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Perceiving the connection between the bone healing process and biodegradation of biodegradable metal implants through precise bioadaptability principle

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Journal of Materials Science & Technology 2023年第16期147卷 132-144页

作者： Yufeng Zheng Xiao Liu Danni Shen Wenting Li Yan Cheng Ming Yang Yuhui Kou baoguo jiang Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China School of Materials Science and Engineering Peking UniversityBeijing 100871China International Research Organization for Advanced Science and Technology(IROAST) Kumamoto UniversityKumamoto 860-8555Japan Department of Orthopaedics and Traumatology Peking University People’s HospitalBeijing 100044China Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijing 100044China National Center for Trauma Medicine Beijing 100044China

The implants made of metallic biomaterials help healing the bone fracture but also affect the bone repair *** proposed in Matter 4(2021)2548–2650 by Wang et al.,a precisely adaptable biomaterial ought to recapitulate the targeted tissue with spatiotemporal precision and hierarchical accuracy,ranging from atoms and molecules(genes,proteins,etc.)to cells(including organelles)and to tissues and *** comparison to traditional bio-inert metallic bone implants such as Co-based alloys and Ti alloys,biodegradable metal(Mg and Zn alloys)bone implants had been developed and might arise many unexpected variables in the bone repair,due to their bioactive *** this paper,the bone repair without and with the presence of metallic implants is ***,the perspectives concerning the interactions between the bone tissues and biodegradable metal implants are put forward,and how to better mimic in vivo biodegradation by in vitro experiments is proposed for further research and development of biodegradable metals.

关键词： Biodegradable metals Magnesium Zinc Bone healing Precise bioadaptability

A Temporal–Spatial Atlas of Peripheral Nerve Evoked Cortex Potential in Rat:A Novel Testbed to Explore the Responding Patterns of the Brain to Peripheral Nerves

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Engineering 2022年第7期8卷 147-155页

作者： Xiaofeng Yin Jiuxu Deng Bo Chen Bo Jin Xinyi Gu Zhidan Qi Kunpeng Leng baoguo jiang Department of Trauma and Orthopedics Peking University People’s HospitalBeijing 100044China

Observing the dynamic progress of the brain in response to peripheral nerve stimulation as a whole is the basis for a deeper understanding of overall brain function;however,it remains a great *** this work,a novel mini-invasive orthogonal recording method is developed to observe the overall evoked cortex potential(ECP)in rat brain.A typical ECP atlas with recognizable waveforms in the rat cortex corresponding to the median,ulnar,and radial nerve trunks and subdivided branches is *** exciting temporal–spatial progress in the rat brain is obtained and visualized for the first *** in the ECPs and exciting sequences in the cortex four months after median nerve transection are also *** results suggest that the brain’s response to peripheral stimulation has precise and reproducible temporal–spatial *** resource can serve as a testbed to explore the overall functional interaction and dynamic remodeling mechanisms between the peripheral and central nervous systems over time.

关键词： Peripheral nerve Brain Evoked cortex potential Temporal–spatial Atlas

Long-term bone and lung consequences associated with hospital-acquired severe acute respiratory syndrome:a 15-year follow-up from a prospective cohort study

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Bone Research 2020年第1期8卷 107-114页

作者： Peixun Zhang Jia Li Huixin Liu Na Han Jiabao Ju Yuhui Kou Lei Chen Mengxi jiang Feng Pan Yali Zheng Zhancheng Gao baoguo jiang Department of Orthopedics and Trauma Peking University People’s HospitalBeijingChina Department of Respiratory Medicine Peking University People’s HospitalBeijingChina Department of Clinical Epidemiology and Biostatistics Peking University People’s HospitalBeijingChina Department of Central Laboratory Peking University People’s HospitalBeijingChina Department of Education Peking University People’s HospitalBeijingChina Department of Radiology Peking University People’s HospitalBeijingChina

The most severe sequelae after rehabilitation from SARS are femoral head necrosis and pulmonary fibrosis. We performed a 15-year follow-up on the lung and bone conditions of SARS patients. We evaluated the recovery from lung damage and femoral head necrosis in an observational cohort study of SARS patients using pulmonary CT scans, hip joint MRI examinations, pulmonary function tests and hip joint function questionnaires. Eighty medical staff contracted SARS in 2003. Two patients died of SARS, and78 were enrolled in this study from August 2003 to March 2018. Seventy-one patients completed the 15-year follow-up. The percentage of pulmonary lesions on CT scans diminished from 2003(9.40 ± 7.83)% to 2004(3.20 ± 4.78)%(P < 0.001) and remained stable thereafter until 2018(4.60 ± 6.37)%. Between 2006 and 2018, the proportion of patients with interstitial changes who had improved pulmonary function was lower than that of patients without lesions, as demonstrated by the one-second ratio(FEV1/FVC%, t = 2.21, P = 0.04) and mid-flow of maximum expiration(FEF25%–75%, t = 2.76, P = 0.01). The volume of femoral head necrosis decreased significantly from 2003(38.83 ± 21.01)% to 2005(30.38 ± 20.23)%(P = 0.000 2), then declined slowly from 2005 to 2013(28.99 ± 20.59)% and plateaued until 2018(25.52 ± 15.51)%. Pulmonary interstitial damage and functional decline caused by SARS mostly recovered, with a greater extent of recovery within 2 years after rehabilitation. Femoral head necrosis induced by large doses of steroid pulse therapy in SARS patients was not progressive and was partially reversible.

关键词： doses consequences slowly

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我国创伤体救治体系建设的现状与思考

中华医学杂志 2019年第43期99卷 3382-3384页

作者：姜保国北京大学创伤医学中心北京大学人民医院创伤骨科北京100044

严重创伤的救治不但需要科学、高效的处理规范,还需建立相应的救治体系.本文就我国区域创伤救治体系建设的进展与现状进行总结并对下一步主要工作进行展望.

关键词：创伤救治体系建设

Ultrasonic Characteristics and Severity Assessment of Lung Ultrasound in COVID-19 Pneumonia:A Retrospective,Observational Study

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Engineering 2021年第3期7卷 367-375页

作者： Fengxue Zhu Xiujuan Zhao Tianbing Wang Zhenzhou Wang Fuzheng Guo Haiyan Xue Panpan Chang Hansheng Liang Wentao Ni Yaxin Wang Lei Chen baoguo jiang Trauma Center Citical Care Medicine DepartmentPeking University People's HospitalBeijing 100044China Trauma Center Key Laboratory of Trauna and Neurad Regeneration(Peling Univerity)Minisiry of EducationPeking Universty Peole's Hiospital lejing 100044China Anesthesioogy Department Peking Uhniversity People's HospitalBeijing 100044China Respiratory and Griticnl Care Medicine Depariment Peking Lniversity People's HospitalBeiing 10004China Raiology Deparment Peking University People's HospitalBeijing 100044China

The clinical application of lung ultrasound(LS)in the assessment of coronavirus disease 2019(COVID-19)pneumonia severity remains limited,Herein,we investigated the role of LUS imaging in CoVID-19pneumonia patients and the relationship between LUS findings and disease *** was a retro-spective,observational study at Tongji Hospital,on 48 recruited patients with COVID-19 pneu-monia,including 32 non-critically ill patients and 16critically ill *** was performed and the respiratory rate oxygenation(ROX)index,disease severity,and confusion,blood urea nitrogen,respira-tory rate,blood pressure,and age(CURB-65)score were recorded on days 0-7,8-14,and 15-21 after *** images were divided into 12 regions,and the luS score(0-36 points)was *** tomography(CT)scores(0-20 points)were also recorded on days *** between the LUS score,ROX index,and CURB-65 scores were *** detected COVID-19 pneumonia in *** signs included B lines(34/38,89.5%),consolidations(6/38,15.8%),and pleural effusions(2/38,5.3%).Most cases showed more than one lesion(32/38,84.2%)and involved both lungs(28/38,73.7%).Compared with non-critically ill patients,the LUS scores of critically ill patients were higher(12(10-18)vs 2(0-5),p<0.001).The LUS score showed significant negative cor-relations with the ROX indexon days O-7(r=-0.85,p<0.001),days 8-14(r=-0.71,p<0.001),and days 15-21(r=-0.76,p<0.001)after symptom ***,the LUS score was positively correlated with the CT score(r=0.82,p<0.001).The number of patients with LUS-detected lesions decreased from 27 cases(81.8%)to 20 cases(46.5%),and the lus scores significantly decreased from 4(2-10)to 0(0-5),(p<0.001) from days O-7 to *** conclude that LUS can detect lunglesions in COVID-19 pneumo-nia patients in a portable,real-time,and safe ***,LUS is helpful in assessing COVID-19 pneu-monia severity in critically ill patients.

关键词： Coronavirus disease 2019 Lung ultrasound Pneumonia

两岸民事判决相互认可和执行实证研究:兼论互惠不均衡状态之克服

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法学评论 2019年第4期37卷 95-107页

作者：江保国华南农业大学人文与法学学院

海峡两岸均认为区际司法互助有别于国际司法协助,总体上对民事判决的相互认可和执行持积极的支持态度,表现在判决认可率较高、对公共秩序保留的适用较为审慎等方面,并实现了从默契互惠到协议互惠的转换。台湾地区在此方面先行一步,起始... 详细信息

海峡两岸均认为区际司法互助有别于国际司法协助,总体上对民事判决的相互认可和执行持积极的支持态度,表现在判决认可率较高、对公共秩序保留的适用较为审慎等方面,并实现了从默契互惠到协议互惠的转换。台湾地区在此方面先行一步,起始阶段认可和执行人民法院的民事判决数量相对较多,但大陆具有明显的后发优势,在深度和广度上已后来居上,出现了两岸互惠的不均衡状态。克服这种状态的可能路径主要有二:一是立法修改,即或者通过双边协商沟通促进立法修改,或者是基于互惠原则单边主动进行立法修改;二是司法解释,通过司法机关在个案中对规则的解释,克服严格法条主义对民事判决范围和既判力的褊狭理解。

关键词：两岸民事判决认可和执行不均衡状态

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我国创伤救治面临的挑战

中华外科杂志 2015年第6期53卷 401-404页

作者：姜保国北京大学人民医院创伤骨科北京大学交通医学中心 100044

随着我国城市化进程的加快和社会经济的不断发展,创伤在整体疾病致死和致残中的比重日益突出,现已经成为45岁以下人群中第一死亡原因.与其他疾病的救治相比,我国在创伤救治方面面临诸多问题和挑战,具体表现在3个方面：创伤尚未得到医学... 详细信息

随着我国城市化进程的加快和社会经济的不断发展,创伤在整体疾病致死和致残中的比重日益突出,现已经成为45岁以下人群中第一死亡原因.与其他疾病的救治相比,我国在创伤救治方面面临诸多问题和挑战,具体表现在3个方面：创伤尚未得到医学领域和社会的足够重视,缺乏真正意义上的创伤中心;创伤救治水平参差不齐,创伤救治人员缺乏规范化培训;缺乏科学统一、与国际接轨的救治流程和符合地域特点的区域创伤救治体系.鉴于上述现状及存在的问题,借鉴国外成功经验,我们认为应该从以下3个方面着手逐步改变我国创伤救治的现状：建立专门研究创伤、培养创伤人才、传播创伤相关知识的系统学科;建立适合中国国情的创伤救治体系;建立以“基础培养”和“针对性培养”相结合的创伤专科医师培训体系;建立严重创伤多学科协作诊疗模式.借此提高我国创伤综合救治水平,降低创伤致残、致死率,进而推动我国创伤救治向前发展.

关键词：创伤和损伤急诊处理死亡率预后

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积极开展足踝部创伤的临床研究

中华创伤骨科杂志 2016年第3期18卷 185-186页

作者：姜保国北京大学人民医院创伤骨科 100044

足踝部创伤临床上非常常见，手术例数在很多医院的创伤骨科中能占到1／3左右。过去，很多医院对足踝部创伤重视程度不够，以踝关节骨折为例，经常是住院医师或是低年资的主治医师完成手术，由于对踝关节骨折的复杂程度认识不足，处理不... 详细信息

足踝部创伤临床上非常常见，手术例数在很多医院的创伤骨科中能占到1／3左右。过去，很多医院对足踝部创伤重视程度不够，以踝关节骨折为例，经常是住院医师或是低年资的主治医师完成手术，由于对踝关节骨折的复杂程度认识不足，处理不当而导致严重的后遗症。近年来，随着足踝创伤研究的深入，大家对它的认识也越来越深刻。目前，在足踝部创伤领域，既有共识，也存在很多争议。

关键词：创伤骨科临床研究足踝部踝关节骨折重视程度主治医师住院医师低年资

Reply to “Can femoral head necrosis induced by steroid therapy in patients infected with coronaviruses be reversed?”

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Bone Research 2021年第2期9卷 249-249页

作者： Peixun Zhang Jiabao Ju Na Han baoguo jiang Department of Orthopedics and Trauma Peking University People’s HospitalBeijingChina

The authors reply:We deeply appreciated your interest in our *** our study,the conclusion that femoral head necrosis induced by large doses of steroid pulse therapy in SARS patients was partially reversible was based on the results of the volume of femoral head necrosis on MRI combined with the ARCO *** volume of osteonecrosis decreased significantly from 2003(38.83%±21.01%)to 2005(30.38%±20.23%)(P=0.0002),then declined slowly from 2005 to 2013(28.99%±20.59%)and plateaued in 2018(25.52%±15.51%).The ARCO stages of 17 limbs in ten patients stabilized or improved during follow-up,while the stages of six limbs in four patients reflected deterioration.

关键词： patients femoral doses