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Characteristics of early gastric tumors with different differentiation and predictors of long-term outcomes after endoscopic submucosal dissection

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World Journal of Gastroenterology 2024年第14期30卷 1990-2005页

作者： Hong-Yi Zhu Jie Wu Yuan-Miao Zhang Fang-Lan Li Jin Yang Bin Qin Jiong jiang Ning Zhu Meng-Yao Chen Bai-Cang zou Department of Gastroenterology The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina Department of Pathology The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina Department of Gastroenterology Xianyang Hospital of Yan'an UniversityXianyang 712000Shaanxi ProvinceChina Department of Gastroenterology The First Hospital of Xi'anXi'an 710000Shaanxi ProvinceChina

BACKGROUND Gastric cancer is a common malignant tumor of the digestive tract,and endosco-pic submucosal dissection(ESD)is the preferred treatment for early-stage gastric *** analysis of the epidemiological characteristics of gastric mucosal tumors with different differentiation degrees and the influencing factors of long-term ESD efficacy may have certain significance for revealing the development of gastric cancer and *** To analyze the features of gastric mucosal tumors at different differentiation levels,and to explore the prognostic factors of *** We retrospectively studied 301 lesions in 285 patients at The Second Affiliated Hospital of Xi'an Jiaotong University from 2014 to 2021,according to the latest Japanese guidelines(sixth edition),and divided them into low-grade intrae-pithelial neoplasia(LGIN),high-grade intraepithelial neoplasia(HGIN),and computed tomography at 3,6 and 12 months after *** compared clinicopathologic characteristics,ESD efficacy,and complications with different degrees of differentiation,and analyzed the related factors associated with *** HGIN and differentiated carcinoma patients were significantly older compared with LGIN patients(P<0.001)and accounted for more 0-IIc(P<0.001),atrophic gastritis was common(P<0.001),and irregular microvascular patterns(IMVPs)and demarcation lines(DLs)were more obvious(P<0.001).There was more infiltration in the undifferentiated carcinoma tissue(P<0.001),more abnormal folds and poorer mucosal peristalsis(P<0.001),and more obvious IMVPs,irregular microsurface patterns and DLs(P<0.05)than in the LGIN and HGIN *** disease-free survival rates at 2,5,and 8 years after ESD were 95.0%,90.1%,and 86.9%,***-tiated lesions(HR 5.066),white moss(HR 7.187),incomplete resection(HR 3.658),and multiple primary cancers(HR 2.462)were significantly associated with poor *** Differentiations of gastric mucosal tumors have different epidemiological and

关键词： Gastric mucosal epithelial neoplasia Differentiated early gastric cancer Undifferentiated early gastric cancer Endoscopic submucosal dissection Long-term outcomes

The water-soluble TF3 component from Eupolyphaga sinensis Walker promotes tibial fracture healing in rats by promoting osteoblast proliferation and angiogenesis

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Journal of Traditional Chinese Medical Sciences 2024年第2期11卷 245-254页

作者： Binghao Shao Xing Chen Jin'ge Du Shuang zou Zhaolong Chen Jing Wang Huaying jiang Ruifang Lu Wenlan Wang Chunmei Wang School of Life Sciences Beijing University of Chinese MedicineBeijing102488China School of Materia Medica Beijing University of Chinese MedicineBeijing102488China King's British Heart Foundation Center School of Cardiovascular and Metabolic Medicine and SciencesLondonSE59NUUK

Objective To determine the active components of Eupolyphaga sinensis Walker(Tu Bie Chong)and explore the mechanisms underlying its fracture-healing *** A modified Einhorn method was used to develop a rat tibial fracture *** of bone healing was assessed using radiological *** O/fast green and CD31 immunohistochemical staining were performed to evaluate the growth of bone cells and angiogenesis at the fracture *** blue and wound healing assays were used to analyze cell viability and *** Transwell assay was used to explore the invasion capacity of the *** formation assays were used to assess the angiogenesis capacity of human vascular endothelial cells(HUVECs).qRT-PCR was used to evaluate the changes in gene transcription *** Tu Bie Chong fraction 3(TF3)significantly shortened the fracture healing time in model rats.X-ray results showed that on day 14,fracture healing in the TF3 treatment group was significantly better than that in the control group(P=.0086).Tissue staining showed that cartilage growth and the number of H-shaped blood vessels at the fracture site of the TF3 treatment group were better than those of the control *** vitro,TF3 significantly promoted the proliferation and wound healing of MC3T3-E1s and HUVECs(all P<.01).Transwell assays showed that TF3 promoted the migration of HUVECs,but inhibited the migration of MC3T3-E1 *** formation experiments confirmed that TF3 markedly promoted the ability of vascular endothelial cells to form *** expression analysis revealed that TF3 significantly promoted the expression of VEGFA,SPOCD1,NGF,and NGFR in *** MC3T3-E1 cells,the transcript levels of RUNX2 and COL2A1 were significantly elevated following TF3 *** TF3 promotes fracture healing by promoting bone regeneration associated with the RUNX2 pathway and angiogenesis associated with the VEGFA pathway.

关键词： Tu Bie Chong Water-solube component Fracture Rats Osteoblast Angiogenesis

A telomere-to-telomere genome assembly of Hongyingzi,a sorghum cultivar used for Chinese Baijiu production

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The Crop Journal 2024年第2期12卷 635-640页

作者： Yanqing Ding Yilin Wang Jianxia Xu Feng jiang Wenzhen Li Qiaoling Zhang Longping Yang Zhenyu Zhao Bin Cheng Ning Cao Xu Gao Xin Zhang Guihua zou Fan Yang Liyi Zhang Guizhou Institute of Upland Crops Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouChina Kweichow Moutai Co. Ltd.Maotai TownRenhuai 564501GuizhouChina Kweichow Moutai Distillery(Group)Hongyingzi Agricultural Technology Development Co. Ltd.Maotai TownRenhuai 564501GuizhouChina Wuhan GrandOmics Biosciences Co. Ltd.Grandomics BiosciencesWuhan 430000HubeiChina Institute of Crop and Nuclear Technology Utilization Zhejiang Academy of Agricultural SciencesZhejiang

Sorghum(Sorghum bicolor(L.)Moench)is a world cereal crop used in China for producing Baijiu,a distilled *** report a telomere-to-telomere genome assembly of the Baijiu cultivar Hongyingzi,HYZ-T2T,using ultralong *** 10 chromosome pairs contained 33,462 genes,of which 93%were functionally *** 20 telomeres and 10 centromeric regions on the HYZ-T2T chromosomes were predicted and two consecutive large inversions on chromosome 2 were characterized.A 65-gene reconstruction of the metabolic pathway of tannins,the flavor substances in Baijiu,was performed and may advance the breeding of sorghum cultivars for Baijiu production.

关键词： Sorghum Telomere-to-telomere assembly Hongyingzi(HYZ) Chinese Baijiu-making cultivar

Summer Arctic sea fog

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Acta Oceanologica Sinica 2001年第2期20卷 183-196页

作者： Xie Simei, Xue Zhenhe, jiang Dezhong, zou Bin, Qu Shaohou (1. National Research Center for Marine Environment Forecasts, Beijing 100081, China 2. Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China) Natl. Res. Ctr. for Marine Envrn. Fo Beijing 100081 China

Synchronous or quasi-synchronous sea-land-air observations were conducted using advanced sea ice, atmospheric and marine instruments during China's First Arctic Expedition. *** on the Precious data from the expedition, it was found that in the Arctic Ocean, most part of which is covered with ice or is mixed with ice, various kinds of sea fog formed such as advection fog, radiation fog and vapor fog. Each kind he its own characteristic and mechanics of creation. In the southern part of the Arctic Ocean, due to the sufficient warm and wet flow there, it is favorable for advection fog to form, which is dense and lasts a long time. On ice cap or vast floating ice, due to the strong radiation cooling effect, stable radiating fog is likely to form. In floating ice area there forms vapor fog with the appearance of masses of vapor from a boiling pot, which is different from short-lasting land fog. The study indicates that the reason why there are many kinds of sea fog form in the Arctic Ocean is because of the complicated cushion and the consequent sea-air interaction caused by the sea ice distribution and its unique physical characteristics. Sea fog is the atmospheric phenomenon of sea-air heat exchange. Especially, due to the high albedo of ice and snow surface, it is diffcult to absorb great amount of solar radiation during the polar days. Besides, ice is a poor conductor of heat; it blocks the sea-air heat exchange. The sea-air exchange is active in floating ice area where the ice is broken. The sea sends heat to the atmosphere in form of latent heat; vapor fog is a way of sea-air heat exchange influencing the climate and an indicator of the extent of the exchange. The study also indicates that the sea also transports heat to the atmosophere in form of sensible heat when vapor fog occurs.

关键词： Arctic sea fog vapor fog radiation fog advection fog mechanism of the creation of sea fog

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广东省东南部菜地水田砷含量空间分布

农业工程学报 2016年第23期32卷 263-268,F0004页

作者：姜晓璐邹滨汤景文涂宇龙中南大学有色金属成矿预测与地质环境监测教育部重点实验室长沙410083 中南大学冶金与环境学院国家重金属污染防治工程技术研究中心长沙410083

针对稀疏采样条件下农用地土壤砷含量空间分布难以高效准确识别的问题,以广东省东南部农用地为例,采集表层土壤（0-20 cm）样本104个,借助空间分析与多元回归建模手段,分菜地、水田和果园3类农用地分析土壤砷含量统计特征、模拟揭示土... 详细信息

针对稀疏采样条件下农用地土壤砷含量空间分布难以高效准确识别的问题,以广东省东南部农用地为例,采集表层土壤（0-20 cm）样本104个,借助空间分析与多元回归建模手段,分菜地、水田和果园3类农用地分析土壤砷含量统计特征、模拟揭示土壤砷含量空间分异的成因与空间分布格局。结果表明：1）研究区农用地土壤砷含量总体上达标,但个别样点土壤砷含量值高达137.80 mg/kg,显著高于国家土壤环境质量二级标准（GB156182-1995）;2）3类农用地中菜地土壤砷含量最高、水田次之、果园相对较低,均值分别为11.04、9.89和2.54 mg/kg;3）各类农用地土壤砷污染来源不同,菜地砷污染主要在不同地形条件下,受河流污水灌溉和烟囱排放的废气沉降随地表径流累积影响,在空间上呈现北部偏高、其他地区偏低的分布格局;4）水田砷污染受河流污水灌溉影响显著,空间上呈现南北部偏高、中部地区偏低的污染格局。研究结果对在稀疏采样监测地区开展农用地土壤重金属污染制图与精细防控策略的制定提供了一种行之有效的方法。

关键词：土壤重金属污染砷多元回归建模空间分析

Noteworthy impacts of COVID-19 pandemic on cancer screening:A systematic review

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Fundamental Research 2024年第3期4卷 484-494页

作者： Huilin Wang Min Yang Wei Xiong Quan Wang Bobo Zheng Yang Bai Kaiyong zou Jibin Li Jiansong Ren Wanqing Chen Jingbo Zhai jiang Li Office for Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Comprehensive Intervention National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Gynecology Endocrine&Reproductive Center National Clinical Research Center for Obstetric&Gynecologic Diseases Department of Obstetrics and GynecologyPeking Union Medical College HospitalPeking Union Medical College/Chinese Academy of Medical SciencesBeijing 100005China Ambulatory Surgery Center of Xijing Hospital Fourth Military Medical UniversityXi'an 710068China Department of General Surgery Shaanxi Provincial People’s HospitalXi'an 710068China College of Clinical Medicine Capital Medical UniversityBeijing 100069China School of Public Health Tianjin University of Traditional Chinese MedicineTianjin 301617China

The sudden onset of the coronavirus disease 2019(COVID-19)in January 2020 has affected essential global health ***-screening services that can reduce cancer mortality are strongly ***,the specific role of COVID-19 in cancer screening is not fully *** study aimed to assess the efficiency of global cancer screening programs before and during the COVID-19 pandemic and to promote potential cancer-screening strategies for the next *** searches in PubMed,Embase,and Web of Science,and manual searches were performed between January 1,2020 and March 1,*** studies that reported the number of participants who underwent cancer screening before and during the COVID-19 pandemic were *** methodological quality of the included studies was assessed using the Newcastle-Ottawa *** in cancer-screening rates were estimated using the incidence rate ratio(IRR).Fifty-five cohort studies were included in this *** screening rates of colorectal cancer using invasive screening methods(Pooled IRR=0.52,95%CI:0.42 to 0.65,p<0.01),cervical cancer(Pooled IRR=0.56,95%CI:0.47 to 0.67,p<0.01),breast cancer(Pooled IRR=0.57,95%CI:0.49 to 0.66,p<0.01)and prostate cancer(Pooled IRR=0.71,95%CI:0.56 to 0.90,p<0.01)during the COVID-19 pandemic were significantly lower than those before the COVID-19 *** screening rates of lung cancer(Pooled IRR=0.77,95%CI:0.58 to 1.03,p=0.08)and colorectal cancer using noninvasive screening methods(Pooled IRR=0.74,95%CI:0.50 to 1.09,p=0.13)were reduced with no statistical *** subgroup analyses revealed that the reduction in cancer-screening rates varied across *** results suggest that the COVID-19 pandemic has had a noteworthy impact on colorectal,cervical,breast,and prostate cancer *** innovative cancer-screening technologies is important to promote the efficiency of cancer-screening services in the post-COVID-19 era and prepare fo

关键词： Cancer screening COVID-19 pandemic Cohort study Incidence rate ratio Meta-analysis

Primary Studies on Burnup Estimation of Irradiated Uranium by Dtermining 236U/238U in Contaminated Environmental Samples jiang Xiao-yan,ZHANG Ji-long,zou Wei,Chang Zhi-yuan

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Primary Studies on Burnup Estimation of Irradiated Uranium b...

Endoplasmic reticulum-targeted delivery of celastrol and PD-L1 siRNA for reinforcing immunogenic cell death and potentiating cancer immunotherapy

作者： jiang Xiao-yan ZHANG Ji-long zou Wei Chang Zhi-yuan

U/U of the environmental sample can indicate the existence of uranium irradiation,and even can be uesd to estimate the burnup of nuclear spent fuel.A study on the burnup estimation of irradiated uranium which was mixed with natural uranium was carried out by measuring the U/U and U/U in the samples by using MC-ICP-MS. According to the equation(1) and(2),a programme for calculating the burnup of the irradiated

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3643-3660页

作者： Jie Wang Zilong Zhang Yan Zhuo Zhuan Zhang Rongrong Chen Li Liang Xiaohe jiang Di Nie Chang Liu Zhiwen zou Xiang Li Jiaxin Li Bingqi Wang Rui Wang Yong Gan Miaorong Yu School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghai 201203China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China jiangxi Medical College Nanchang UniversityNanchang 330006China School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients National Institutes for Food and Drug ControlBeijing 100050China

The prospect of employing chemoimmunotherapy targeted towards the endoplasmic reticulum(ER)presents an opportunity to amplify the synergistic effects of chemotherapy and *** this study,we initially validated celastrol(CEL)as an inducer of immunogenic cell death(ICD)by promoting ER stress and autophagy in colorectal cancer(CRC)***,an ER-targeted strategy was posited,involving the codelivery of CEL with PD-L1 small interfering RNAs(siRNA)using KDEL peptide-modified exosomes derived from milk(KME),to enhance chemoimmunotherapy *** findings demonstrate the efficient transportation of KME to the ER via the Golgi-to-ER *** to their non-targeting counterparts,KME exhibited a significant augmentation of the CEL-induced ICD ***,it facilitated the release of danger signaling molecules(DAMPs),thereby stimulating the antigen-presenting function of dendritic cells and promoting the infiltration of T cells into the ***,the ER-targeted delivery of PD-L1 siRNA resulted in the downregulation of both intracellular and membrane PD-L1 protein expression,consequently fostering the proliferation and activity of CD8^(+)T ***,the ER-targeted formulation exhibited enhanced anti-tumor efficacy and provoked anti-tumor immune responses against orthotopic colorectal tumors in ***,a robust ER-targeted delivery strategy provides an encouraging approach for achieving potent cancer chemoimmunotherapy.

关键词： Chemoimmunotherapy Targeted drug delivery Endoplasmic reticulum Endoplasmic reticulum stress Immunogenic cell death siRNA Chemoimmunotherapy Targeted drug delivery Endoplasmic reticulum Endoplasmic reticulum stress Immunogenic cell death siRNA

Multisim在漏电开关保护技术设计中的应用

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计算机仿真 2010年第9期27卷 333-336页

作者：刘刚高平邹剑温州科技职业学院浙江温州325006 浙江正泰电器股份有限公司技术中心浙江温州325603

针对电子电路设计受到元器件、实验仪器的制约,介绍了Multisim软件在电子电路设计方面的应用。分析了漏电保护技术的基本原理,研究了基于运算放大电路实现漏电保护的技术,然后通过Multisim仿真软件对基于运算放大电路实现的漏电保护所... 详细信息

针对电子电路设计受到元器件、实验仪器的制约,介绍了Multisim软件在电子电路设计方面的应用。分析了漏电保护技术的基本原理,研究了基于运算放大电路实现漏电保护的技术,然后通过Multisim仿真软件对基于运算放大电路实现的漏电保护所需要实现的不同电路功能进行了仿真,并且给出了具体的仿真波形。仿真的波形表明采用Multisim仿真软件可以直接通过修改仿真元器件的参数方便地实现漏电保护器的各种功能,可见将Multisim软件应用于漏电保护器产品进行仿真开发是一种切实可行的方法。

关键词：漏电保护开关剩余电流放大器仿真