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Research Advance of Chinese Medicine in Treating Atherosclerosis:Focus on Lipoprotein-Associated Phospholipase A2

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Chinese Journal of Integrative Medicine 2024年第3期30卷 277-288页

作者： WANG Lu-ming ZHANG Wen-lan LYU Nuan SUO Yan-rong YANG Lin YU Bin jiang xi-juan School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin301617China Department of Traditional Chinese Medicine Ganzhou People’s HospitalGanzhouJiangxi Province341000China School of Medical Technology Tianjin University of Traditional Chinese MedicineTianjin301617China

As a serious cardiovascular disease,atherosclerosis(AS)causes chronic inflammation and oxidative stress in the body and poses a threat to human health.Lipoprotein-associated phospholipase A2(Lp-PLA2)is a member of the phospholipase A2(PLA2)family,and its elevated levels have been shown to contribute to AS.Lp-PLA2 is closely related to a variety of lipoproteins,and its role in promoting inflammatory responses and oxidative stress in AS is mainly achieved by hydrolyzing oxidized phosphatidylcholine(ox PC)to produce lysophosphatidylcholine(lyso PC).Moreover,macrophage apoptosis within plaque is promoted by localized Lp-PLA2 which also promotes plaque instability.This paper reviews those researches of Chinese medicine in treating AS via reducing Lp-PLA2 levels to guide future experimental studies and clinical applications related to AS.

关键词： lipoprotein-associated phospholipase A2 atherosclerosis inflammation oxidative stress apoptosis Chinese medicine

Lensless opto-electronic neural network with quantum dot nonlinear activation

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Photonics Research 2024年第4期12卷 682-690页

作者： WANxiN SHI xi jiang ZHENG HUANG XUE LI YUYANG HAN SIGANG YANG HAIZHENG ZHONG HONGWEI CHEN Beijing National Research Center for Information Science and Technology(BNRist) Department of Electronic EngineeringTsinghua UniversityBeijing 100084China China Mobile Research Institute Beijing 100053China MIIT Key Laboratory for Low-dimensional Quantum Structure and Devices School of Materials Sciences&EngineeringBeijing Institute of TechnologyBeijing 100081China

With the swift advancement of neural networks and their expanding applications in many fields, optical neural networks have gradually become a feasible alternative to electrical neural networks due to their parallelism, high speed, low latency, and power consumption. Nonetheless, optical nonlinearity is hard to realize in free-space optics, which restricts the potential of the architecture.

关键词： network neural networks

Inferring Mycobacterium Tuberculosis Drug Resistance and Transmission using Whole-genome Sequencing in a High TB-burden Setting in China

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Biomedical and Environmental Sciences 2024年第2期37卷 157-169页

作者： FAN Yu Feng LIU Dong xin CHEN Yi Wang OU xi Chao MAO Qi Zhi YANG Ting Ting WANG xi jiang HE Wen Cong ZHAO Bing LIU Zhen jiang ABULIMITI Maiweilanjiang AIHEMUTI Maimaitiaili GAO Qian ZHAO Yan Lin Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032China National Tuberculosis Reference Laboratory Chinese Center for Disease Control and PreventionBeijing 102206China Hangzhou Red Cross Hospital Hangzhou 310005ZhejiangChina xinjiang Uygur Autonomous Region Center for Disease Control and Prevention Urumqi 830026XinjiangChina Tuberculosis Dispensary of Kashgar Prefecture Kashgar 844099XinjiangChina

Objective China is among the 30 countries with a high burden of tuberculosis(TB)worldwide,and TB remains a public health concern.Kashgar Prefecture in the southern xinjiang Autonomous Region is considered as one of the highest TB burden regions in China.However,molecular epidemiological studies of Kashgar are lacking.Methods A population-based retrospective study was conducted using whole-genome sequencing(WGS)to determine the characteristics of drug resistance and the transmission patterns.Results A total of 1,668 isolates collected in 2020 were classified into lineages 2(46.0%),3(27.5%),and 4(26.5%).The drug resistance rates revealed by WGS showed that the top three drugs in terms of the resistance rate were isoniazid(7.4%,124/1,668),streptomycin(6.0%,100/1,668),and rifampicin(3.3%,55/1,668).The rate of rifampicin resistance was 1.8%(23/1,290)in the new cases and 9.4%(32/340)in the previously treated cases.Known resistance mutations were detected more frequently in lineage 2 strains than in lineage 3 or 4 strains,respectively:18.6%vs.8.7 or 9%,P<0.001.The estimated proportion of recent transmissions was 25.9%(432/1,668).Multivariate logistic analyses indicated that sex,age,occupation,lineage,and drug resistance were the risk factors for recent transmission.Despite the low rate of drug resistance,drug-resistant strains had a higher risk of recent transmission than the susceptible strains(adjusted odds ratio,1.414;95%CI,1.023–1.954;P=0.036).Among all patients with drug-resistant tuberculosis(DR-TB),78.4%(171/218)were attributed to the transmission of DR-TB strains.Conclusion Our results suggest that drug-resistant strains are more transmissible than susceptible strains and that transmission is the major driving force of the current DR-TB epidemic in Kashgar.

关键词： Mycobacterium tuberculosis Whole-genome sequencing(WGS) Transmission Drug resistance xinjiang

体育事业发展中重点领域、新兴领域、涉外领域立法论纲——以高质量的体育立法助推体育强国建设

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成都体育学院学报 2024年第1期50卷 72-82页

作者：姜熙上海政法学院体育法治研究院上海201701

加强体育事业发展中重点领域、新兴领域、涉外领域立法是中国体育法治建设的重要任务,也是体育强国建设的重要保障。文章运用文献资料法、逻辑分析法等方法,就加强体育事业发展中重点领域、新兴领域、涉外领域立法的战略意义、基本遵循... 详细信息

加强体育事业发展中重点领域、新兴领域、涉外领域立法是中国体育法治建设的重要任务,也是体育强国建设的重要保障。文章运用文献资料法、逻辑分析法等方法,就加强体育事业发展中重点领域、新兴领域、涉外领域立法的战略意义、基本遵循、主要立法内容进行了探讨。研究认为,体育事业发展中重点领域的立法主要应该加强全民健身保障立法、青少年与学校体育配套立法、竞技体育领域立法、体育产业促进立法、职业体育立法、体育市场监管立法、体育组织治理的立法;体育事业发展中新兴领域的立法主要应该重视数字体育立法、体育领域市场竞争立法、体育投融资立法、打击操纵比赛的立法;涉外体育领域的立法应该重点围绕建立起在国际体育活动中保护国家利益的法律制度来展开,并就各类涉外体育事务建立起法治化的规章制度。

关键词：体育强国体育法体育法治立法

Acute diffuse peritonitis secondary to a seminal vesicle abscess:A case report

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World Journal of Clinical Cases 2023年第3期11卷 645-654页

作者： Kun Li Nan-Bin Liu jiang-xi Liu Quan-Ning Chen Bao-Min Shi Department of General Surgery Tongji Hospital of Tongji UniversityShanghai 200065China National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710000Shaanxi ProvinceChina

BACKGROUND Seminal vesicle abscess(SVA)is the manifestation of a relatively rare urinary system infection.In response to urinary system inflammation,an abscess forms in special locations.However,acute diffuse peritonitis(ADP)induced by SVA is unusual.CASE SUMMARY We report a case of a left SVA in a male patient complicated with pelvic abscess,ADP,multiple organ dysfunction syndrome,infectious shock,bacteremia,and acute appendiceal extraserous suppurative inflammation as a result of a long-term indwelling urinary catheter.The patient received a course of morinidazole+cefminol antibiotics but showed no obvious relief,so the perineal SVA underwent puncture drainage and abdominal abscess drainage+appendectomy was performed.The operations were successful.After the operation,anti-infection,anti-shock,and nutritional support treatments were continued and various laboratory indicators were regularly reviewed.The patient was discharged from the hospital after recovery.This disease is a challenge for the clinician because of the unusual spreading path of the abscess.Moreover,appropriate intervention and adequate drainage of abdominal and pelvic lesions are necessary,especially when the primary focus cannot be determined.CONCLUSION The etiology of ADP varies,but acute peritonitis secondary to SVA is very rare.In this patient,the left SVA not only affected the adjacent prostate and bladder but also spread retrogradely through the vas deferens,forming a pelvic abscess in the loose tissues of the extraperitoneal fascia layer.Inflammation involving the peritoneal layer led to ascites and pus accumulation in the abdominal cavity,and appendix involvement led to extraserous suppurative inflammation.In clinical practice,surgeons need to consider the results of various laboratory tests and imaging examinations to make comprehensive judgments involving the diagnosis and treatment plan.

关键词： Seminal vesicle abscess Acute diffuse peritonitis Acute appendicitis Multiple organ dysfunction syndrome Case report

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氧化铜精矿熔炼过程中铜、钴、铁的还原行为

东北大学学报（自然科学版） 2024年第3期45卷 337-345页

作者：张磊蒋开喜谢锋路殿坤东北大学冶金学院辽宁沈阳110819 矿冶科技集团有限公司北京100044 福州大学紫金地质与矿业学院福建福州350108

针对刚果金含钴氧化铜精矿采用铁橄榄石渣型进行了焦炭还原熔炼,考察了m(CaO)/m(SiO_(2)),m(FeO)/m(SiO_(2))和焦比等对铜、钴还原率的影响.对铜、钴、铁和硅氧化物的还原顺序和还原条件进行了热力学分析,借助金属氧化物还原热力学模型... 详细信息

针对刚果金含钴氧化铜精矿采用铁橄榄石渣型进行了焦炭还原熔炼,考察了m(CaO)/m(SiO_(2)),m(FeO)/m(SiO_(2))和焦比等对铜、钴还原率的影响.对铜、钴、铁和硅氧化物的还原顺序和还原条件进行了热力学分析,借助金属氧化物还原热力学模型与焦炭气化动力学对铜、钴、铁氧化物的还原进程进行了量化分析.研究结果表明,氧化铜精矿中金属铜、钴、铁的还原分为前期的竞争性快速还原期和后期的铜、钴慢速还原期,在慢速还原期已经还原的金属铁还会发生再氧化;金属铁前期大量的竞争性还原和后期的再氧化会降低铜、钴、铁的还原率和焦炭的有效利用率.揭示了粗铜表面铁合金层的形成机制.

关键词：氧化铜精矿铜钴 FeO还原热力学模型铁橄榄石

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A Comprehensive Framework for Decoding Salty Taste Information from EEG Signals: Distinguishing Brain Reactions to Saltiness of Comparable Intensity

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Food Science and Human Wellness 2024年

作者： Jingjing Liu Yifei Xu xingwang Lian Tianming Liu Haohao Ning xi jiang Shixin Yu Shikun Liu Lu Huang xiaojun Sun jiangyong Li Dongfu Xu School of Life Science and Technology University of Electronic Science and Technology of China Department of Computer Science the University of Georgia School of Automation Engineering Northeast Electric Power University

The perception of salty taste is crucial for individuals to make healthy food choices. Yet， the brain electrophysiological signals underlying salty taste perception have been poorly described. In this study， electroencephalography (EEG) was used to record brain activity induced by NaCl solution as a salty taste stimulus. A combination of a custom delivery device and stimulation paradigm was employed to preserve the salty taste signal clearly. A stimulus-response capture method was proposed that could adapt to individual differences in brain responses to salty taste and accurately segment salty taste response signals. Applying this method to the EEG processing workflow can form a complete data processing framework. The results showed that the neural response induced by salty taste reached a high activity level in the initial stage within a short period (0.2s)， and there was a sustained periodic response within 0.75s after the stimulation. Moreover， the salty taste information in the EEG signal was decoded， and discrimination of two similar concentrations of salty taste solutions was achieved far above the chance level (average identification rate: 89.66%). This study demonstrated experimental paradigms and research methods for understanding salty taste perception， which could provide references for research on other basic tastes.

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靶向铁死亡增强胶质母细胞瘤的辐射敏感性

生物化学与生物物理进展 2024年第6期51卷 1284-1291页

作者：蒋希忠乔诗宇姜曈阎英徐莹吴彤中国医科大学北部战区总医院研究生培养基地沈阳110016 北部战区总医院放射治疗科沈阳110016

胶质母细胞瘤是一种高度恶性的脑肿瘤,具有快速生长、广泛浸润、高致死率的特点。放射治疗是利用电离辐射杀伤肿瘤细胞作为治疗胶质母细胞瘤的重要手段。由于胶质瘤患者五年生存率极低,因此迫切需要一些新的有效治疗策略。近年来,铁死... 详细信息

胶质母细胞瘤是一种高度恶性的脑肿瘤,具有快速生长、广泛浸润、高致死率的特点。放射治疗是利用电离辐射杀伤肿瘤细胞作为治疗胶质母细胞瘤的重要手段。由于胶质瘤患者五年生存率极低,因此迫切需要一些新的有效治疗策略。近年来,铁死亡作为一种新型的调节性细胞死亡方式,在胶质母细胞瘤的治疗中发挥了重要作用。已有研究揭示了铁死亡的关键过程,包括细胞内铁蓄积、活性氧产生、脂质过氧化、谷胱甘肽过氧化物酶4和胱氨酸-谷氨酸反向转运体活性抑制。研究表明,辐射可以通过产生活性氧、抑制抗氧化系统信号轴、耗竭谷胱甘肽、上调酰基辅酶A合成酶长链家族成员4以及诱导自噬来触发铁死亡。在放射治疗中可通过诱导铁超载、破坏抗氧化系统和线粒体功能等途径靶向铁死亡来增强胶质母细胞瘤的辐射敏感性。靶向铁死亡的辐射增敏治疗策略在胶质瘤的治疗中具有重要的潜在价值。本文综述了铁死亡及其发生机制,分析辐射诱导铁死亡的分子机理,介绍了调控铁死亡在提高胶质母细胞瘤放疗敏感性方面的应用和挑战,可为改善胶质母细胞瘤的治疗现状提供参考。

关键词：胶质母细胞瘤辐射铁死亡辐射增敏

北宋粮食储备与流通对当前我国粮食安全的启示

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中国流通经济 2024年第4期38卷 26-37页

作者：姜锡东季发玲河北大学宋史研究中心河北保定071000

当前,我国仍存在耕地数量降低、农民务农数量减少和种粮收益不高等问题,需要从国家到个人、思想到行动两个层面上采取措施,才能有效缓解。我国宋代粮食市场突出特点是地区间转运贸易发达,随着北宋粮食贸易的日渐活跃,百姓获得粮食渠道... 详细信息

当前,我国仍存在耕地数量降低、农民务农数量减少和种粮收益不高等问题,需要从国家到个人、思想到行动两个层面上采取措施,才能有效缓解。我国宋代粮食市场突出特点是地区间转运贸易发达,随着北宋粮食贸易的日渐活跃,百姓获得粮食渠道的拓宽,在一定程度上缓解了国家的粮食储备压力,影响了当时的粮食安全标准。北宋农民的赋税负担十分繁重,富民、地主粮食储备较为可观,官方与民间的粮食储备总量存在差距,具备藏粮于富民的特征。宋朝廷利用制度性和市场性的手段,将粮商作为国家的后备粮仓,灵活地缓解了官民粮食储备差距悬殊的矛盾。粮食流通在不同区域呈现出明显的地域性特征,不同的粮食来源和运输距离揭示了政治力量与经济力量在南、北救荒上的不同分配,北方地区的灾荒救济以官方力量为主,南方地区则以民间力量为主,粮食的性质、流通方式存在较大区别,影响着救荒效果。以北宋时期为鉴,当前我国应切实关注民生问题,构建多种形式的土地耕种格局;合理统筹全国区域性粮食流通,完善重大灾情下的粮食供给体系;树立科学粮食储备观,全方位增强社会戒奢从俭意识。

关键词：北宋粮食储备区域流通粮食安全当代价值