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Stability and variability of molecular subtypes:comparative analysis of primary and metastatic triple-negative breast cancer

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Cancer Biology & Medicine 2024年第9期21卷 784-798页

作者： Xiuzhi Zhu Xiaohan ying Yin Liu Yunyi Wang Li Chen Zhiming Shao Xi Jin Yizhou jiang Zhonghua Wang Key Laboratory of Breast Cancer in Shanghai Shanghai Institute of Infectious Disease and BiosecurityDepartment of OncologyShanghai Medical CollegeFudan UniversityShanghai 200000China Department of Breast Surgery Fudan University Shanghai Cancer CenterShanghai 200000China

Objective:Triple-negative breast cancer(TNBC)is a heterogeneous and aggressive *** our previous study classified primary TNBC into four subtypes,comprehensive longitudinal investigations are ***:We assembled a large-scale,real-world cohort comprised of 880 TNBC patients[465 early-stage TNBC(eTNBC)and 415 metastatic TNBC(mTNBC)patients]who were treated at Fudan University Shanghai Cancer *** longitudinal dynamics of TNBC subtypes during disease progression were elucidated in this patient *** analysis was performed to compare primary and metastatic lesions within specific TNBC ***:The recurrence and metastasis rates within 3 years after initial diagnosis in the eTNBC cohort were 10.1%(47/465).The median overall survival(OS)in the mTNBC cohort was 27.2 months[95%confidence interval(CI),24.4–30.2 months],which indicated a poor *** prognostic significance of the original molecular subtypes in both eTNBC and mTNBC patients was *** molecular subtypes were maintained in 77.5%of the patients throughout disease progression with the mesenchymal-like(MES)subtype demonstrating a tendency for subtype transition and brain ***,a precision treatment strategy based on the metastatic MES subtype of target lesions resulted in improved progression-free survival in the FUTURE ***:Our longitudinal study comprehensively revealed the clinical characteristics and survival of patients with the original TNBC subtypes and validated the consistency of most molecular subtypes throughout disease ***,we emphasize the major importance of repeat pathologic confirmation of the MES subtype.

关键词： Triple-negative breast cancer molecular subtype metastasis primary tumor overall survival

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Association between Serum Ferritin Levels and Metabolic-associated Fatty Liver Disease in Adults:a Cross-sectional Study Based on the NHANES

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Current Medical Science 2024年第3期44卷 494-502页

作者： jiang-hui LI Xue-yao MA Yun YI Lu-rao LI Zhi-yong XU ying CHANG Department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhan430071China Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases Wuhan430071China Endoscopy Center The People’s Hospital of YingshanHuanggang438799China

Objective Ferritin,initially acting as an iron-storage protein,was found to be associated with metabolic *** study was designed to investigate the association between serum ferritin and metabolic-associated fatty liver disease(MAFLD)using data from the National Health and Nutrition Examination Survey(NHANES)of the United State of *** A cross-sectional study was conducted,enrolling a total of 2145 participants from the NHANES in the 2017–2018 *** steatosis and liver fibrosis were assessed by ultrasound images and several non-invasive *** regression analysis was conducted to determine the associations between serum ferritin concentration and MAFLD and liver *** The analysis revealed that participants with higher serum ferritin levels(Q3 and Q4 groups)had a higher prevalence of MAFLD than those with the lowest serum ferritin levels[Q3 vs.Q1:OR=2.17(1.33,3.53),P<0.05 in fatty liver index(FLI);Q4 vs.Q1:OR=3.13(1.91,5.13),P<0.05 in FLI].Additionally,participants with the highest serum ferritin levels(Q4 group)displayed a higher prevalence of liver fibrosis[Q4 vs.Q1:OR=2.59(1.19,5.62),P<0.05 in liver stiffness measurement;OR=5.06(1.12,22.94),P<0.05 in fibrosis-4 index],with significantly increased risk observed in participants with concomitant diabetes[OR=7.45(1.55,35.72),P=0.012].Conclusion Our study revealed that elevated serum ferritin levels are associated with a higher prevalence of MAFLD and advanced liver fibrosis in *** serum ferritin levels combined with diabetes are important risk factors for liver fibrosis.

关键词： serum ferritin liver fibrosis metabolic-associated fatty liver disease National Health and Nutrition Examination Survey

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Recent advances in multifunctional metal-organic frameworks for lithium metal batteries

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Science China Chemistry 2024年第3期67卷 759-773页

作者： Jiaqi Li Zheng Weng Zuosu Qin ying Zhang Ning Zhang Xiaohe Liu Chuankun Jia Gen Chen jiang Zhou School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan ProvinceCentral South University Zhongyuan Critical Metals Laboratory Zhengzhou University College of Materials Science and Engineering Changsha University of Science&Technology

In view of novel materials in the field of lithium metal batteries(LMBs), metal-organic frameworks(MOFs) have attracted extensive research interest owing to their controllable pore size, unsaturated metal sites and multifunctional organic groups. A variety of MOFs have been elaborately calculated and synthesized to be applied as separator coating, electrolyte modulators and solid-state electrolyte fillers in LMBs. In this mini-review, we summarize the mechanism of MOFs to limit the migration of anions, improve the Li-ion transference number and prolong the lifespan of LMBs. Suitable pore structure of MOFs can physically restrict the movement of Li^(+). Unsaturated metal sites can adsorb anions by electrostatic interaction. In addition,multifunctional organic functional groups that limit the migration of anions are discussed. Finally, the key challenges and perspectives in the development direction of MOFs-based separators and electrolytes are further elaborated.

关键词： metal-organic frameworks lithium metal battery separator electrolyte

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Treatment of hypocalcemia caused by hypoparathyroidism or pseudohypoparathyroidism with domestic-made calcitrioh a prospective and self-controlled clinical trial

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Chinese Medical Journal 2009年第3期122卷 279-283页

作者： WANG Ou XING Xiao-ping MENG Xun-wu XIA Wei-bo LI Mei jiang Yan HU ying-ying LIU Huai-cheng Department of Endocrinology Key Lab of Endocrinology Ministryof Health Peking Union Medical College Hospital ChineseAcademy of Medical Sciences Beijing 100730 China

Background Parathyroid hormone deficiency or resistance may cause hypocalcemia with related symptoms and signs. Lifelong treatment of calcium combined with vitamin D or its metabolites is always necessary for these patients. Here we reported a prospective and open-label trial to investigate the efficacy and safety of domestic-made calcitriol in treatment of hypocalcemia caused by hypoparathyroidism or pseudohypoparathyroidism. Methods Twenty-four patients with confirmed hypoparathyroidism or pseudohypoparathyroidism aged （36.5±11.0） years old were studied. Among them, 16 patients had idiopathic hypoparathyroidism, 2 had pseudohypoparathyroidism and 6 had hypoparathyroidism secondary to cervical surgery. Serum calcium levels were lower than 1.88 mmol/L. Oral calcitriol was administered twice or three times with elemental calcium 1.2 g per day. All patients were followed every 4 weeks throughout the 12-week period. Dose adjustments of calcitriol were based on serum and urinary calcium levels and symptoms of hypocalcemia. Results Twenty patients were included by the end of this study. Muscular weakness, cramps, extremity paresthesia, Chovestek＇s sign and Trousseau＇s sign were relieved in 76.9%, 100%, 94.4%, 93.3% and 78.9% of patients, respectively. Serum calcium, plasma ionized calcium and serum phosphorus levels were （1.54±0.25） mmol/L, （0.64±0.10） mmol/L and （2.00±0,46） mmol/L at baseline, and reached （2.20±0.20） mmol/L, （0.95±0.06） mmol/L and （1.68±0.25） mmol/L （P 〈0.01） at the 12th week of treatment, respectively. Eighty percent of patients were assessed as effective and 20% as partly effective. Three, four and eight patients had hypercalciuria at the 4th, 8th and 12th week of treatment, respectively, which were reduced by thiazide diuretics. The final dose of calcitriol was （1.09±0.50） ug/d. Conclusions Calcitriol combined with calcium can be used in treatment of hypocalcemia caused by hypoparathyroidism or pseudohypoparathyroidism effectively and safely. Serum a

关键词： hypocalcemia hypoparathyroidism pseudohypoparathyroidism calcitriol

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A vicinal oxygen chelate protein facilitates viral infection by triggering the unfolded protein response in Nicotiana benthamiana

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Journal of Integrative Plant Biology 2024年第7期66卷 1481-1499页

作者： Zhihong Guo Ning jiang Menglin Li Hongfang Guo Qi Liu Xinyu Qin Zongying Zhang Chenggui Han ying Wang Ministry of Agriculture and Rural Affairs Key Laboratory of Pest Monitoring and Green Management College of Plant ProtectionChina Agricultural UniversityBeijing 100193China

Vicinal oxygen chelate(VOC)proteins are members of an enzyme superfamily with dioxygenase or non-dioxygenase ***,the biological functions of VOC proteins in plants are poorly ***,we show that a VOC in Nicotiana benthamiana(NbVOC1)facilitates viral ***1 was significantly induced by infection by beet necrotic yellow vein virus(BNYVV).Transient overexpression of NbVOC1 or its homolog from Beta vulgaris(BvVOC1)enhanced BNYVV infection in ***,which required the nuclear localization of *** with this result,overexpressing NbVOC1 facilitated BNYVV infection,whereas,knockdown and knockout of NbVOC1 inhibited BNYVV infection in transgenic *** ***1 interacts with the basic leucine zipper transcription factors bZIP17/28,which enhances their self-interaction and DNA binding to the promoters of unfolded protein response(UPR)-related *** propose that bZIP17/28 directly binds to the NbVOC1 promoter and induces its transcription,forming a positive feedback loop to induce the UPR and facilitating BNYVV ***,our results demonstrate that NbVOC1 positively regulates the UPR that enhances viral infection in plants.

关键词： beet necrotic yellow vein virus bZIP17/28 Nicotiana benthamiana unfolded protein response VOC1

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Multivariate modular metabolic engineering and medium optimization for vitamin B_(12)production by Escherichia coli

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Synthetic and Systems Biotechnology 2024年第3期9卷 453-461页

作者： Feitao Chen Huan Fang jianghua Zhao Pingtao jiang Huina Dong ying Zhao Huiying Wang Tongcun Zhang Dawei Zhang College of Biotechnology Tianjin University of Science&TechnologyTianjin300457China Tianjin Institute of Industrial Biotechnology Chinese Academy of SciencesTianjin300308China University of Chinese Academy of Science Beijing100049China Key Laboratory of Engineering Biology for Low-Carbon Manufacturing Tianjin Institute of Industrial BiotechnologyChinese Academy of SciencesTianjin 300308China National Center of Technology Innovation for Synthetic Biology Tianjin300308China

Vitamin B_(12)is a complex compound synthesized by *** industrial production of vitamin B_(12)relies on specific microbial fermentation *** has been utilized as a host for the de novo biosynthesis of vitamin B_(12),incorporating approximately 30 heterologous ***,a metabolic imbalance in the intricate pathway significantly limits vitamin B_(12)*** this study,we employed multivariate modular metabolic engineering to enhance vitamin B_(12)production in *** by manipulating two modules comprising a total of 10 genes within the vitamin B_(12)biosynthetic *** two modules were integrated into the chromosome of a chassis cell,regulated by T7,J23119,and J23106 promoters to achieve combinatorial pathway *** highest vitamin B_(12)titer was attained by engineering the two modules controlled by J23119 and T7 *** inclusion of yeast powder to the fermentation medium increased the vitamin B_(12)titer to 1.52 mg/*** enhancement was attributed to the effect of yeast powder on elevating the oxygen transfer rate and augmenting the strain’s isopropyl-β-D-1-thiogalactopyranoside(IPTG)***,vitamin B_(12)titer of 2.89 mg/L was achieved through scaled-up fermentation in a 5-liter *** strategies reported herein will expedite the development of industry-scale vitamin B_(12)production utilizing ***.

关键词： Vitamin B_(12) Multivariate modular metabolic engineering E.coli Organic nitrogen sources Fed-batch fermentation

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Heparin is an effective treatment for preventing liver failure after hepatectomy

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World Journal of Gastroenterology 2024年第22期30卷 2881-2892页

作者： Zhi-ying Xu Min Peng Ming-Ming Fan Qi-Fei Zou Yi-Ran Li Dong jiang Hepatic Surgery IV Shanghai Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai 200433China Ultrasound Diagnosis PLA Naval Medical CenterShanghai 200437China Department of Ultrasound Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai 200433China

BACKGROUND Posthepatectomy liver failure(PHLF)is one of the most important causes of death following liver ***,an established anticoagulant,can protect liver function through a number of mechanisms,and thus,prevent liver *** To look at the safety and efficacy of heparin in preventing hepatic dysfunction after *** The data was extracted from Multiparameter Intelligent Monitoring in Intensive Care III(MIMIC-III)v1.4 pinpointed patients who had undergone hepatectomy for liver cancer,subdividing them into two cohorts:Those who were injected with heparin and those who were *** statistical evaluations used were unpaired ttests,Mann-Whitney U tests,chi-square tests,and Fisher’s exact tests to assess the effect of heparin administration on PHLF,duration of intensive care unit(ICU)stay,need for mechanical ventilation,use of continuous renal replacement therapy(CRRT),incidence of hypoxemia,development of acute kidney injury,and ICU *** regression was utilized to analyze the factors related to PHLF,with propensity score matching(PSM)aiming to balance the preoperative disparities between the two *** In this study,1388 patients who underwent liver cancer hepatectomy were *** yielded 213 matched pairs from the heparin-treated and control *** univariate analyses indicated that heparin potentially reduces the risk of PHLF in both matched and unmatched *** analysis in the matched cohorts confirmed a significant association,with heparin reducing the risk of PHLF(odds ratio:0.518;95%confidence interval:0.295-0.910;P=0.022).Additionally,heparin treatment correlated with improved short-term postoperative outcomes such as reduced ICU stay durations,diminished requirements for respiratory support and CRRT,and lower incidences of hypoxemia and ICU *** Liver failure is an important hazard following hepatic *** ICU care heparin administration has been proved to decr

关键词： Liver resection Posthepatectomy liver failure Prophylactic treatment Heparin Prognosis of hepatectomy

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Construction and validation of a pancreatic cancer prognostic model based on genes related to the hypoxic tumor microenvironment

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World Journal of Gastroenterology 2024年第36期30卷 4057-4070页

作者： Fan Yang Na jiang Xiao-Yu Li Xing-Si Qi Zi-Bin Tian ying-Jie Guo Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Pancreatic cancer is one of the most lethal malignancies,characterized by poor prognosis and low survival *** prognostic factors for pancreatic cancer offer inadequate predictive accuracy,often failing to capture the complexity of the *** hypoxic tumor microenvironment has been recognized as a significant factor influencing cancer progression and resistance to *** study aims to develop a prognostic model based on key hypoxia-related molecules to enhance prediction accuracy for patient outcomes and to guide more effective treatment strategies in pancreatic *** To develop and validate a prognostic model for predicting outcomes in patients with pancreatic cancer using key hypoxia-related *** This pancreatic cancer prognostic model was developed based on the expression levels of the hypoxia-associated genes CAPN2,PLAU,and *** results were validated in an independent *** study also examined the correlations between the model risk score and various clinical features,components of the immune microenvironment,chemotherapeutic drug sensitivity,and metabolism-related ***-time quantitative PCR verification was conducted to confirm the differential expression of the target genes in hypoxic and normal pancreatic cancer cell *** The prognostic model demonstrated significant predictive value,with the risk score showing a strong correlation with clinical features:It was significantly associated with tumor grade(G)(bP<0.01),moderately associated with tumor stage(T)(aP<0.05),and significantly correlated with residual tumor(R)status(bP<0.01).There was also a significant negative correlation between the risk score and the half-maximal inhibitory concentration of some chemotherapeutic ***,the risk score was linked to the enrichment of metabolism-related pathways in pancreatic *** The prognostic model based on hypoxia-related genes effectively predicts pancreati

关键词： Pancreatic cancer Hypoxia Prognostic model Immune microenvironment Metabolism pathway

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理性选择与社会信任:迈向经济学和社会学的新综合

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南京大学学报（哲学．人文科学．社会科学） 2009年第2期46卷 135-141页

作者：徐琴姜莹莹江苏省社科院社会学所南京210013 南京大学社会学系南京210093

信任与理性的关系经历了综合—分离—新综合三个阶段,理性选择理论沟通了长期分离的经济学和社会学,并推动两者不断迈向新综合。在这个过程中,以威廉姆森为代表的经济学家秉承理性选择理论,坚持认为在市场中选择信任是非理性行为。社会... 详细信息

信任与理性的关系经历了综合—分离—新综合三个阶段,理性选择理论沟通了长期分离的经济学和社会学,并推动两者不断迈向新综合。在这个过程中,以威廉姆森为代表的经济学家秉承理性选择理论,坚持认为在市场中选择信任是非理性行为。社会学家通过对信任的不同解释,积极回应了理性选择理论:格兰诺维特证实经济行动嵌入社会结构,将社会结构作为个人理性选择的背景;科尔曼将理性选择理论引入社会学,并对其进行了扩展;福山则通过信任研究提供了理性选择之外的解释道路。时代发展到今天,社会学和经济学的融合趋势日渐明显,社会信任和理性选择作为经济学和社会学共同关注的领域,在促进两学科的研究者展开对话,并构建经济学和社会学新综合的格局中发挥着作用。

关键词：信任理性选择新综合

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Bromocriptine protects perilesional spinal cord neurons from lipotoxicity after spinal cord injury

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Neural Regeneration Research 2024年第5期19卷 1142-1149页

作者： ying Peng Zhuoxuan Li Zhiyang Zhang yinglun Chen Renyuan Wang Nixi Xu Yuanwu Cao Chang jiang Zixian Chen Haodong Lin Trauma Center Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Orthopedics Zhongshan HospitalFudan UniversityShanghaiChina Department of Rehabilitation Medicine Shanghai Geriatric Medical CenterShanghaiChina

Recent studies have revealed that lipid droplets accumulate in neurons after brain injury and evoke lipotoxicity,damaging the ***,how lipids are metabolized by spinal cord neurons after spinal cord injury remains ***,we investigated lipid metabolism by spinal cord neurons after spinal cord injury and identified lipid-lowering compounds to treat spinal cord *** found that lipid droplets accumulated in perilesional spinal cord neurons after spinal cord injury in *** droplet accumulation could be induced by myelin debris in HT22 *** debris degradation by phospholipase led to massive free fatty acid production,which increased lipid droplet synthesis,β-oxidation,and oxidative *** oxidative phosphorylation increased reactive oxygen species generation,which led to increased lipid peroxidation and HT22 cell *** was identified as a lipid-lowering compound that inhibited phosphorylation of cytosolic phospholipase A2 by reducing the phosphorylation of extracellular signal-regulated kinases 1/2 in the mitogen-activated protein kinase pathway,thereby inhibiting myelin debris degradation by cytosolic phospholipase A2 and alleviating lipid droplet accumulation in myelin debris-treated HT22 *** function,lipid droplet accumulation in spinal cord neurons and neuronal survival were all improved in bromocriptine-treated mice after spinal cord *** results suggest that bromocriptine can protect neurons from lipotoxic damage after spinal cord injury via the extracellular signal-regulated kinases 1/2-cytosolic phospholipase A2 pathway.

关键词： bromocriptine central nervous system cytosolic phospholipase A2 high-content screening lipid droplet lipid metabolism lipotoxicity mitogen-activated protein kinase spinal cord injury spinal cord neurons

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