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度普利尤单抗治疗炎症性皮肤病临床应用研究进展

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中国药业 2025年第1期34卷 124-128页

作者：费来仪焦晴晴季江苏州大学附属第二人民医院江苏苏州215500 苏州大学附属第一人民医院江苏苏州215000

目的了解临床应用度普利尤单抗治疗慢性炎症性皮肤病的研究进展。方法采用计算机检索PubMed,Web of Science等数据库中2017年1月至2023年12月度普利尤单抗治疗慢性炎症性皮肤病的相关文献,总结度普利尤单抗治疗慢性炎症性皮肤病的有效... 详细信息

目的了解临床应用度普利尤单抗治疗慢性炎症性皮肤病的研究进展。方法采用计算机检索PubMed,Web of Science等数据库中2017年1月至2023年12月度普利尤单抗治疗慢性炎症性皮肤病的相关文献,总结度普利尤单抗治疗慢性炎症性皮肤病的有效性和安全性。结果度普利尤单抗治疗湿疹、慢性瘙痒症、大疱性皮肤病、斑秃、慢性荨麻疹、内瑟顿综合征、嗜酸性皮肤病等炎症性皮肤病的临床疗效良好;药品不良反应(ADR)发生率均较低,最常见的ADR为结膜炎、感染和嗜酸性粒细胞增多、眼部不适等,但多轻微,停药后可缓解。结论度普利尤单抗治疗慢性炎症性皮肤病的有效性及安全性良好,应用前景较好。

关键词：度普利尤单抗炎症性皮肤病慢性瘙痒症大疱性皮肤病斑秃慢性荨麻疹内瑟顿综合征嗜酸性皮肤病有效性安全性

Using Chebyshev polynomial interpolation to improve the computational efficiency of gravity models near an irregularly-shaped asteroid

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Research in Astronomy and Astrophysics 2017年第12期17卷 15-26页

作者： Shou-Cun Hu jiang-Hui ji CAS Key Laboratory of Planetary Sciences Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China

In asteroid rendezvous missions, the dynamical environment near an asteroid’s surface should be made clear prior to launch of the mission. However, most asteroids have irregular shapes,which lower the efficiency of calculating their gravitational field by adopting the traditional polyhedral method. In this work, we propose a method to partition the space near an asteroid adaptively along three spherical coordinates and use Chebyshev polynomial interpolation to represent the gravitational acceleration in each cell. Moreover, we compare four different interpolation schemes to obtain the best precision with identical initial parameters. An error-adaptive octree division is combined to improve the interpolation precision near the surface. As an example, we take the typical irregularly-shaped nearEarth asteroid 4179 Toutatis to demonstrate the advantage of this method; as a result, we show that the efficiency can be increased by hundreds to thousands of times with our method. Our results indicate that this method can be applicable to other irregularly-shaped asteroids and can greatly improve the evaluation efficiency.

关键词： minor planets,asteroids:individual(4179 Toutatis) methods:numerical Chebyshev polynomials

Mass transfer model,preparation and applications of zeolite membranes for pervaporation dehydration:A review

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Chinese Journal of Chemical Engineering 2017年第11期25卷 1627-1638页

作者： Chun Zhang Li Peng ji jiang Xuehong Gu State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringSynergetic Innovation Center for Advanced MaterialsNanjing Tech UniversityNanjing 210009China

Pervaporation(including vapor permeation) is a kind of new membrane separation technology, possessing the advantages of high efficiency, energy saving and convenient operation. It has promising application in the separation and purification of organic solvents. Dehydration is an important step in the production and recovery of organic solvents. Zeolite membranes have attracted wide attention for pervaporation dehydration due to their high separation performance and good thermal/chemical stability. So far, zeolite membranes have been preliminarily industrialized for dehydration of organic solvents. This paper reviews the recent development of zeolite membranes for pervaporation dehydration, including mass transfer models, preparation and applications of zeolite membranes. The review also discusses the current industrial applications of zeolite membranes and their future development in pervaporation.

关键词： Zeolite membrane Pervaporation Organic solvent dehydration Mass transfer

Fabrication and properties of Al matrix composites strengthened by in situ alumina particulates

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Journal of University of Science and Technology Beijing 2006年第3期13卷 263-266页

作者： Gaofeng Fu Lan jiang ji Liu Yue Wang School of Materials and Metallurgy Northeastern University Shenyang 110004 China

New aluminum matrix composites strengthened by Al2O3 particulates through stirring cast by adding NH4Al（SO4）2 to the molten aluminum have been fabricated. TEM observation shows that in-situ Al2O3 particulates are generally spherical and they are uniformly distributed in the Al matrix. Dry sliding wear test results show that the volume loss of the unreinforced Al matrix is about three times that of the Al2O3 reinforced metal matrix composite （MMC） and the volume loss of the MMC fabricated by adding Al2O3 is larger than that of the MMC by adding NH4Al（SO4）2. Lubricating sliding wear test results show that the volume loss of the MMCs increases more slowly than that of the matrix with the increasing of the load.

关键词： aluminum matrix composite alumina microstructure wear

Self-healing elastomer modified proppants for proppant flowback control in hydraulic fracturing

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Petroleum Science 2022年第1期19卷 245-253页

作者： jian-Da Li Gui-Cai Zhang ji-jiang Ge Wen-Li Qiao Ping jiang Hai-Hua Pei School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongPR China

To address proppant flowback issues during post-fracturing treatments and production,self-healing elastomer modified proppants(SMPs)are *** to their inherent self-aggregation behavior,the SMPs can aggregate together spontaneously to prevent proppant flowback and increase the pack *** is noteworthy that the SMPs have a firm and dry self-healing elastomer(SE)coating,making their storage,transport and use as conventional proppants *** SE synthesized through polymerization is rich in amidogens and carbonyl groups as characterized by Fourier transform infrared spectroscopy and the proton nuclear magnetic *** and thermomechanical properties of the SE coating are revealed by the thermogravimetric analysis,the differential scanning calorimetry and the rheological *** self-aggregation behavior of the SMPs is demonstrated by the adhesion force *** reversible hydrogen bonding interactions in SE coating contribute to the self-aggregation behavior of the SMPs,which is revealed by the thixotropy test and the FTIR analysis at different *** the self-aggregation behavior,the crushed proppants can aggregate in situ to form a stable structure again and therefore reduce the threat of narrowing down the fracture and proppant flowback,which has an important practical significance during oil and gas production.

关键词： Proppant flowback Self-healing elastomer Self-aggregation Adhesion force

Application of a new semi-analytical method to periodic motion due to the J_(22) tesseral harmonic

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Research in Astronomy and Astrophysics 2015年第6期15卷 896-908页

作者： Shou-Cun Hu jiang-Hui ji Yu-Hui Zhao Key Laboratory of Planetary Sciences Purple Mountain Observatory Chinese Academy of Sciences

We revisit the issue of constructing the first-order periodic solution that incorporates the J22 tesseral harmonic and developing a new semi-analytical solution that may apply to any orbital eccentricity in [0,1）. In our work, the solution is expressed in a finite compact form composed of several definite integrals with varying integration intervals constrained in [0,Tr], in which the traditional Hansen coefficients are no longer involved. Numerical experiments are also given and compared with the traditional series expansion method, and the results show that the derived solution is capable of dealing with highly eccentric orbits. Therefore, the solution given can provide a new technique to analyze the perturbation characteristics arising from the J22 harmonic.

关键词： celestial mechanics

Synthesis of Vitamin E Succinate from Candida rugosa Lipase in Organic Medium

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Chemical Research in Chinese Universities 2013年第2期29卷 223-226页

作者： jiang Xiang-jun HU Yi jiang Ling GONG ji-hong HUANG He School of Biotechnology and Pharmaceutical Engineering Nanjing University of Technology Nanjing 210009 P. R. China

A screening of commercially available lipases for the synthesis of vitamin E succinate showed that lipase from Candida rugosa presented the highest yield. The synthesis of vitamin E succinate in organic solvents with dif- ferent lgP values ranging from -1.3 to 3.5 was investigated. Of particular interest was that dimethyl sulfoxide （DMSO） with the lowest lgP exhibited the highest yield among all the organic solvents used. It suggests that lgP is incapable of satisfactorily predicting the biocompatibility of organic solvents due to the complexity of enzymatic reaction with hydrophilic and hydrophobic substrates in organic solvent. Effects of different operating conditions, such as molar ratio of substrate, enzyme concentration, reaction temperature, mass transfer, and reaction time were also studied. Under the optimum conditions of 10 g/L enzyme, a stirring rate of 100 r/min, a substrate molar ratio of 5：1 at 55℃ for 18 h, a satisfactory yield（46.95%） was obtained. The developed method has a potential to be used for efficient enzymatic production of vitamin E succinate.

关键词： Vitamin E succinate Candida rugosa lipase Operating condition

Unlocking the potentials of gel conformance for water shutoff in fractured reservoirs: Favorable attributes of the double network gel for enhancing oil recovery

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Petroleum Science 2023年第2期20卷 1005-1017页

作者： Qian-Hui Wu ji-jiang Ge Lei Ding Gui-Cai Zhang School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongPR China Laboratoire Sciences et Ingénierie de la Matière Molle ESPCI ParisPSL University75005ParisFrance Total Energies SE. E&PPôle d’Etudes et Recherche de LacqBP 47LACQ64170France

The double-network prepared with an in-situ monomer gel and a fast-crosslinked Cr(III) gel is introduced to develop a thixotropic and high-strength gel (THSG), which is found to have many advantages over the traditional gels. The THSG gel demonstrates remarkable thermal stability, and no syneresis is observed after 12 months with high salinity brine (95,500 mg/L). Moreover, the SEM and XRD results indicate that the gel is intercalated into the lamellar structures of Na-MMT, where the gel can form a uniform and compact structure. In addition, the THSG gel has an excellent swelling behavior, even in the high salinity brine. In the slim tube experiments, the THSG gel exhibits high rupture pressure and improves blocking capacity after being ruptured. The core flooding results show that a layer of gel filter cake is formed on the face of the fracture, which may be promoted by a high matrix permeability, a small aperture fracture, and a high injection rate. After the gel treatment, the fracture can be completely blocked by the THSG gel. It is found that a high incremental oil recovery (65.3%) can be achieved when the fracture was completely blocked, compared to 40.2% if the gel is ruptured. Although the swelling of ruptured gel can improve oil recovery, part of the injected brine may be channeled through the gel-filled fractures, resulting in a decrease in the sweep efficiency. Therefore, the improved blocking ability by gel swelling (e.g., in fresh water) may be less efficient to contribute to an enhancement of oil recovery. It is also found that the pressure gradient and residual resistance factor to water (Frrw) are higher if the matrix is less permeable, indicating that the fractured reservoir with lower matrix permeability may require a higher gel strength for treatment. The findings of this study may provide novel insights on designing robust double network gels for water shutoff in fractured reservoirs.

关键词： Double network structure Gel swelling Rupture pressure Fractured core Oil recovery factor

On the Mixed Propagator Approach to ρ-ω Mixing

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Communications in Theoretical Physics 2002年第8期38卷 195-199页

作者： YAN Mu-Lin jiang ji-Hao WANG Xiao-Jun CCAST World Laboratory P.O. Box 8730 Beijing 100080 China Center for Fundamental Physics University of Science and Technology of China Hefei 230026 China CCAST World Laboratory P.O. Box 8730 Beijing 100080 China Center for Fundamental Physics University of Science and Technology of China Hefei 230026 China Instite of Theoretical Physics Academia Sinica Beijing 100080 China

The mixed propagator (MP) approach to ρ-ω mixing is discussed. It is found that under the pole-approximation assumption the results of MP approach is not compatible both with the effective Lagrangian theory andwith the experiment measurement criterion. To overcome these inconsistent, we propose a new MP approach in whichthe physical states of ρ and ω are determined by the requirement of experimental measurement to meson resonance. Interms of this new MP approach, the EM pion form factor Fπ and form factors of ρo →π0γ and of ω→πo γ are *** results of Fπ are in good agreement with data. The form factor of ρo →π0γ exhibits a hidden charge-asymmetryenhancement effect which agrees with the prediction of the effective Lagrangian theory.

关键词： isospin breaking, VMD, ρ-ω mixing, decay of vector mesons