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Peripheral blood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy

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Neural Regeneration Research 2025年第6期20卷 1764-1775页

作者： Zhenzhong Zheng Jialin Chen Jinghong Xu bin jiang Lei li Yawei li Yuliang Dai bing Wang Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse *** numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical *** study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic *** analysis identified 128 differentially expressed genes that were enriched in patients with neurological *** least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,*** of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%*** results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.

关键词： biomarkers candidate genes degenerative cervical myelopathy gene expression analysis immune cell types neurological disabilities peripheral blood RNA profiles spinal cord injury

Clinical features of retinal diseases masquerading as retrobulbar optic neuritis

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Chinese Medical Journal 2013年第17期126卷 3301-3306页

作者： jiang li-bin SHEN Ce-ying CHEN Fei YAN Wei-yu Timothy Y. Y WANG Ning-li Beijing Tongren Eye Center Beijing 100730 China Beijing Institute of Ophthalmology Beijing 100730 China Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology & Visual Sciences Key Laboratory Beijing 100730 China Department of Ophthalmology & Visual Sciences Hong Kong Eye Hospital Chinese University of Hong Kong Kowloon Hung Kong

Background Managements of optic neuritis （ON） included high-dose corticosteroids or combined with systemic immunomodulatory agents. It was important to make a correct diagnosis of ON before initiation of treatment. The purpose of the study was to report and analyze the clinical features of retinal diseases in patients who were misdiagnosed as having retrobulbar ON. Methods Retrospective review of 26 patients （38 eyes） initially diagnosed with retrobulbar ON but were ultimately diagnosed with retinal or macular diseases. Data obtained from fundus examination, fluorescence fundus angiography （FFA）, automated static perimetry, full-field electroretinogram （ffERG）, multifocal electroretinogram （mfERG）, and optical coherence tomography （OCT） were evaluated. Results Thirty-eight eyes of 26 patients were found to have misdiagnosis of retrobulbar ON, based on normal or slight abnormal fundus findings and abnormal visual evoked potentials （VEP）. The mean age of the patients was 34 years and the correct diagnosis of the patients included acute zonal occult outer retinopathy （AZOOR, 15 eyes, 14 patients）, occult macular dystrophy （OMD, 8 eyes, 4 patients）, cone or cone-rod dystrophy （10 eyes, 5 patients）, acute macular neuroretinopathy （AMNR, 3 eyes, 2 patients）, and cancer-associated retinopathy （CAR, 2 eyes, 1 patient）. Conclusion When attempting to diagnose retrobulbar ON in clinical practice, it is crucial to carry out necessary examinations of the retinal function and morphology to decrease misdiagnosis.

关键词： retrobulbar optic neuritis retina macula misdiagnosis

Metal nanoparticles decorated CoFe-(oxy)hydroxysulfides nanosheets fabricated by a general strategy for electrocatalytic water splitting

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Journal of Energy Chemistry 2025年第1期100卷 26-38页

作者： Xiaodong Yang Haochen Shen Xiaoming Xiao Zhichao li Qi Zhou Wei Yang bin jiang Yongli Sun Luhong Zhang Zhenhua Yan School of Chemical Engineering and Technology Tianjin University Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University

This study presents a novel method to fabricate metal-decorated,sulfur-doped layered double hydroxides （M/SLDH） through spontaneous redox and sulfurization *** developed Ag/SLDH and Pt/SLDH catalysts with abundant heterogeneous interfaces and hierarchical nanostructures demonstrated outstanding oxygen evolution reaction （OER） and hydrogen evolution reaction （HER） performance,achieving low overpotentials of 212 and 35 mV at 10 mA cm-2in 1 M KOH,*** both anode and cathode in water splitting,they required only 1.47 V to reach 10 mA cm-2and exhibited high structural robustness,maintaining stability at 1000 mA cm-2for 300 ***-situ Raman analysis revealed that the synergistic effects of metal nanoparticles and S doping significantly promote the transformation into the S-Co1-xFexOOH layer,which serves as the active phase for water ***,ultraviolet photoelectron spectroscopy （UPS） and density functional theory （DFT） analyses indicated that incorporating metal nanoparticles and S doping increase electron density near the Fermi level and reduce reaction energy barriers,thus enhancing intrinsic OER and HER *** study provides a scalable strategy for synthesizing high-performance electrocatalysts for water splitting,with promising potential for broader applications.

关键词： Ultraviolet photoelectron spectroscopy

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He li li Sai Wang Shao-jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Controlled cationic ring-opening polymerization of L-lactide by organic ion pair: novel approach to isotactic-rich and crystalline polylactide

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Science China Chemistry 2025年第1期68卷 394-402页

作者： Zhiqiang Ding Mingqian Wang Zijing Zhou bin Wang Yuesheng li Tianjin Key Laboratory of Composite & Functional Materials School of Materials Science and Engineering Tianjin University

living/controlled cationic ring-opening polymerization （ROP） of L-lactide is a promising approach to isotactic-rich and crystalline poly（L-lactide）.In contrast with the unsubstituted lactones,L-LA can not be polymerized by organic Lewis acids or carbenium ions,and the state of the art in this field is the cationic ROP of L-LA catalyzed by Br?nsted acid/alcohol system via activated monomer ***,we reported the first example of controlled cationic ROP of L-LA by using Meerweintype ion pair[Me3O]+[B（C6F5）4]-as the catalyst.[Me3O]+[B（C6F5）4]-promoted rapid L-LA cationic polymerization in the absence of alcohol,producing isotactic-rich and crystalline PLLA without transesterification and epimerization side *** activated chain end mechanism,involving twice SN2 substitution and configuration-inversion （S→R→S） with the assistance of released Me2O,was proposed and further verified by density functional theory and control *** work expands the catalytic toolbox of isotactic-rich and crystalline polylactide *** represents a unique example of cationic-controlled polymerization of L-LA catalyzed by an organic ion pair.

关键词： organic ion pair controlled cationic ring-opening polymerization activated chain end mechanism isotactic-rich polylactide

加卸载条件下石英岩蠕变–渗流耦合规律试验研究

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岩土工程学报 2017年第10期39卷 1832-1841页

作者：江宗斌姜谙男李宏王善勇大连海事大学道桥研究所辽宁大连116026 大连理工大学岩石破裂与失稳研究中心辽宁大连116026 澳大利亚纽卡斯尔大学土木系

以大东山隧道的石英岩为研究对象,进行循环加卸载条件下岩石蠕变–渗流耦合试验,分析了岩石加卸载过程中的蠕变、渗透性变化规律和渗流–蠕变耦合机理,得到压密阶段、裂纹扩展阶段和裂纹贯通阶段岩石体积应变的发展规律,总结了渗透率与... 详细信息

以大东山隧道的石英岩为研究对象,进行循环加卸载条件下岩石蠕变–渗流耦合试验,分析了岩石加卸载过程中的蠕变、渗透性变化规律和渗流–蠕变耦合机理,得到压密阶段、裂纹扩展阶段和裂纹贯通阶段岩石体积应变的发展规律,总结了渗透率与体积应变之间的关系。试验表明:轴向荷载0~50 MPa为压密阶段,继续加载则产生不可恢复变形,当达到160 MPa时蠕变曲线进入加速段;随着轴向荷载水平的增加,渗透率总体趋势先降低后增高,最小值出现在最大压密点,蠕变过程进入加速段以后渗透率急剧增大。采用FLAC3D中的Cvisc模型为蓝本,以体积应变为桥梁建立ZSI(zone state index)与渗透率的关系,自主开发了基于应变软化的改进非线性蠕变西原模型,对试验结果进行验证。数值模拟表明:靠近进水端的渗透率比出水端变化快,不同应力下ZSI值云图的破损区与试验中岩样的"V"型剪切带破坏模式基本一致,渗透率的理论曲线与计算曲线吻合较好。说明提出的模型能够很好地反映加卸载条件下岩石蠕变–渗流耦合特性和局部破坏规律。

关键词：循环加卸载蠕变–渗流耦合渗透率体积应变单元安全指标

Data analysis of 36 cases with intraductal papillary mucinous neoplasm of the pancreas for their clinicopathological features, diagnosis, and treatment

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Chinese Medical Journal 2014年第23期127卷 4087-4091页

作者： Yuan Chunhui Xiu Dianrong Tao Ming Ma Zhaolai jiang bin li Zhifei li Lei Wang liang Wang Hangyan Zhang Tonglin Department of General Surgery Peking University Third Hospital Beiiing 100191 China

Background Intraductal papillary mucinous neoplasm （IPMN） is a rare pancreatic cystic neoplasm,accounting for 1％ of all exocrine pancreatic *** study aimed to summarize the clinicopathological and biological behaviors,as well as the experience in diagnosis and treatment of *** Clinicopathological data were collected from 36 cases with IPMN who were treated in Department of General Surgery,Peking University Third Hospital from May 2001 to July *** The 36 cases of IPMN patients included 27 males and 9 females （M∶F=3∶1）.The age of patients ranged from 52 to 78 years,with an average of 67.3 *** tumor location,20 tumors were located in pancreatic head,3 in pancreatic neck,10 in pancreatic body and tail,and 3 in the whole *** the 36 cases underwent surgical treatment,with 13 cases of pancreaticoduodenectomy,3 cases of middle pancreatectomy,7 cases of tumor resection plus pancreaticojejunostomy,3 cases of distal pancreatectomy,7 cases of distal pancreatectomy plus spleen resection,and 3 cases of total *** the 36 patients,9 patients underwent the operations under *** 36 cases included main duct type （14 cases,38.9％）,branch duct type （10 cases,27.7％）,and mixed duct type （12 cases,33.3％）.Pathologically,of the 36 cases,there were 7 IPMN adenomas,11 borderline IPMNs,6 IPMN with carcinomas in situ,and 12 IPMNs with invasive *** the 36 cases were followed *** an average of 42 months follow-up period （26-129 months）,no recurrence *** IPMN,which primarily occurs in male,is a low-grade malignancy which may involve any part of the pancreas,with specific clinicopathological *** is a different malignancy type from pancreatic ductal *** and laboratory examination are helpful for the diagnosis and differential *** prediction of invasive IPMN is still *** resection is recommended as the first choice of ***

关键词： pancreatic neoplasms diagnosis treatment intraductal papillary mucinous neoplasm laparoscopy

生物大分子冷冻电镜结构解析技术研究进展：2017年诺贝尔化学奖解读

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中国科学：化学 2018年第3期48卷 277-281页

作者：蒋滨李从刚刘买利中国科学院武汉物理与数学研究所波谱与原子分子物理国家重点实验室武汉430071

生物大分子的结构研究是从原子分子水平上阐述生命过程的规律、探索重大疾病发生发展机制和高靶向性药物研发的关键.解析生物大分子三维结构的主要技术有X射线晶体学(X-ray)、核磁共振(NMR)和冷冻电镜(Cryo-EM).近年来,冷冻电镜技术发... 详细信息

生物大分子的结构研究是从原子分子水平上阐述生命过程的规律、探索重大疾病发生发展机制和高靶向性药物研发的关键.解析生物大分子三维结构的主要技术有X射线晶体学(X-ray)、核磁共振(NMR)和冷冻电镜(Cryo-EM).近年来,冷冻电镜技术发展迅速,其分辨率可以达到原子水平(约3?,在超大复合物结构解析方面优势明显.2017年三位科学家因发展了冷冻电镜解析生物大分子三维结构的方法获得诺贝尔化学奖.本文简要评析了此次诺贝尔化学奖获奖工作的科学背景及应用前景.

关键词：冷冻电镜生物大分子结构解析诺贝尔化学奖

税务信息化发展的问题及对策探讨——基于“诺兰”阶段模型的分析

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财务与金融 2009年第5期 81-85页

作者：蒋丽斌中南林业科技大学商学院

信息化是推动社会经济发展的重要力量,也是历史发展的一种必然趋势。税务信息化是税务部门顺应信息化时代的要求,主动迎接信息时代挑战而采取的积极措施。文章以"诺兰"阶段模型理论为基础,将我国税务信息化的发展历程分为起步、初步应... 详细信息

信息化是推动社会经济发展的重要力量,也是历史发展的一种必然趋势。税务信息化是税务部门顺应信息化时代的要求,主动迎接信息时代挑战而采取的积极措施。文章以"诺兰"阶段模型理论为基础,将我国税务信息化的发展历程分为起步、初步应用、快速发展和数据集中四个阶段。在此基础上,着重从思想意识、规划部署、征管改革和设备功能发挥四个方面分析了我国税务信息化建设中存在的诸多问题,并提出了推动和规范我国税务信息化建设的对策措施。

关键词：税务信息化信息化管理“诺兰”模型