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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui jiang Hui-Li Kang yi jiang Hua-Wei Zhang Xiao-Mei Song Yu-Ze Li Wen-Li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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Hybrid Block Diagonalization Precoding for Multi-User Weighted Sum-Rate Maximization

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China Communications 2024年第8期21卷 127-141页

作者： Su Xiaofeng jiang yi Key Laboratory for Information Science of Electromagnetic Waves(MoE) Department of Communication Science and EngineeringFudan UniversityShanghai 200433China

This paper studies large-scale multi-input multi-output(MIMO)orthogonal frequency division multiplexing(OFDM)communications in a broadband frequency-selective channel,where a massive MIMO base station(BS)communicates with multiple users equipped with *** develop a hybrid precoding design to maximize the weighted sum-rate(WSR)of the users by optimizing the digital and the analog precoders *** the digital part,we employ block-diagonalization to eliminate inter-user interference and apply water-filling power allocation to maximize the *** the analog part,the optimization of the PSN is formulated as an unconstrained problem,which can be efficiently solved by a gradient descent *** results show that the proposed block-diagonal hybrid precoding algorithm can outperform the existing works.

关键词： block-diagonal gradient descent hybrid precoding iterative optimization MIMO-OFDM multi-user water-filling power allocation weighted sum-rate maximization

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Multi-channel blind deconvolution algorithm for multiple-input multiple-output DS/CDMA system

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Journal of Systems Engineering and Electronics 2007年第3期18卷 454-461页

作者： Cheng Hao Guo Wei jiang yi National Key Lab of Communication Univ. of Electronic Science and Technology Chengdu 610054 P. R. China

Direct sequence spread spectrum transmission can be realized at low SNR, and has low probabilityof detection. It is aly problem how to obtain the original users＇ signal in a non-cooperative context. In practicality, the DS/CDMA sources received are linear convolute mixing. A more complex multichannel blind deconvolution MBD algorithm is required to achieve better source separation. An improved MBD algorithm for separating linear convolved mixtures of signals in CDMA system is proposed. This algorithm is based on minimizing the average squared cross-output-channel-correlation. The mixture coefficients are totally unknown, while some knowledge about temporal model exists. Results show that the proposed algorithm can bring about the exactness and low computational complexity.

关键词： DS/CDMA signal non-cooperative MBD stochastic gradient algorithms for MBD.

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Detection Probability for Moving Ground Target of Normal Distribution Using an Imaging Satellite

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Chinese Journal of Electronics 2018年第6期27卷 1309-1315页

作者： GUO Zhaoming jiang yi BI Shihua School of Physics and Electronic Information Yan'an University School of Aerospace Beijing Institute of Technology

The detection probability for a moving target is an important issue, we aim to discuss the detection probability for a moving ground target such as military vehicles using a visible light imaging satellite. First, a basic detection model for a regional ground target using a satellite was discussed and the probability of detection was calculated. Next, a basic model for the recognition of a ground target using a visible light imaging satellite was developed based on above model. Then, a basic model of the detection probability for a moving ground target using a visible light imaging satellite was studied. As the normal distribution has the maximum entropy, the normal distribution of a moving ground target such as military vehicles was analyzed, and based on our conclusions, a basic probability model for the detection of a moving ground target using a visible light satellite was developed. Finally, the simulation was carried on.

关键词： Detection probability Visible light imaging satellite Regional ground target Moving ground target

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Characterization and Crystal Structures of Two Copper(Ⅱ) Complexes Constructed by a Flexible Double Betaine Ligand

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Chinese Journal of Structural Chemistry 2007年第2期26卷 199-205页

作者： jiang Ning-yi LI Song-Lin Department of Chemistry College of Science Tianjin University Tianjin 300072 China

A flexible double betaine 1,4-bis（pyridinil-4-carboxylato）-1,4-dimethylbenzene L has been used to generate two Cu（Ⅱ）-containing metal complexes that exhibit different polymeric structures： [Cu（H2O）2 L].2NO3 1 and [Cu（H2O）3 L].2Cl.H2O 2. The crystal structures of 1 and 2 have been determined by single-crystal X-ray diffraction method. Crystal data for 1： triclinic, space group PT, a = 5.253（2）, b = 7.406（3）, c = 14.792（5） A, α = 84.195（5）, β = 80.014（5）, γ = 78.053（5）°, V= 553.2（3）A^3, Z = 1, F（000） = 293, Dc = 1.717 g/cm^3, the final R = 0.0385 and wR = 0.1079 for 1883 observed reflections （I 〉 2σ（I））; and those for 2： monoclinic, space group P21/c, a = 10.222（3）, b = 25.287（7）, c = 9.277（3）A, β = 93.572（5）°, V = 2393.2（12）A^3, Z = 4, F（000） = 1140, Dc = 1.540 g/cm^3, the final R = 0.0472 and wR = 0.0956 for 3204 observed reflections （I 〉2o（/））.

关键词： 1,4-bis(pyridinio-4-earboxylato)-l,4-dimethylbenzene copper(Ⅱ) complex double betaine

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Synthesis and Structural Characterization of a New Hydrogen-bonded Polyrotaxane of [Co(H_2O)_6]_(2+) with 1,1′-(Propane-1,3-diyl)dipyridinium-4-carboxylate

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Chinese Journal of Structural Chemistry 2006年第8期25卷 957-964页

作者： jiang Ning-yi LI Song-Lin Department of Chemistry College of Science Tianjin University Tianjin 300072 China

A new double betaine 1,1′-（propane-1,3-diyl）dipyridinium-4-carboxylate L has been synthesized. Reaction of 1, 1′-（propane-1,3-diyl）dipyridinium-4-carboxylate tetrahydrate 1 with Co（ClO4）2-6H2O leads to the formation of a new Co（Ⅱ） coordination compound, namely [Co（H2O）6]-2H2O-2L-2ClO4 2. The crystal structures of 1 and 2 have been determined by single-crystal X-ray diffraction method. Crystal data for 1. monoclinic, space group C2/c, a = 18.945（4）, b = 7.700（2）, c = l 1.888（2）A,β = 101.67（3）°, V = 1698.3（6） A^3, Z = 4, F（000） = 760.0, Dc = 1.402 g/cm^3, the final R = 0.0607 and wR = 0.1607 for 950 observed reflections （1 〉 2σ（I））; and those for 2： monoclinic, space group P21/c, a = 17.982（1）, b = 15.879 （1）, c = 7.0716（5）/A,β= 100.675（1）°, V= 1984.3（3） ,A^3 Z= 4, F（000） = 1010.0, Dc = 1.631 g/cm^3, the final R = 0.0316 and wR = 0.0896 for 3784 observed reflections （1 〉20（I））. Crystal structure analysis indicates that in 1, molecules of L in a ＂V-shaped＂ conformation are linked to chains sustained by O-H…O hydrogen bonds between carboxylate groups and solvent water molecules. The chains are joined by O-H…O and C-H…O hydrogen bonds to further expand into a three-dimensional structure. For 2, molecules of L in a ＂Z-shaped＂ conformation are linked by hydrogen bonds between carboxylate groups and aqua ligands to form a chain of loops running down the b axis. The （2D→2D） polythreading in compound 2 represents the mode of parallel interpenetration of 2D sheets, having polyrotaxane character.

关键词： 1,1′-(propane-1,3-diyl)dipyridinium-4-carboxylate polyrotaxane hydrogen bonding betaine derivative

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Study on the local time asymmetry of the Earth's ring currents based on multiple low-Earth-orbit satellite magnetic observations

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Science China(Technological Sciences) 2024年第11期67卷 3354-3364页

作者： OU JiaMing jiang yi YAN Qing State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao 999078China Macao Institute of Space Technology and Application Macao 999078China Zhuhai MUST Science and Technology Research Institute Macao University of Science and TechnologyZhuhai 519085China

The azimuthal morphology of Earth's ring currents has consistently shown asymmetry during extreme space weather events at low latitudes,particularly during geomagnetic storms.A dawn-dusk pattern has been detected during the storm main phase through near-Earth and in-situ magnetic *** asymmetry is believed to arise from asymmetric solar windmagnetosphere coupling and is linked to the closure of the ring *** evidence has confirmed the existence of asymmetric ring currents during quiet times and the storm recovery *** phenomenon may be closely related to the evolution of ring currents,including plasma injection and decay *** this study,the local time asymmetry of the ring current is estimated using data from low-Earth-orbit Swarm and Macao Science Satellite-1(MSS-1)*** harmonics models are developed to quantify the magnetic field of ring currents through external Gauss coefficients during both quiet periods and the storm recovery *** features of dawn-dusk asymmetry are observed in various cases in different months.(1)The maximum difference in magnetic value across local time ranges from 3 to 10 nT,showing relative invariance compared with various Sym-H levels.(2)Stronger magnetic signals are detected at the premidnight sector during quiet times and at the afternoon sector during the storm recovery phase.(3)Magnetic perturbations remain at a lower level during the postmidnight and morning *** the pattern of local time asymmetry differs between quiet times and the recovery phase,dawn-dusk asymmetry remains the most pronounced feature,affecting the trapping and loss of charged particles in the inner *** Swarm and MSS-1 magnetic observations can enable convenient monitoring of the detailed azimuthal local time effects of the ring current at various disturbance levels in the future.

关键词： Earth's ring currents local time asymmetry SHA model Macao Science Satellite-1

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Monkeys pass the mirror test after training

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Science China(Life Sciences) 2015年第4期58卷 405-406页

作者： ZHOU Wen jiang yi Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences CAS Center for Excellence in Brain Science Institute of Psychology Chinese Academy of Sciences State Key Laboratory of Brain and Cognitive Science Institute of Psychology Chinese Academy of Sciences

There is no experiencing without an experiencer, the self. Whether the experiencer knows it is ＂the self＂ that is experiencing is a different and tricky philosophical issue. Dating back to Ivan Pavlov＇s dogs, the ＂experience＂ of animals has been the subject of scientific research for over a century, yet to which extent different animals possess the sense of self is still hotly debated today. From human＇s perspective, the sense of self is the corner stone of feelings, thoughts, and social interactions--a necessity of higher intelligence.

关键词：测试镜子培训猴子哲学问题巴甫洛夫科学研究自我意识

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Experiment on the Nonlinear Phenomena in an Electron Cyclotron Resonance Plasma

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Chinese Physics Letters 1996年第12期13卷 916-918页

作者： YAO Xin-zi jiang De-yi Institute of Physics Chinese Academy of SciencesBeijing 100080

Two hysteresis loops and tristable states in an electron cyclotron resonance plasma system have been observed and oscillatory waveforms and their power spectra in different stable state are described in this *** the microwave power was increased,the oscillation with original fundamental frequency gradually transferred to harmonic frequencies and then sudden jumped to a regular oscillation with single fourth harmonic frequency.

关键词： harmonic oscillation Electron

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Data-driven cooperative optimal output regulation for linear discrete-time multi-agent systems by online distributed adaptive internal model approach

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Science China(Information Sciences) 2023年第7期66卷 30-45页

作者： Kedi XIE yi jiang Xiao YU Weiyao LAN Department of Automation Xiamen University Department of Electrical Engineering City University of Hong Kong Key Laboratory of Control and Navigation(Xiamen University) Fujian Province University

In this study, a data-driven learning algorithm was developed to estimate the optimal distributed cooperative control policy, which solves the cooperative optimal output regulation problem for linear discretetime multi-agent systems. Notably, the dynamics of all the agent systems and exo-system is completely unknown. By combining adaptive dynamic programming with an internal model, a model-free off-policy learning method is proposed to estimate the optimal control gain and the distributed adaptive internal model by only accessing the measurable data of multi-agent systems. Moreover, different from the traditional cooperative adaptive controller design method, a distributed internal model is approximated online. Convergence and stability analyses show that the estimate controller generated by the proposed data-driven learning algorithm converges to the optimal distributed controller. Finally, simulation results verify the effectiveness of the proposed method.

关键词： adaptive dynamic programming cooperative control distributed adaptive internal model multi-agent systems optimal output regulation

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