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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-tao jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

非编码RNA与间充质干细胞研究的相关计量学分析

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中国组织工程研究 2025年第1期29卷 87-94页

作者：周嘉欣陶疆上海交通大学医学院附属第九人民医院口腔综合科上海交通大学口腔医学院国家口腔医学中心国家口腔疾病临床医学研究中心上海市口腔医学重点实验室上海市口腔医学研究所中国医学科学院口腔颌面再生医学创新单元上海市200011

背景:非编码RNA作为一类不编码蛋白质的RNA分子,在细胞调控中发挥关键作用。同时,间充质干细胞具有多向分化潜能,对组织修复和再生至关重要。近年来,研究者们对非编码RNA在调控间充质干细胞功能中的作用展开了深入探讨。目的:通过文献... 详细信息

背景:非编码RNA作为一类不编码蛋白质的RNA分子,在细胞调控中发挥关键作用。同时,间充质干细胞具有多向分化潜能,对组织修复和再生至关重要。近年来,研究者们对非编码RNA在调控间充质干细胞功能中的作用展开了深入探讨。目的:通过文献计量学分析方法系统地了解非编码RNA与间充质干细胞相关研究的发展趋势与关键领域。方法:从Web of Science核心合集1990年至今的科学引文索引扩展获取非编码RNA与间充质干细胞相关研究的文献数据,运用VOSviewer和Cite Space计量学软件对年份、国家或地区、研究机构、被引文献和关键词进行发文量、聚类、被引频次、突增性和中介中心性进行分析,揭示该研究领域的知识基础及前沿热点。结果与结论:(1)最终纳入5348篇文献,发表在1997-2021年,相关文献呈现明显的增长趋势,尽管在2022年略有减少,其发文量仍保持较高水平,中国在该领域的研究中占据主导地位,其中上海交通大学为最活跃的机构。(2)对被引文献分析发现,高突增性、高中介中心性、高被引的文献主要与微小RNA、细胞外囊泡和骨代谢等内容相关,这些文献构成了非编码RNA与间充质干细胞研究领域的重要知识基础。(3)对关键词进行突增性分析发现,至今保持高突增性的关键词包括外泌体、环状RNA、细胞外囊泡和损伤。(4)对关键词进行聚类演变分析,发文量仍保持增长趋势的关键词聚类包括:肿瘤微环境、骨关节炎、氧化应激和细胞外囊泡,这些关键词反映了目前以及未来该领域的研究热点。(5)文章结果不仅展示了非编码RNA与间充质干细胞研究领域的研究态势,更重要的是有望为研究人员提供潜在的方向和启示。

关键词：非编码RNA 间充质干细胞计量学分析可视化分析热点前瞻知识基础 CiteSpace 作用机制细胞外囊泡转化应用

Heat Transfer and Friction Characteristics of Printed Circuit Heat Exchangers with Different Channel Structures for S-CO_(2) Power System

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Journal of Thermal Science 2024年第3期33卷 1132-1147页

作者： jiang tao LI Mingjia Key Laboratory of Thermo-Fluid Science and Engineering of Ministry of Education School of Energy and Power EngineeringXi’an Jiaotong UniversityXi’an710049China School of Mechanical Engineering Beijing Institute of TechnologyBeijing100081China

Printed circuit heat exchanger(PCHE)has been widely used in supercritical carbon dioxide(S-CO_(2))power systems because of its high heat transfer efficiency and good ***,due to the large variety of PCHE configurations,channel selection in practical applications lacks a ***,this paper discussed the heat transfer and friction characteristics and the synergy of three fields in the channel under the guidance of the field synergy principle for four typical PCHE ***,the comprehensive performance of four channels was ***,the heat transfer and friction factor correlations for S-CO_(2)in four channels were *** findings demonstrate that the synergy of velocity and pressure fields of the straight channel PCHE is better(β≈180°),so its resistance loss is relatively *** zigzag and sinusoidal wavy channels and the airfoil fins can reduce the angle a between the temperature gradient and velocity,thus enhancing the heat *** sinusoidal wavy channel can reduce flow resistance compared to the zigzag channel due to the rounded *** streamlined airfoil structure can guide the flow and reduce backflow,thus reducing resistance *** the range of Re studied in this paper,the maximum error of the proposed heat transfer and friction factor correlations of PCHE is 7.0%,which shows good fitting *** research in this paper can provide a reference for the selection and design of PCHE with different channel configurations.

关键词： printed circuit heat exchanger supercritical carbon dioxide typical channel structure field synergy analysis

Vortex Channel Modelling for the Radio Vortex System

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China Communications 2018年第4期15卷 121-129页

作者： Qibiao Zhu tao jiang School of Electronic Information and Communications Huazhong University of Science and TechnologyWuhan 430074China School of Information Engineering Nanchang UniversityNanchang 330031China

In this paper, a free-space vortex channel model of the radio vortex system is proposed to describe the propagation characteristics of vortex signals over the vortex channel. The key idea is to combine the Laguerre-Gaussian(LG) modes in the optical field with the free-space propagation model in the radio field. The proposed free-space vortex channel model is derived from the electric field expression of the LG modes and the freespace channel transfer function of the freespace propagation model theoretically. Simulation results verify that the proposed model could reflect the vortex channel characteristics better than the currently used free-space propagation model.

关键词： vortex channel model radiovortex free-space laguerre-gaussian modes channel transfer function

Information-Defined Networks:A Communication Network Approach for Network Studies

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China Communications 2021年第7期18卷 197-210页

作者： Wenjie Jia tao jiang School of Electronic Information and Communications Huazhong University of Science and TechnologyWuhan 430074China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China

The research of complex networks facilitates the progress of various disciplines,including biology,chemistry,social science,computer,and communication ***,it is popular to utilize complex networks to study the communication networks,such as designing efficient routing strategies and robust communication ***,exploiting the advantages of communication networks to investigate networks in various disciplines beyond telecommunications is still in *** of this situation,this paper proposes an information-defined network(IDN)framework by which a complex network can be abstracted as a communication network associated with multiple intelligent ***,each component and dynamic process in this framework can be defined by *** show that the IDN framework promotes the research of unsolved problems in the current complex network field,especially for detecting new interaction types in realworld networks.

关键词： network data analysis label detection complex network communication network network evolution

Metadata Feedback and Utilization for Data Deduplication Across WAN

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Journal of Computer Science & Technology 2016年第3期31卷 604-623页

作者： Bing Zhou jiang-tao Wen State Key Laboratory on Intelligent Technology and Systems Tsinghua University Beijing 100084 China Tsinghua National Laboratory for Information Science and Technology Tsinghua University Beijing 100084 China Department of Computer Science and Technology Tsinghua University Beijing 100084 China

Data deduplication for file communication across wide area network （WAN） in the applications such as file synchronization and mirroring of cloud environments usually achieves significant bandwidth saving at the cost of significant time overheads of data deduplication. The time overheads include the time required for data deduplication at two geographi- cally distributed nodes （e.g., disk access bottleneck） and the duplication query/answer operations between the sender and the receiver, since each query or answer introduces at least one round-trip time （RTT） of latency. In this paper, we present a data deduplication system across WAN with metadata feedback and metadata utilization （MFMU）, in order to harness the data deduplication related time overheads. In the proposed MFMU system, selective metadata feedbacks from the receiver to the sender are introduced to reduce the number of duplication query/answer operations. In addition, to harness the metadata related disk I/O operations at the receiver, as well as the bandwidth overhead introduced by the metadata feedbacks, a hysteresis hash re-chunking mechanism based metadata utilization component is introduced. Our experimental results demonstrated that MFMU achieved an average of 20%~40% deduplication acceleration with the bandwidth saving ratio not reduced by the metadata feedbacks, as compared with the ＂baseline＂ content defined chunking （CDC） used in LBFS （Low-bandwith Network File system） and exiting state-of-the-art Bimodal chunking algorithms based data deduplication solutions.

关键词： data deduplication wide area network (WAN) metadata feedback metadata utilization

A Data Deduplication Framework of Disk Images with Adaptive Block Skipping

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Journal of Computer Science & Technology 2016年第4期31卷 820-835页

作者： Bing Zhou jiang-tao Wen State Key Laboratory on Intelligent Technology and Systems Tsinghua University Beijing 100084 China

We describe an efficient and easily applicable data deduplication framework with heuristic prediction based adaptive block skipping for the real-world dataset such as disk images to save deduplication related overheads and improve deduplication throughput with good deduplication efficiency maintained. Under the framework, deduplication operations are skipped for data chunks determined as likely non-duplicates via heuristic prediction, in conjunction with a hit and matching extension process for duplication identification within skipped blocks and a hysteresis mechanism based hash indexing process to update the hash indices for the re-encountered skipped chunks. For performance evaluation, the proposed framework was integrated and implemented in the existing data domain and sparse indexing deduplication algorithms. The experimental results based on a real-world dataset of 1.0 TB disk images showed that the deduplication related overheads were significantly reduced with adaptive block skipping, leading to a 30%-80% improvement in deduplication throughput when deduplieation mctadata were stored on the disk for data domain, and 25%-40% RAM space saving with a 15%-20% improvement in deduplication throughput when an in-RAM sparse index was used in sparse indexing. In both cases, the corresponding deduplication ratios reduced were below 5%.

关键词： data deduplication metadata adaptive block skipping

Improving Metadata Caching Efficiency for Data Deduplication via In-RAM Metadata Utilization

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Journal of Computer Science & Technology 2016年第4期31卷 805-819页

We describe a data deduplication system for backup storage of PC disk images, named in-RAM metadata utilizing deduplication （IRwMUD）. In-RAM hash granularity adaptation and miniLZO based data compression are firstly proposed to reduce the in-RAM metadata size and thereby reduce the space overheads required by the in-RAM metadata caches. Secondly, an in-RAM metadata write cache, as opposed to the traditional metadata read cache, is proposed for further reducing metadata-related disk I/O operations and improving deduplication throughput. During deduplication, the metadata write cache is managed following the LRU caching policy. For each manifest that is hit in the metadata write cache, an expensive manifest reloading operation from the disk is avoided. After deduplieation, all the manifests in the metadata write cache are cleared and stored on the disk. Our experimental results using 1.5 TB real-world disk image dataset show that I） IR-MUD achieved about 95% size reduction for the deduplication metadata, with a small time overhead introduced, 2） when the metadata write cache was not utilized, with the same RAM space size for the metadata read cache, IR-MUD achieved a 400% higher RAM hit ratio and a 50% higher deduplication throughput, as compared with the classic Sparse Indexing deduplication system where no metadata utilization approaches are utilized, and 3） when the metadata write cache was utilized and enough RAM space was available, IR-MUD achieved a 500% higher RAM hit ratio compared with Sparse Indexing and a 70% higher deduplication throughput compared with IR-MUD with only a single metadata read cache. The in-RAM metadata harnessing and metadata write caching approaches of IR-MUD can be applied in most parallel deduplication systems for improving metadata caching efficiency.

关键词： data deduplication cache metadata utilization

Theoretical foundations of triboelectric nanogenerators(TENGs)

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Science China(Technological Sciences) 2020年第7期63卷 1087-1109页

作者： SHAO JiaJia jiang tao WANG ZhongLin Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 100083China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China School of Materials Science and Engineering Georgia Institute of TechnologyAtlanta GA 30332-0245USA

Triboelectric nanogenerator(TENG) is an emerging powerful technology for converting ambient mechanical energy into electrical energy through the effect of triboelectricity. Starting from the expanded Maxwell’s equations, the theoretical framework of TENGs has been gradually established. Here, a review is given about its recent progress in constructing of this general theory. The fundamental mechanism of TENGs is constructed by the driving force—Maxwell’s displacement current, which is essentially different from that of electromagnetic generators. Theoretical calculations of the displacement current from a threedimensional mathematical model are presented, as well as the theoretical studies on the TENGs according to the capacitor models. Furthermore, the figure-of-merits and standards for quantifying the TENG’s output characteristics are discussed, which will provide important guidelines for optimizing the structure and performance of TENGs toward practical applications. Finally,perspectives and challenges are proposed about the basic theory of TENGs and its future technology development.

关键词： triboelectric nanogenerator theoretical foundations displacement current three-dimensional model capacitor model figure-of-merits