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Effect and mechanism of huanglianjiedu decoction on high fat-induced atherosclerosisrats and metabolomics study by ultra-performance liquid chromatography-mass spectrometry

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中国药理学与毒理学杂志 2018年第4期32卷 289-290页

作者： li jiang Bing-tao li Xiao-jun YAN Hong-ning liU Yu CHEN Guo-liang XU Research Center for Differentiation and Development of TCM Basic Theory Jiangxi University of Traditional Chinese Medicine jiangxi Provincial key laboratory of TCM etiopathogenisis key laboratory of Pharmacology of Traditional Chinese Medicine i

OBJECTIVE To explore the biomarkers and molecular mechanism of huanglianjiedu decoction(HJD) on high fat diet-induced experimental atherosclerosis in *** SD male rats were randomly dividedinto five groups(n=8):normal control group,model group,and three dosage groups(1.5,3 and 6 g crude drug per kilogram of body weight).Atherosclerosis was induced by the combination of regular intraperitoneal injection of vitamin D3 and high fat diet for 8 *** was administered by oral gavage from the third week once per day and until the end of the *** the final administration,the blood samples were collected for biochemical analyses [total cholesterol(TC),triglycerides(TG),highdensity lipoprotein(HDL-C),low-density cholesterol(LDL-C)] and blood gas analyses(PaO_2,PaCO_2,pH,ctHb,etc);the abdominal aorta sections were stained with hematoxylin and eosin for histopathology;the liver homogenate were determined for MDA,SOD,OX-LDL,MCP-1 and *** plasma samples were detected using ultraper formance liquid chromatography coupled with quadrupole-time-of-flight tandem mass spectrometry(UPLC-Q-TOF-MS).The data of endogenous compounds were preliminarily preprocessed by software Progenesis QI and then analyzed by *** statistical analysis software EZinfo 2.0 to screen the distinguished biomarkers and the metabolic pathways were analyzed through website http://***/.RESULTS Compared with the normal control group,the content of TC,TG,LDL-C,PaCO_2,MDA,Ox-LDL,MCP-1 and VCAM-1 were significantly increased and HDL-C,PaO_2,ctHb and SOD decreased in the atherosclerosis *** could significantly attenuated the high fat-induced atherosclerosis pathological injury and the abovementioned indexes(Plites has

关键词：黄连解毒汤高脂饮食动脉硬化治疗方法

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基于文献计量的土壤环境对砾石响应研究进展

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节水灌溉 2024年第9期9卷 37-46页

作者：高素素牛宵宵李王成贾振江吴洋洋马东祥陈继虹宁夏大学土木与水利工程学院银川750021 旱区现代农业水资源高效利用教育部工程研究中心银川750021 省部共建西北土地退化与生态恢复国家重点实验室银川750021 宁夏回族自治区黄河水联网数字治水重点实验室银川750021

砾石广泛分布于土壤内部和表面,显著影响着土壤特性和生态系统功能。为系统了解土壤环境对砾石响应相关领域研究进展,探究其研究热点与未来发展趋势,基于Web of Science核心数据库(WoS)和中国知网数据库(CNKI),借助Citespace和VOSviewe... 详细信息

砾石广泛分布于土壤内部和表面,显著影响着土壤特性和生态系统功能。为系统了解土壤环境对砾石响应相关领域研究进展,探究其研究热点与未来发展趋势,基于Web of Science核心数据库(WoS)和中国知网数据库(CNKI),借助Citespace和VOSviewer可视化软件,从发文数量、发文作者、发文国家、发文机构、刊载期刊、关键词共现及其演变进程等方面对2000-2022年国内外土壤环境对砾石响应相关领域研究进行定量综述和可视化分析。结果表明:国内外在该领域发表文献数量呈快速增长态势,且中文文献发文量高于英文文献;中国、美国、比利时、英国是英文文献发文量排名前四的国家,中国学者发表论文数量最多,占英文文献总量的4..34.,是土壤环境对砾石响应研究领域的主力军;国内外对该领域的研究主要聚焦在砾石单一特征(砾石覆盖度、砾石尺寸、砾石位置等)对水文过程、生态演替及环境效益等影响。因此,未来应继续加强土壤水文过程对砾石响应机制、营养元素在砾石-土壤-植物之间的迁移机制以及“砾石-微生物-植物”系统内部互作效应等方面的研究。可为全球具有相似土壤情况的生态系统服务和农业生产提供新思路、新方法,从而实现节水、高效、高产的农业生产目标,为水土保持等生态服务提供理论依据。

关键词：砾石土壤环境水文过程生态演替环境效应文献计量

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Comparison of Micromorphological Features of Two Agricultural Cultivated Soils in Guanzhong Areas, Shaanxi Province, china

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Agricultural Sciences in china 2007年第9期6卷 1089-1098页

作者： PANG jiang-li QIU Hai-yan huaNG Chun-chang CHA Xiao-cun ZHANG Xu College of Tourism and Environmental Sciences Shaanxi Normal University Xi＇an 710062 P.R.China State key laboratory of Loess and Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences （CAS） Xi＇an 710075. P.R.China

By comparing micromorphological features of irrigated and non-irrigated soils in Guanzhong areas, china, this paper tries to illustrate the influences of farming management methods on the soil-forming process. The micromorphology was observed under a petrographic microscope and its image was quantificationally measured by Nikon NISBR 2.2 software. Both irrigated and non-irrigated soils have the same soil profile pattern, Ap1- AP2- BC, but the former has a more obvious profile dissimilation. The minerals assemblage of soil profiles A and B are very similar, which is mainly composed of Q and P1. Compared with non-irrigated soil, grains of irrigated soil remarkably decrease in length, area, eqdiameter, perimeter, elongation, roundness, and C/F10μm ratio; voids are characterized by more regular void shape and more smooth void wall; there is more abundant residual clay and small amount of illuvial clay. All results in this study suggest that the farming management method has influences on soil profile dissimilation and micromorphology. Agricultural irrigation could strengthen the degree of weathering, make smaller and rounder soil grains, cause a significant increase of residual clay and appearance of illuvial clay. But no significant change has been observed in the minerals assemblage of coarse grains.

关键词： micromorphology irrigation Guanzhong areas

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A Retrospective Survival Analysis of Anatomic and Prognostic Stage Group Based on the American Joint Committee on Cancer 8th Edition Cancer Staging Manual in Luminal B Human Epidermal Growth Factor Receptor 2-negative Breast Cancer

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Chinese Medical Journal 2017年第16期130卷 1945-1952页

作者： ling Xu jiang-Hong li Jing-Ming Ye Xue-Ning Duan Yuan-Jia Cheng ling Xin Qian liu Bin Zhou Yin-hua liu Breast Disease Center Peking University First Hospital Beijing 100034 China Department of General Surgery The Third Hospital of Shijiazhuang Shijiazhuang Hebei 050011 China

Background： Current understanding of tumor biology suggests that breast cancer is a group of diseases with different intrinsic molecular subtypes. Anatomic staging system alone is insufficient to provide future outcome information. The American Joint Committee on Cancer （AJCC） expert panel updated the 8th edition of the staging manual with prognostic stage groups by incorporating biomarkers into the anatomic stage groups. In this study, we retrospectively analyzed the data from our center in china using the anatomic and prognostic staging system based on the AJCC 8th edition staging manual. Methods： We reviewed the data from January 2008 to December 2014.for cases with Luminal B Human Epidermal Growth Factor Receptor 2 （HER2）-negative breast cancer in our center. All cases were restaged using the AJCC 8th edition anatomic and prognostic staging system. The Kaplan-Meier method and log-rank test were used to compare the survival differences between different subgroups. SPSS software version 19.0 （IBM Corp., Armonk, NY, USA） was used for the statistical analyses. Results： This study consisted of 796 patients with Luminal B HER-negative breast cancer. The 5-year disease-free survival （DFS） of 769 Stage I-III patients was 89.7%, and the 5-year overall survival （OS） of all 796 patients was 91.7%. Both 5-year DFS and 5-year OS were significantly different in the different anatomic and prognostic stage groups, There were 372 cases （4..7%） assigned to a different group. The prognostic Stage II and III patients restaged from anatomic Stage III had significant differences in 5-year DFS （v2 = 11.319; P = 0.001） and 5-year OS （χ2 = 5.225, P = 0.022）. In addition, cases restaged as prognostic Stage I, II, or III from the anatomic Stage II group had statistically significant differences in 5-year DFS （χ2 = 6.510, P = 0.039） but no significant differences in 5-year OS （χ2 = 5.087, P = 0.079）. However, the restaged prognostic Stage I and II cases from anatomic Stage I had no statist

关键词： American Joint Committee on Cancer Biomarker Breast Cancer Cancer Stage Luminal B Human EpidermalGrowth Factor Receptor 2-negative Prognostic Factors

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涡旋压缩机平衡铁结构对阻力矩的影响研究

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压缩机技术 2024年第1期 8-13,37页

作者：刘兴旺蒋强强刘晓明陈荣道李远航李登辉兰州理工大学石油化工学院甘肃兰州730050 压缩机技术国家重点实验室(压缩机技术安徽省实验室) 合肥安徽230031

针对涡旋压缩机平衡铁随主轴旋转时产生的阻力损失问题,提出了圆角结构及机翼型结构平衡铁。运用Fluent有限元分析软件,结合滑移网格技术对平衡铁工作区域模拟,研究了3种不同结构平衡铁所受的压差阻力矩和摩擦阻力矩,对比分析了不同结... 详细信息

针对涡旋压缩机平衡铁随主轴旋转时产生的阻力损失问题,提出了圆角结构及机翼型结构平衡铁。运用Fluent有限元分析软件,结合滑移网格技术对平衡铁工作区域模拟,研究了3种不同结构平衡铁所受的压差阻力矩和摩擦阻力矩,对比分析了不同结构产生的阻力矩大小。结果表明:压差阻力矩占总阻力矩的90%以上,总阻力矩随转速的增大而增大;相对于样机平衡铁,前后端面为圆角的平衡铁总阻力矩减小了30%~50%之间;机翼型平衡铁总阻力矩减小了55%~65%之间。

关键词：涡旋压缩机有限元分析平衡铁阻力矩结构优化

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Threshold Ring Signature Scheme Based on TPM

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china Communications 2012年第1期9卷 80-85页

作者： Gong Bei jiang Wei lin li li Yu Zhang Xing College of Computer Science Beijing University of Technology Beijing 100124 P. R. China Institute of Electronic Technology Information Engineering University Zhengzhou 450004 P. R. China State key laboratory of Information Security Institute of Sottware Chinese Academy of Sciences Beijing Beijing 100049 P. R. China key laboratory of Information and Network Security 3rd Research Institute Ministry of Public Security Shanghai 201204 P. R. China

The conventional ring signature schemes cannot address the scenario where the rank of members of the ring needs to be distinguished, for example, in electronically commerce application. To solve this problem, we presented a Trusted Platform Module （TPM）-based threshold ring signature schen. Employing a reliable secret Share Distribution Center （SDC）, the proposed approach can authenticate the TPM-based identity rank of members of the ring but not track a specific member＇s identity. A subset including t members with the same identity rank is built. With the signing cooperation of t members of the subset, the ring signature based on Chinese remainder theorem is generated. We proved the anonymity and unforgeability of the proposed scheme and compared it with the threshold ring signature based on Lagrange interpolation polynomial. Our scheme is relatively simpler to calculate.

关键词： ring signature TPM threshold Chinese remainder theorem rank

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Evolution mechanism of crystallographic orientation in grain continuator bars of a Ni-based single-crystal superalloy prepared by Bridgman technology during directional solidification

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china Foundry 2022年第1期19卷 35-45页

作者： Jiu-han Xiao Wei-guo jiang Dong-yu Han Kai-wen li Guo-jun Tong Yu-zhang Lu Lang-hong Lou Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Weifang university of Science and Technology Shouguang 262700ShandongChina Powerplant Engineering Technical Managements Division Shenyang Maintenance&Overhaul Base China Southern AirlinesShenyang 110000China

Single-crystal rods with different diameters and deviation angles with respect to the solidification direction were produced by Bridgman rapid solidification method at withdrawal rates of 3 and 6 mm·min^(-1) and used as grain *** crystallographic orientation of the rods,which cross-sections were perpendicular to the solidification direction at different solidification heights,was measured by electron backscattered diffraction,while the corresponding microstructures were observed by optical *** mushy zone morphology and the distribution of the temperature gradient were simulated by the finite element analysis {4. *** experimental results indicate that the crystallographic orientation of the single-crystal rods corresponds to the statistical average value of all the dendrite orientations in *** crystallographic orientation of the primary and secondary dendrites of each single-crystal rod at different cross-sections fluctuates irregularly within a small range(less than 4.).The crystallographic orientation of the dendrite in each single-crystal rod is not exactly consistent with each other and is affected by their branching mode of dendrites in the solidification *** addition,the simulation results show that the mushy zone shapes and the temperature gradient of single-crystal rods change with the increase of solidification height during the solidification ***,the evolution mechanism of the crystallographic orientations and the corresponding influence factors were analyzed and discussed.

关键词： single-crystal superalloy dendrite growth orientation evolution solidification space withdrawal rate cross-section size

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结合双线性网络和注意力的蓝藻图像识别方法

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水利信息化 2024年第3期 37-44页

作者：李水艳朱玉东蒋金磊戚荣志陈春雨河海大学数学学院江苏南京211100 太湖流域水文水资源监测中心江苏无锡214024 华能澜沧江水电股份有限公司云南昆明650214 河海大学计算机与软件学院江苏南京211100 水利部水利大数据重点实验室(河海大学) 江苏南京211100

针对实际工程环境中采集的蓝藻图像数量不均衡、复杂光照条件影响、蓝藻图像局部区域特征捕捉不全面等问题,提出一种结合双线性网络和注意力的蓝藻图像识别方法。首先构建蓝藻图像数据集,并使用图像增强算法对数据集进行优化,再使用双... 详细信息

针对实际工程环境中采集的蓝藻图像数量不均衡、复杂光照条件影响、蓝藻图像局部区域特征捕捉不全面等问题,提出一种结合双线性网络和注意力的蓝藻图像识别方法。首先构建蓝藻图像数据集,并使用图像增强算法对数据集进行优化,再使用双线性网络充分提取蓝藻图像特征信息,同时结合卷积块注意力机制,聚焦重要的局部特征,忽视无用信息,进一步提升对无蓝藻、颗粒状蓝藻、带状蓝藻和片状蓝藻等4.不同形态蓝藻图像的分类效果。在构建的Algea-ultimate蓝藻数据集上进行实验,结果表明:相比识别效果最好的经典网络模型ResNet18,所提方法在识别准确率上提升7.29%,识别精度有明显提升。识别方法可用于太湖流域水质监测和预警平台中,提供蓝藻图像自动识别功能,为实时监测水体蓝藻形态提供智能化解决方案。

关键词：图像识别蓝藻双线性网络注意力

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基于数据挖掘探讨针灸治疗卒中后丘脑痛的选穴规律

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针灸临床杂志 2024年第1期40卷 53-60页

作者：张金胜史少静赵紫璇邹鑫姜涛李晶天津中医药大学第一附属医院天津300193 国家中医针灸临床医学研究中心天津300193

目的:基于数据挖掘探讨针灸治疗卒中后丘脑痛的选穴组方规律。方法:电子检索中国期刊全文数据库(CNKI)、万方数据知识服务平台(Wanfang)、维普资讯中文期刊服务平台(VIP)、中国生物医学文献数据库(SinoMed)和PubMed数据库中针灸治疗卒... 详细信息

目的:基于数据挖掘探讨针灸治疗卒中后丘脑痛的选穴组方规律。方法:电子检索中国期刊全文数据库(CNKI)、万方数据知识服务平台(Wanfang)、维普资讯中文期刊服务平台(VIP)、中国生物医学文献数据库(SinoMed)和PubMed数据库中针灸治疗卒中后丘脑痛的文献,通过纳排标准对数据进行筛选。利用Microsoft Excel 2019建立数据库;应用SPSS 21.0软件、SPSS Modeler 18.0软件及Cytoscape3.9.1软件进行腧穴频次与归经、特定穴分析、关联规则分析及聚类分析。结果:共纳入34.有效文献,提取针灸处方34.,涉及腧穴91个,总频次368次;使用频次最高的腧穴为曲池、三阴交;最常涉及的经脉为足少阳胆经、手少阳三焦经与手阳明大肠经;特定穴以交会穴、五腧穴与八脉交会穴使用最多;聚类分析获得7个有效聚类群;核心关联规则分3类:“曲池-环跳-肩髃-外关-风市”、醒脑开窍针刺法主穴和百会-曲鬓,置信度均≥90%、支持度均≥35%。结论:针灸治疗卒中后丘脑痛以水沟-内关-极泉-委中-三阴交为主穴,重视阳经、夹脊穴和郄穴的应用,同时结合头针及肢体腧穴,可取得更加满意的疗效。

关键词：中风丘脑痛针灸选穴规律数据挖掘

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基于网络药理学和分子对接技术探究经典名方辛夷散治疗过敏性鼻炎的潜在作用机制

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右江医学 2024年第4期52卷 303-312页

作者：龚元勋赵净洁罗妙蒋彩英韦洁莹李玉丽右江民族医学院附属医院学科建设与科技创新管理办公室广西百色533000 湖南中医药大学中西医结合学院湖南长沙410208 右江民族医学院附属医院生命科学与临床医学研究中心广西百色533000 湖南省中医药研究院中医药文献信息研究所湖南长沙410013

目的利用网络药理学和分子对接技术研究古代经典名方辛夷散用于过敏性鼻炎防治的潜在作用机制。方法通过TCMSP数据库检索经典名方辛夷散的活性成分并确定作用靶点,通过GeneCards Database、Online Mendelian Inheritance in Man数据库... 详细信息

目的利用网络药理学和分子对接技术研究古代经典名方辛夷散用于过敏性鼻炎防治的潜在作用机制。方法通过TCMSP数据库检索经典名方辛夷散的活性成分并确定作用靶点,通过GeneCards Database、Online Mendelian Inheritance in Man数据库查询与过敏性鼻炎有关的分子靶点,获取两个数据库交集靶点基因。通过Search tool for the retrival of interacting genes/proteins数据库构建上述交集靶点的蛋白质相互作用网络,并导入Cytoscape 3.7.1软件中将分析结果可视化,进一步根据拓扑学数据筛选关键靶点。利用Metascape数据库对交集靶点进行GO和KEGG富集分析。运用AutoDockTools1.5.6软件将活性化合物与核心靶点蛋白进行分子对接。结果筛选得到辛夷散活性化合物184.,相关靶点224.,辛夷散与过敏性鼻炎共同的靶点104.。利用拓扑学筛选得到17个关键靶点,主要包括IL-6、TNF、AKT1、IL1B、VEGFA等。GO功能富集分析表明辛夷散治疗过敏性鼻炎可能涉及脂多糖的反应、细胞对有机环状化合物反应、氧化应激反应等1780条生物过程。KEGG通路结果显示主要参与IL-17信号通路、HIF-1信号通路、糖尿病并发症中的AGE-RAGE信号通路、癌症通路等。分子对接结果显示方中主要活性成分山奈酚、维斯体素、柚皮素、β-谷甾醇、芒柄花黄素等与IL-6、TNF、AKT1、IL1B、VEGFA等均能实现自发结合。结论经典名方辛夷散可能通过多成分、多靶点及多种通路治疗过敏性鼻炎,为深入研究辛夷散的作用机制提供了理论参考。

关键词：辛夷散经典名方网络药理学分子对接过敏性鼻炎

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