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TGF-β-regulated different iron metabolism processes in the development and cisplatin resistance of ovarian cancer

Oncology Research 2024年第2期32卷 373-391页

作者： jianfa WU QIANYI LIAO LI ZHANG SUQIN WU ZHOU liu Department of Gynecology Shanghai University of Medicine&Health Sciences Affiliated Zhoupu HospitalShanghaiChina Department of Gynecology Shanghai University of Medicine&Health SciencesShanghaiChina Department of Gynecology Gongshan People’s HospitalNujiang Lisu Autonomous PrefectureChina

The impact of different iron metabolism processes(DIMP)on ovarian cancer remains unclear.In this study,we employed various gene chips and databases to investigate the role of DIMP in the initiation and development of ovarian cancer.cBioPortal was used to determine mutations in DIMP-associated genes in ovarian cancer.Kaplan-Meier plotter was used to examine the influence of DIMP on the prognosis of ovarian cancer.By analyzing 1669 serous ovarian cancer cases,we identified a range of mutations in iron metabolism genes,notably in those coding for the transferrin receptor(19%),melanotransferrin(19%),and ceruloplasmin(10%)in the iron import process,and glucose-6-phosphate isomerase(9%),hepcidin antimicrobial peptide(9%),metal regulatory transcription factor 1(8%),and bone morphogenetic protein 6(8%)in the iron regulation process.Compared to the unaltered group,the group with gene alterations exhibited a higher tumor mutation burden count(43 vs.54)and more advanced histologic grade(78.19%vs.87.90%).Compared to the normal ovarian counterparts,a reduction in expression was observed in 9 out of the 14 genes involved in iron utilization and 4 out of the 5 genes involved in iron export in ovarian cancer;in contrast,an increase in expression was observed in 2 out of the 3 genes involved in iron storage in ovarian cancer.Furthermore,in cisplatin-resistant cells compared to cisplatin-sensitive ones,the expression of all genes in iron storage and 13 out of 14 genes in iron import was decreased,while that of 8 out of the 10 genes in iron utilization was increased.In addition,survival curve analysis indicated that a higher expression in the majority of genes in the iron import process(12/21),or a reduced expression in most genes in the iron export process(4/5)correlated with poor progression-free survival.Additionally,TGF-βcould regulate the expression of most iron metabolism-associated genes;particularly,expression of genes involved in the iron storage process(2/2)was inhibited after TGF-β1 or TGF-β2 treatment.In conclusion,DIMP

关键词： Chemoresistance Cisplatin Iron Ovarian neoplasms TGF-β

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Porous framework materials for energy&environment relevant applications:A systematic review

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Green Energy & Environment 2024年第2期9卷 217-310页

作者： Yutao liu Liyu Chen Lifeng Yang Tianhao Lan Hui Wang Chenghong Hu Xue Han Qixing liu jianfa Chen Zeming Feng Xili Cui Qianrong Fang Hailong Wang Libo Li Yingwei Li Huabin Xing Sihai Yang Dan Zhao Jinping Li College of Chemical Engineering and Technology Shanxi Key Laboratory of Gas Energy Efficient and Clean UtilizationTaiyuan University of TechnologyTaiyuan030024China School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou510640China Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China Department of Chemistry The University of ManchesterManchesterM139PLUK Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585Singapore ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou311215China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin UniversityChangchun130012China Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline Materials Department of ChemistryUniversity of Science and Technology BeijingBeijing100083China

Carbon peaking and carbon neutralization trigger a technical revolution in energy&environment related fields.Development of new technologies for green energy production and storage,industrial energy saving and efficiency reinforcement,carbon capture,and pollutant gas treatment is in highly imperious demand.The emerging porous framework materials such as metal–organic frameworks(MOFs),covalent organic frameworks(COFs)and hydrogen-bonded organic frameworks(HOFs),owing to the permanent porosity,tremendous specific surface area,designable structure and customizable functionality,have shown great potential in major energy-consuming industrial processes,including sustainable energy gas catalytic conversion,energy-efficient industrial gas separation and storage.Herein,this manuscript presents a systematic review of porous framework materials for global and comprehensive energy&environment related applications,from a macroscopic and application perspective.

关键词： Porous framework materials Catalysis Separation Gas storage Carbon neutrality

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Intrinsic polarization conversion and avoided-mode crossing in X-cut lithium niobate microrings

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Chinese Physics B 2024年第6期33卷 398-403页

作者：谭泽林张检发朱志宏陈伟邵铮铮刘肯秦石乔 College of Advanced Interdisciplinary Studies&Hunan Provincial Key Laboratory of Novel Nano Optoelectronic Information Materials and Devices National University of Defense TechnologyChangsha 410073China Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China School of Physics Central South UniversityChangsha 410083China

Compared with well-developed free space polarization converters, polarization conversion between TE and TM modes in the waveguide is generally considered to be caused by shape birefringence, like curvature, morphology of waveguide cross section and scattering. Here, we study the polarization conversion mechanism in 1-THz-FSR X-cut lithium niobate microrings with multiple-resonance condition, that is the conversion can be implemented by birefringence of waveguides,which will also introduce an avoided-mode crossing. In the experiment, we find that this mode crossing results in severe suppression of one sideband in local nondegenerate four-wave mixing and disrupts the cascaded four-wave mixing on this side. Simultaneously, we propose one two-dimensional method to simulate the eigenmodes(TE and TM) in X-cut microrings, and the mode crossing point. This work will provide one approach to the design of polarization converters and simulation for monolithic photonics integrated circuits, and may be helpful to the studies of missed temporal dissipative soliton formation in X-cut lithium niobate rings.

关键词： polarization conversion birefringence nondegenerate four-wave mixing

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Effects of Parasitic Diseases on the Cardiovascular System

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Journal of Biosciences and Medicines 2022年第6期10卷 90-102页

作者： Tao Zhang Jun Jiang jianfa liu Department of Parasitology Ningbo University School of Medicine Ningbo China Department of Cardiology Fenghua People’s Hospital Ningbo China Department of Infectious Disease School of Medicine The Affiliated Hospital of Ningbo University Ningbo China

The parasitic disease can significantly affect the cardiovascular system through various mechanisms;even though it is traditionally regarded as a disease characterized by parasitic sites’ mechanical damage and some immune responses. Recent studies have shown that the role of parasitic factors in the cause of death due to cardiovascular events cannot be ignored. Considering the worldwide prevalence of parasitic diseases, exploring the effects of parasitic diseases on the cardiovascular system becomes increasingly essential. Here we summarize the latest understanding of common parasitic infections, explore the possible mechanisms of cardiovascular responses to parasitic infections, and propose feasible strategies for preventing and treating parasite-induced cardiac reactions.

关键词： Parasite Parasitic Diseases Chagas Cardiomyopathy Cardiovascular System

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数字化交付技术在油库工程建设中的应用

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化工管理 2024年第9期 75-77,113页

作者：陶建发曾勇昭刘华冰中国石化销售股份有限公司广西石油分公司广西南宁530020

随着信息化技术发展,数字化技术应用于各领域中。在工程开发与管理过程中,石油化工行业进行数字化建设,可有效提高信息收集、存储、检索应用等方面的效率与质量。基于此,文章从销售企业油库数字化交付以及数字油库建设内容、方法、途径... 详细信息

随着信息化技术发展,数字化技术应用于各领域中。在工程开发与管理过程中,石油化工行业进行数字化建设,可有效提高信息收集、存储、检索应用等方面的效率与质量。基于此,文章从销售企业油库数字化交付以及数字油库建设内容、方法、途径等方面进行了总结分析,重点探讨了数字化交付在油库工程建设中的应用,并从数字智慧油库的角度分析了未来油库建设发展趋势。

关键词：数字化交付数字油库工程建设

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High performance electro-optic modulator based on thin-film lithium niobate

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Optoelectronics Letters 2022年第10期18卷 583-587页

作者： liu Leshu liu Ning ZHANG jianfa ZHU Zhihong liu Ken College of Advanced Interdisciplinary Studies&Hunan Provincial Key Laboratory of Novel Nano-Optoelectronic Information Materials and Devices National University of Defense TechnologyChangsha410073China

Electro-optic(EO) modulator plays a very critical role in the optical communication systems. Here, we report a stimulated thin-film lithium niobate(LN) modulator with a half-wave voltage-length product of 1.8 V·cm, which can successfully achieve modulation and demodulation of a 1 GHz sinusoidal signal with an amplitude of 5 V in experiment. The optical loss caused by metal electrodes is reduced by optimizing the waveguide structure and depositing silica onto the waveguide, and group-velocity matching and characteristic impedance matching are achieved by optimizing the buffer silica layer and the electrode structure for larger bandwidth, which simultaneously improves the modulation efficiency and bandwidth performance. Our work demonstrated here paves a foundation for integrated photonics.

关键词： modulator waveguide lithium

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四川盆地金秋气田:一个典型以中生界沉积岩为氦源岩的含氦-富氦气田

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石油与天然气地质 2024年第1期45卷 185-199页

作者：张宝收张本健汪华陈践发刘凯旋豆霜戴鑫陈双玲中国石油西南油气田分公司勘探开发研究院四川成都610041 中国石油大学(北京)地球科学学院北京102249

氦气成藏长期以来研究较少,成藏条件与成藏机理还不十分清楚,氦源岩类型和形成条件争议较大。通过解剖含氦-富氦的金秋气田认为:(1)金秋气田氦气含量主要分布在0.05%~0.10%,平均为0.07%,部分井含量超过0.10%,最高为0.20%。同位素分析认... 详细信息

氦气成藏长期以来研究较少,成藏条件与成藏机理还不十分清楚,氦源岩类型和形成条件争议较大。通过解剖含氦-富氦的金秋气田认为:(1)金秋气田氦气含量主要分布在0.05%~0.10%,平均为0.07%,部分井含量超过0.10%,最高为0.20%。同位素分析认为氦气为壳源成因,没有幔源的贡献。(2)金秋气田是一个典型以中生界沉积岩为氦源岩的含氦-富氦气田。上三叠统须家河组和侏罗系具有较高的铀、钍元素含量和较大的地层厚度,在金秋地区具有较高的氦气生气强度,是形成含氦-富氦气藏的氦源基础。氦气应该主要来源于侏罗系储层,而非上三叠统须家河组烃源岩层系。(3)金秋气田含氦-富氦气田的形成受3个主要因素控制,具有高氦气生气强度的氦源岩提供了很好的物质基础;具有适度充注强度的烃类气体的存在有利于氦气富集;地层抬升剥蚀温、压下降导致的原位溶解氦气脱溶作用是氦气富集的有益补充。

关键词：充注强度溶解度脱溶量氦气生气强度氦源岩氦气金秋气田四川盆地

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鄂尔多斯盆地含氦天然气地球化学特征与富集影响因素

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石油与天然气地质 2024年第2期45卷 384-392页

作者：刘成林丁振刚范立勇康锐洪思婕朱玉新陈践发王海东许诺中国石油大学(北京)油气资源与探测国家重点实验室北京102249 中国石油大学(北京)地球科学学院北京102249 中国石油长庆油气田公司勘探开发研究院陕西西安710018 中国石油油气和新能源分公司北京100007 中国石化石油勘探开发研究院北京102206

鄂尔多斯盆地天然气资源丰富,部分地区天然气中的氦气含量较高,亟需深入研究含氦天然气地球化学特征与富集影响因素。通过采集天然气样品并进行组分和同位素等实验分析测试,结合地质条件,研究了鄂尔多斯盆地含氦天然气的分布、地球化学... 详细信息

鄂尔多斯盆地天然气资源丰富,部分地区天然气中的氦气含量较高,亟需深入研究含氦天然气地球化学特征与富集影响因素。通过采集天然气样品并进行组分和同位素等实验分析测试,结合地质条件,研究了鄂尔多斯盆地含氦天然气的分布、地球化学特征和影响因素,研究结果表明:(1)鄂尔多斯盆地天然气主要为烃类气体,氦气含量为0.016%~0.487%,平均值为0.060%;(2)鄂尔多斯盆地含氦天然气甲烷碳同位素值分布在-53.88‰~-29.23‰,甲烷、乙烷、丙烷和丁烷碳同位素表明烃类气为有机成因;(3)鄂尔多斯盆地含氦天然气3He/4He含量比值为20.10×10^(-9)~120.00×10^(-9),平均值为42.00×10^(-9),R/Ra值为0.014~0.085,平均值为0.030,为壳源氦的特征,不受天然气成因类型和成熟度等因素影响;(4)氦气含量较高的天然气主要分布在鄂尔多斯盆地北部东胜气田、西南部庆阳气田和东南部黄龙气田的上古生界石炭系-二叠系,其分布与古今构造位置、基底断裂、生氦强度及生烃强度相对强弱等因素密切相关。根据含氦天然气地球化学特征评价出富氦-中氦区、低氦区及贫氦区。

关键词：地球化学氦源岩氦气天然气鄂尔多斯盆地

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miR-519e-5p/SAT1轴介导铁死亡信号通路调节子宫内膜异位症的发生发展

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中国优生与遗传杂志 2024年第4期32卷 667-673页

作者：王鹰吴建发胡晓英姜伶俐柳洲上海健康医学院附属周浦医院妇产科上海201318

目的探讨微小RNA-519e-5p(miR-519e-5p)靶向调节精胺N1-乙酰基转移酶1(SAT1)对子宫内膜异位症(EMS)的影响。方法收集2023年1—6月在上海健康医学院附属周浦医院住院治疗的卵巢子宫内膜异位症患者的异位内膜组织,检测miR-519e-5p、SAT1... 详细信息

目的探讨微小RNA-519e-5p(miR-519e-5p)靶向调节精胺N1-乙酰基转移酶1(SAT1)对子宫内膜异位症(EMS)的影响。方法收集2023年1—6月在上海健康医学院附属周浦医院住院治疗的卵巢子宫内膜异位症患者的异位内膜组织,检测miR-519e-5p、SAT1蛋白表达;从异位病变组织分离细胞,将细胞分为Control组、anti-miR-NC组、anti-miR-519e-5p组、anti-miR-519e-5p+NC组、anti-miR-519e-5p+sh-SAT1组,分别检测萤光素酶活性、细胞活性、活细胞数和死细胞数、Fe^(2+)、ROS、GSH和MDA;普鲁士蓝染色观察铁颗粒分布情况;RT-qPCR检测miR-519e-5p、SAT1 mRNA表达;Western blot检测SAT1、GPX4、SLC7A11、MUC1、ACSL4蛋白表达。结果与正常子宫内膜组织比较,子宫内膜异位症患者异位内膜组织中miR-519e-5p显著增加,SAT1表达显著降低(P<0.05);萤光素酶报告基因检测结果显示,miR-519e-5p与SAT1存在靶向关系;抑制miR-519e-5p后,细胞活性、GSH、GPX4、SLC7A11、MUC1显著降低,Fe平均光密度值、Fe^(2+)、MDA、ROS、ACSL4显著增加(P<0.05);沉默SAT1并抑制miR-519e-5p表达,细胞活性、GSH、GPX4、SLC7A11、MUC1显著增加,Fe平均光密度值、Fe^(2+)、MDA、ROS、ACSL4显著降低(P<0.05)。结论miR-519e-5p在子宫内膜异位症中上调表达,抑制miR-519e-5p表达可激活铁死亡信号通路,抑制子宫内膜异位症的发生。

关键词：微小RNA-519e-5p 精胺N1-乙酰基转移酶1 铁死亡子宫内膜异位症细胞活性

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Development and Research of Non⁃Stirring Conveying Device for Waste Resin in Nuclear Power Plant

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Journal of Harbin Institute of Technology(New Series) 2023年第3期30卷 45-59页

作者： jianfa Li Yongzhen Hua Mingmei liu Rui Zhang Taishan Lou R&D Center of China Nuclear Power Engineering Co. Ltd.Beijing 100840China

Blockage in the storage and transportation of waste resin is a difficult problem in the radioactive waste treatment process of nuclear power plants.In this study,in order to solve the problems of unstable resin transport concentration and easy blockage of conveying equipment and pipelines in nuclear power plants in China,a set of non⁃stirring conveying devices is developed,and theoretical calculations,simulation analysis and experimental verification are carried out.By transporting resin using the no stirring conveying device developed in this paper,it is not only to eliminate the risk of blockage and ensure the safety of transportation,but also to adjust the concentration of conveying resin to change the transport efficiency according to the operating conditions.The effective bearing rate of waste resin storage tank can be improved,so that the comprehensive performance of waste resin storage and transportation in nuclear power plants can be greatly improved.

关键词： nuclear power plant ion exchange resin transportation no stirring device no blockage

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