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TGF-β-regulated different iron metabolism processes in the development and cisplatin resistance of ovarian cancer

Oncology Research 2024年第2期32卷 373-391页

作者： jianfa wu QIANYI LIAO LI ZHANG SUQIN wu ZHOU LIU Department of Gynecology Shanghai University of Medicine&Health Sciences Affiliated Zhoupu HospitalShanghaiChina Department of Gynecology Shanghai University of Medicine&Health SciencesShanghaiChina Department of Gynecology Gongshan People’s HospitalNujiang Lisu Autonomous PrefectureChina

The impact of different iron metabolism processes(DIMP)on ovarian cancer remains *** this study,we employed various gene chips and databases to investigate the role of DIMP in the initiation and development of ovarian *** was used to determine mutations in DIMP-associated genes in ovarian ***-Meier plotter was used to examine the influence of DIMP on the prognosis of ovarian *** analyzing 1669 serous ovarian cancer cases,we identified a range of mutations in iron metabolism genes,notably in those coding for the transferrin receptor(19%),melanotransferrin(19%),and ceruloplasmin(10%)in the iron import process,and glucose-6-phosphate isomerase(9%),hepcidin antimicrobial peptide(9%),metal regulatory transcription factor 1(8%),and bone morphogenetic protein 6(8%)in the iron regulation *** to the unaltered group,the group with gene alterations exhibited a higher tumor mutation burden count(43 vs.54)and more advanced histologic grade(78.19%vs.87.90%).Compared to the normal ovarian counterparts,a reduction in expression was observed in 9 out of the 14 genes involved in iron utilization and 4 out of the 5 genes involved in iron export in ovarian cancer;in contrast,an increase in expression was observed in 2 out of the 3 genes involved in iron storage in ovarian ***,in cisplatin-resistant cells compared to cisplatin-sensitive ones,the expression of all genes in iron storage and 13 out of 14 genes in iron import was decreased,while that of 8 out of the 10 genes in iron utilization was *** addition,survival curve analysis indicated that a higher expression in the majority of genes in the iron import process(12/21),or a reduced expression in most genes in the iron export process(4/5)correlated with poor progression-free ***,TGF-βcould regulate the expression of most iron metabolism-associated genes;particularly,expression of genes involved in the iron storage process(2/2)was inhibited aft

关键词： Chemoresistance Cisplatin Iron Ovarian neoplasms TGF-β

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Hydrocarbon accumulation and key exploration & development technologies of Changning-Weiyuan marine shale gas field, southern Sichuan

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Petroleum Research 2021年第1期6卷 1-15页

作者： Xiao He jianfa wu Rui Yong Shengxian Zhao PetroChina Southwest Oil&Gas Field Company Chengdu610051China

China is rich in shale gas resources and has broad prospects for development. However, the quality ofshale gas resources in China is different from that in the United States, so independent unique technologies are urgently required in China. In this regard, PetroChina has carried out theoretical andtechnical researches systematically on shale gas in Longmaxi Formation in southern Sichuan according toits geology-engineering characteristics. Guided by the “three-control” theory for marine shale gasenrichment and high yield (i.e. sedimentary diagenesis controls reservoir, preservation conditions control accumulation, and continuous thickness of Type I reservoir controls production), six key explorationand development technologies in southern China have been innovatively developed for marine shale gaswhich experienced multi-stage tectonic evolution. The technologies include comprehensive geologicalevaluation technology, development optimization technology, optimal and fast drilling technology forhorizontal well, volume fracturing technology for horizontal well, factory-like operation technology, andefficient clean production technology. These technologies have enabled the large-scale commercial recovery of shale gas. By the end of 2019, PetroChina had obtained proved geological reserves of1.06 1012 m3, had built production capacity of 10 109 m3, and had cumulative gas production of20 109 m3 in southern Sichuan. The remarkable results of application are of great significance forvigorously developing shale gas industry to reduce external dependence, ensure national energy security,and realize the strategy of "ecological priority and green development".

关键词： Shale gas Exploration and development Hydrocarbon accumulation condition Horizontal well Optimization Fracturing Changning-weiyuan area Southern sichuan

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Numerical investigation on ball-sealers transport and diversion performance in shale gas horizontal well based on semi-resolved CFD-DEM

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Particuology 2024年第10期93卷 137-153页

作者： Yinjian Huang Jinzhou Zhao Lan Ren Ran Lin jianfa wu Cheng Shen Jianjun wu Bing Li National Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500China Tianfu Yongxing Laboratory Chengdu610213China Shale Gas Research Institute PetroChina Southwest Oil&Gasfield CompanyChengdu610056China PetroChina Coalbed Methane Company Limited Xi’an710082China

In the staged multi-cluster fracturing of shale gas horizontal wells, ball sealers are used to ensure uniform fluid distribution among clusters, a strategy that is both cost-effective and operationally beneficial. Despite these advantages, comprehending the ball sealers' dynamics within the wellbore and their plugging behavior at perforations is still challenging. This complexity results in prediction difficulties regarding their diversion efficiency. To address this, our study utilized a semi-resolved CFD-DEM model based on kernel approximation to simulate the behavior of medium-sized ball sealers in single and multiple cluster scenarios. Our findings from a single cluster scenario reveal that the plugging probability is co-determined by velocity gradients in the fluid ingestion area near the perforation, backflow region, and inertial forces of the ball sealers. As the critical flow rate is achieved, the plugging probability negatively correlated with fluid viscosity and displacement, and positively correlated with the perforation flow ratio (PFR), the difference in particle-fluid density, ball sealer’s diameter, and the ball sealer’s offset from the pipeline center. Temporary plugging control efficiency was used to evaluate the flow balance effect among multiple clusters. The results indicate that an increased number of ball sealers enhances the fault tolerance during the temporary plugging process. Nevertheless, excessive ball sealers might undermine the temporary plugging control efficiency, as perforations with lower fluid inflow rates are unexpectedly plugging. Higher differences in fluid injection rates between clusters led to increased efficiency in temporary plugging control. Premature deployment of ball sealers cannot effectively plug perforations with marginally higher fluid inflow rates, but instead accidently plug intermediate clusters with lower fluid inflow rates. These findings offer a theoretical basis for optimizing the design of ball sealers.

关键词： Gas shale Horizontal wells Ball sealer Semi-resolved CFD-DEM Diversion

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Evaluation and Application of Flowback Effect in Deep Shale Gas Wells

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Fluid Dynamics & Materials Processing 2024年第10期20卷 2301-2321页

作者： Sha Liu jianfa wu Xuefeng Yang Weiyang Xie Cheng Chang Shale Gas Research Institute PetroChina Southwest Oil&Gas field CompanyChengdu610051China

The pivotal areas for the extensive and effective exploitation of shale gas in the Southern Sichuan Basin have recently transitioned from mid-deep layers to deep *** challenges such as intricate data analysis,absence of effective assessment methodologies,real-time control strategies,and scarce knowledge of the factors influencing deep gas wells in the so-called flowback stage,a comprehensive study was undertaken on over 160 deep gas wells in Luzhou block utilizing linear flow models and advanced big data analytics *** research results show that:(1)The flowback stage of a deep gas well presents the characteristics of late gas channeling,high flowback rate after gas channeling,low 30-day flowback rate,and high flowback rate corresponding to peak production;(2)The comprehensive parameter AcmKm1/2 in the flowback stage exhibits a strong correlation with the Estimated Ultimate Recovery(EUR),allowing for the establishment of a standardized chart to evaluate EUR classification in typical shale gas wells during this *** enables quantitative assessment of gas well EUR,providing valuable insights into production potential and performance;(3)The spacing range and the initial productivity of gas wells have a significant impact on the overall effectiveness of gas ***,it is crucial to further explore rational well patterns and spacing,as well as optimize initial drainage and production technical strategies in order to improve their performance.

关键词： Deep shale gas flowback characteristic EUR forecast effect evaluation main controlling factors

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CO_(2),N_(2),and CO_(2)/N_(2)mixed gas injection for enhanced shale gas recovery and CO_(2)geological storage

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Frontiers in Energy 2023年第3期17卷 428-445页

作者： jianfa wu Haoran HU Cheng CHANG Deliang ZHANG Jian ZHANG Shengxian ZHAO Bo WANG Qiushi ZHANG Yiming CHEN Fanhua ZENG Shale Gas Research Institute Petro-China Southwest Oil and Gas-field CompanyChengdu 610051China Faculty of Engineering and Applied Science University of ReginaSK S4S 0A2Canada Department of Petroleum and Natural Gas Engineering Liaoning Petrochemical UniversityFushun 113001China

In this work,using fractured shale cores,isothermal adsorption experiments and core flooding tests were conducted to investigate the performance of injecting different gases to enhance shale gas recovery and CO_(2)geological storage efficiency under real reservoir *** adsorption process of shale to different gases was in agreement with the extended-Langmuir model,and the adsorption capacity of CO_(2)was the largest,followed by CH_(4),and that of N_(2)was the smallest of the three pure *** addition,when the CO_(2)concentration in the mixed gas exceeded 50%,the adsorption capacity of the mixed gas was greater than that of CH4,and had a strong competitive adsorption *** the core flooding tests,pure gas injection showed that the breakthrough time of CO_(2)was longer than that of N_(2),and the CH_(4)recovery factor at the breakthrough time(Rch,)was also higher than that of N_(2).The RcH of CO_(2)gas injection was approximately 44.09%,while the RcH,of N_(2)was only 31.63%.For CO_(2)/N_(2)mixed gas injection,with the increase of CO_(2)concentration,the RcH,increased,and the RcH,for mixed gas CO_(2)/N_(2)=8:2 was close to that of pure CO_(2),about 40.24%.Moreover,the breakthrough time of N_(2)in mixed gas was not much different from that when pure N_(2)was injected,while the breakthrough time of CO_(2)was prolonged,which indicated that with the increase of N_(2)concentration in the mixed gas,the breakthrough time of CO_(2)could be ***,an abnormal surge of N_(2)concentration in the produced gas was observed after N_(2)*** regards to CO_(2)storage efficiency(S_(Storage-CO_(2)),as the CO_(2)concentration increased,S storage-co_(2)also *** S storage-co_(2),of the pure CO_(2)gas injection was about 35.96%,while for mixed gas CO_(2)/N_(2)=8:2,S sorage-co,was about 32.28%.

关键词： shale gas gas injection competitive adsorption enhanced shale gas recovery CO_(2)geological storage

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Trajectory optimization of SUAV communication relay based on GWO algorithm in the environments with sea breeze

Trajectory optimization of SUAV communication relay based on...

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第三十九届中国控制会议

作者： Yuebin Lun Honglun Wang jianfa wu Yanxiang Wang School of Automation Science and Electrical Engineering Beihang University Science and Technology on Aircraft Control Laboratory Beihang University Shenyuan Honors College Beihang University

The study is based on the combination of communication relay and energy absorption of solar-powered unmanned aerial vehicle（SUAV）,which is a multiple extremum *** SUAV kinematics model is changed from two dimensions to three dimensions with adding the interference of sea breeze to reduce or offset the impact of wind on mission optimization and improve the energy *** the performance of the on-line optimization of SUAVs,the particle swarm optimizer（PSO） algorithm is replaced by a faster grey wolf optimizer（GWO） *** order to accelerate the convergence speed of the algorithm and avoid falling into local optimality,a penalty function is added in this paper to judge whether there is a SUAV as the last branch of the communication *** results prove the necessity of the model with consideration of the wind and the effectiveness of the methods.

关键词： SUAV sea breeze communication relay energy absorption optimal trajectories distributed model predictive control(DMPC) GWO

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大跨时空任务背景下的太阳能无人机任务规划技术研究进展

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航空学报 2020年第3期41卷 59-79页

作者：吴健发王宏伦黄宇北京航空航天大学自动化科学与电气工程学院北京100083 北京航空航天大学飞行器控制一体化技术重点实验室北京100083 北京航空航天大学高等理工学院北京100083 北京信息科技大学自动化学院北京100192

通过任务规划技术合理的优化太阳能无人机的飞行轨迹和动力学参数,能够有效提高太阳能无人机的能量利用率,使其胜任许多大范围跨时间跨空间飞行任务。从能量建模、续航评估和能量管理策略3个方面对大跨时空任务背景下太阳能无人机任务... 详细信息

通过任务规划技术合理的优化太阳能无人机的飞行轨迹和动力学参数,能够有效提高太阳能无人机的能量利用率,使其胜任许多大范围跨时间跨空间飞行任务。从能量建模、续航评估和能量管理策略3个方面对大跨时空任务背景下太阳能无人机任务规划技术的研究进展进行了综述。在能量建模方面,介绍了当前主流的太阳辐射模型和能量生产基本框架;在续航评估方面,分析了目前的指标设计和应用方法;在能量管理策略方面,从能量综合应用、风力滑翔机制、轨迹优化方法和面向特定任务的应用4个角度,梳理了当前的研究现状。最后,对该领域未来可能的研究方向进行了展望。

关键词：任务规划技术太阳能无人机大跨时空飞行任务能量建模续航评估能量管理策略

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Comprehensive Evaluation of Geological and Engineering Sweet Spots of Shale Gas Reservoir: A Case Study of the Luzhou Block, Sichuan Basin

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International Journal of Geosciences 2021年第11期12卷 1021-1039页

作者： Yuan Wang jianfa wu Li Fu Haoyong Huang Gang Chen Cheng Chang CNPC Engineering Technology R & D Company Limited Beijing China Southwest Oil and Gas Field Company of CNPC Chengdu China

There is a huge amount of marine shale gas resources in the southern Sichuan Basin in China, and most of the resources are at the buried depth of 3500 - 4500 meters. At present, deep shale gas is in the early stage of exploration and development. In order to achieve large-scale efficient development, in addition to optimizing favorable blocks, it is also to identify the optimal target in the vertical direction combine geology, drilling, and fracturing. Therefore, Taking the Longmaxi formation shale in the Luzhou block as the research object, based on drilling, logging, and core experiment data, through single well and 3D geomechanical modeling methods, analyze the characteristics of organic matter abundance, porosity, pore pressure, collapse pressure, mineral composition and in-situ stress of different layers of shale in Longmaxi formation. Systematically summarized the main controlling factors of the “sweet spot” of deep shale gas and establish the comprehensive evaluation system of deep shale gas “sweet spots”, to clarify the optimal “sweet spots” of geology, drilling, and fracturing in the Longmaxi reservoir. Results show that the total organic carbon content, porosity, and gas saturation of the long111 layer are higher than other layers. The Long111 layer has a low collapse pressure and a high compressive strength, the risk of wellbore instability is relatively low. The stress difference coefficient of All layers is less than 0.3, and the brittleness index of the Long111 layer is 62.35%. A complex fracture network is easier to form after fracturing. The conclusion shows that the Long111 layer is the optimal reservoir section of the Longmaxi Formation. Ensure the drilled rate of the Long111 layer and maximize the length of the horizontal section can obtain higher production.

关键词： Deep Shale Gas Geological Sweet Spots Engineering Sweet Spots Geomechanical Modeling

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航天器反应式碎片规避动作规划方法

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宇航学报 2023年第2期44卷 221-232页

作者：吴健发魏春岭张海博北京控制工程研究所北京100094 空间智能控制技术重点实验室北京100094

提出一种航天器反应式碎片规避动作规划方法,首先以扰动流体动态系统(IFDS)算法作为动作规划的基础算法,通过其中的总和扰动矩阵对航天器的轨道速度矢量进行修正,实现轨道机动规避;然后,建立基于双延迟深度确定性策略梯度(TD3)深度强化... 详细信息

提出一种航天器反应式碎片规避动作规划方法,首先以扰动流体动态系统(IFDS)算法作为动作规划的基础算法,通过其中的总和扰动矩阵对航天器的轨道速度矢量进行修正,实现轨道机动规避;然后,建立基于双延迟深度确定性策略梯度(TD3)深度强化学习算法的反应式动作规划方法,通过TD3在线优化IFDS规划参数,实现对碎片群的“状态-动作”最优、快速规避决策。在此基础上,将优先级经验回放和渐进式学习策略引入该方法中,提升训练效率。最后,仿真结果表明,所提方法可使航天器安全规避多发、突发、动态且形状各异的空间碎片群,且具有较好的实时性。

关键词：空间碎片碰撞规避深度强化学习航天器安全

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页岩气井长水平段压裂一体化动态评估--以长宁国家级页岩气示范区为例

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天然气工业 2022年第2期42卷 123-132页

作者：沈骋吴建发付永强曾波中国石油西南油气田公司页岩气研究院中国石油西南油气田公司

四川盆地南部地区(以下简称川南地区)的长宁国家级页岩气示范区是四川盆地页岩气开发的主战场,为厘清页岩气井水平段及压裂长度增加带来的气井产能动态影响,以川南地区的长宁区块奥陶系五峰组—志留系龙马溪组的336口气井为研究对象,采... 详细信息

四川盆地南部地区(以下简称川南地区)的长宁国家级页岩气示范区是四川盆地页岩气开发的主战场,为厘清页岩气井水平段及压裂长度增加带来的气井产能动态影响,以川南地区的长宁区块奥陶系五峰组—志留系龙马溪组的336口气井为研究对象,采用大数据分析方法,深入剖析影响气井效益开发的靶体、压裂、排采生产一体化动态因素。研究结果表明:①高产气井具有靶体钻遇率大于70%、钻遇长度大于1200 m的特征,改进钻井工艺技术可保障高靶体钻遇率进而保障产量;②流体压力降和孔眼摩阻会削弱施工作业强度,严重影响压裂效果,采用低黏压裂液和差异化射孔工艺可有效克服该难题;③前序段“相对低排量+相对密簇距”、后序段“相对高排量+相对大簇距”可实现有效改造,并能解决邻井长期生产带来的影响;④跟端和趾端垂深差异较大易造成井底积液,严重影响前序压裂段簇效率和产量,跟趾端垂深差异在±300 m、斜率在±0.15内有利于气井高产。结论认为,长水平段压裂是气井一体化动态影响因素的综合反映,长宁区块最优水平段压裂长度为2200 m左右,研究成果为后续川南地区页岩气规模效益开发提供了理论支撑。

关键词：长宁国家级页岩气示范区长水平井段压裂一体化动态评估簇间距垂深差异最优压裂段长规模效益开发

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