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Food Science and Human Wellness 2024年第2期13卷 909-919页

作者： Xiangxin Li Yijing pu Bangdi Liu Xiaoming Fang wenjun Peng Weibo jiang wenli Tian Institute of Apicultural Research Chinese Academy of Agricultural SciencesBeijing 100093China College of Food Science and Nutritional Engineering China Agricultural UniversityBeijing 100083China Academy of Agricultural Planning and Engineering Ministry of Agriculture and Rural AffairsBeijing 100125China

Free cholesterol has been considered to be a critical risk factor of nonalcoholic fatty liver disease(NAFLD).It remains unknown whether dietary intake of condensed tannins(CTs)have distinguishable effects to alleviate liver damage caused by a high cholesterol *** C57BL/6 mice were fed a high cholesterol diet for 6 weeks,and given CTs treatment at a dosage of 200 mg/(kg·day)at the same *** results indicated that compared with mice fed a normal diet,a high cholesterol diet group resulted in significant weight loss,dysregulation of lipid metabolism in blood and liver,and oxidative stress in the liver,but CTs treatment dramatically reversed these negative *** and eosin(H&E)staining and frozen section observation manifested that CTs treatment could effectively reduce the deposition of liver cholesterol and tissue necrosis caused by high cholesterol *** alleviated liver injury mainly by regulating the expression of related genes in cholesterol metabolism pathway and AMPK *** results confirmed that CTs have remarkable cholesterol lowering and anti-liver injury effects in vivo.

关键词： Condensed tannins High cholesterol Liver injury Antioxidants Transcriptomic analysis

Bibliometric analysis of Journal of Plant Ecology during 2017-2021

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Journal of Plant Ecology 2022年第6期15卷 1316-1323页

作者： pu Wang Lijuan Liu Bi-Cheng Dong wen-Hao Zhang Bernhard Schmid Center for Documentation and Information Institute of BotanyChinese Academy of SciencesBeijing 100093China School of Ecology and Nature Conservation Beijing Forestry UniversityBeijing 100083China State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China Department of Geography Remote Sensing LaboratoriesUniversity of Zurich8057 ZurichSwitzerland

Journal of Plant Ecology(JPE)was founded in *** is sponsored by the Botanical Society of China and the Institute of Botany,Chinese Academy of Sciences,and published by Oxford University Press,*** publishes diverse types of articles that fall into the broad scope of plant ecology,including plant ecophysiology,population ecology,community ecology,ecosystem ecology,landscape ecology,conservation ecology,evolutionary ecology,theoretical ecology and global change ecology.

关键词： landscape ecology. ecology

Multiferroicity and giant in-plane negative Poisson’s ratio in wurtzite monolayers

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npj Computational Materials 2022年第1期8卷 489-499页

作者： Zhuang Ma pu Huang Jin Li Peng Zhang Jiaxin Zheng wen Xiong Fei Wang Xiuwen Zhang Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen University518060ShenzhenChina School of Advanced Materials Peking UniversityShenzhen Graduate School518055ShenzhenChina Chongqing Institute of Green and Intelligent Technology Chinese Academy of Sciences400714ChongqingChina School of Physics and Microelectronics Zhengzhou University450001ZhengzhouChina

Monolayers of layered materials,such as graphite and molybdenum dichalcogenides,have been the focus of materials science in the last ***,we reveal benign stability and intriguing physical properties in the thinnest monolayer wurtzite(wz)semiconductors,which can be exfoliated from their bulk and stacked to reform the wz *** candidate ZnX and CdX(X=S,Se,Te)monolayers possess low cleavage energy and direct bandgaps,which harbor strongly coupled ferroelectricity and ferroelasticity with low transition barriers,giant in-plane negative Poisson’s ratio,as well as giant Rashba spin splitting,enabling the co-tunability of spin splitting and auxetic magnitudes via multiferroic *** wz monolayers can be used as building blocks of devices structures,due to their inherent“self-healable”capacity,which offer more flexibility for semiconductor fabrication and provide a natural platform to probe the interplay of multiple physical effects,bringing light into the rich physics in tetrahedral semiconductors.

关键词： plane splitting molybdenum

Geochemical Characteristics and Genesis of the Luxi-Xianrenzhang Diabase Dikes in Xiazhuang Uranium Orefield, Northern Guangdong Province

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Acta Geologica Sinica(English Edition) 2005年第4期79卷 497-506页

作者： LING Hongfei SHEN Weizhou DENG Ping jiang Shaoyong jiang Yaohui YE Haimin pu Wei TAN Zhengzhong State Key Laboratory of Mineral Deposit Research and Department of Earth Sciences Nanjing University Nanjing Jiangsu 210093 Research Institute No. 290 CNNC Shaoguan Guangdong 512026

The Luxi-Xianrenzhang diabase dikes were emplaced into the eastern part of the Guidong composite granitoids in northern Guangdong Province at the end of the Early Cretaceous. They show tholeiitic features, enrichment in large ion lithophile elements, slight enrichment in light rare earth elements, depletion in Zr and Hf, and basically no depletion in Nb and Ta and no Eu anomaly. They are similar to intraplate basalt in terms of trace element characteristics. They have high εNd（t） values （3.6-4.9）, initial ^87Sr/^86Sr ratios （0.70530-70641） and δ^18O values and Dupal anomaly of Pb isotope compositions. Their Sr-Nd, Pb-Sr, Pb-Nd and Pb-Pb isotopes plot between DMM and EMII, with Pb similar to EMII, Nd relatively close to DMM and Sr in between. This profile suggests that the diabase dikes studied were derived from partial melting of a mantle source that had been subjected to metasomatism by fluids originated from a subduction zone under a tectonic environment of crustal extension and lithosphere thinning in the late Yanshanian.

关键词： geochemistry main and trace elements Nd-Sr-Pb-O isotopes diabase dikes Guangdong

Grain Growth Behavior of Inconel 625 Superalloy

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Journal of Iron and Steel Research International 2016年第10期23卷 1111-1118页

作者： Min LIU wen-jie ZHENG Jin-zhong XIANG Zhi-gang SONG En-xiang pu Han FENG School of Physics Science and Technology Yunnan University Kunming 650093 Yunnan China Central Iron and Steel Research Institute Beijing 100081 China School of Materials Science and Engineering Tsinghua University Beijing 100084 China

The grain growth（GG）behavior of Inconel 625 superalloy was studied in the temperature range of 900-1 250 ℃and holding time range of 10-80 *** of the alloy were characterized by optical metallography,scanning electron microscopy（SEM）and transmission electron microscopy（TEM）.Grains grew obviously with either increasing temperature or extending holding time at temperatures above 1 050℃.However,at temperatures lower than 1 050 ℃,the GG was sluggish due to the pinning effect of carbide particles on grain boundary（GB）.Threshold temperature for transition from mixed grain structure to uniform one was considered to be around 1 100℃.Once the temperatures surpassed 1 200℃,an instant increase in the grain size occurred showing no dependence on holding *** analysis showed that the dominant second phase formed heterogeneously on the GB was M6 C,which significantly impeded grain *** the basis of experimental data,the mathematical model of GG was established,which can describe GG behavior of Inconel 625 alloy during solution treatment（ST）at 1 100-1 250 ℃.The activation energy for GG of Inconel 625 alloy was 207.3kJ,which suggested that the GG of Inconel 625 alloy was controlled by the process of GB diffusion.

关键词： Inconel 625 alloy growth kinetics solution treatment precipitation

Preface:Development and utilization of pumped storage in closed/abandoned mines

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Journal of Central South University 2024年第8期31卷 2545-2548页

作者： wen Zhi-jie jiang Yu-jing ZHAO Guang-ming LI Li-ping pu Hai YANG Sheng-li Mining College Guizhou UniversityGuiyang 550025China Graduate School of Engineering Nagasaki UniversityNagasaki 852-8521Japan School of Safety Science and Engineering Anhui University of Science and TechnologyHuainan 232001China School of Qilu Transportation Shandong UniversityJi’nan 250002China State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China School of Energy and Mining China University of Mining and Technology-BeijingBeijing 100083China

China has embarked on an extensive and sustained endeavor to harness its coal resources for a substantial ***,the depletion of coal reserves in mining regions has necessitated the closure or abandonment of numerous mines,resulting in a marked increase in the number of such *** to this,China is vigorously advancing the development of a novel energy power system,aimed at transitioning the power sector from a high-carbon,fossil fuel-dependent paradigm to a low-carbon,clean energy footing.

关键词： pumped sustained closure

Dermatitis bullosa caused by the immune checkpoint inhibitor camrelizumab:A case report

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World Journal of Clinical Cases 2025年第8期13卷 15-21页

作者： Yuan-Jing jiang Lu Wu Xiao Yang Yu pu Bing-Jie Ning Na Peng Xiao-Ju Zhu Cancer Center Daping HospitalArmy Medical UniversityChongqing 400042China

BACKGROUND Since the advent of the 20th century,alongside the progression of medical science and technological advancements,immunotherapy has emerged as a pivotal thera-peutic approach for tumor patients subsequent to undergoing radiotherapy and ***(camrelizumab),a flagship drug in the realm of immuno-therapy,functions as a monoclonal antibody specifically targeting the progra-mmed death protein 1(PD-1).This drug engages with the human PD-1 receptor,effectively inhibiting the PD-1/programmed death ligand 1 signaling *** inhibition results in the restoration of T cell activity and the induction of an anti-tumour ***,it is noteworthy that such interference could lead to immune-related adverse events resembling autoimmune *** grow-ing availability and clinical use of immune checkpoint inhibitors have raised sig-nificant clinical concerns regarding their *** instances of immune-related adverse reactions and the associated management strategies have been extensively *** identification and diagnosis,coupled with multidi-sciplinary consultation and the prompt administration of immunosuppressants,can effectively address severe immune-related adverse *** SUMMARY Arimab(camrelizumab),a monoclonal antibody targeting programmed death protein 1(PD-1),disrupts the PD-1/programmed death ligand 1(PD-L1)inter-action,reactivating T cell function and triggering anti-tumor ***,this disruption may trigger immune-mediated adverse events akin to autoim-mune *** 2.8%of such events manifest as immune-related dermatologic reactions,with 0.7%classified as grade 3,which are infrequently ***,this study describes a case of grade 3 bullous dermatitis occur-ring 15 days after initiating camrelizumab *** patient,a 67-year-old male with oesophageal squamous cell carcinoma,received camrelizumab plus paclitaxel alongside chemotherapy and radiotherapy in early ***

关键词： Camrelizumab Anti-programmed cell death protein-1 blockade Skin-related adverse events Immune-related dermatitis Case report

Nucleophilic Substitution Polymerization-Induced Emission of 1,3-Dicarbonyl Compounds as a Versatile Approach for Aggregation-Induced Emission Type Non-Traditional Intrinsic Luminescence

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Chinese Journal of Chemistry 2023年第14期41卷 1705-1712页

作者： Yu-Jiao Chen Meng-Qin pu Liang-Tao Wu Xiao-Li Sun wen-Ming Wan College of Environment and Resources Engineering Research Center of Polymer Green Recycling of Ministry of EducationFujian Key Laboratory of Pollution Control&Resource ReuseFujian Normal UniversityFuzhouFujian350007 China Key Laboratory of Coal to Ethylene Glycol and Its Related Technology State Key Laboratory of Structural ChemistryCenter for Excellence in Molecular SynthesisFujian Institute of Research on the Structure of MatterChinese Academy of Sciences155 Yangqiao Road WestFuzhouFujian350002 China College of Chemistry and Materials Science Fujian Normal UniversityFuzhouFujian350007 China

Nucleophilic substitution reaction and 1,3-dicarbonyl compounds play significant roles in organic chemistry, and non-traditional intrinsic luminescence (NTIL) has become an emerging research area. Here, we demonstrate the successful nucleophilic substitution polymerization of 1,3-dicarbonyl compounds, including acetylacetone, 3,5-heptanedione, methyl acetoacetate, cyclopentane-1,3-dione, 1,3-indandione, 1-phenyl-1,3-butanedione and dibenzoylmethane, where reactive hydrogens at α position of 1,3-dicarbonyl compounds are involved. Through this base catalyzed nucleophilic substitution polycondensation between 1,3-dicarbonyl compounds and α,α’-dibromo xylene, a series of nonconjugated poly(1,3-dicarbonyl)s have been successfully prepared with high yield (up to >99%) under mild conditions. Investigations reveal that this nucleophilic substitution polycondensation exhibits self-accelerating effect and flexible stoichiometry characteristics, which exhibits advantages over traditional polycondensation methods. This polymerization also exhibits intriguing polymerization-induced emission (PIE) characteristics, where nonconjugated poly(1,3-dicarbonyl)s exhibit intriguing chemical structure dependent aggregation-induced emission (AIE) type NTIL. This work therefore expands the monomer, method, chemical structure and property libraries of polymer chemistry, which may cause inspirations to polymerization methodology, PIE, AIE and NTIL.

关键词： Polymerization Luminescence Polymerization-induced emission Ketones Aggregation-induced emission

Self Ordering of Nematic Liquid Crystal Molecules in HPDLC Bragg Gratings

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Chinese Physics Letters 2012年第6期29卷 215-218页

作者： CHENG wen-Kai GAO Bin pu Hai-Hui LIU Jian-Hua Department of Optical Science and Engineering Key Lab for Micro and Nanophotonic Structures(Ministry of Education)Shanghai Ultra-Precision Optical Manufacturing Engineering CenterFudan UniversityShanghai 200433

Using the simple treatments of back refilling and subsequent annealing above the clear point of the liquid crystal,the self ordering of liquid crystal molecules is observed in a holographic polymer dispersed liquid crystal (HPDLC)Bragg grating without orientational layers or mechanical *** curve fitted anisotropy of the liquid crystal (△n) is in good agreement with its nominal value.

关键词： crystal nominal holographic

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运动干预与细胞焦亡在骨关节炎中的作用

中国组织工程研究 2025年第8期29卷 1667-1675页

作者：王秋月靳攀蒲锐长江大学教育与体育学院湖北省荆州市434023 长江大学医学部湖北省荆州市434023 长江大学运动人体科学实验室湖北省荆州市434023

背景:细胞焦亡参与软骨细胞外基质降解、滑膜炎症以及疼痛,在骨关节炎防治中发挥重要作用。此外,运动可通过抑制细胞焦亡调控骨关节炎的发生,已成为防治骨关节炎的研究热点。目的:总结细胞焦亡在骨关节炎中的调控作用,以及运动介导细胞... 详细信息

背景:细胞焦亡参与软骨细胞外基质降解、滑膜炎症以及疼痛,在骨关节炎防治中发挥重要作用。此外,运动可通过抑制细胞焦亡调控骨关节炎的发生,已成为防治骨关节炎的研究热点。目的:总结细胞焦亡在骨关节炎中的调控作用,以及运动介导细胞焦亡在改善骨关节炎中的机制。方法:以“pyroptosis,osteoarthritis,chondrocyte pyroptosis,synovial cell pyroptosis,exercise”和“细胞焦亡,骨关节炎,软骨细胞焦亡,滑膜细胞焦亡,运动”为关键词,检索pubMed与中国知网数据库1992-2024年间发表的相关文献,根据纳入及排除标准选择71篇文献进行综述。结果与结论:①骨关节炎是以软骨细胞外基质降解、滑膜炎症和软骨下骨重塑等为特点的慢性退行性关节疾病,易引起骨的器质性病变、疼痛并引发功能障碍。②细胞焦亡作为一种特殊的程序性死亡机制,其特征为细胞裂解死亡释放炎症因子引发强烈的炎症反应,与骨关节炎的发生发展关系密切。细胞焦亡可导致大量炎症因子释放,进而激活核因子κB转录,增加焦亡蛋白的产生,进而加剧骨关节炎的发生发展,因此细胞焦亡可作为骨关节炎防治的新方向。③运动可通过下调焦亡蛋白信号通路和抑制相关炎症因子表达等途径抑制软骨细胞和滑膜细胞的焦亡,从而在骨关节炎防治中发挥重要作用。有氧和无氧运动可通过抑制细胞焦亡的发生延缓骨关节炎的病理进程,中等强度的有氧运动通过抑制细胞焦亡信号通路改善骨关节炎的效果较好,无氧运动可通过提高肌肉质量进而对骨关节炎产生有益效应。

关键词：细胞焦亡骨关节炎运动运动调控信号通路综述