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Vesicular drug delivery systems for oral absorption enhancement

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Chinese Chemical Letters 2024年第7期35卷 73-88页

作者： Linghui Zou Meng Cheng Kaili Hu jianfang Feng Liangxing Tu Jiangxi University of Chinese Medicine Nanchang 330006China Guangxi University of Chinese Medicine Nanning 530200China Shanghai University of Traditional Chinese Medicine Shanghai 201203China

Oral administration is the most acceptable route of drug delivery at this stage due to its convenience,safety,and ***,drugs given orally are exposed to a complex gastrointestinal environment,causing a tremendous challenge for their successful absorption into the *** the past decades,researchers have developed various novel pharmaceutical technologies to improve oral absorption,among which the vesicular drug delivery system(like liposomes,niosomes and transfersomes)has received extensive ***,there have been several investigations confirming the improved effect of vesicular drug delivery systems on oral drug ***,the clinical translation of oral vesicular drug delivery systems has been less impressive than implied by the positive results,and few vesicular formulations for oral use have been marketed *** this background,this article provides an overview of the current applications and challenges associated with the vesicular delivery systems available for oral drug delivery,specifically liposomes,niosomes,transfersomes,chitosomes and *** composition,formation mechanism,drug delivery advantages and application cases of these carriers in oral drug delivery are *** possible mechanisms by which vesicular carriers enhance oral drug absorption are analyzed in terms of the in vivo process of oral ***,the challenges that oral vesicular carriers now face,such as safety,undefined in vivo fate,and scale-up production,are summarized,while possible strategies to deal with them are *** reviewing the aforementioned,it can facilitate a more comprehensive knowledge of vesicular systems that can be used for oral drug delivery,providing a theoretical basis and reference for the design of oral formulations.

关键词： Vesicular Oral Mechanism Drug delivery Liposome Niosomes Transfersomes Chitosomes Bilosomes

Designing salt stress-resilient crops:Current progress and future challenges

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Journal of Integrative Plant Biology 2024年第3期66卷 303-329页

作者： Xiaoyan Liang jianfang Li Yongqing Yang Caifu Jiang Yan Guo State Key Laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBeijing 100094China State Key Laboratory of Nutrient Use and Management College of Resources and Environmental SciencesChina Agricultural UniversityBeijing 100194China Center for Crop Functional Genomics and Molecular Breeding China Agricultural UniversityBeijing 100094China Frontiers Science Center for Molecular Design Breeding China Agricultural UniversityBeijing 100193China

Excess soil salinity affects large regions of land and is a major hindrance to crop production ***,understanding the molecular mechanisms of plant salt tolerance has scientific importance and practical *** recent decades,studies have characterized hundreds of genes associated with plant responses to salt stress in different plant *** studies have substantially advanced our molecular and genetic understanding of salt tolerance in plants and have introduced an era of molecular design breeding of salt-tolerant *** review summarizes our current knowledge of plant salt tolerance,emphasizing advances in elucidating the molecular mechanisms of osmotic stress tolerance,salt-ion transport and compartmentalization,oxidative stress tolerance,alkaline stress tolerance,and the trade-off between growth and salt *** also examine recent advances in understanding natural variation in the salt tolerance of crops and discuss possible strategies and challenges for designing salt stress-resilient *** focus on the model plant Arabidopsis(Arabidopsis thaliana)and the four most-studied crops:rice(Oryza sativa),wheat(Triticum aestivum),maize(Zea mays),and soybean(Glycine max).

关键词： molecular design breeding salt stress-resilient crop salt tolerance

Multivariate Analysis of Female Stress Urinary Incontinence and Establishment of a Prediction Model

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Biomedical and Environmental Sciences 2024年第8期37卷 931-935页

作者： Lei Li Lin Luo Junnai wang Ying Hong jianfang Geng Department of Gynecology and Obstetrics The Third Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052 HenanChina Department of Suizhou Central Hospital Suizhou 441300HenanChina

Stress urinary incontinence(SUI)is a symptom of uncontrolled urine outflow that affects millions of women worldwide[1].SUI is a significant healthcare issue that affects the quality of life of women across numerous do... 详细信息

关键词： urine urinary Multivariate

猪细环病毒1型间接ELISA抗体检测方法的建立

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北京农学院学报 2024年第1期39卷 43-46页

作者：杨敩校刘芊麟陈丙生蒋小玲王建舫董虹肖兴周双海北京农学院动物科学技术学院北京102206 衡阳市畜牧水产事务中心湖南衡阳421001

【目的】建立一种检测猪细环病毒1型抗体的血清学方法。【方法】以猪细环病毒1型衣壳蛋白为包被抗原,筛选和优化抗体检测反应条件来建立一种检测猪细环病毒1型衣壳蛋白抗体的间接ELISA方法,之后进行特异性和重复性试验,并进行初步临床... 详细信息

【目的】建立一种检测猪细环病毒1型抗体的血清学方法。【方法】以猪细环病毒1型衣壳蛋白为包被抗原,筛选和优化抗体检测反应条件来建立一种检测猪细环病毒1型衣壳蛋白抗体的间接ELISA方法,之后进行特异性和重复性试验,并进行初步临床应用检测。【结果】确定了检测猪细环病毒1型衣壳蛋白抗体的间接ELISA方法的各项最佳反应条件;对8种猪源病毒阳性血清的检测结果显示只有猪细环病毒1型阳性血清为阳性,显示出良好的特异性;批内变异系数均小于5%,批间变异系数均小于10%,显示出良好的重复性。对来源于北京和湖南地区的400份猪血清样品的检测结果显示,猪细环病毒1型衣壳蛋白抗体阳性率为75.25%,PCR阳性率为71.00%,二者之间没有显著差异(P>0.05),表明这两个地区存在较多的的猪细环病毒1型感染。【结论】建立了一种特异性和重复性都良好的检测猪细环病毒1型衣壳蛋白抗体的间接ELISA,可用于猪细环病毒1型抗体的临床检测。

关键词：猪细环病毒1型衣壳蛋白间接ELISA 抗体检测

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情境语义学视野下的限定摹状词

学术研究 2010年第9期 33-38页

作者：王建芳中国政法大学哲学系

以限定摹状词的意义和解释为出发点,巴威斯等分析和刻画了限定摹状词的五种不同用法:指称性用法、外在归属性用法、内在归属性用法、同位性用法以及函数性用法。这些用法的提出,推进和深化了罗素、斯特劳森、唐奈兰、克里普克以来的摹... 详细信息

以限定摹状词的意义和解释为出发点,巴威斯等分析和刻画了限定摹状词的五种不同用法:指称性用法、外在归属性用法、内在归属性用法、同位性用法以及函数性用法。这些用法的提出,推进和深化了罗素、斯特劳森、唐奈兰、克里普克以来的摹状词理论研究,有助于澄清学界在限定摹状词用法方面存在的一些争议,对与限定摹状词相关的逻辑原则(如替换原则)的探讨亦具有重要意义。

关键词：情境语义学限定摹状词的意义限定摹状词的用法

Enhancing Tropical Cyclone Intensity Estimation from Satellite Imagery through Deep Learning Techniques

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Journal of Meteorological Research 2024年第4期38卷 652-663页

作者： Wen YANG jianfang FEI Xiaogang HUANG Juli DING Xiaoping CHENG College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410008 Beijing Institute of Applied Meteorology Beijing 100029

This study first utilizes four well-performing pre-trained convolutional neural networks(CNNs) to gauge the intensity of tropical cyclones(TCs) using geostationary satellite infrared(IR) *** models are trained and tested on TC cases spanning from 2004 to 2022 over the western North Pacific *** enhance the models performance,various techniques are employed,including fine-tuning the original CNN models,introducing rotation augmentation to the initial dataset,temporal enhancement via sequential imagery,integrating auxiliary physical information,and adjusting *** optimized CNN model,i.e.,visual geometry group network(VGGNet),for TC intensity estimation is ultimately *** applied to the test data,the model achieves a relatively low mean absolute error(MAE) of 4.05 m s~(-1).To improve the interpretability of the model,the SmoothGrad combined with the Integrated Gradients approach is *** analyses reveal that the VGGNet model places significant emphasis on the distinct inner core region of a TC when estimating its ***,it partly takes into account the configuration of cloud systems as input features for the model,aligning well with meteorological *** several improvements made to this model's performance offer valuable insights for enhancing TC intensity forecasts through deep learning.

关键词： tropical cyclone intensity deep learning satellite imagery

态度语境中的同一替换问题——巴威斯等对弗雷格方案、罗素方案的分析和评判

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南京社会科学 2008年第12期 144-149页

作者：王建芳中国政法大学逻辑研究所副教授博士北京102249

巴威斯等认为弗雷格对涵义和所指的区分不能合理解释替换规则在态度语境中所遇到的问题,原因在于:(1)态度报告从句中的表达式有时不能提供概念性内容,有时不能提供合适的概念性内容;(2)态度报告中语言表达式指示其通常涵义的做法,是对... 详细信息

巴威斯等认为弗雷格对涵义和所指的区分不能合理解释替换规则在态度语境中所遇到的问题,原因在于:(1)态度报告从句中的表达式有时不能提供概念性内容,有时不能提供合适的概念性内容;(2)态度报告中语言表达式指示其通常涵义的做法,是对语义无辜原则的放弃;同样,罗素对态度语境中同一替换问题的处理也不能令人满意,因为他放弃了两个重要的常识:(1)摹状词是语法单位,(至少在某些情况下)其语义值是个体;(2)一个通名的语义值是个体。针对如上不足,巴威斯等重新确立了态度语义研究的目标,对态度语境中同一替换原则的适用性问题做出了新的解释。

关键词：态度动词替换原则摹状词语义无辜

Potassium isotopic signatures of modern offshore detrital sediments from different climatic regimes and the implications

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Science China Earth Sciences 2024年第2期67卷 405-419页

作者： Jun MU Tianyu CHEN Qian YU Shichao AN jianfang CHEN Xuefa SHI Weiqiang LI State Key Laboratory for Mineral Deposits Research School of Earth Sciences and EngineeringNanjing UniversityNanjing210023China Ministry of Education Key Laboratory for Coast and Island Development School of Geography and Ocean ScienceNanjing UniversityNanjing210023China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou310012China Key Laboratory of Marine Geology and Metallogeny First Institute of OceanographyMinistry of Natural ResourcesQingdao266061China

Potassium isotopes are a novel tracer for continental *** K isotope studies on chemical weathering generally targeted weathering profiles under a particular climate region,yet the effects of chemical weathering on K isotopes under different climatic backgrounds remain ***,little is known about the K isotope signatures of modern unconsolidated detrital ***,we report K isotopic data of surficial seafloor sediments from continental shelves along the east coast of China(ECC),as well as those around the tropical Hainan island in the northern South China *** ECC sediments have a relatively narrow distribution ofδ^(41)K(with reference to NIST3141a)values,which range from(-0.40±0.01)‰to(-0.57±0.04)‰,with an average of(-0.51±0.09)‰.By contrast,δ^(41)K values of Hainan offshore sediments display a larger variation,ranging from(-0.28±0.07)‰to(-0.67±0.02)‰.Theδ^(41)K values of Hainan offshore sediments exhibit negative correlations with the chemical index of alteration(CIA),Al/K,Ti/K,and total iron(FeT),which underlines the control of chemical weathering on K isotopic signatures of detritus inputs into *** also measured Mg isotope compositions for the same samples;interestingly,the variability inδ^(26)Mg of the samples is small(~0.24‰)for all ECC and Hainan offshore sediments,andδ^(26)Mg values do not show clear correlations with indexes of chemical *** study demonstrates the link between K isotopic variability of detrital sediments and climatic conditions including rainfall intensity,which indicates that K isotopes of the detrital component of marine sediments could be applied to study Earth’s climate in deep ***δ^(41)K values of the offshore detrital sediments are significantly less variable than those of pelagic marine sediments,highlighting the importance of distinguishing the effects of diagenesis and neoformation of clay minerals from continental weathering in attempts to study deep-time climate-weathering

关键词： Potassium isotopes Magnesium isotopes Chemical weathering Detrital sediments Climatic regimes Mean annual precipitation

忒修斯之船疑难的消解:经典方案反思与新路径建构

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世界哲学 2023年第3期 153-159,F0003页

作者：王建芳中国政法大学哲学系

“唯靠X和Y原则”和“最佳候选者理论”是忒修斯之船疑难的两类经典消解方案,二者各执一端,无论从本体论还是认识论视角看都存有不足。跟随亚里士多德的观点并加以修正,将形式因和质料因看作忒修斯之船的本质属性,从本体论视角看,拆装... 详细信息

“唯靠X和Y原则”和“最佳候选者理论”是忒修斯之船疑难的两类经典消解方案,二者各执一端,无论从本体论还是认识论视角看都存有不足。跟随亚里士多德的观点并加以修正,将形式因和质料因看作忒修斯之船的本质属性,从本体论视角看,拆装船与原船“同一”,修补船与原船“相同”但不“同一”;从意向性指称理论视角看,原船、修补船与拆装船的同一性判定往往受认知主体的意图和意向性影响并随之改变;从作为内在因素的本质属性与作为外在因素的意图、意向性两方面来衡量,二者在不同情境下作用力大小不同,产生的合力不同,引发的判断自然有所不同。由此,就可以有效地弥补经典消解方案的不足,同时合理地修正“否定忒修斯之船本体同一”和“否定存在本体同一标准”的认识。

关键词：忒修斯之船唯靠X和Y原则最佳候选者理论意向性指称理论