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Two different autorefractors for vision screening in children and adolescents

International Journal of Ophthalmology(English edition) 2024年第2期17卷 331-338页

作者： Xiao-Jun Chen Lin-Jie Liu Bing Sun dan-dan jiang Shu-Shu Zuo Yan-Hui Wang Chun-Hua Zhang Yan-Yan Chen School of Optometry and Ophthalmology Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To compare the consistency of two autorefractors(Tianle RM-9000 and Topcon KR-800)for school-age myopia children,and to provide a basis for largescale data analysis and comparison.METHODS:The refractive error in 909 subjects(age 4–18y)were measured using both autorefractors without cycloplegia.The data were analyzed using Fourier decomposition and the correlation coefficients,intraclass correlation coefficients(ICC),and Bland-Altman limits of agreement(LoA)for each parameter were calculated.RESULTS:There was a strong correlation between the spherical equivalent(SE),sphere diopter(DS),and cylinder diopter(DC)readings of the Tianle RM-9000 and those of the Topcon KR-800,with correlation coefficient values of 0.98,0.98 and 0.83 and ICC values of 0.99,0.99 and 0.93,respectively.However,the correlation coefficients and ICC values of J0 and J45 were unreliable(R=-0.004,-0.034;both ICC<0.10).Bland-Altman analysis revealed that SE,DS,and DC measured by the Tianle RM-9000 were significantly biased toward myopia compared with the Topcon KR-800,and the mean differences were-0.072,-0.026,-0.091 D,respectively(all P<0.01).The minimum absolute value of the difference within the 95%LoA for SE,DS,and DC was 0.63 D,0.50 D,0.62 D,respectively;all these values were in the clinically acceptable range.For J0 and J45,the mean differences were close to zero(P=0.43,0.84);however,the 95%LoA were relatively wide(J0 SD:0.53;95%CI:-1.00,1.10;J45 SD:0.52;95%CI:-1.00,1.00).CONCLUSION:The two autorefractors are consistent with each other,as the differences in SE,DS,and DC were within the clinically acceptable range.Readers can compare the data measured by either device in different studies and use the two devices in the same study to generate a dataset that can be analyzed together.However,the J0 and J45 vectors are unreliable and should not be used to assess astigmatism.

关键词： refractive error autorefractors school-age myopia children

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The role of vitamin E in polyunsaturated fatty acid synthesis and alleviating endoplasmic reticulum stress in sub-adult grass carp(Ctenopharyngodon idella)

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Animal Nutrition 2024年第1期16卷 275-287页

作者： Ke Yao Lin Feng Wei-dan jiang Yang Liu Lu Zhang Hai-Feng Mi Xiao-Qiu Zhou Pei Wu Animal Nutrition Institute Sichuan Agricultural University Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province Sichuan Agricultural University Key Laboratory of Animal Disease-Resistance Nutrition Ministry of Education Ministry of Agriculture and Rural Affairs Key Laboratory of Sichuan Province Tongwei Co. Ltd. Healthy Aquaculture Key Laboratory of Sichuan Province

Vitamin E(VE) is an essential lipid-soluble vitamin that improves the fish flesh quality. However, the underlying molecular mechanisms remain unclear. This study aimed to investigate the effects of VE on growth performance and flesh quality in sub-adult grass carp(Ctenopharyngodon idella). A total of 450fish(713.53 ± 1.50 g) were randomly divided into six treatment groups(three replicates per treatment)and fed for nine weeks with different experimental diets(dietary lipid 47.8 g/kg) that contained different levels of VE(5.44, 52.07, 96.85, 141.71, 185.66, and 230.12 mg/kg diet, supplemented as dl-a-tocopherol acetate). Notably, the treatment groups that were fed with dietary VE ranging from 52.07 to230.12 mg/kg diet showed improvement in the percent weight gain, special growth rate, and feed efficiency of grass carp. Moreover, the treatment groups supplemented with dietary VE level of 141.71,185.66, and 230.12 mg/kg diet showed enhancement in crude protein, lipid, and a-tocopherol contents in the muscle, and the dietary levels of VE ranging from 52.07 to 141.71 mg/kg diet improved muscle pH24h and shear force but reduced muscle cooking loss in grass carp. Furthermore, appropriate levels of VE(52.07 to 96.85 mg/kg diet) increased the muscle polyunsaturated fatty acid content in grass carp. Dietary VE also increased the mRNA levels of fatty acid synthesis-related genes, including fas, scd-1, fad,elovl, srebp1, pparγ, and lxra, and up-regulated the expression of SREBP-1 protein. However, dietary VE decreased the expression of fatty acid decomposition-related genes, including hsl, cpt1, acox1, and ppara,and endoplasmic reticulum stress-related genes, including perk, ire1, atf6, eif2a, atf4, xbp1, chop, and grp78, and down-regulated the expression of p-PERK, p-IRE1, ATF6, and GRP78 proteins. In conclusion,dietary VE increased muscle fatty acid synthesis, which may be partly associated with the alleviation of endoplasmic reticulum stress, and ultimately improves fish flesh quality. Moreover, the VE requirements for sub

关键词： Vitamin E Flesh quality Muscle polyunsaturated fatty acid level Endoplasmic reticulum stress Growth performance Grass carp

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《民法典合同编通则解释》司法适用若干问题探讨——《法律适用》专题学习交流会会议综述

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法律适用 2024年第3期2024卷 158-170页

作者：姜丹不详

《法律适用》民法典合同编通则解释学习交流会探讨了《民法典合同编通则解释》司法适用若干问题,包括债权多重转让、无权处分适用、替代交易法司法适用、以物抵债协议的性质与履行等。四位嘉宾深入解读了相关条文的起草背景与理解适用,... 详细信息

《法律适用》民法典合同编通则解释学习交流会探讨了《民法典合同编通则解释》司法适用若干问题,包括债权多重转让、无权处分适用、替代交易法司法适用、以物抵债协议的性质与履行等。四位嘉宾深入解读了相关条文的起草背景与理解适用,强调在处理债权多重转让问题时不应给债务人增加负担,探讨了无权处分、替代交易的场景化适用,明确提出清偿型以物抵债调解书不具有无权变动效力、担保型以物抵债协议具有担保功能等。

关键词：债权多重转让无权处分替代交易以物抵债

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Emerging role of vitamin D3 in alleviating intestinal structure injury caused by Aeromonas hydrophila in grass carp（Ctenopharyngodon idella）

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Animal Nutrition 2024年第1期16卷 202-217页

作者： Yao Zhang Xiao-Qiu Zhou Wei-dan jiang Pei Wu Yang Liu Hong-Mei Ren Lu Zhang Hai-Feng Mi Ling Tang Cheng-Bo Zhong Lin Feng Animal Nutrition Institute Sichuan Agricultural University Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province Sichuan Agricultural University Key Laboratory for Animal Disease-Resistant Nutrition of China Ministry of Education Sichuan Agricultural University Healthy Aquaculture Key Laboratory of Sichuan Province Tongwei Co. Ltd. Sichuan Animal Science Academy Sichuan Animtech Feed Co. Ltd.

Bacterial pathogens destroy the structural integrity of functional organs in fish, leading to severe challenges in the aquaculture industry. Vitamin D3（VD3） prevents bacterial infections and strengthens immune system function via vitamin D receptor（VDR）. However, the correlation between VD3/VDR and the structural integrity of functional organs remains unclarified. This study aimed to investigate the influence of VD3supplementation on histological characteristics, apoptosis, and tight junction characteristics in fish intestine during pathogen infection. A total of 540 healthy grass carp（257.24 ± 0.63 g） were fed different levels of VD3（15.2, 364.3, 782.5, 1,167.9, 1,573.8, and 1,980.1 IU/kg） for 70 d. Subsequently, fish were challenged with Aeromonas hydrophila, a pathogen that causes intestinal inflammation. Our present study demonstrated that optimal supplementation with VD3（1） alleviated intestinal structural damage, and inhibited oxidative damage by reducing levels of oxidative stress biomarkers;（2） attenuated excessive apoptosisrelated death receptor and mitochondrial pathway processes in relation to p38 mitogen-activated protein kinase signaling（P < 0.05）;（3） enhanced tight junction protein expression by inhibiting myosin light chain kinase signaling（P < 0.05）; and（4） elevated VDR isoform expression in fish intestine（P < 0.05）.Overall, the results demonstrated that VD3alleviates oxidative injury, apoptosis, and the destruction of tight junction protein under pathogenic infection, thereby strengthening pathogen defenses in the intestine. This finding supports the rationale for VD3intervention as an essential practice in sustainable aquaculture.

关键词： Aeromonas hydrophila Antibacterial property Grass carp ( Ctenopharyngodon idella ) Intestinal health Vitamin D 3

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视光与干眼联合诊疗模式的探索

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中华眼视光学与视觉科学杂志 2024年第6期26卷 401-409页

作者：姜丹陈蔚温州医科大学附属眼视光医院国家眼耳鼻喉疾病临床医学研究中心(眼部疾病) 温州

干眼是一种常见的眼部疾病, 会导致眼部不适和视功能障碍, 严重影响患者的生活和工作质量。近年来, 随着环境和生活方式的改变, 干眼发病率逐年上升, 特别是近视或者近视防控患者中配戴接触镜产生的干眼引发了广泛关注。但仅依靠现有眼... 详细信息

干眼是一种常见的眼部疾病, 会导致眼部不适和视功能障碍, 严重影响患者的生活和工作质量。近年来, 随着环境和生活方式的改变, 干眼发病率逐年上升, 特别是近视或者近视防控患者中配戴接触镜产生的干眼引发了广泛关注。但仅依靠现有眼科医疗资源难以满足全国干眼诊疗需求。因此, 建立视光与干眼联合诊疗模式具有重要的意义。已有多个国家和地区进行了视光与干眼联合诊疗的实践, 但国内仍处于初期探索阶段。笔者通过分析干眼诊疗现状及国际视光干眼联合诊疗的经验, 为我国视光与干眼联合诊疗体系的建设提供参考。

关键词：干眼视光视光中心联合诊疗

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Evidence-based expert consensus on clinical management of safety of Bruton's tyrosine kinase inhibitors(2024)

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Chinese Journal of Cancer Research 2024年第3期36卷 240-257页

作者： Zaiwei Song dan jiang Lingling Yu Yixuan Chen Daobin Zhou Yue Li Depei Wu Lingli Zhang Liyan Miao Jun Ma Jun Zhu Hongmei Jing Rongsheng Zhao Department of Hematology and Oncology Harbin Institute of Hematology and Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Lymphoma Peking University Cancer Hospital&Institute Department of Hematology Peking University Third Hospital the Steering Committee the Consensus Panel and the Evidence Synthesis Group Evidence-based Pharmacy Professional Committee of Chinese Pharmaceutical Association(CPA) Hospital Pharmacy Professional Committee of Chinese Pharmaceutical Association(CPA) Division of Therapeutic Drug Monitoring of Chinese Pharmacological Society(CPS) Expert Committee on Lymphoma of Chinese Society of Clinical Oncology(CSCO) Expert Committee on Leukemia of Chinese Society of Clinical Oncology(CSCO) Society of Integrative Cardio-Oncology of China Anti-Cancer Association(CACA) Department of Pharmacy Peking University Third Hospital Chinese Society of Hematology of Chinese Medical Association(CMA) Hospital Pharmacy Professional Committee of Cross-Straits Medicine Exchange Association(SMEA) Institute for Drug Evaluation Peking University Health Science Center Therapeutic Drug Monitoring and Clinical Toxicology Center Peking University Department of Pharmacy Administration and Clinical Pharmacy School of Pharmaceutical Sciences Peking University Department of Hematology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Cardiology the First Affiliated Hospital Harbin Medical University Department of Hematology the First Affiliated Hospital of Soochow University Department of Pharmacy Evidence-based Pharmacy Center West China Second Hospital Sichuan University Department of Pharmacy the First Affiliated Hospital of Soochow University

Bruton's tyrosine kinase inhibitors(BTKis) have revolutionized the treatment of B-cell lymphomas. However,safety issues related to the use of BTKis may hinder treatment continuity and further affect clinical efficacy. A comprehensive and systematic expert consensus from a pharmacological perspective is lacking for safety issues associated with BTKi treatment. A multidisciplinary consensus working group was established, comprising 35 members from the fields of hematology, cardiovascular disease, cardio-oncology, clinical pharmacy, and evidence-based medicine. This evidence-based expert consensus was formulated using an evidence-based approach and the Delphi method. The Joanna Briggs Institute Critical Appraisal(JBI) tool and Grading of Recommendations Assessment, Development, and Evaluation(GRADE) approach were used to rate the quality of evidence and grade the strength of recommendations, respectively. This consensus provides practical recommendations for BTKis medication based on nine aspects within three domains, including the management of common adverse drug events such as bleeding, cardiovascular events, and hematological toxicity, as well as the management of drug-drug interactions and guidance for special populations. This multidisciplinary expert consensus could contribute to promoting a multi-dimensional, comprehensive and standardized management of BTKis.

关键词： Consensus BTK inhibitors safety adverse drug events drug-drug interactions

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升序还是降序?商品排序对在线购物车废弃行为的影响研究

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中国管理科学 2024年第3期32卷 178-187页

作者：蒋丹张广玲荆楚理工学院经济与管理学院湖北荆门448000 武汉大学经济与管理学院湖北武汉430073

电商的蓬勃发展使得网络购物车的容量不断增加,数字购物车除了拥有加入商品和结账的功能外,消费者还使用购物车的收藏商品、信息比较、促销凑单等多种功能。基于此目的,海量的商品被加入到网络购物车中,但是却并没有被“清空”,由此产... 详细信息

电商的蓬勃发展使得网络购物车的容量不断增加,数字购物车除了拥有加入商品和结账的功能外,消费者还使用购物车的收藏商品、信息比较、促销凑单等多种功能。基于此目的,海量的商品被加入到网络购物车中,但是却并没有被“清空”,由此产生将商品滞留在购物车中的行为被称为在线购物车废弃行为。以往的文献研究了大量影响在线购物车废弃行为的前因变量,包括在线购物前决策阶段的平台感知因素、消费者主观因素、购物行为因素和产品因素等。但并没有从在线购物后决策阶段,即数字购物车内商品排序规则的视角研究对在线购物车废弃行为的影响,且缺乏对中介机制和边界机制的讨论。本研究立足在线购物后决策阶段,提出按商品加入时间排序(升序或降序)对在线购物车废弃行为的影响作用,验证了选择超载的中介作用,同时排除了遗忘和心理所有权的替代解释。通过一个访谈和两个实验室研究,结果显示,时间升序的排序方式缓解了消费者的选择超载问题,有效减少了在线购物车废弃行为。

关键词：在线购物车废弃行为排序选择超载遗忘心理所有权

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LncRNA MIR503HG靶向miR-32-5p调控 ITGA6表达对非小细胞肺癌增殖与迁移的影响

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中国老年学杂志 2024年第6期44卷 1411-1418页

作者：姜丹丹罗喜钢锦州医科大学辽宁锦州121001 锦州医科大学附属第三医院检验科

目的探讨长链非编码RNA(LncRNA)MIR503HG、微小RNA(miRNAs)-32-5p、整合素α(ITGA)6在非小细胞肺癌(NSCLC)中的表达及其对NSCLC细胞增殖和迁移的影响。方法从癌症基因组图谱(TCGA)数据库中提取273例NSCLC患者癌组织及其对应癌旁组织的... 详细信息

目的探讨长链非编码RNA(LncRNA)MIR503HG、微小RNA(miRNAs)-32-5p、整合素α(ITGA)6在非小细胞肺癌(NSCLC)中的表达及其对NSCLC细胞增殖和迁移的影响。方法从癌症基因组图谱(TCGA)数据库中提取273例NSCLC患者癌组织及其对应癌旁组织的LncRNA、miRNA及转录组mRNA的芯片数据,R软件中MAX STAT函数包统计分析LncRNA MIR503HG、miR-32-5p、ITGA6在NSCLC中的表达。实时荧光定量聚合酶链反应(qRT-PCR)检测80例NSCLC患者癌组织标本和NSCLC细胞系中LncRNA MIR503HG、miR-32-5p、ITGA6 mRNA表达。双荧光素酶实验证明LncRNA MIR503HG、miR-32-5p、ITGA6的关系。依次以LncRNA MIR503HG-mimic-NC、LncRNA MIR503HG-mimic、miR-32-5p-agomir-NC、miR-32-5p-agomir、LncRNA MIR503HG-mimic+miR-32-5p-agomir、LncRNA MIR503HG-mimic+miR-32-5p-agomir+pcDNA3.1-ITGA6、miR-32-5p-agomir+pcDNA3.1-ITGA6转染H1299细胞,另设定正常(Normal)组细胞。EDU染色实验与Transwell小室实验检测各组细胞体外增殖与转移活性;裸鼠体内皮下种植肿瘤模型检测细胞体内生长与转移能力。Western印迹检测ITGA6、E-钙黏蛋白(cadherin)和波形蛋白(Vimentin)表达。结果在线分析结果显示,与癌旁组织和BEAS-2B细胞相比,LncRNA MIR503HG、ITGA6 mRNA在NSCLC组织和NSCLC细胞表达升高,miR-32-5p mRNA下降,差异具有统计意义(均P<0.05)。双荧光素酶实验证实LncRNA MIR503HG靶向miR-32-5p表达,miR-32-5p靶向ITGA6表达。过表达LncRNA MIR503HG可增强H1299细胞的体外增殖与转移及体内生长与转移能力,ITGA6和Vimentin表达升高,E-cadherin表达降低,miR-32-5p-agomir可部分逆转这一作用,而pcDNA3.1-ITGA6可部分修复这一逆转作用,差异均具有统计意义(P<0.05)。结论下调LncRNA MIR503HG表达能降低H1299细胞增殖与转移能力,发挥抑癌效应,其机制可能与靶向miR-32-5p调控ITGA6表达水平有关,为NSCLC的治疗提供靶点。

关键词：长链非编码RNA MIR503HG 微小RNA-32-5p 整合素α6 非小细胞肺癌增殖迁移

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Structure and electrical properties of PZT/LNO/PT multilayer films on stainless steel substrates

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Rare Metals 2012年第3期31卷 272-275页

作者： Zhao, Xuelian jiang, dan Yu, Shengwen Cheng, Jinrong School of Materials Science and Engineering Shanghai University Shanghai 200072 China

PbZr0.53Ti0.47O3 (PZT) ferroelectric thin films were deposited on LaNiO3 (LNO) by sol-gel method. The PbTiO3 (PT) seed layer was deposited between the LNO buffer layer and stainless steel (SS) substrate, which effectively decreased the annealing temperature of LNO layer from 750 °C to 650 °C. X-ray diffraction (XRD) reveals that LNO layers with PT layer crystallize into a perovskite phase on annealing at 650 °C for 10 min. PZT deposited on LNO buffer layer with PT seed layer exhibits good ferroelectric property.

关键词： PT seed layer LNO PZT ferroelectric thin films

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征服还是同盟:南诏政权属性考论

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昆明学院学报 2024年第2期46卷 116-124页

作者：姜丹昆明学院人文学院云南昆明650214

文章运用文献考据、比较、统计等历史研究法,结合旨在文化意义解释的民族学研究方法,基于对历史文献的深度阅读与分析,认为:“南诏武力征服或兼并‘白蛮’”,或“南诏基于武力胁迫‘白蛮’放弃领导权力”的传统研究结论与以《南诏图传... 详细信息

文章运用文献考据、比较、统计等历史研究法,结合旨在文化意义解释的民族学研究方法,基于对历史文献的深度阅读与分析,认为:“南诏武力征服或兼并‘白蛮’”,或“南诏基于武力胁迫‘白蛮’放弃领导权力”的传统研究结论与以《南诏图传》为代表的某些云南地方历史文献在实际叙事语境及文本内涵上存在明显差异,与历史事实也存在逻辑上的抵牾,不能反映南诏与“白蛮”真实的历史关系和南诏政权的真实属性。南诏政权并未通过武力征服或兼并洱海地区的“白蛮”。南诏的缔造者蒙氏家族与洱海区域“白蛮”具有相互联合的经济、文化基础和相似的发展诉求,以及互补的政治、经济优势;南诏政权是蒙氏家族与“白蛮”在相对平等的基础上结成的同盟。该同盟确认并保全了“白蛮”在洱海地区长期以来既有的文化主导地位,令“白蛮”业已衰微的政治、社会地位得以巩固和强化。《南诏图传》等云南地方历史文献中的相关祭铁柱场景就是南诏与“白蛮”双方缔结同盟的写照。南诏方参与结盟的是南诏二代王逻盛,南诏与“白蛮”的结盟时间当是7世纪晚期的最后10年。南诏、“白蛮”同盟的缔结及其所确认的文化发展方针对南诏文化和社会结构的形态产生了深远的影响。

关键词：南诏政权更迭南诏图传同盟关系

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