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上颌牵张成骨术与Le Fort I型前徙术治疗复杂唇腭裂上颌发育不全的效果比较

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中华整形外科杂志 2024年第8期40卷 846-856页

作者：张天赐赵寰卓蒋曼王涛周建萍曹礼郑雷蕾重庆医科大学附属口腔医院正畸科重庆400016 口腔疾病与生物医学重庆市重点实验室重庆400016 重庆市高校市级口腔生物医学工程重点实验室重庆400016 重庆医科大学附属口腔医院正颌外科重庆400016

目的比较上颌牵张成骨术与Le FortⅠ型前徙术治疗复杂唇腭裂上颌发育不全患者的效果。方法回顾性收集2015年1月至2022年12月就诊于重庆医科大学附属口腔医院需正畸-正颌联合治疗的唇腭裂骨性Ⅲ类错畸形患者的临床资料,根据上颌骨的手术... 详细信息

目的比较上颌牵张成骨术与Le FortⅠ型前徙术治疗复杂唇腭裂上颌发育不全患者的效果。方法回顾性收集2015年1月至2022年12月就诊于重庆医科大学附属口腔医院需正畸-正颌联合治疗的唇腭裂骨性Ⅲ类错畸形患者的临床资料,根据上颌骨的手术方式分为3组,分别行全上颌截骨牵张术(TMD,A组)、上颌前部截骨牵张术(AMD,B组)和Le FortⅠ型前徙术(LFⅠ,C组)。搜集术前1个月和牵张器拆除时(若无牵张器则为术后3个月)患者头颅侧位X线片及锥形束CT(CBCT)影像资料,利用Mimics 21.0及Dolphin Imaging 11.9软件对患者治疗前后的CBCT进行三维重建,分别评估颅颌面以及气道的变化。采用SPSS 25.0进行数据分析,同组内手术前后比较采用Wilcoxon秩和检验,3组间比较采用Kruskal-Wallis H检验。结果共纳入15例患者,每组各5例,其中男8例,女7例,年龄15~21岁。3组性别、年龄分布及唇腭裂分类差异无统计学意义(P>0.05)。经过手术治疗,3组患者的上颌发育不全均得到一定程度改善。与术前比较,术后3组由上牙槽座点、鼻根点及下牙槽座点所构成的角(ANB角)增加(P均0.05),3组牙槽嵴缺隙面积均有增加趋势(P>0.05);下颌平面与眶耳平面的交角(FMA角)在B组术后减小,而其余2组均有增加趋势,但差异均无统计学意义(P>0.05);A、B组术后气道体积增加或有增加趋势(A组P0.05),但C组气道体积有所减小(P>0.05)。组间比较显示,3组间术前后由蝶鞍中心、鼻根点及上牙槽座点所构成的角(SNA角)及前鼻棘点至冠状面的垂直距离(ANS-CP)的变化量差异有统计学意义(P0.05)。结论对复杂唇腭裂上颌发育严重不足的患者,采用TMD能够明显改善上颌骨的发育不足并增加上气道体积,但可能扩大牙槽嵴的缺隙面积、增加上下颌骨的垂直高度。AMD的上颌骨位置的变化量小于TMD,主要用于上颌牙列重度拥挤需增加牙弓长度、上下颌骨矢状向差异较小或术前已发现有腭咽功能异常的患者。LFⅠ其上颌骨位置的变化量同样小于TMD,但同AMD无明显组间差异,适用于上颌发育中度不足伴上颌牙列轻度拥挤的患者,LFⅠ的优势在于其术后的精确咬合设计及三维方向上的颌骨精确移动。

关键词：外科,口腔复杂唇腭裂正畸-正颌联合治疗牵张成骨三维重建锥形束CT

Clinicopathological characteristics and prognosis of gastric signet ring cell carcinoma

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World Journal of Clinical Cases 2022年第29期10卷 10451-10466页

作者： hua-Kai Tian Zuo Zhang Zhi-Kun Ning jiang liu Zi-Tao liu Hao-Yu huang Zhen Zong Hui li Department of General Surgery First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Obstetrics and Gynecology Second Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Day Ward First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Gastrointestinal Surgery Second Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Rheumatology and Immunology First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND The clinicopathological features and prognosis of gastric signet ring cell carcinoma(GSRC)remain controversial,particularly with regard to sensitivity to postoperative adjuvant *** To compare the pathological features of GSRC with those of gastric adenocarcinoma of different degrees of differentiation and the differences in survival prognosis between the different disease *** By screening gastric cancer patients from 2010 to 2015 in the database of Surveillance,Epidemiology and End Results,and collecting the clinicopathological and prognostic data of gastric cancer patients who underwent surgery from January 2014.to December 2016 in the Second Affiliated Hospital of Nanchang university,we analyzed the general pathological characteristics of GSRC by the chi-square *** and multivariate analyses were conducted to compare the factors affecting the survival and prognosis of early and advanced gastric *** Kaplan-Meier curves were plotted to reveal the survival difference between early and advanced GSRC and different differentiated types of gastric *** prognosis model of advanced GSRC was established with R software,and the area under curve(AUC)and C-index were used to assess the accuracy of the *** Analysis of pathological features revealed that signet ring-cell carcinoma(SRC)was more frequently seen in younger(5 cm(31.15%vs 27.10%)compared to the differentiated type,while the opposite was true compared to the undifferentiated *** prognostic analysis found no significant difference in the prognosis of SRC patients among EGC *** contrast,among advanced gastric cancer(AGC)patients,the prognosis of SRC patients was correlated with age,race,tumour size,AJCC stage,T-stage,and postop

关键词： Gastric adenocarcinoma Gastric signet ring cell carcinoma Pathological features Survival prognosis Prognostic model Adjuvant therapy

Toward accurate detection on change barriers

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Science china(Information Sciences) 2021年第3期64卷 88-104页

作者： Tingting LV Zhilei REN Xiaochen li Guojun GAO He jiang School of software Dalian University of Technology

In software development, it is easy to introduce code smells owing to the complexity of projects and the negligence of programmers. Code smells reduce code comprehensibility and maintainability, making programs error-prone. Hence, code smell detection is extremely important. Recently, machine learning-based technologies turn to be the mainstream detection approaches, which show promising performance. However,existing machine learning methods have two limitations:(1) most studies only focus on common smells, and(2) the proposed metrics are not effective when being used for uncommon code smell detection, e.g., change barrier based code smells. To overcome these limitations, this paper investigates the detection of uncommon change barrier based code smells. We study three typical code smells, i.e., Divergent Change, Shotgun Surgery, and Parallel Inheritance, which all belong to change barriers. We analyze the characteristics of change barriers and extract domain-specific metrics to train a Logistic Regression model for detection. The experimental results show that our method achieves 81.8%–100% precision and recall, outperforming existing algorithms by 10%–30%. In addition, we analyze the correlation and importance of the utilized metrics. We find our domain-specific metrics are important for the detection of change barriers. The results would help practitioners better design detection tools for such code smells.

关键词： code smells change barrier logical regression machine learning software development

基于UPLC-Q-Exactive-Orbitrap-MS/MS和网络药理学的七龙天胶囊治疗低氧性肺动脉高压的作用机制研究

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中国医院药学杂志 2024年第18期44卷 2075-2081页

作者：李煜苗曹东怡陈冰李争艳余晓玲王欣钰袁小淋姜艳艳北京中医药大学中药学院北京102488 昆明市中医医院药学部云南昆明650500 昆明学院医学院云南昆明650500

目的:基于入血成分分析、网络药理学及分子对接技术,探讨七龙天胶囊治疗低氧性肺动脉高压(hypoxic pulmonary hypertension,HPH)的作用机制。方法:采用超高效液相色谱-四级杆-静电场轨道阱质谱对七龙天胶囊含药血浆中化学成分进行系统... 详细信息

目的:基于入血成分分析、网络药理学及分子对接技术,探讨七龙天胶囊治疗低氧性肺动脉高压(hypoxic pulmonary hypertension,HPH)的作用机制。方法:采用超高效液相色谱-四级杆-静电场轨道阱质谱对七龙天胶囊含药血浆中化学成分进行系统定性分析。通过PharmMapper、GeneCards等数据库筛选入血成分及疾病的相关靶点,运用String平台进行PPI分析;通过Metascape数据库进行GO功能与KEGG通路富集分析。采用AutoDock软件对主要活性成分与关键靶点进行分子对接验证。结果:灌胃给予七龙天胶囊内容物后,自大鼠含药血浆中鉴定出32个入血成分,包括22个代谢产物和10个原型成分。化合物-疾病共有靶点120个,PPI分析筛选出10个核心靶点。KEGG富集分析发现,七龙天胶囊可能通过PI3K-Akt、HIF-1、MAPK等信号通路发挥治疗HPH的作用。结论:本研究明确了七龙天胶囊的入血成分,预测了其发挥治疗HPH的作用机制可能与调控PI3K-Akt信号通路、HIF-1α信号通路有关,为进一步研究七龙天胶囊作用机制奠定基础,并为其临床应用提供科学依据。

关键词：七龙天胶囊超高效液相色谱-四级杆-静电场轨道阱质谱入血成分网络药理学分子对接

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网络拥塞控制方法综述

软件学报 2024年第8期35卷 3952-3979页

作者：蒋万春李昊阳陈晗瑜王洁王建新阮昌中南大学计算机学院湖南长沙410012 长沙理工大学计算机与通信工程学院湖南长沙411014

网络拥塞控制方法是决定网络传输性能的关键因素.近几年,网络不断普及、网络带宽不断增长、用户对网络性能的需求不断提升,为拥塞控制算法的设计带来挑战.为适应不同的网络环境,近期不少新颖的拥塞控制算法被研究者们提出来,极大地提升... 详细信息

网络拥塞控制方法是决定网络传输性能的关键因素.近几年,网络不断普及、网络带宽不断增长、用户对网络性能的需求不断提升,为拥塞控制算法的设计带来挑战.为适应不同的网络环境,近期不少新颖的拥塞控制算法被研究者们提出来,极大地提升网络的传输性能,改善用户体验.综述最新拥塞控制算法设计思想,将其分为预约调度式、直接测量式、基于机器学习式以及迭代探测式4.类,分别介绍相应的代表性拥塞控制算法,并进一步对各种拥塞控制思想方法的优缺点进行对比和分析,最后展望拥塞控制的未来发展方向,以启发该领域的研究.

关键词：拥塞控制网络环境吞吐量延时数据中心

Efficient Group Blind Signature for Medical Data Anonymous Authentication in Blockchain-Enabled IoMT

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Computers, Materials & Continua 2023年第7期76卷 591-606页

作者： Chaoyang li Bohao jiang Yanbu Guo Xiangjun Xin College of software Engineering Zhengzhou University of Light IndustryZhengzhou450002China

Blockchain technology promotes the development of the Internet of medical things(IoMT)from the centralized form to distributed trust mode as blockchain-based Internet of medical things(BIoMT).Although blockchain improves the cross-institution data sharing ability,there still exist the problems of authentication difficulty and privacy *** paper first describes the architecture of the BIoMT system and designs an anonymous authentication model for medical data *** BIoMT system is divided into four layers:perceptual,network,platform,and *** model integrates an anonymous authentication scheme to guarantee secure data sharing in the network *** the untampered blockchain ledger can protect the privacy of medical data and system ***,an anonymous authentication scheme called the group blind signature(GBS)scheme is *** scheme can provide anonymity for the signer as that one member can represent the group to sign without exposing his *** blind property also can protect the message from being signed as it is anonymous to the ***-over,this GBS scheme is created with the lattice assumption,which makes it more secure against quantum *** addition,the security proof shows that this GBS scheme can achieve the security properties of dynamical-almost-full anonymity,blindness,traceability,and *** comparison analysis and performance evaluation of key size show that this GBS scheme is more efficient than similar schemes in other literature.

关键词： Blockchain Internet of medical things signature privacy-preserving

基于网络药理学和动物体内试验验证云实感冒合剂对呼吸道合胞病毒作用

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中华微生物学和免疫学杂志 2024年第2期44卷 170-182页

作者：徐庆胜李玉迁蒋立娜魏洪迟茜文廖思睿陈维娇贵州医科大学基础医学院国家级实验教学中心微生物学教研室贵州省普通高校学校病原生物学特色重点实验室贵阳550025 贵州医科大学基础医学院微生物学教研室贵州省普通高校学校病原生物学特色重点实验室贵阳550025 贵州医科大学基础医学院国家级实验教学中心贵阳550025

目的基于网络药理学和体内试验探讨云实感冒合剂抗呼吸道合胞病毒(respiratory syncytial virus,RSV)的作用机制。方法网络药理学预测:运用TCMSP、GeneCards等数据库预测云实感冒合剂干预RSV的活性成分及作用靶点。利用Cytoscape 3.2.1... 详细信息

目的基于网络药理学和体内试验探讨云实感冒合剂抗呼吸道合胞病毒(respiratory syncytial virus,RSV)的作用机制。方法网络药理学预测:运用TCMSP、GeneCards等数据库预测云实感冒合剂干预RSV的活性成分及作用靶点。利用Cytoscape 3.2.1软件构建中药成分-疾病靶点网络图。通过STRING数据库分析蛋白质相互作用关系。借助Metascape数据库进行富集分析。采用分子对接技术分析验证网络药理学结果。云实感冒合剂干预RSV感染验证试验:滴鼻法建立RSV小鼠模型,灌胃合剂后检测血常规、肺指数,观察肺组织病理变化,流式细胞术检测外周血T细胞亚群,EliSA检测血清TNF-α、IL-6、IL-1β含量,RT-PCR检测肺组织中TLR4.NF-κB和RSV-N基因mRNA相对水平。结果分析获得云实感冒合剂有效活性成分4.个,抗RSV靶点111个,富集得到167条信号通路,主要是PI3K/AKT、MAPK、Toll-like等信号通路。分子对接结果显示,云实感冒合剂活性成分木犀草素、山奈酚、槲皮素与RSV-G、RSV-F、PI3K、AKT1、Bcl-2结合能均小于0 kcal/mol。体内试验结果显示,与RSV组相比,云实感冒合剂高剂量组白细胞、淋巴细胞计数升高、肺指数降低,差异有统计学意义(P4.(+)、CD8^(+)T淋巴细胞数量明显升高,CD4.(+)/CD8^(+)T细胞数量比值降低,血清中TNF-α、IL-6、IL-1β含量下降,肺组织中病毒载量和TLR4.NF-κB mRNA水平降低,差异均具有统计学意义(P4.NF-κB通路激活有关。

关键词：云实感冒合剂网络药理学呼吸道合胞病毒体内试验分子对接

A decomposition based algorithm for maximal contractions

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Frontiers of Computer Science 2013年第6期7卷 801-811页

作者： Dongchen jiang Wei li Jie LUO Yihua LOU Zhengzhong liAO State key laboratory of Computer Architecture Institute of Computing Technology Chinese Academy of Sciences Beijing 100190 China State key laboratory of software Development Environment Beihang University Beijing 100191 China Tencent Technology (Beijing) Company limited Beijing 100080 China

This paper proposes a decomposition based algo- rithm for revision problems in classical propositional logic. A set of decomposing rules are presented to analyze the satis- fiability of formulas. The satisfiability of a formula is equivalent to the satisfiability of a set of literal sets. A decomposing function is constructed to calculate all satisfiable literal sets of a given formula. When expressing the satisfiability of a formula, these literal sets are equivalent to all satisfied models of such formula. A revision algorithm based on this decomposing function is proposed, which can calculate maximal contractions of a given problem. In order to reduce the memory requirement, a filter function is introduced. The improved algorithm has a good performance in both time and space perspectives.

关键词： belief change maximal contraction decomposing rules revision algorithm

CSLabel： An Approach for Labelling Mobile App Reviews

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Journal of Computer Science & Technology 2017年第6期32卷 1076-1089页

作者： li Zhang Xin-Yue huang Jing jiang Ya-Kun Hu State key laboratory of software Development Environment Beihang University Beijing 100191 China

Mobile apps （applications） have become a popular form of software, and the app reviews by users have become an important feedback resource. Users may raise some issues in their reviews when they use apps, such as a functional bug, a network lag, or a request for a feature. Understanding these issues can help developers to focus on users＇ concerns, and help users to evaluate similar apps for download or purchase. However, we do not know which types of issues are raised in a review. Moreover, the amount of user reviews is huge and the nature of the reviews＇ text is unstructured and informal. In this paper, we analyze 3 902 user reviews from 11 mobile apps in a Chinese app store -- 360 Mobile Assistant, and uncover 17 issue types. Then, we propose an approach CSLabel that can label user reviews based on the raised issue types. CSLabel uses a cost-sensitive learning method to mitigate the effects of the imbalanced data, and optimizes the setting of the support vector machine （SVM） classifier＇s kernel function. Results show that CSLabel can correctly label reviews with the precision of 66.5%, the recall of 69.8%, and the F1 measure of 69.8%. In comparison with the state-of-the-art approach, CSLabel improves the precision by 14., the recall by 30%, the F1 measure by 22%. Finally, we apply our approach to two real scenarios： 1） we provide an overview of 1 076 786 user reviews from 1 100 apps in the 360 Mobile Assistant and 2） we find that some issue types have a negative correlation with users＇ evaluation of apps.

关键词： mobile app user review classification