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Diabetic macular edema in proliferative stage treated with anti-vascular endothelial growth factor agent and triamcinolone acetonide by laser-based strategies

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International Journal of Ophthalmology(English edition) 2017年第7期10卷 1113-1119页

作者： Gang Qiao Wan-jiang dong Yan Dai Zhen-Hua jiang Hai-Ke Guo Department of Ophthalmology Guangdong General Hospital Affiliated to Southern Medical University Department of Ophthalmology Mianyang Wan-Jiang Eye Hospital Department of Ophthalmology Mianyang Central Hospital

AIM： To appraise the effect of treatment for diabetic macular edema（DME） in proliferative stage with sufficient panrentinal photocoagulation（PRP） therapy and intravitreal injections（IV） Conbercept and posterior subtenon＇s triamcinolone acetonide（STTA） sequential ***： This prospective clinical randomized controlled trial of cross-over design was conducted in three phases. The participants included cases of DME in proliferative stage. They were divided into two groups and treated with PRP before enrollment. Group A were treated with IVConbercept 0.5 mg for one month in the 1^st phase. Group B were treated with STTA 40 mg（twice per two weeks）. The interventions were exchanged in the second phase（2mo） between the two groups. In the third phase（3-6mo） no other treatment was given. Best corrected visual acuity（BCVA）, central macular thickness（CMT） measured by OCT and complications were ***： After phase I： in Group A, BCVA improved from 0.201±0.17 to 0.37±0.24（F=5.88, P=0.004）. CMT changed from 449±155.10 to 304.1±84.70 μm（F=14.9, P〈0.01）. In Group B, BCVA changed from 0.195±0.19 to 0.26±0.20（F=0.76, P=0.41） while CMT changed from 463.82±152.92 to 366.00±115.40 μm（F=3.70, P〈0.03）. The improvement of BCVA was better in Group A（P〈0.05）. After phase II： in Group A, BCVA raised to 0.47±0.27（F=0.26, P〈0.01）, CMT reduced to 260.67±62.97 μm（F=-188.3, P〈0.01）; in Group B, BCVA raised to 0.51±0.26（F=0.31, P〈0.01）, CMT reduced to 261.93±50.15 μm（F=-201.9, P〈0.01）. But there were no difference between two groups（P〉0.05）. After phase III： in Group A, BCVA maintained 0.42±0.25（F=0.22, P=0.001）, CMT maintained 267.8±58.34 μm,（F=-0.27, P〈0.01）; in Group B, BCVA was 0.47±0.25（F=-0.27, P〈0.01）, CMT was 272.71±49.16 μm（F=-191.1, P〈0.01）. No serious complications happened in all ***： PRP＋Conbercept is better than PRP＋STTA in DME with proliferative stage but PRP＋Conbercept＋STTA sequential therapy may be a wiser choice for persistent effectiveness on anat

关键词： Conbercept sequential therapy cross-over design diabetic macular edema

Establishment of drug-resistant HBV small-animal models by hydrodynamic injection

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Acta Pharmaceutica Sinica B 2014年第4期4卷 270-276页

作者： Junjun Cheng Yanxing Han Jian-dong jiang State Key Laboratory of Bioactive Substances and Function of Natural Medicine Institute of Materia MedicaChinese Academy of Medical SciencesBeijing 100050China

In antiviral therapy of hepatitis B virus(HBV)infection,drug resistance remains a huge obstacle to the long-term effectiveness of nucleoside/tide analogs(NAs).Primary resistance mutation(rtM204V)contributes to lamivudine(LAM)-resistance,and compensatory mutations(rtL180M and rtV173L)restore viral fitness and increase replication *** evaluation of new anti-viral agents against drug-resistant HBV is limited by the lack of available small-animal *** established LAM-resistance HBV replication mice models based on clinical LAM-resistant HBV ***(rtM204VþrtL180M)or triple(rtM204VþrtL180MþrtV173L)lamivudine-resistant mutations were introduced into HBV expression vector,followed by hydrodynamic injection into tail vein of NOD/SCID *** was detected on days 5,9,13 and 17 and liver HBV DNA was detected on day 17 after *** serum and liver HBV DNA levels in LAM-resistant model carrying triple mutations are the highest among the *** NAs,LAM and entecavir(ETV),were used to test the availability of the *** and ETV inhibited viral replication on wild-type *** was no longer effective on LAM-resistant models,but ETV retains a strong ***,these models can be used to evaluate anti-viral agents against lamivudine-resistance,affording new opportunities to establish other drug-resistant HBV small-animal models.

关键词： Drug-resistance Animal models Hepatitis B virus Hydrodynamic injection

Recent advances in the anti-HCV mechanisms of interferon

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Acta Pharmaceutica Sinica B 2014年第4期4卷 241-247页

作者： Menghao Huang Jian-dong jiang Zonggen Peng Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Interferon(IFN)in combination with ribavirin has been the standard of care(SOC)for chronic hepatitis C for the past few *** the current SOC lacks the desired efficacy,and 4 new direct-acting antiviral agents have been recently approved,interferons are still likely to remain the cornerstone of therapy for some ***,as an important cytokine system of innate immunity,host interferon signaling provides a powerful antiviral ***,the mechanisms by which HCV infection controls interferon production,and how interferons,in turn,trigger anti-HCV activities as well as control the outcome of HCV infection remain to be *** this report,we review current progress in understanding the mechanisms of IFN against HCV,and also summarize the knowledge of induction of interferon signaling by HCV infection.

关键词： Interferon Hepatitis C virus Antiviral agent Molecular mechanism

Design and Imaging Application of Room-Temperature Terahertz Detector with Micro-Bolometer Focal Plane Array

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Journal of Electronic Science and Technology 2016年第2期14卷 98-102页

作者： Jun Wang Jun Gou Zhi-Ming Wu Ya-dong jiang School of Optoelectronic Information University of Electronic Science and Technology of China

Room-temperature terahertz （THz） detectors indicate a great potential in the imaging application because of their real-time, compact bulk, and wide spectral band responding characteristics. THz detectors with different dimensions based on a micro-bridge structure have been designed and fabricated to get optimized micro-bolometer parameters from the test results of membrane deformation. A nanostructured titanium （Ti） thin film absorber is integrated in the micro-bridge structure of the VOx micro-bolometer by a combined process of magnetron sputtering and reactive ion etching （RIE）, and its improvement of THz absorption is verified by an optical characteristics mesurement. Continuous-wave THz detection and imaging are demonstrated by using a 2.52 THz far infrared CO2 laser and a 320x240 vanadium oxide micro-bolometer focal plane array with an optimized cell structure. With this detecting system, THz imaging of metal concealed in a wiping cloth and an envelope is demonstrated, respectively.

关键词： Index Terms---Focal plane array micro-bolometer structure real-time imaging room temperatureterahertz detector

Perturbation Solutions for Thermal Process of Honeycomb Regenerator

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Journal of Iron and Steel Research International 2007年第4期14卷 6-10,48页

作者： AI Yuan-fang MEI Chi HUANG Guo-dong jiang Shao-iian School of Energy Science and Engineering Central South University Changsha 410083 Hunan China

A parameter perturbation for the unsteady-state heat-transfer characteristics of honeycomb regenerator is presented. It is limited to the cases where the storage matrix has a small wall thickness so that no temperature variation in the matrix perpendicular to the flow direction is considered. Starting from a two-phase transient thermal model for the gas and storage matrix, an approximate solution for regenerator heat transfer process is derived using the multiple-scale method for the limiting case where the longitudinal heat conduction of solid matrix is far less than the convective heat transfer between the gas and the solid. The regenerator temperature profiles are expressed as Taylor series of the coefficient of solid heat conduction item in the model. The analytical validity is shown by comparing the perturbation solution with the experiment and the numerical solution. The results show that it is possible for the perturbation to improve the effectiveness and economics of thermal research on regenerators.

关键词： honeycomb regenerator thermal process asymptotic analysis semi-analytic method

Heavy metal exposure reduces hatching success of Acartia pacifica resting eggs in the sediment

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Journal of Environmental Sciences 2007年第6期19卷 733-737页

作者： jiang Xiao-dong WANG Gui-zhong LI Shao-jing HE Jian-feng Department of Oceanography Xiamen University Xiamen 361005 China State Key Laboratory of Marine Environmental Science Xiamen University Xiamen 361005 China SOA Key Laboratory for Polar Science Polar Research Institute of China Shanghai 200136 China

The potential effects of three heavy metals （Cu, Pb, and Cd） on hatching success ofAcartia pacifica resting eggs in the sediment of Xiamen Bay were experimentally investigated. The number ofA. pacifica nauplii hatched from the sediment sharply decreased with the increase of metal concentration and exposure time from 3 to 30 d. An increase of the Cu concentration from 34.8 to 348 mg/kg, reduced the number of hatched nauplii by 46.6%-100%. An increase of the Pb concentration from 75.2 to 752 mg/kg, reduced the number of hatched nauplii by 21.4%-78.9%. An increase of the Cd concentration from 0.68 to 6.8 mg/kg, reduced the number of hatched nauplii by 31.6%-94.7%. The number of nauplii also significantly decreased with the increase of mixed-metal concentration and exposure time in the mixed-metal test. Trimmed Spearman-Karber analysis gave sediment metal 72-h LC50 values of 1.25 mmol Cu/kg, 1.73 mmol Pb/kg, and 0.054 mmol Cd/kg, which suggested that Cd was the most toxic to A. pacifica resting eggs in the three tested metals. The results indicate that heavy metals with higher concentrations can reduce recruitment of A. pacifica nauplii from benthic resting eggs to planktonic population.

关键词： metal resting egg hatching success Acartia pacifica

Mitigating corrosion of deposit-covered carbon steel in solution containing sulfate-reducing bacteria by purging nitrogen

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Journal of Iron and Steel Research International 2023年第9期30卷 1879-1887页

作者： Zheng-rong Ye Jie Yang Zheng-bin Wang Xiang Zhou Wei-dong jiang Ran Yi Xiao-dong Cui Zhi-hong Zhao Research Institute of Petroleum Exploration and Development PetroChinaBeijing 100083China CAS Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016LiaoningChina School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026AnhuiChina

The corrosion behavior of a carbon steel covered by sand deposits in the solution containing sulfate-reducing bacteria(SRB)under nitrogen purging conditions was studied by electrochemical measurements and surface analyses,aiming at clarifying the mitigation effects of nitrogen purging on SRB-involved under-deposit *** electrochemical results show that the variation trend of polarization resistance with immersion time is unchanged,but the corrosion current density is the lowest in the presence of SRB and deposits under nitrogen purging conditions,as compared to that without purging nitrogen,which are confirmed by the cross-sectional corrosion morphology observation after removing the sand ***,it is found that there are no positive synergistic effects between SRB and deposits on corrosion under nitrogen purging conditions,corresponding to the corrosion *** mitigation on corrosion can be attributed to the less amount of SRB-produced H2S exhausted by purging nitrogen,which is supported by X-ray photoelectron spectrometry ***,purging nitrogen to the solution could be a practically effective way to mitigate the corrosion of deposit-covered carbon steels in SRB-containing solutions.

关键词： Carbon steel Deposit Sulfate-reducing bacteria Nitrogen purging Corrosion mitigation

Research and design of the protection circuits in LD controller

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The Journal of China Universities of Posts and Telecommunications 2006年第4期13卷 73-76页

作者： SHAN jiang-dong TIAN Xiao-jian DENG Jun ZHANG Shuang College of Electronic Science and Engineering Jilin University Changchun 130012 China

According to the parameters and applications of laser diode （LD）, three protection circuits were designed： the time-delay soft-start protection circuit, the power-on impulse protection circuit and the limit-current protection circuit. In this article, the structure and the principle of every protection circuit have been detailed. From several tests and feedbacks from customers, the expected goals have been completed.

关键词： LD protection circuits time-delay soft-start protection circuit power-on impulse protection circuit limit-current protection circuit

Lithological Discrimination of the Mafic-Ultramafic Complex, Huitongshan, Beishan, China: Using ASTER Data

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Journal of Earth Science 2014年第3期25卷 529-536页

作者： Lei Liu Jun Zhou dong jiang Dafang Zhuang Lamin R Mansaray Key Laboratory of Western Mineral Resources and Geological Engineering of Ministry of Education School of Earth Sciences and Resources Chang'an University Lanzhou AuriferouStone Mining Services Co. Ltd. Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences

The Beishan area has more than seventy mafic-ultramafic complexes sparsely distributed in the area and is of a big potential in mineral resources related to mafic-ultramafic intrusions. Many mafic-ultramafic intrusions which are mostly in small sizes have been omitted by previous works. This research takes Huitongshan as the study area, which is a major district for mafic-ultramafic occurrences in Beishan. Advanced spaceborne thermal emission and reflection radiometer（ASTER） data have been processed and interpreted for mapping the mafic-ultramafic complex. ASTER data were processed by different techniques that were selected based on image reflectance and laboratory emissivity spectra. The visible near-infrared（VNIR） and short wave infrared（SWIR） data were transformed using band ratios and minimum noise fraction（MNF）, while the thermal infrared（TIR） data were processed using mafic index（MI） and principal components analysis（PCA）. ASTER band ratios（6/8, 5/4, 2/1） in RGB image and MNF（1, 2, 4） in RGB image were powerful in distinguishing the subtle differences between the various rock units. PCA applied to all five bands of ASTER TIR imagery highlighted marked differences among the mafic rock units and was more effective than the MI in differentiating mafic-ultramafic rocks. Our results were consistent with information derived from local geological maps. Based on the remote sensing results and field inspection, eleven gabbroic intrusions and a pyroxenite occurrence were recognized for the first time. A new geologic map of the Huitongshan area was created by integrating the results of remote sensing, previous geological maps and field inspection. It is concluded that the workflow of ASTER image processing, interpretation and ground inspection has great potential for mafic-ultramafic rocks identifying and relevant mineral targeting in the sparsely vegetated arid region of northwestern China.

关键词： mafic-ultramafic complex ASTER data band ratio minimum noise fraction mafic index principal component analysis.