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A comparative study on the levels of serum cytokines and cortisol among post-traumatic stress disorder patients of Li and Han ethnicities in Hainan

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Chinese Medical Journal 2014年第15期127卷 2771-2774页

作者： Chen Tao Guo Min Gao Yunsuo Chen Feng Guo Juncheng Liu Tao Wu Duoyu jiang xianglin Department of Neurology Hainan People's Hospital Haikou Hainan570311 China Medical Records Room Hainan People's Hospital Haikou Hainan570311 China Departmentof Radiology Hainan People's Hospital Haikou Hainan570311 China

Background Post-traumatic stress disorder （PTSD） is a mental disorder with delayed or chronic onset caused by unusual,threatening,or disastrous psychological trauma,and it is an important manifestation of post-disaster mental and behavioral *** have shown that IL-6 is a cytokine associated with PTSD *** study aimed to explore the role of cytokine and ethnicity in the pathogenesis of PTSD by examining levels of serum cytokines IL-2,IL-6,IL-8,TNF-α,and cortisol in PTSD patients of Li and Han ethnic *** Levels of serum cytokines IL-2,IL-6,IL-8,TNF-α,and cortisol were examined by enzyme-linked immunoabsorbent assay （ELISA） method and assessed by PCL-C scale among 30 PTSD patients of Han ethnicity and 30 of Li ethnicity,and compared with 30 normal controls of Han and Li ethnicity,*** PTSD patients of Li ethnicity scored higher than PTSD patients of Han ethnicity,and normal controls of Li and Han ethnic groups in each of the re-experiencing,avoidance/numbing,and hyperarousal *** differences reached statistical significance （P 〈0.05）.In PTSD patients of Li ethnicity compared to patients of Han ethnicity and normal controls of either Li or Han ethnicity,the levels of IL-2,IL-6,IL-8,and TNF-α were higher,and the level of cortisol was *** There are ethnic differences in re-experiencing,avoidance/numbing,and hyperarousal symptoms among PTSD *** levels of serum cortisol and cytokines are strongly associated with the race.

关键词： Li ethnicity and Han ethnicity cytokine, cortisol post-traumatic stress disorder

Screening of the carcinogenesis associated gene in gastric mucosa by gene chip

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The Chinese-German Journal of Clinical Oncology 2007年第1期6卷 32-36页

作者： Shenhua Xu Chuanding Yu Hangzhou Mou Zhiming jiang Chihong Zhu xianglin Liu Zhejiang Cancer Research Institute Hangzhou 310022 China

Objective： To study the difference of gene expression and screen the carcinogenesis associated gene in gastric mucosa by oligonucleotide microarray. Methods： Using the U133A gene chip to detect the gene expression profile difference between pericancerous mucosa （mucosa inside nearly 2 cm by cancer） and normal section of gastric mucosa. Bioinformatics was used to analyze the detected result on their localization and function in chromosome. Results＂（1） A total of 150 genes with a difference of more than 3 times in expression levels by comparing the pericancerous mucosa with normal gastric mucosa, of 130 genes were up-regulated （SLR〉I.5）, and 20 were down- regulated （SLR〈 -1.5）. From the gene expression difference was to do the function classification, among those 22 enzyme and 6 enzyme regular genes were most one （18.7%）. The next were 17 nucleic acid binding associated genes （11.3%）. The third were 15 signal transduction associated genes （10%）. Fourth, were 13 protein binding associated genes （8.7%）. Besides the 40 genes were unknown their function, above mentioned 4 groups were 48.7% of the gene total number; （2） The pericancerous mucosa （P） and gastric cancer （T） were simultaneously compared with normal gastric mucosa, which had 71 genes with the same expression difference, of 61 genes were up-regulated （pericancerous SLR〉I.5）, and other 10 genes were down-regulated （pericancerous SLR〈 -1.5）. From their localization on the chromosome, there was simultaneously 71 genes appearance both in the pericancerous mucosa and in gastric cancer. The most one was 11 abnormal genes on the No. 19 chromosome. The next was No. 1, 2, 16 and 17 chromosomes which had 6 genes, respectively. It was not finding an abnormal gene on the No. 5, 14, 22 and Y chromosome. Conclusion： It suggested those genes may be related to the promotion in early gastric carcinogenesis and their progress. Four main groups （enzyme and enzyme regular, nucleic acid binding, signal transduction, protein binding

关键词： pericancerous mucosa gene expression profile carcinogenesis associated gene localization in chromosome

Gene Expression Profile Differences in Gastric Cancer and Normal Gastric Mucosa by Oligonucleotide Microarrays

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Chinese Journal of Clinical Oncology 2006年第1期3卷 41-48页

作者： Chuanding Yu Shenhua Xu HangZhou Mou Zhiming jiang Chihong Zhu xianglin Liu Zhejiang Cancer Research Institute Hangzhou 310022 China

OBJECTIVE To study the difference of gene expression in gastric cancer (T) and normal tissue of gastric mucosa (C), and to screen for associated novel genes in gastric cancers by oligonucleotide microarrays. METHODS U133A (Affymetrix, Santa Clara, CA) gene chip was used to detect the gene expression profile difference in T and C. Bioinformatics was used to analyze the detected results. RESULTS When gastric cancers were compared with normal gastric mucosa, a total of 270 genes were found with a difference of more than 9 times in expression levels. Of the 270 genes, 157 were up-regulated (Signal Log Ratio [SLR] ≥3), and 113 were down-regulated (SLR ≤-3). Using a classification of function, the highest number of gene expression differences related to enzymes and their regulatory genes (67, 24.8%), followed by signal-transduction genes (43,15.9%). The third were nucleic acid binding genes (17, 6.3%), fourth were transporter genes (15, 5.5%) and fifth were protein binding genes (12, 4.4%). In addition there were 50 genes of unknown function, accounting for 18.5%. The five above mentioned groups made up 56.9% of the total gene number. CONCLUSION The 5 gene groups (enzymes and their regulatory proteins, signal transduction proteins, nucleic acid binding proteins, transporter and protein binding) were abnormally expressed and are important genes for further study in gastric cancers.

关键词： gastric cancer normal gastric mucosa gene-expression profile.

基于离散单元法的环氧沥青混凝土虚拟断裂试验研究

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东南大学学报（自然科学版） 2014年第1期44卷 173-177页

作者：江祥林钱振东宋鑫长安大学公路学院西安610100 江西省桥梁检(监)测及加固重点实验室南昌330038 东南大学教育部智能运输系统工程研究中心南京210096

为明晰环氧沥青混凝土的断裂力学行为特征,基于数字图像处理技术,采用离散元方法建立了切口小梁二维模型,开展了环氧沥青混凝土的虚拟弯曲断裂试验.从细观角度分析了环氧沥青混凝土断裂过程中的力学响应,探讨了其断裂机理及裂纹扩展路径... 详细信息

为明晰环氧沥青混凝土的断裂力学行为特征,基于数字图像处理技术,采用离散元方法建立了切口小梁二维模型,开展了环氧沥青混凝土的虚拟弯曲断裂试验.从细观角度分析了环氧沥青混凝土断裂过程中的力学响应,探讨了其断裂机理及裂纹扩展路径,并与室内试验结果进行了对比.结果表明,采用离散元方法可较好地反映环氧沥青混凝土的断裂力学特性,数值模拟过程中虚拟试件的力学响应与理论结果相符.虚拟试验获取的材料强度参数与室内试验的测试结果接近,误差仅为0.25%,但前者所得的劲度模量因破坏挠度偏大,较后者低16.56%.在裂纹扩展过程中,破坏易产生于黏结较为薄弱的集料-砂浆界面.虚拟试验与室内试验的对比分析结果验证了离散元模型以及参数取值的正确性.

关键词：环氧沥青混凝土离散单元法断裂模型虚拟试验

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混合梁结合部受力机理模型试验研究

土木建筑与环境工程 2014年第6期36卷 48-53页

作者：江祥林刘玉擎孙璇长安大学公路学院西安710064 江西省交通科学研究院南昌330038 同济大学土木工程学院上海200092

为揭示混合梁结合部的承载性能、破坏形态和受力机理,以主跨为818m的九江长江公路大桥为研究背景,选取混合梁压剪式结合部典型格室,并设计进行比较的承剪式结合部格室,开展了两个缩尺比为1∶2的结合部局部模型承载性能试验,测试了钢与... 详细信息

为揭示混合梁结合部的承载性能、破坏形态和受力机理,以主跨为818m的九江长江公路大桥为研究背景,选取混合梁压剪式结合部典型格室,并设计进行比较的承剪式结合部格室,开展了两个缩尺比为1∶2的结合部局部模型承载性能试验,测试了钢与混凝土的应变及相对滑移。研究结果表明:压剪式结合部承载能力是承剪式的两倍;压剪式结合部承压板传力约占总轴力的62.5%,承压板传力减小了钢格室应力,限制了钢-混凝土间相对滑移,降低了连接件传力比例,使结合部受力更合理。

关键词：斜拉桥混合梁结合部模型试验受力机理

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斜拉索杠杆质量阻尼器减振性能参数化研究

世界地震工程 2013年第2期29卷 117-123页

作者：王波汪正兴江祥林中铁大桥局集团武汉桥梁科学研究院有限公司湖北武汉430034 武汉大学土木工程博士后流动站湖北武汉430072 江西省交通科学研究院江西南昌330038

为探讨杠杆质量阻尼器(LMD)对超长斜拉索的综合减振效果,推导了斜拉索-LMD系统的状态向量方程及LMD的等效阻尼力模型,求得了斜拉索前15阶模态的对数衰减率。以LMD索夹安装高度位置比、LMD杠杆放大倍数及LMD与斜拉索模态质量比为状态变... 详细信息

为探讨杠杆质量阻尼器(LMD)对超长斜拉索的综合减振效果,推导了斜拉索-LMD系统的状态向量方程及LMD的等效阻尼力模型,求得了斜拉索前15阶模态的对数衰减率。以LMD索夹安装高度位置比、LMD杠杆放大倍数及LMD与斜拉索模态质量比为状态变量进行了参数化分析及模型试验研究。研究结果表明:LMD由于惯性项、刚度项及阻尼项的三重反馈作用,同时由于杠杆的调节放大作用,其减振效果优于相同安装高度的粘性剪切型阻尼器(VSD)。斜拉索各阶模态的对数衰减率随着LMD索夹安装高度位置比的增加而增大,增大LMD杠杆放大倍数,斜拉索各阶模态对数衰减率随之增大,且所需阻尼参数值减小,随着LMD与斜拉索模态质量比的增大,斜拉索低阶模态与高阶模态对数衰减率增减趋势不一致,存在系统最优模态质量比。LMD综合减振效果较好,可为千米级甚至更大跨度的斜拉桥拉索减振提供有效的解决方案。

关键词：斜拉索杠杆质量阻尼器对数衰减率模态质量比

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实物期权法评估高科技企业股价模型

科技管理研究 2005年第4期25卷 146-148页

作者：吴晓霖蒋祥林天津大学管理学院天津300072 复旦大学金融研究院上海200433

由于经济环境和价值评估对象的特性改变,评估传统企业价值的方法已经不适用于评估高科技企业的价值。本文运用实物期权理论与方法建立了评估高科技产业股价的模型,并讨论了具体的实施细节。

关键词：高科技企业价值评估实物期权

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存货质押业务质物组合价格风险决策

管理评论 2013年第11期25卷 163-176页

作者：何娟王建蒋祥林西南交通大学交通运输与物流学院成都610031 西南交通大学供应链金融服务创新研究所成都610031 复旦大学金融研究院上海200433

为缓释现行供应链金融业务单一质物价格剧烈波动诱发的集中度风险,基于Markowitz风险分散理论,从金融时间序列一般规律出发,分析价格随机波动现货质物的收益率统计特征,模型化收益率序列尖峰厚尾、波动集聚性和自相关特性,建立刻画质物... 详细信息

为缓释现行供应链金融业务单一质物价格剧烈波动诱发的集中度风险,基于Markowitz风险分散理论,从金融时间序列一般规律出发,分析价格随机波动现货质物的收益率统计特征,模型化收益率序列尖峰厚尾、波动集聚性和自相关特性,建立刻画质物组合间非线性相关结构的二元Copula-GARCH族模型,研究不同秩相关系数下两组质物组合对数收益率间的条件相关性,通过样本外滚动预测方法进行动态组合VaR预测;构造模拟生成新质物组合的数据生成方法,拓展研究不同相关性对组合VaR的影响;提出长周期预测视角中考虑资金成本的动态质押率模型效率损失检验以及基于Kupiec模型精度检验全面回测模型。实证结果显示:捕捉质物收益率下尾部相关结构变化的Clayton-Copula能够合理预测两组真实质物组合风险和模拟质物组合风险,且能更好地发挥组合分散风险的能力。为风险限额管理下的商业银行提供了一种质物组合风险管理的新框架和新模式。

关键词：供应链金融存货质押质物组合 Copula-GARCH VaR

高强耐蚀钢筋的全寿命周期腐蚀行为特征及寿命预测

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建筑结构学报 2019年第1期40卷 132-139页

作者：艾志勇蒋金洋江祥林俞博宋丹王丹芊刘瑶东南大学材料科学与工程学院江苏南京211189 江西省交通科学研究院长大桥梁建设关键技术及装备交通运输行业研发中心江西南昌330200 东南大学江苏省土木工程材料重点实验室江苏南京211189 河海大学力学与材料学院江苏南京210098

文中系统研究了00Cr10MoV新型高强耐蚀钢筋(引入普通碳素钢筋进行对比)全寿命周期内的腐蚀行为特征及耐蚀机理,并预测了其混凝土构件服役寿命。研究结果表明:00Cr10MoV耐蚀钢筋耐蚀性能贯穿钝化、维钝-破钝及腐蚀扩展各阶段,呈现连续耐... 详细信息

文中系统研究了00Cr10MoV新型高强耐蚀钢筋(引入普通碳素钢筋进行对比)全寿命周期内的腐蚀行为特征及耐蚀机理,并预测了其混凝土构件服役寿命。研究结果表明:00Cr10MoV耐蚀钢筋耐蚀性能贯穿钝化、维钝-破钝及腐蚀扩展各阶段,呈现连续耐蚀特征。在钝化阶段,耐蚀钢筋的强钝化性能源自于其Cr氧化物和Fe氧化物构成的双层结构钝化膜;在维钝-破钝阶段,耐蚀钢筋的高抗氯盐侵蚀性得益于其含Cr钝化膜的高稳定性及强修复性;在腐蚀扩展阶段,耐蚀钢筋的低腐蚀速率得益于其Cr元素富集的致密锈层对侵蚀介质渗入的阻滞作用。利用菲克第二定律计算耐蚀钢筋腐蚀诱导期持续时间,氯盐侵蚀下耐蚀钢筋混凝土构件服役寿命可提高约23倍。

关键词：高强耐蚀钢筋腐蚀行为耐蚀机理寿命预测