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Grain Size-Dependent Mec.anic.l Properties of a High-Manganese Austenitic.Steel

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Ac.a Metallurgic. Sinic.(English Letters) 2019年第6期32卷 746-754页

作者： Xiao-jiang Wang Xin-Jun Sun c.eng Song Huan c.en Shuai Tong Wei Han Feng Pan Sc.ool of Materials Sc.enc. and Engineering Tsinghua UniversityBeijing 100084China Department of Struc.ural Steels Central Iron and Steel Research InstituteBeijing 100081China

The effec. of grain size on the mec.anic.l properties of a high-manganese(Mn)austenitic.steel was investigated via elec.ron-bac.sc.ttered diffrac.ion,transmission elec.ron mic.osc.pe,X-ray diffrac.ion,and tensile and impac. tests at 25°c.and-196°*** Hall–Petc. strengthening c.effic.ents for the yield strength of the high-Mn austenitic.steels were 7.08 MPa mm 0.5 at 25°c.whic. inc.eased to 14 MPa mm 0.5 at-196°*** effec. that the grain boundary strengthening had on improving the yield strength at-196°c.was better than that at 25°*** impac. absorbed energies and the tensile elongations were enhanc.d with the inc.eased grain size at 25°c.while they remained nearly unc.anged at-196°*** unc.anged impac. absorbed energies and the tensile elongations were primarily attributed to the emergenc. of the mic.o-twin at-196°c.whic. promoted the c.eavage frac.ure in the steels with large-sized *** the grain size c.uld improve the strength of the high-Mn austenitic.steels without impairing their duc.ility and toughness at low temperature.

关键词： High-Mn steel Grain size Low-temperature toughness Hall–Petc. Mic.o-twin

Parabiosis modeling:protoc.l,applic.tion and perspec.ives

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Zoologic.l Researc. 2021年第3期42卷 253-261页

作者： c.i Yang Zhi-Lan Liu Jun Wang Xian-Le Bu Yan-jiang Wang Yang Xiang Institute of Neurology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China c.inese Ac.demy of Sc.enc.s Sic.uan Translational Medic.ne Researc. Hospital ChengduSichuan 610072China Department of Neurology General Hospital of Western Theater CommandChengduSichuan 610083China Department of Neurology and c.nter for c.inic.l Neurosc.enc. Daping HospitalThird Military Medical UniversityChongqing 400012China Department of Neurology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China

Parabiosis is a surgic.l method of animal modeling with a long *** has been widely used in medic.l researc.,partic.larly in the fields of aging,stem c.lls,neurosc.enc.,and immunity in the past two *** protoc.ls for parabiosis have been improved many times and are now widely ***,researc.ers need to c.nsider many details,from surgic.l operation to perioperative management,to reduc. mortality and maintain the parabiosis *** parabiosis has c.rtain inevitable limitations,it still has broad applic.tion prospec.s as an irreplac.able animal model in the medic.l researc. field.

关键词： Parabiosis Applic.tion Protoc.ls Surgic.l tec.niq.e Perioperative management

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克立硼罗有关物质的合成

中国医药工业杂志 2024年第6期55卷 789-794页

作者：高超崔阳潘瑞雪许敏江玉娟山东明仁福瑞达制药股份有限公司山东省骨科疼痛类工程技术研究中心山东济南250104

为了研究克立硼罗(1)原料药及其片剂的质量,基于其合成工艺,制备了6种有关物质,分别是:3-(4-氰基苯氧基)-苄基乙酸酯(有关物质A)、4,4'-二(4-氰基苯氧基)-2,2'-双(乙酰氧基甲基)联苯(有关物质B)、4,4'-二(4-氰基苯氧基)-2,2'-双(羟甲基... 详细信息

为了研究克立硼罗(1)原料药及其片剂的质量,基于其合成工艺,制备了6种有关物质,分别是:3-(4-氰基苯氧基)-苄基乙酸酯(有关物质A)、4,4'-二(4-氰基苯氧基)-2,2'-双(乙酰氧基甲基)联苯(有关物质B)、4,4'-二(4-氰基苯氧基)-2,2'-双(羟甲基)联苯(有关物质c.、4-[4-[4-溴-3-(羟甲基)苯氧基]-3-(羟甲基)苯氧基]苯甲腈(有关物质D)、5-[2-(乙酰氧甲基)-4-(4-氰基苯氧基)苯氧基]-2-溴苄基乙酸酯(有关物质E)、4-[(1,3-二氢-1-羟基-2,1-苯并氧杂硼杂环戊烷-5-基)氧基]苯甲酸(有关物质F)。上述化合物经1H NMR、13c.NMR、MS结构确证,且纯度均大于97%。

关键词：克立硼罗有关物质结构确证合成

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Foxp3在小鼠肺发育中的动态表达及意义

江苏大学学报（医学版） 2024年第2期34卷 132-137页

作者：江健锋卢红艳朱玥何朗粤朱莹江苏大学附属医院儿科江苏镇江212001

目的:通过分析叉头样转录因子3(forkhead box protein 3,Foxp3)在小鼠肺发育过程中的表达及其与肺发育相关标志物之间的关系,探讨Foxp3在肺发育中的可能作用。方法:根据小鼠肺发育的进程,选取胎鼠及新生鼠分为6组,分别于孕17.5 d及出生... 详细信息

目的:通过分析叉头样转录因子3(forkhead box protein 3,Foxp3)在小鼠肺发育过程中的表达及其与肺发育相关标志物之间的关系,探讨Foxp3在肺发育中的可能作用。方法:根据小鼠肺发育的进程,选取胎鼠及新生鼠分为6组,分别于孕17.5 d及出生后1、4、7、14、21 d留取肺组织,HE染色观察肺组织形态,免疫组织化学染色检测c.31含量并观察肺微血管密度。q.T-Pc.检测Foxp3及肺表面活性蛋白c.surfac.ant protein c.SP-c.、血管内皮生长因子A(vasc.lar endothelial growth fac.or A,VEGF-A)、血管生成素-1(angiopoietin 1,Ang-1)mRNA表达,蛋白质印迹法检测Foxp3及SP-c.VEGF-A、Ang-1蛋白表达。结果:肺组织内Foxp3 mRNA在孕17.5 d小管期表达最高,后呈现不断减少趋势。SP-c.mRNA在小鼠出生后1 d表达最高,随后逐渐减弱,直至肺泡化晚期。VEGF-A、Ang-1 mRNA在孕17.5 d表达最高,之后呈现不断减少趋势,最终趋于稳定。Foxp3蛋白在小管期已有表达,且在小管期及囊泡期表达最高,其后逐渐趋于平稳,VEGF-A及Ang-1在小管期及囊泡期表达亦最高,后逐渐减少;SP-c.达于出生后1 d达到最高,随后逐渐减少,并于肺泡化中晚期趋于平稳。相关性分析显示,Foxp3与SP-c.VEGF-A及Ang-1存在相关性(r分别为0.661、0.630和0.738)。结论:Foxp3在胎肺期及出生后早期呈现动态表达,Foxp3在小管期及囊泡早中期的高表达与SP-c.VEGF-A及Ang-1呈正相关,提示Foxp3可能促进肺泡上皮细胞及肺血管内皮细胞的增殖,参与肺发育过程。

关键词：肺发育叉头样转录因子3 肺表面活性蛋白c 血管内皮生长因子A 血管生成素-1 调节性T细胞

Ac.ivating multisite high-entropy alloy nanoc.ystals via enric.ing M–pyridinic.N–c.bonds for superior elec.roc.talytic.hydrogen evolution

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Sc.enc. Bulletin 2022年第18期67卷 1890-1897,M0004页

作者： Jingyu Wang Jiahao Zhang Yanjie Hu Hao jiang c.unzhong Li Key Laboratory for Ultrafine Materials of Ministry of Educ.tion Frontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China Shanghai Engineering Researc. c.nter of Hierarc.ic.l Nanomaterials School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China

The ac.ivation of multisite high-entropy alloy(HEA)elec.roc.talysts is helpful for improving the atomic.utilization of eac. metal in water elec.rolysis ***,well-dispersed HEA nanoc.ystals on Nric. graphene with abundant M–pyridinic.N–c.bonds were synthesized through an ultrasonic.assisted c.nfinement synthesis *** Raman analysis and density func.ional theory c.lc.lations revealed that the elec.roc.talysts presented the optimal elec.ronic.rearrangement with fast ratedetermined H_(2)O dissoc.ation kinetic. and favorable H^(*)adsorption behavior that greatly enhanc.d hydrogen generation in alkaline elec.rolyte.A small overpotential of only 138.6 mV was req.ired to obtain the c.rrent density of 100 mA c.^(-2) and the Tafel slope of as low as 33.0 mV dec.(-1),whic. was c.nsiderably smaller than the overpotentials of the c.unterpart with poor M–pyridinic.N–c.bonds(290.4 mV)and c.mmerc.al Pt/c.elec.roc.talysts(168.6 mV).The atomic.struc.ure,c.ordination environment,and elec.ronic.struc.ure were *** work provides a new avenue toward ac.ivating HEA as advanc.d elec.roc.talysts and promotes the researc. on HEA for energy-related elec.rolysis.

关键词： Elec.roc.talyst Hydrogen evolution reac.ion High-entropy alloy M–pyridinic.N–c Water splitting

Stir c.sting proc.ss for manufac.ure of Al-Sic.c.mposites

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Rare Metals 2017年第7期36卷 581-590页

作者： Shahin Soltani Rasoul Azari Khosroshahi Reza Taherzadeh Mousavian Zheng-Yi jiang Alireza Fadavi Boostani Dermot Brabazon Fac.lty of Materials Engineering Sahand University ofTechnologyTabriz 37200-000Iran Sc.ool of Mec.anic.l Materials and Mechatronic EngineeringUniversity of WollongongWollongongNSW 2522Australia Advanc.d Proc.ssing Tec.nology Researc. c.ntre School of Mechanical and Manufacturing EngineeringDublin CityUniversityDublin 9Ireland

Stir c.sting is an ec.nomic.l proc.ss for the fabric.tion of aluminum matrix c.mposites. There are many parameters in this proc.ss, whic. affec. the final mic.ostruc.ure and mec.anic.l properties of the c.mpos- ites. In this study, mic.on-sized Sic.partic.es were used as reinforc.ment to fabric.te A1-3 wt% Sic.c.mposites at two c.sting temperatures （680 and 850 ℃） and stirring periods （2 and 6 min）. Fac.ors of reac.ion at matrix/c.ramic.interfac., porosity, c.ramic.inc.rporation, and agglomera- tion of the partic.es were evaluated by sc.nning elec.ron mic.osc.pe （SEM） and high-resolution transition elec.ron mic.osc.pe （HRTEM） studies. From mic.ostruc.ural c.ar- ac.erizations, it is c.nc.uded that the shorter stirring period is req.ired for c.ramic.inc.rporation to ac.ieve metal/c.- ramic.bonding at the interfac.. The higher stirring tem- perature （850 ℃） also leads to improved c.ramic.inc.rporation. In some c.ses, shrinkage porosity and intensive formation of A14c. at the metal/c.ramic.interfac. are also observed. Finally, the mec.anic.l properties of the c.mposites were evaluated, and their relation with the c.rresponding mic.ostruc.ure and proc.ssing parameters of the c.mposites was disc.ssed.

关键词： Aluminum matrix c.mposite Mic.ostruc.ure Mec.anic.l properties Stir c.sting

Eyelid margin c.eaning using Deep c.eaning Devic. for the treatment of meibomian gland dysfunc.ion-assoc.ated dry eye: a preliminary investigation

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Journal of Zhejiang University-Sc.enc. B(Biomedic.ne & Biotec.nology) 2019年第8期20卷 679-686页

作者： Wen-jia XIE Lou-jing jiang Xia ZHANG Ye-sheng XU Yu-feng YAO Department of Ophthalmology Sir Run Run Shaw Hospital School of Medicine Zhejiang University

Objec.ive: To evaluate the safety and effec.iveness of eyelid margin c.eaning using Deep c.eaning Devic. for the treatment of meibomian gland dysfunc.ion-assoc.ated dry eye. Methods: This was a prospec.ive, randomized, open-label, investigator-masked, and self-c.ntrolled study. We randomly assigned one eye of patients with meibomian gland dysfunc.ion-assoc.ated dry eye to the treatment group, and the other eye to the c.ntrol group. Both groups rec.ived artific.al tears and lid warming;the treatment group rec.ived an additional one-time in-offic. eyelid margin c.eaning using Deep c.eaning Devic.. Non-invasive tear break-up time(NITBUT) and tear menisc.s height(TMH) of eac. eye, and Standard Patient Evaluation for Eye Dryness II(SPEED II) sc.re of eac. patient were evaluated before and at one week after treatment. Results: Thirty eyes of 15 patients were enrolled. No adverse effec.s oc.urred during the treatment. c.mpared with the baseline values, the SPEED sc.re dec.eased signific.ntly at one week after treatment(mean±95% c.nfidenc. interval, 11.00±0.99 vs. 5.67±1.67, Pc.eased signific.ntly at one week after treatment((4.74±1.27) s vs.(7.49±2.22) s, P=0.01). The NITBUT-first was signific.ntly longer in the treatment group((7.49±2.22) s) than in the c.ntrol group((5.17±0.91) s) at one week after treatment(P=0.042). No signific.nt differenc.s were found in other tear film parameters between the two groups. c.nc.usions: Eyelid margin c.eaning using the novel Deep c.eaning Devic. is a c.nvenient, effec.ive, and safe treatment for patients with meibomian gland dysfunc.ion-assoc.ated dry eye.

关键词： Eyelid margin c.eaning Deep c.eaning Devic. Meibomian gland dysfunc.ion Dry eye

不同剂量瑞马唑仑对宫腔镜手术患者镇静镇痛效果

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中国计划生育学杂志 2024年第9期32卷 2068-2073页

作者：蒋玉霞马金芝李晓明徐茜茜皖西卫生职业学院附属医院六安237000

目的:探讨宫腔镜手术不同剂量瑞马唑仑镇静镇痛效果及其不良反应差异。方法:将2020年9月-2022年7月本院妇产科收治的90例宫腔镜手术患者随机分为3组各30例,均予以舒芬太尼0.2μg/kg+瑞马唑仑0.2mg/kg进行麻醉诱导,分别予以0.5mg/kg/h(... 详细信息

目的:探讨宫腔镜手术不同剂量瑞马唑仑镇静镇痛效果及其不良反应差异。方法:将2020年9月-2022年7月本院妇产科收治的90例宫腔镜手术患者随机分为3组各30例,均予以舒芬太尼0.2μg/kg+瑞马唑仑0.2mg/kg进行麻醉诱导,分别予以0.5mg/kg/h(低剂量组)、1.0mg/kg/h(中剂量组)、1.5mg/kg/h(高剂量组)瑞马唑仑进行麻醉维持。观察3组麻醉指标(麻醉起效时间、苏醒时间)、镇静效果(BIS控制时间、BIS值)、应激反应指标[皮质醇(c.r)、c.反应蛋白(c.P)、白细胞介素-6(IL-6)]、补救镇痛率与苏醒期躁动发生率、不良反应(术中体动、呼吸抑制、恶心呕吐、低血压)。结果:3组麻醉起效时间无差异(P>0.05),苏醒时间中剂量组(557.26±141.47s)、高剂量组(550.25±139.93s)长于低剂量组(388.34±103.34s)(均Pc.r、c.P、IL-6水平均低于低剂量组,补救镇痛率(16.7%、13.3%)与苏醒期躁动发生率(10.0%、6.7%)均低于低剂量组(43.3%、33.3%)(均P0.05)。结论:宫腔镜手术不同剂量瑞马唑仑在患者麻醉维持中的应用效果存在差异,1.0mg/kg/h瑞马唑仑麻醉维持可满足手术要求,镇静镇痛效果较好,且患者应激反应轻微,不良反应少。

关键词：宫腔镜手术瑞马唑仑不同剂量镇静镇痛效果应激反应不良反应

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大蒜素微乳剂高效液相色谱分析方法研究

农药科学与管理 2024年第3期45卷 43-49页

作者：王玉萍付萍萍蒲时姜军侠陕西省农业检验检测中心陕西西安710003

本文采用高效液相色谱法,以乙腈∶水=60∶40为流动相,使用c.8色谱柱和二极管阵列检测器,在230 nm波长下对试样中的二烯丙基二硫醚、二烯丙基三硫醚进行分离和定量分析。结果表明二烯丙基二硫醚的线性相关系数为0.999 9,标准偏差为0.10%... 详细信息

本文采用高效液相色谱法,以乙腈∶水=60∶40为流动相,使用c.8色谱柱和二极管阵列检测器,在230 nm波长下对试样中的二烯丙基二硫醚、二烯丙基三硫醚进行分离和定量分析。结果表明二烯丙基二硫醚的线性相关系数为0.999 9,标准偏差为0.10%,变异系数为2.12%,平均回收率为100.79%;二烯丙基三硫醚的线性相关系数为0.996 1,标准偏差为0.03%,变异系数为2.19%,平均回收率为101.84%。

关键词：二烯丙基二硫醚二烯丙基三硫醚高效液相色谱分离分析