compression injury tha

关键词： nerve regeneration chronic nerve compression carpal tunnel syndrome nerve conduction velocity N-butyl-cyanoacrylate hypoesthesia demyelination remyelination intrinsic muscles collagen deposition axonal irregularity neural regeneration

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Muscle Fiber Type Changes in Lumbrical Muscles at Early Stages of Chronic Nerve Compression

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Current Medical Science 2019年第1期39卷 59-66页

作者： Zhen-yu LIU jiang-hai chen Zhen-bing chen Department of Hand Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Chronic nerve compression(CNC)neuropathy is a common disease in the clinic and provokes paraesthesia,or numbness at early *** changes in muscle fiber composition and motor nerve terminal morphology in distal muscles were studied in this study.A well-established CNC model was used to assess the changes in the *** were measured by von Frey filament test The myosin heavy chain isoforms and neuromuscular junctions(NMJs)were stained by immunofluorescence to show the muscle fiber types composition and motor nerve terminals morphologic changes in the flexor digitorum longus(FDL)and lumbrical *** fiber cross-sectional areas of different muscle fiber types were *** small-fiber degeneration of cutaneous nerve fibers was examined by detecting the protein gene product 9.5(PGP9.5)with *** 2nd month after compression,the proportion of type I and type IIB fibers was markedly decreased,and that of type n A fibers was increased in the lumbrical *** was no significant change in composition of muscle fiber types in FDL and NMJ morphology of FDL and lumbrical ***-epidermal nerve fibre density(IENFD)declined at 2nd month after the *** study reveals the morphological changes of the FDL and lumbrical muscle at an early stage of *** findings may be helpful to understand muscle damage and pathophysiological development of the nerve compression,and provide new evidence for early treatment of CNC.

关键词： chronic nerve compression neuropathy carpal tunnel syndrome lumbrical muscles intra-epidermal nerve fiber density neuromuscular junctions

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Lanthanum Prevents Salt Stress-induced Programmed Cell Death in Rice Root Tip Cells by Controlling Early Induction Events

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Journal of Integrative Plant Biology 2007年第7期49卷 1024-1031页

作者： Jian-You Li Ai-Liang jiang hai-Yan chen Ying Wang Wei Zhang Department of Biochemistry and Molecular Biology College of Life Science Nanjing Agricultural University Nanjing 210095 China

In a previous study, a salt stress-induced programmed cell death （PCD） model was established in rice root tip cells. Here, by using Wuyunjing 8th rice seedlings, the effects of lanthanum on salt stress-induced PCD early events were studied. The results indicated that low concentrations （10 μmol/L）, but not high concentrations （100 μmol/L） of LaCl3 could effectively prevent salt stress-induced PCD. Further study demonstrated that in the early stages of salt-induced PCD process, 10 μmol/L of La^3＋ could prevent the increase of cytoplasmic calcium levels, inhibit reactive oxygen species （ROS） production, and enhance the ROS-scavenging enzyme activities such as superoxide dismutases （SOD） and ascorbate peroxidase （APX）. Imidazole （20 mmol/L）, the inhibitor of nicotinamide adenine dinucleotide phosphate-oxidase （NADPH oxidase）, could alleviate the occurrence of PCD obviously, and such alleviation could be enhanced by the addition of La^3＋, indicating the involvement of NADPH oxidase in the salt stress-induced PCD process. Taken together, lanthanum could prevent salt stress-induced PCD occurrence in the rice root tip cells by blocking the calcium influx under stress, which was followed by inhibiting calcium-dependent NADPH oxidase activity to prevent O2^·- production and, enhancing the cytosolic antioxidative enzyme activities to scavenge the reactive oxygen species.

关键词： Ca^2+ Oryza sativa programmed cell death reactive oxygen species salt stress.

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Synthesis of a novel multivalent galactoside with high hepatocyte targeting for gene delivery

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Chinese Chemical Letters 2008年第2期19卷 127-129页

作者： Qing Lin jiang Li hai Lei chen Jiao Lu Zhi Rong Zhang Yong Wu Key Laboratory of Drug Targeting of Education Ministry West China School of Pharmacy Sichuan University Chengdu 610041 China

A novel bifunctional glycolipid which carded a cluster of thiogalactosides as the hepatocyte targeting ligand for gene delivery was prepared. Hexa-antennary alcohol 1 was used as the core scaffold to attach a cholesterol molecule by a poly（ethylene glycol） chain, while its remaining branches were linked with five acetylgalactosides, which would be deacetylated later to produce pentaantennary galactoside. Liposome containing the galactoside showed high affinity and transfection activity in hepatoma cells HepG2.

关键词： Clustered glycosides Targeting Galactosylated ligand Hepatocyte Gene delivery

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New triazole derivatives containing substituted 1,2,3-triazole side chains:Design,synthesis and antifungal activity

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Chinese Chemical Letters 2017年第4期28卷 913-918页

作者： hai-jiang chen Yan-Juan jiang Yong-Qiang Zhang Qi-Wei Jing Na Liu Yan Wang Wan-Nian Zhang Chun-Quan Sheng School of Pharmacy Fujian University of Traditional Chinese Medicine School of Pharmacy Second Military Medical University School of Pharmacy East China University of Science and Technology

In order to discover new generation of triazole antifungal agents,a series of novel antifungal triazoles were designed and synthesized by structural simplification of our previously identified triazolepiperdine-heterocycle lead *** target compounds showed good antifungal activity with a broad *** particular,compound 71 was highly active against Candida albicans and Candida ***,compound 71 showed potent in vivo antifungal efficacy in the Caenorhabditis *** infection model.

关键词： Triazole derivatives Antifungal activities Click reaction Molecular docking CYP51

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Budd-Chiari syndrome:Diagnosis with three-dimensional contrast-enhanced magnetic resonance angiography

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World Journal of Gastroenterology 2003年第10期9卷 2317-2321页

作者： jiang Lin Xiao-hai chen Kang-Rong Zhou Zu-Wang chen Jian-Hua Wang Zhi-Ping Yan Ping Wang, Department of Radiology, Affiliated Zhongshan Hospital, Fudan University, Shanghai 200032, China Department of Radiology Affiliated Zhongshan Hospital Fudan University Shanghai 200032 China. linjiang@***

AIM:To evaluate the role of three-dimensional contrastenhanced magnetic resonance angiography (3D CE MRA) in the diagnosis of Budd-Chiari syndrome (BCS).METHODS: Twenty-three patients with BCS underwent 3D CE MRA examination, in which 13 cases were secondary to either hepatocellular carcinoma (11 cases), right adrenal carcinoma (1 case) or thrombophlebitis (1 case) and 10suffered from primary BCS. The patency of the inferior vena cava (IVC), hepatic and portal veins as well as the presence of intra- and extrahepatic collaterals, liver parenchymal abnormalities and porto-systemic varices were evaluated. Inferior vena cavography was performed in 10 cases. The diagnosis of IVC obstruction by 3D CE MRA was compared with that demonstrated by inferior vena ***: The major features of BCS could be clearly displayed on 3D CE MRA. Positive hepatic venous signs included tumor thrombosis (9 cases), tumor compression (2 cases), nonvisualization (4 cases) and focal stenosis (2 cases). Positive IVC findings were noted as severe stenosis or occlusion (10 cases), tumor invasion (2 cases), thrombosis (3 cases), thrombophlebitis (1 case) and septum formation (3 cases). Intrahepatic collaterals were shown in 9 patients,2 of them with 'spider web' sign. The displayed extrahepatic collaterals included dilated azygos and hemi-azygos veins (13 cases) and left renal-inferior phrenic-pericardiophrenic veins (2 cases). The occlusion of the left intrahepatic portal veins was found in 2 cases. Porto-systemic varices were detected in 10 patients. Liver parenchymal abnormalities displayed by 3D CE MRA were enlargement of the caudate lobe (7 cases), heterogenous enhancement (18 cases) and complicated tumors (13 cases). Compared with the inferior vena cavography performed in 10 cases, the accuracy of 3D CE MRA was 100% in the diagnosis of IVC ***: 3D CE MRA can display the major features of BCS and provide an accurate diagnosis.

关键词：布-加综合征核磁共振三维图像诊断肝血管

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Simulation and experimental research on line throwing rocket with flight

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Defence Technology（防务技术） 2014年第2期10卷 149-153页

作者： Wen-bin GU Ming LU Jian-qing LIU Qin-xing DONG Zhen-xiong WANG jiang-hai chen College of Field Engineering PLA University of Science and Technology Wuhan Ordnance N.C.O School

The finite segment method is used to model the line throwing rocket system.A dynamic model of line throwing rocket with flight motion based on Kane's method is presented by the kinematics description of the system and the consideration of the forces acting on the *** experiment designed according to the parameters of the dynamic model is *** simulation and experiment results,such as range,velocity and flight time,are compared and *** simulation results are basically agreed with the test data,which shows that the flight motion of the line throwing rocket can be predicted by the dynamic model.A theoretical model and guide for the further research on the disturbance of rope and the guidance,flight control of line throwing rocket are provided by the dynamic modeling.

关键词：火箭系统飞行运动实验仿真动态模型有限段方法参数设计飞行时间

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Numerical investigation on hydrogen production by CH_4-Rich combustion in an alumina foam

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Science China(Technological Sciences) 2009年第8期52卷 2960-2966页

作者： ZHAO PingHui, YE TaoHong, ZHU MinMing, jiang hai & chen YiLiang Thermal Science & Energy Engineering Department, University of Science & Technology of China, Hefei 230027, China Thermal Science & Energy Engineering Department University of Science & Technology of China Hefei China

The two-phase volume-averaged model with the detailed chemistry reaction mechanism GRI 3.0 was adopted in the quasi-steady-state simulation of hydrogen production by CH4-rich filtration combustion in an alumina foam under fully developed conditions. The relations among the combustion wave velocity, the inlet gas velocity and the equivalence ratio were discussed, and their influences on the distributions of temperature and species in the alumina foam and on H2 yield, CH4 conversion, H2 selectivity and CO selectivity were analyzed in detail. The results show that the combustion wave velocity increases with the increase of equivalence ratio or inlet gas velocity. The H2 yield exceeded 50% with equivalence ratio between 2.0 and 3.0 and combustion wave velocity larger than 0.4 mm/s. The H2 selectivity exceeded 50% with equivalence ratio larger than 2.0 and CO selectivity exceeded 80% with equivalence ratio between 1.8 and 2.0 and combustion wave velocity larger than 0.4 mm/s.

关键词： fuel-rich combustion in an alumina foam combustion wave velocity superadiabatic flame temperature H2 yield H2 selectivity

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Toward understanding the role of genomic repeat elements in neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 646-659页

作者： Zhengyu An Aidi jiang Jingqi chen Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan UniversityShanghaiChina Zhangjiang Fudan International Innovation Center ShanghaiChina

Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements.

关键词： Alzheimer's disease ataxia deep learning long-read sequencing neurodegeneration neurodegenerative diseases Parkinson's disease repeat element structural variant

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主体功能区下协作性土地利用规划管理机制研究

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中国土地科学 2016年第12期30卷 10-17页

作者：李志刚姜海陈海洋南京农业大学中国土地问题研究中心江苏南京210095 淮安市国土资源局江苏淮安223001

研究目的:基于土地利用总体规划面临的困境,结合主体功能区规划管理,探讨应用协作式规划理论完善中国土地利用规划管理机制的思路。研究方法:文献分析法,比较分析法,案例分析法。研究结果:协作式规划的理论基础是沟通理性,倡导参与主体... 详细信息

研究目的:基于土地利用总体规划面临的困境,结合主体功能区规划管理,探讨应用协作式规划理论完善中国土地利用规划管理机制的思路。研究方法:文献分析法,比较分析法,案例分析法。研究结果:协作式规划的理论基础是沟通理性,倡导参与主体多元化、沟通过程民主化、以公众利益为导向、转变规划师角色、共识导向的规划成果;主体功能区规划通过区域差别化定位、错位竞争等途径,为改善土地利用总体规划冲突提供了重要机遇。研究结论:应在规划地位上强化土地功能区规划的引领作用,在规划过程中加强自然、经济上紧密联结的地区间协调沟通,破除土地利用总体规划单纯按照行政区划管理的弊端,提升地区间土地开发保护分工与协作水平,更充分地发挥土地利用总体规划的整体优化功能。

关键词：土地规划主体功能区土地利用规划协作式规划机制创新

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