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Journal of Mountain Science 2024年第1期21卷 84-99页

作者： QIN Zipeng TIAN Yan GAO Siyuan zhou jianfen HE Xiaohui HE Weizhong GAO Jingquan School of Water Conservancy and Environment Engineering Zhejiang University of Water Resources and Electric PowerHangzhou 310018China Department of Civil Engineering Imperial College LondonLondonSW71BFEngland Lanxi Water Affairs Bureau Lanxi 321102China Zhejiang Water Conservancy Engineering Consulting Co. LtdHangzhou 310051China

The stability of the ancient flood control levees is mainly influenced by water level fluctuations, groundwater concentration and rainfalls. This paper takes the Lanxi ancient levee as a research object to study the evolution laws of its seepage, displacement and stability before and after reinforcement with the upside-down hanging wells and grouting curtain through numerical simulation methods combined with experiments and observations. The study results indicate that the filled soil is less affected by water level fluctuations and groundwater concentration after reinforcement. A high groundwater level is detrimental to the levee's long-term stability, and the drainage issues need to be fully considered. The deformation of the reinforced levee is effectively controlled since the fill deformation is mainly borne by the upside-down hanging wells. The safety factors of the levee before reinforcement vary significantly with the water level. The minimum value of the safety factors is 0.886 during the water level decreasing period, indicating a very high risk of the instability. While it reached 1.478 after reinforcement, the stability of the ancient levee is improved by a large margin.

关键词： Stability analysis Multiple factors Antiseepage reinforcement Upside-down hanging well Grouting curtain Ancient levee

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肝移植受者手术部位感染危险因素荟萃分析

中华临床感染病杂志 2024年第2期17卷 150-155页

作者：周建芬沈鸣雁贺田韩琳秋浙江树人学院树兰国际医学院附属树兰杭州医院肝移植科杭州310022 浙江树人学院树兰国际医学院附属树兰杭州医院护理部杭州310022 浙江树人学院杭州310015

目的系统评价肝移植受者发生手术部位感染的危险因素。方法计算机检索PubMed、Web of Science、EMbase、The Cochrane Library、中国知网、万方、维普及中国生物医学文献数据库,从建库至2023年7月10日关于肝移植受者发生手术部位感染危... 详细信息

目的系统评价肝移植受者发生手术部位感染的危险因素。方法计算机检索PubMed、Web of Science、EMbase、The Cochrane Library、中国知网、万方、维普及中国生物医学文献数据库,从建库至2023年7月10日关于肝移植受者发生手术部位感染危险因素的文献。完成文献筛选及质量评价后使用RevMan 5.4软件和Stata 16软件进行荟萃分析。结果最终纳入10篇文献,共计3113例成人肝移植受者,发生手术部位感染723例。荟萃分析结果显示,Roux-en-Y胆道重建(OR=2.60,95%CI 1.45~4.65)、胆漏(OR=17.22,95%CI 8.48~34.96)、重复手术(OR=7.22,95%CI 4.25~12.26)、再移植(OR=13.88,95%CI 7.71~24.97)、手术时长(MD=0.52,95%CI 0.19~0.84)、透析(OR=3.44,95%CI 2.41~4.91)、住院时间(MD=11.42,95%CI 5.73~17.12)是肝移植受者发生手术部位感染的危险因素。结论Roux-en-Y胆道重建、胆漏、重复手术、再移植、手术时长、透析及住院时间是肝移植受者手术部位感染发生的危险因素。临床应加强对这些因素的评估与筛查,及早识别并进行有效干预,从而改善肝移植受者的临床结局。

关键词：肝移植手术部位感染危险因素荟萃分析

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传统工科专业的数字化升级路径与实践

佳木斯大学学报（自然科学版） 2024年第6期42卷 125-128页

作者：周建芬徐存东陈斌刘丹史立秋浙江水利水电学院水利与环境工程学院浙江杭州310018 浙江工业大学土木工程学院浙江杭州310014

产业升级驱动应用型高校的传统工业专业数字化升级并为其提供技术支持。传统工科专业实现高质量发展应从两方面着手:第一,人才培养体系适配产业升级对人才结构的需求;第二,传统工科专业升级以跨学科发展为基础。本文研究跨学科教育理论... 详细信息

产业升级驱动应用型高校的传统工业专业数字化升级并为其提供技术支持。传统工科专业实现高质量发展应从两方面着手:第一,人才培养体系适配产业升级对人才结构的需求;第二,传统工科专业升级以跨学科发展为基础。本文研究跨学科教育理论框架下的专业数字化升级路径,从组织框架、教学过程和评价方法三个维度,适配人才培养目标、课程体系、实践基础设施、管理评价制度,达到辅助教师终身学习、提升学生学习体验的目的。基于数字教育理论研究,实施数字化教学范式跃迁。以传统工科水利水电工程专业数字化升级为例,构建全过程沉浸式数字化实践平台,解决该专业实践教学点多面广、周期长、场景复杂的难题,同时适配课程评价管理制度。

关键词：传统工科跨学科教育数字化升级水利类专业虚拟实践平台

All-stage targeted therapy for the brain metastasis from triple-negative breast cancer

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Acta Pharmaceutica Sinica B 2023年第1期13卷 359-371页

作者： Zimiao Luo Sunyi Wu jianfen zhou Weixia Xu Qianzhu Xu Linwei Lu Cao Xie Yu Liu Weiyue Lu Department of Pharmaceutics School of PharmacyKey Laboratory of Smart Drug DeliveryFudan UniversityShanghai 201203China Department of Integrative Medicine Huashan HospitalInstitutes of Integrative Medicine of Fudan UniversityShanghai 200041China Minhang Branch Zhongshan Hospital and Institute of Fudan-Minghang Academic Health SystemMinghang HospitalFudan UniversityShanghai 201199China State Key Laboratory of Medical Neurobiology Collaborative Innovation Center for Brain ScienceFudan UniversityShanghai 200032China

Brain metastasis is a common and serious complication of breast cancer,which is commonly associated with poor survival and *** particular,the treatment of brain metastasis from triplenegative breast cancer(BM-TNBC)has to face the distinct therapeutic challenges from tumor heterogeneity,circulating tumor cells(CTCs),blood-brain barrier(BBB)and blood-tumor barrier(BTB),which is in unmet clinical ***,combining with the advantages of synthetic and natural targeting moieties,we develop a“Y-shaped”peptide pVAP-decorated platelet-hybrid liposome drug delivery system to address the all-stage targeted drug delivery for the whole progression of *** from the activated platelet,the hybrid liposomes still retain the native affinity toward ***,the peptide-mediated targeting to breast cancer cells and transport across BBB/BTB are demonstrated in vitro and in *** resultant delivery platform significantly improves the drug accumulation both in orthotopic breast tumors and brain metastatic lesions,and eventually exhibits an outperformance in the inhibition of BM-TNBC compared with the free ***,this work provides a promising prospect for the comprehensive treatment of BMTNBC,which could be generalized to other cell types or used in imaging platforms in the future.

关键词： Breast cancer Brain metastasis from breast cancer Platelet-hybrid liposome pVAP peptide Nanocrystal Cabazitaxel Targeted drug delivery Drug delivery system

基于古海塘活态遗产价值保护理念的海塘安澜工程设计策略

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浙江水利水电学院学报 2024年第4期36卷 1-7页

作者：王建华魏小旺陈振华叶建军周建芬浙江省钱塘江流域中心浙江杭州310016 浙江省钱塘江管理局勘测设计院有限公司浙江杭州310016 浙江水利水电学院浙江省农村水利水电资源配置与调控关键技术重点实验室浙江杭州310018

拟实施的钱塘江北岸海塘安澜工程位于老盐仓至尖山段,涉及全国重点文物保护单位钱塘江海宁段鱼鳞大石塘及“海宁海塘·潮文化景观”遗产保护。通过分析古海塘存在的遗产价值,提出将古海塘作为活态遗产保护的设计理念,阐述海塘安澜工程... 详细信息

拟实施的钱塘江北岸海塘安澜工程位于老盐仓至尖山段,涉及全国重点文物保护单位钱塘江海宁段鱼鳞大石塘及“海宁海塘·潮文化景观”遗产保护。通过分析古海塘存在的遗产价值,提出将古海塘作为活态遗产保护的设计理念,阐述海塘安澜工程设计方案中海塘加固、水文化展示、施工组织与安全监测等文物保护措施,可为类似工程方案设计提供参考。

关键词：古海塘活态遗产海塘安澜工程

应用型本科人才培养“产教协同、理实融通、专创融合”模式的探索与实践——以水利类专业为例

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大学教育 2024年第11期 129-132页

作者：陈斌徐存东黄赛花周建芬段永刚陈一帆浙江水利水电学院浙江杭州310018

新工科背景下的应用型本科人才培养以校企合作为纽带,全方位实施产教协同,开展专业课程改革,构建实践育人校企合作机制。通过创新实践教学方式方法,人才培养方案增设课内“非实验实践性教学”和“工程训练”等环节,全面推行毕业设计“... 详细信息

新工科背景下的应用型本科人才培养以校企合作为纽带,全方位实施产教协同,开展专业课程改革,构建实践育人校企合作机制。通过创新实践教学方式方法,人才培养方案增设课内“非实验实践性教学”和“工程训练”等环节,全面推行毕业设计“真题真做”、校企“双导师制”,建立完整的实践教学体系。将实践教学和创新创业教育融为一体,促使产教协同“提质增效”,在理实融通的教学过程中提高学生的学习效果,在专业教育与创新创业教育融合中激发学生的创新活力,实现应用型人才的高质量培养。

关键词：新工科水利专业应用型人才培养理实融通专创融合

Engineered platelets-based drug delivery platform for targeted thrombolysis

同方期刊数据库博看期刊评论

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Acta Pharmaceutica Sinica B 2022年第4期12卷 2000-2013页

作者： Songli Wang Ruifeng Wang Nana Meng Linwei Lu Jun Wang jianfen zhou Jiasheng Lu Qianzhu Xu Cao Xie Changyou Zhan Yao Li Yang Yu Weiyue Lu Min Liu Department of Pharmaceutics School of PharmacyKey Laboratory of Smart Drug Delivery(Ministry of Education and PLA)Fudan UniversityShanghai 201203China The Department of Integrative Medicine Huashan HospitalFudan University and the Institutes of Integrative Medicine of Fudan UniversityShanghai 200041China Department of Pharmacology School of Basic Medical SciencesFudan UniversityShanghai 200032China The National Facility for Protein Science in Shanghai(NFPS) Shanghai 201210China State Key Laboratory of Medical Neurobiology and the Collaborative Innovation Center for Brain Science and Department of Pharmacology School of Basic Medical SciencesFudan UniversityShanghai 200032China Minhang Branch Zhongshan Hospital and Institute of Fudan-Minhang Academic Health SystemMinhang HospitalFudan UniversityShanghai 201199China

Thrombolytic agents have thus far yielded limited therapeutic benefits in the treatment of thrombotic disease due to their short half-life,low targeting ability,and association with serious adverse reactions,such as bleeding *** by the natural roles of platelets during thrombus formation,we fabricated a platelet-based delivery system(NO@uPA/PLTs)comprising urokinase(uPA)and arginine(Arg)for targeted thrombolysis and inhibition of *** anchoring of uPA to the platelet surface by lipid insertion increased the thrombotic targeting and in vivo circulation duration of uPA without disturbing platelet *** oxide(NO)generated by the loaded Arg inhibited platelet aggregation and activation at the damaged blood vessel,thereby inhibiting ***@uPA/PLTs effectively accumulated at the thrombi in pulmonary embolism and carotid artery thrombosis model mice and exerted superior thrombolytic *** addition,the platelet delivery system showed excellent thrombus recurrence prevention ability in a mouse model of secondary carotid artery *** coagulation indicators in vivo showed that the platelet-based uPA and NO co-delivery system possessed a low hemorrhagic risk,providing a promising tool for rapid thrombolysis and efficient inhibition of posttreatment re-embolism.

关键词： Platelet Urokinase Nitric oxide Targeted thrombolysis Thrombus reformation

降雨入渗条件下兰溪市某防洪古城墙稳定性分析

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水利水电科技进展 2022年第6期42卷 66-72,104页

作者：董志勇庞鑫杰周建芬浙江工业大学土木工程学院浙江杭州310023 浙江水利水电学院水利与环境工程学院浙江杭州310018

基于ABAQUS有限元软件,建立了兰溪市某防洪古城墙渗流边坡稳定分析模型,采用渗流-应力耦合计算方法模拟了在降雨入渗条件下古城墙边坡孔隙水压力变化过程,并比较分析了有防渗设施、有排水设施和无排水设施对墙后土体渗流特性和古城墙稳... 详细信息

基于ABAQUS有限元软件,建立了兰溪市某防洪古城墙渗流边坡稳定分析模型,采用渗流-应力耦合计算方法模拟了在降雨入渗条件下古城墙边坡孔隙水压力变化过程,并比较分析了有防渗设施、有排水设施和无排水设施对墙后土体渗流特性和古城墙稳定性的影响。结果表明:在降雨入渗条件下,有防渗设施和无排水设施的古城墙边坡土体的孔隙水压力不断增大,倾覆力矩也不断增大,不利于古城墙的稳定;有排水设施的古城墙边坡土体的孔隙水压力通过排水通道得到了大幅度的降低,倾覆力矩也随之减小,更有利于古城墙的稳定。

关键词：防洪古城墙降雨入渗边坡稳定孔隙水压力稳定性 ABAQUS 兰溪市

A pentapeptide enabled AL3810 liposome-based glioma-targeted therapy with immune opsonic effect attenuated

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Acta Pharmaceutica Sinica B 2021年第1期11卷 283-299页

作者： Jinyang Li Jiasheng Lu Haiyan Guo jianfen zhou Songli Wang Kuan Jiang Zhilan Chai Shengyu Yao Xiaoyi Wang Linwei Lu Cao Xie Yi Chen Weiyue Lu Department of Pharmaceutics School of PharmacyFudan University&Key Laboratory of Smart Drug Delivery(Fudan University)Ministry of Education and PLAShanghai 201203China Chinese Academy of Sciences Shanghai Institute of Materia Medica Shanghai 201203China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain ScienceFudan UniversityShanghai 200032China The Institutes of Integrative Medicine of Fudan University Shanghai 200041China Minhang Branch Zhongshan Hospital and Institute of Fudan-Minghang Academic Health SystemMinghang HospitalFudan UniversityShanghai 201199China

AL3810,a molecular dual inhibitor of the vascular endothelial growth factor receptor(VEGFR)and fibroblast growth factor receptor(FGFR),has earned the permission of phase II clinical trial for tumor treatment by China *** a reversible ATP-competitive inhibitor,AL3810 targets ATP-binding site on intracellular region of VEGFR and FGFR,whereas,AL3810 lacking interplay with extracellular region of receptors rendered deficient bloodebrain tumor barrier(BBTB)recognition,poor brain penetration and unsatisfactory anti-glioma *** avb3 overexpressed on capillary endothelial cells of BBTB as well as glioma cells illuminated ligand-modified liposomes for pinpoint spatial delivery into *** widely accepted peptide c(RGDyK)-modified liposome loading AL3810 of multiple dosing caused hypothermia,activated anti-c(RGDyK)-liposome IgG and IgM antibody and pertinent complements C3 b and C5 b-9,and experienced complement-dependent *** newly proposed a pentapeptide mn with superb avb3-binding affinity and tailored AL3810-loaded mn-modified liposome that afforded impervious blood circulation,targeting ability,and glioma therapeutic expertise as vastly alleviated immune opsonization on the underpinning of the finite antibodies and complements *** from attenuated immunogenicity,peptide mn strengthened liposome functions as a promising nanocarrier platform for molecular targeting agents.

关键词： Liposome mn c(RGDyK) Immune opsonization Immunogenicity Anti-glioma efficacy

基于MIKE21的二维数值模拟在防洪评价中的应用

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浙江水利水电学院学报 2023年第5期35卷 54-62页

作者：沈德录周建芬浙江中邦水利科技有限公司浙江杭州310018 浙江水利水电学院水利与环境工程学院浙江杭州310018

为探究涉河涉堤工程建设对水域防洪等功能的影响,以永嘉县沙头镇响山大桥临时钢栈桥为例,采用MIKE21软件建立模型,计算临时钢栈桥建设前后桥址一定区域内河道水位的壅水高度、壅水长度以及流速变化特点和分布规律,分析临时钢栈桥的建设... 详细信息

为探究涉河涉堤工程建设对水域防洪等功能的影响,以永嘉县沙头镇响山大桥临时钢栈桥为例,采用MIKE21软件建立模型,计算临时钢栈桥建设前后桥址一定区域内河道水位的壅水高度、壅水长度以及流速变化特点和分布规律,分析临时钢栈桥的建设对楠溪江河道行洪能力的影响。结果显示:临时钢栈桥桥址附近的水位较建设前水位略有升高,最大壅水高度为0.06 m,发生在桥位上游约110 m处,桥墩间流速较建设前有所增加,最大流速增幅为3.36%,计算数值与采用传统方法得出的数值相差甚微。由于桥墩局部的阻水作用,在河水流向桥墩时,两侧会出现小范围绕流,对河道整体水流运动无较大影响。

关键词：涉河涉堤工程 MIKE21 壅水高度流速变化防洪评价