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GUARANTEED COST CONTROL OF CONTINUOUS-TIME UNCERTAIN SINGULAR SYSTEM WITH BOTH STATE AND INPUT DELAYS

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Annals of Differential Equations 2009年第4期25卷 483-489页

作者： Hai zhang 1,2 , Wei jiang 1 , Jun Du 1,3 (1. school of Mathematical sciences, Anhui university, Hefei 230039, 2. school of Math. and Computation science, Anqing Teachers College, Anqing 246011, Anhui 3. Dept. of Math., Huainan normal university, Huainan 232001, Anhui)

The guaranteed cost control problem for a continuous-time uncertain singular system with state and control delays, and a given quadratic cost function is studied in this paper. Sufficient conditions for the existence of the guaranteed cost controller are derived based on the linear inequality (LMI) approach. A parameterized characterization of the guaranteed cost laws is given in terms of the feasible solutions to a certain LMI, and the cost function of guaranteed cost controller exists an upper bound.

关键词： guaranteed cost control uncertain singular systems delays continuoustime systems LMI

Single-cell genomic profile-based analysis of tissue differentiation in colorectal cancer

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science china.Life sciences) 2021年第8期64卷 1311-1325页

作者： Hao jiang Hongquan zhang Xuegong zhang MOE Key Lab of Bioinformatics and Bioinformatics Division BNRISTDepartment of AutomationTsinghua-Peking Joint Center for Life SciencesCenter for Synthetic and Systems BiologyTsinghua UniversityBeijing 100084China MOE Key Laboratory of Carcinogenesis and Translational Research Department of Human AnatomyHistology and EmbryologyState Key Laboratory of Natural and Biomimetic DrugsPeking University Health Science CenterBeijing 100191China

Colorectal cancer(CRC) progression is associated with cancer cell dedifferentiation and stemness acquisition. Several methods have been developed to identify stemness signatures in CRCs. However, studies that directly measured the degree of dedifferentiation in CRC tissues are limited. It is unclear how the differentiation states change during CRC progression. To address this, we develop a method to analyze the tissue differentiation spectrum in colorectal cancer using normal gastrointestinal singlecell transcriptome data. Applying this method on 281 tumor samples from The Cancer Genome Atlas Colon Adenocarcinoma dataset, we identified three major CRC subtypes with distinct tissue differentiation pattern. We observed that differentiation states are closely correlated with anti-tumor immune response and patient outcomes in CRC. Highly dedifferentiated CRC samples escaped the immune surveillance and exhibited poor outcomes;mildly dedifferentiated CRC samples showed resistance to anti-tumor immune responses and had a worse survival rate;well-differentiated CRC samples showed sustained anti-tumor immune responses and had a good prognosis. Overall, the spectrum of tissue differentiation observed in CRCs can be used for future clinical risk stratification and subtype-based therapy selection.

关键词： colorectal cancer sustained

Complex Network Classification with Convolutional Neural Network

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Tsinghua science and Technology 2020年第4期25卷 447-457页

作者： Ruyue Xin jiang zhang Yitong Shao school of systems science Beijing Normal UniversityBeijing 100875China school of Mathematical sciences Beijing Normal UniversityBeijing 100875China

Classifying large-scale networks into several categories and distinguishing them according to their fine structures is of great importance to several real-life ***,most studies on complex networks focus on the properties of a single network and seldom on classification,clustering,and comparison between different networks,in which the network is treated as a *** methods can hardly be applied on networks directly due to the non-Euclidean properties of *** this paper,we propose a novel framework of Complex Network Classifier(CNC)by integrating network embedding and convolutional neural network to tackle the problem of network *** training the classifier on synthetic complex network data,we show CNC can not only classify networks with high accuracy and robustness but can also extract the features of the networks *** also compare our CNC with baseline methods on benchmark datasets,which shows that our method performs well on large-scale networks.

关键词： complex network network classification Deep Walk Convolutional Neural Network(CNN)

Application of multi-pulse optical imaging to measure evolution of laser-produced counter-streaming flows

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Chinese Physics B 2017年第5期26卷 165-169页

作者：袁大伟李玉同朱保君李彦霏仲佳勇魏会冈刘畅原晓霞张喆梁贵云王菲鹿李芳赵家瑞华能朱宝强朱健强江少恩杜凯丁永坤赵刚张杰 Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences school of Physical sciences University of Chinese Academy of Sciences Collaborative Innovation Center of IFSA(CICIFSA) Shanghai Jiaotong University department of Astronomy Beijing Normal University National Laboratory on High Power Lasers and Physics Research Center for Laser Fusion China Academy of Engineering Physics Key Laboratory for Laser Plasmas(Ministry of Education)and department of Physics and Astronomy Shanghai Jiao Tong University

A counter-streaming flow system is a test-bed to investigate the astrophysical collisionless shock（CS） formation in the laboratory. Electrostatic/electromagnetic instabilities, competitively growing in the system and exciting the CS formation, are sensitive to the flows parameters. One of the most important parameters is the velocity, determining what kind of instability contributes to the shock formation. Here we successfully measure the evolution of the counter-streaming flows within one shot using a multi-pulses imaging diagnostic technique. With the technique, the average velocity of the high-density-part（ne ≥ 8–9 × 10^19cm^-3） of the flow is directly measured to be of ～ 10^6cm/s between 7 ns and 17 ***, the average velocity of the low-density-part（ne ≤ 2 × 10^19cm^-3） can be estimated as ～ 10^7cm/s. The experimental results show that a collisionless shock is formed during the low-density-part of the flow interacting with each other.

关键词： streaming counter interacting exciting instability determining diagnostic colors distinguish gamma

Estimation of the effect of target and normal tissue sparing based on equivalent uniform dose-based optimization in hypofractionated radiotherapy for lung cancer

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Oncology and Translational Medicine 2019年第5期5卷 197-203页

作者： Ying Shao Fuli zhang Shi Wang Weidong Xu Jing jiang Deparment of Radiotherapy The Seventh Medical CenterPLA General Hospital/Beijing Tsinghua Changgeng Hospital affiliated to Tsinghua UniversityBeijing 102218China department of Radiotherapy The Seventh Medical CenterPLA General HospitalBeijing 100700China department of Engineering Physics Tsinghua UniversityBeijing 100084China

Objective This study aims to investigate the dosimetric differences among four planning methods of physical and biological optimization in hypofractionated radiation therapy for non-small cell lung cancer(NSCLC).Methods Ten NSCLC patients receiving radiation therapy were chosen for this retrospective *** modulated arc treatment plans for each patient were remade with dose-volume(DV)functions,biological-physical functions,and biological functions,using the same constraint parameters during *** dosimetric differences between the four types of plans were calculated and *** For the target,equivalent uniform dose(EUD)of the EUD and EUD+DV groups was approximately 2.8%–3.6%and 3.2%–3.7%higher than those of the DV and DV+EUD groups,*** average tumor control probability(TCP)of the EUD and EUD+DV groups was also significantly higher than those of the other two groups(P0.05).For the organs at risk,the differences of EUD,V5,V10,V20,V30 of normal lung tissues were not statistically significant(P>0.05);however,the mean lung dose of the EUD and EUD+DV groups was slightly lower than those of the other two *** The biological optimization method has obvious advantages of improving EUD and TCP of the target,while decreasing the exposed dose of normal *** result is meaningful in choosing plan optimization methods in routine work.

关键词： non-small cell lung cancer(NSCLC) equivalent uniform dose(EUD) hypofractionated radiotherapy plan optimization

The infrared spectral features of circumstellar envelope of evolved low- and intermediate-mass stars

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science china.Physics,Mechanics & Astronomy) 2008年第9期51卷 1187-1199页

作者： zhang Ke jiang BiWei department of Astronomy Beijing Normal UniversityBeijing 100875China

The circumstellar envelope of evolved stars of low- and intermediate-mass is an important site for dust formation. In comparison with the interstellar medium, they have more types of organics and different types of inorganics. Various infrared features in the circumstellar envelope can reveal the composition and abundance of dust, as well as the chemical and physical conditions of the circumstellar shell. Infrared features and their carriers are different in the C-rich or O-rich environment, and the mixed-environment where the C-rich and O-rich circumstellar materials co-exist. The C-rich sources exhibit a series of spectral features which are attrib- uted to organic molecules. They also show two prominent features at 21 μm and 30 μm which emit a large portion of infrared radiation. The O-rich sources exhibit the strong 9.7 μm and 18 μm features attributed to the Si-O bending and O-Si-O stretching modes of amorphous silicate dust. With the ISO/SWS spectrometer, about 50 narrow bands are identified with the crystalline silicate grains, mainly forsterite and enstatite. In addition, a series of features, at 13 μm, 16.8 μm, 19.5 μm and 31.8 μm, appearing to be correlated with each other, are attributed to oxides. Some objects simultaneously show the C-rich and O-rich features, e.g. some C-rich sources have silicate features. There is no well-accepted interpretation for such mixed appearance, though a binary model is suggested.

关键词： star: AGB post-AGB PN star: circumstellar matter infrared: star

Multi-omic Analyses Shed Light on The Genetic Control of High-altitude Adaptation in Sheep

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 43-56页

作者： Chao Li Bingchun Chen Suo Langda Peng Pu Xiaojia Zhu Shiwei Zhou Peter Kalds Ke zhang Meenu Bhati Alexander Leonard Shuhong Huang Ran Li Awang Cuoji Xiran Wang Haolin Zhu Yujiang Wu Renqin Cuomu Ba Gui Ming Li Yutao Wang Yan Li Wenwen Fang Ting Jia Tianchun Pu Xiangyu Pan Yudong Cai Chong He Liming Wang Yu jiang Jian-Lin Han Yulin Chen Ping Zhou Hubert Pausch Xiaolong Wang International Joint Agriculture Research Center for Animal Bio-Breeding Ministry of Agriculture and Rural Affairs/Key Laboratory of Animal GeneticsBreeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Animal Genomics ETH ZürichZürich 8092Switzerland Institute of Animal science Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa 850009China school of Biological and Pharmaceutical Engineering Lanzhou Jiaotong UniversityLanzhou 730070China College of Life sciences Shaanxi Normal UniversityXi’an 710119China Zoology and Evolutionary Biology Department of BiologyUniversity of Konstanz78457 KonstanzGermany College of Life and Geographic sciences Kashi UniversityKashi 844000China beijing Key Laboratory of Captive Wildlife Technologies Beijing ZooBeijing 100044China department of Medical Research Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Key Laboratory of Agricultural Internet of Things Ministry of Agriculture and Rural Affairs/Shaanxi Key Laboratory of Agricultural Information Perception and Intelligent ServiceCollege of Information EngineeringNorthwest A&F UniversityYangling 712100China Institute of Animal Husbandry and Veterinary Medicine Xinjiang Academy of Agricultural and Reclamation SciencesShihezi 832000China State Key Laboratory of Sheep Genetic Improvement and Healthy Production Xinjiang Academy of Agricultural and Reclamation SciencesShihezi 832000China CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China Livestock Genetics Program International Livestock Research InstituteNairobi 00100Kenya

Sheep were domesticated in the Fertile Crescent and then spread globally,where they have been encountering various environmental *** Tibetan sheep has adapted to high altitudes on the Qinghai-Tibet Plateau over the past 3000 *** explore genomic variants associated with high-altitude adaptation in Tibetan sheep,we analyzed Illumina short-reads of 994 whole genomes representing∼60 sheep breeds/populations at varied altitudes,PacBio High fidelity(HiFi)reads of 13 breeds,and 96 transcriptomes from 12 sheep *** testing between the inhabited altitudes and 34,298,967 variants was conducted to investigate the genetic architecture of altitude *** accurate HiFi reads were used to complement the current ovine reference assembly at the most significantly associatedβ-globin locus and to validate the presence of two haplotypes A and B among 13 sheep *** haplotype A carried two homologous gene clusters:(1)HBE1,HBE2,HBB-like,and HBBC,and(2)HBE1-like,HBE2-like,HBB-like,and HBB;while the haplotype B lacked the first *** high-altitude sheep showed highly frequent or nearly fixed haplotype A,while the low-altitude sheep dominated by haplotype *** further demonstrated that sheep with haplotype A had an increased hemoglobin–O2 affinity compared with those carrying haplotype *** highly associated genomic region contained the EGLN1 gene which showed varied expression between high-altitude and low-altitude *** results provide evidence that the rapid adaptive evolution of advantageous alleles play an important role in facilitating the environmental adaptation of Tibetan sheep.

关键词： Environmental adaptation High altitude Hypoxia Selection signature Sheep

区域生态系统可持续发展的生态价值评价——以宁夏灵武市为例

维普期刊数据库评论

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生态学报 2002年第10期22卷 1573-1580页

作者：宗跃光周尚意温良郭瑞华张振世徐宏彦陈红春北京师范大学资源与环境科学系 100875 国地土地估价中心 100785 深圳市规划与国土资源局福田分局 518045

根据我国西部大开发战略 ,从生态经济价值理论出发 ,研究区域生态系统服务功能的价值体系及其基本估价方法。结合我国国情 ,将 Costanza等人单纯自然资本的测算推广到自然、经济、社会综合资本的测算 ,重点突出人类活动干扰下的区域生... 详细信息

根据我国西部大开发战略 ,从生态经济价值理论出发 ,研究区域生态系统服务功能的价值体系及其基本估价方法。结合我国国情 ,将 Costanza等人单纯自然资本的测算推广到自然、经济、社会综合资本的测算 ,重点突出人类活动干扰下的区域生态系统资本价值结构分析。研究表明 :1 997年灵武市牧草地和水域提供的资本价值约占自然资本总价值的97% ,工矿业消耗的自然资本占自然资本总损耗的 84 %。根据本文的全面测算结果 ,1 990～ 1 997年灵武市生态价值总资本年均递增 4 .5 % ,它将部分抵消该市国民生产总值 1 2 .6 %年均增长率。此外 ,如果用自然资本的增减作为强可持续发展的临界指标 ,1 990～ 1 997年本区域自然总资本以年均 4 %的速度递减。

关键词：区域生态系统可持续发展生态价值宁夏灵武环境影响评价

Emerging contaminants:A One Health perspective

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The Innovation 2024年第4期5卷 140-170,139页

作者： Fang Wang Leilei Xiang Kelvin Sze-Yin Leung Martin Elsner Ying zhang Yuming Guo Bo Pan Hongwen Sun Taicheng An Guangguo Ying Bryan WBrooks Deyi Hou Damian EHelbling Jianqiang Sun Hao Qiu Timothy MVogel Wei zhang Yanzheng Gao Myrna JSimpson Yi Luo Scott XChang Guanyong Su Bryan MWong Tzung-May Fu Dong Zhu Karl JJobst Chengjun Ge Frederic Coulon Jean Damascene Harindintwali Xiankui Zeng Haijun Wang Yuhao Fu Zhong Wei Rainer Lohmann Changer Chen Yang Song Concepcion Sanchez-Cid Yu Wang Ali El-Naggar Yiming Yao Yanran Huang Japhet Cheuk-Fung Law Chenggang Gu Huizhong Shen Yanpeng Gao Chao Qin Hao Li Tong zhang Natàlia Corcoll Min Liu Daniel SAlessi Hui Li Kristian KBrandt Yolanda Pico Cheng Gu Jianhua Guo Jianqiang Su Philippe Corvini Mao Ye Teresa Rocha-Santos Huan He Yi Yang Meiping Tong Weina zhang Fidèle Suanon Ferdi Brahushi Zhenyu Wang Syed AHashsham Marko Virta Qingbin Yuan Gaofei jiang Louis A.Tremblay Qingwei Bu Jichun Wu Willie Peijnenburg Edward Topp Xinde Cao Xin jiang Minghui Zheng Taolin zhang Yongming Luo Lizhong Zhu Xiangdong Li DamiàBarceló Jianmin Chen Baoshan Xing Wulf Amelung Zongwei Cai Ravi Naidu Qirong Shen Janusz Pawliszyn Yong-guan Zhu Andreas Schaeffer Matthias C.Rillig Fengchang Wu Gang Yu James M.Tiedje State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China university of Chinese Academy of sciences Beijing 100049China department of Chemistry Hong Kong Baptist UniversityHong KongChina HKBU Institute of Research and Continuing Education Shenzhen Virtual University ParkShenzhenChina Technical university of Munich TUM School of Natural SciencesInstitute of Hydrochemistry85748 GarchingGermany school of Resources&Environment Northeast Agricultural UniversityHarbin 150030China Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourneVICAustralia Faculty of Environmental science&Engineering Kunming University of Science&TechnologyKunming 650500China Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key Laboratory of Environmental Theoretical Chemistry South China Normal UniversityGuangzhouGuangdong 510006China department of Environmental science Baylor UniversityWacoTXUSA Center for Reservoir and Aquatic systems Research(CRASR) Baylor UniversityWacoTXUSA school of Environment Tsinghua UniversityBeijing 100084China school of Civil and Environmental Engineering Cornell UniversityIthacaNY 14853USA Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province Zhejiang University of TechnologyHangzhou 310014China school of Environmental science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Laboratoire d’Ecologie Microbienne Universite Claude Bernard Lyon 1UMR CNRS 5557UMR INRAE 1418VetAgro Sup69622 VilleurbanneFrance department of Pla

Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary *** global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the *** response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental science-Policy Panel on Chemicals,Waste,and Pollution *** review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One Health *** for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international *** actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.

关键词： pollution planet contaminants