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Ultraconformable Integrated Wireless Charging Micro-Supercapacitor Skin

Nano-Micro Letters 2024年第7期16卷 46-58页

作者： Chang Gao Qing You jiancheng huang Jingye Sun Xuan Yao Mingqiang Zhu Yang Zhao Tao Deng School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044People’s Republic of China School of Microelectronics Tianjin UniversityTianjin 300072People’s Republic of China Key Laboratory of Cluster Science Ministry of Education of China Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion MaterialsSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081People’s Republic of China

Conformable and wire-less charging energy storage devices play important roles in enabling the fast development of wearable,non-contact soft ***,current wire-less charging power sources are still restricted by limited flexural angles and fragile connection of components,resulting in the failure expression of performance and constraining their fur-ther applications in health monitoring wearables and moveable artificial ***,we present an ultracompatible skin-like integrated wireless charging micro-supercapacitor,which building blocks(including electrolyte,electrode and substrate)are all evaporated by liquid *** to the infiltration and permeation of the liquid,each part of the integrated device attached firmly with each other,forming a compact and all-in-one *** addition,benefitting from the controllable volume of electrode solution precursor,the electrode thickness is easily regulated varying from 11.7 to 112.5μ*** prepared thin IWC-MSC skin can fit well with curving human body,and could be wireless charged to store electricity into high capacitive micro-supercapacitors(11.39 F cm-3)of the integrated *** believe this work will shed light on the construction of skin-attachable electronics and irregular sensing microrobots.

关键词： Micro-supercapacitor Electronic skin Supercapacitor skin Wireless charging energy storage device

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Genetic variants in the 6p21.3 region influence hepatitis B virus clearance and chronic hepatitis B risk in the Han Chinese population

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肝脏研究（英文） 2024年第1期8卷 54-60页

作者： jiancheng huang Mingkuan Su Fanhui Kong Hongbin Chen Shuiqing Wu Jianfeng Guo Haiying Wu Department of Laboratory Medicine Mindong Hospital Affiliated to Fujian Medical UniversityFuanFujianChina Department of Gastroenterology Mindong Hospital Affiliated to Fujian Medical UniversityFuanFujianChina

Background and aim:A genome-wide association study has indicated the association of numerous genes in the 6p21.3 region with chronic hepatitis B virus(HBV)*** this study,we screened 12 representative single-nucleotide polymorphisms(SNPs)from the 6p21.3 region and investigated their association with the risk of chronic hepatitis B(CHB)to better understand the molecular etiology un-derlying CHB risk in the Han Chinese population.Methods:Between March 2021 and November 2022,we included 183 patients with CHB(case group)and 196 with natural HBV clearance(control group).Allele typing of the selected SNPs was performed using snapshot *** correlation between the 12 chosen SNPs and the risk of chronic HBV infection was examined using binary logistic regression *** genes of the variants were identified,and expression quantitative trait loci(eQTL)were analyzed using the 3DSNP database.Results:We validated 12 previously reported CHB susceptibility sites,including rs1419881 of tran-scription factor 19(TCF19),rs3130542 and rs2853953 of human leukocyte antigen(HLA)-C,rs652888 of euchromatic histone-lysine-methyltransferase 2(EHMT2),rs2856718,rs9276370,rs7756516,and rs7453920 of HLA-DQ,rs378352 of HLA-DOA,and rs3077,rs9277535,and rs9366816 of *** regression analyses revealed that polymorphisms such as rs9276370,rs7756516,rs7453920,rs3077,rs9277535,and rs9366816 were positively correlated with natural HBV clearance in the dominant ***,rs3130542 and rs378352 were identified as risk factors for *** analysis revealed that rs9276370,rs7756516,and rs7453920 in HLA-DQ were TTG and GCA *** the TTG haplotype was positively correlated with a higher risk of CHB,the GCA haplotype significantly influenced the natural clearance of *** analysis demonstrated that rs378352,rs3077,and rs9366816 were located within enhancer states;rs3077 and rs9366816 overlapped with nine tran-scription factor-b

关键词： Chronic hepatitis B (CHB) Expression quantitative trait loci (eQTL) Haplotype Hepatitis B virus (HBV) Human leukocyte antigen (HLA) Single-nucleotide polymorphism (SNP)

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赖氏通元针法治疗脾肾两虚型肾性贫血的疗效观察及对Hb、RBC、HCT水平的影响

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山西中医药大学学报 2024年第5期25卷 530-534页

作者：吴涓白少策黄建成明康文广州医科大学附属中医医院广东广州510100 深圳市坪山区人民医院广东深圳518118

目的:观察赖氏通元针法治疗脾肾两虚型肾性贫血的临床疗效及对血红蛋白(Hb)、红细胞(RBC)、血细胞比容(HCT)的影响。方法:按照纳入和排除标准筛选符合条件的60例维持血液透析的脾肾两虚型肾性贫血患者,随机分为对照组(31例)、试验组(31... 详细信息

目的:观察赖氏通元针法治疗脾肾两虚型肾性贫血的临床疗效及对血红蛋白(Hb)、红细胞(RBC)、血细胞比容(HCT)的影响。方法:按照纳入和排除标准筛选符合条件的60例维持血液透析的脾肾两虚型肾性贫血患者,随机分为对照组(31例)、试验组(31例)。两组患者均予基础治疗,对照组予注射用重组人促红细胞生成素,试验组在对照组治疗基础上联合赖氏通元针法针刺百会、中脘、气海、关元、天枢(双)、足三里(双)、太溪(双)、三阴交(双)、心俞(双)、膈俞(双)、肝俞(双)、脾俞(双)、肾俞(双)。每周3次,两组疗程均为4周。4周后观察两组患者中医证候积分及Hb、RBC、HCT水平的变化,评价赖氏通元针法的疗效。结果:研究过程中两组各脱落1例,最终有效病例每组各30例。(1)两组临床疗效比较,差异无统计学意义(P>0.05),但控效率试验组优于对照组,差异有统计学意义(P<0.05)。(2)治疗后两组患者中医证候积分均降低,试验组治疗后中医证候积分低于对照组,治疗前后中医证候积分差值高于对照组,差异均有统计学意义(P<0.01)。(3)治疗后两组患者Hb、RBC、HCT水平均升高,试验组治疗后Hb、RBC、HCT水平及治疗前后Hb、RBC、HCT水平差值均高于对照组,差异均有统计学意义(P<0.05,P<0.01)。结论:赖氏通元针法治疗脾肾两虚型肾性贫血具有较好的临床疗效,值得在临床推广应用。

关键词：肾性贫血赖氏通元针法脾肾两虚型

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The S267F variant of sodium taurocholate co-transporting polypeptide is strongly associated with resistance to chronic hepatitis B and high level of serum total bile acids

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Liver Research 2022年第3期6卷 186-190页

作者： jiancheng huang Mingkuan Su Hongbin Chen Shuiqing Wu Zongyun Chen Department of Laboratory Medicine Mindong Hospital Affiliated to Fujian Medical UniversityFuanFujianChina Department of Gastroenterology Mindong Hospital Affiliated to Fujian Medical UniversityFuanFujianChina

Background and aims:The sodium taurocholate co-transporting polypeptide(NTCP)is a functional receptor for the hepatitis B virus(HBV),and it is critical for bile acid *** studies of the association between the S267F variant and chronic hepatitis B(CHB)have generated conflicting *** study analyzed the correlation between the NTCP S267F variant and CHB susceptibility by using a large sample of participants classified by gender and age,and this study also analyzed the relationship between this variant and the level of serum total bile ***:In total,543 patients with CHB and 429 control subjects underwent S267F variant genotyping using SNaPshot *** regression was utilized to evaluate any association of the NTCP S267F variant with CHB ***:The S267F variant was inversely correlated with the risk of chronic HBV infection in both the dominant model(GG genotype *** genotype:odds ratio(OR)=0.46,95%confidence interval(CI)0.30 -0.71,P<0.001)and the allele model(G allele vs.A allele:OR=0.50,95%CI 0.33-0.76,P=0.001),and this correlation was not affected by gender and age *** carriers of the heterozygous NTCP variant exhibited higher total bile acids levels than the carriers of wild-type NTCP,regardless of whether they were control subjects or patients with *** carriers exhibited reduced hepatitis B e antigen(HBeAg)-positivity rates and had lower ALT,AST,and lg DNA concentrations compared with wild-type carriers in patients with ***:The S267F variant of NTCP is a protective factor that reduces the risk of chronic HBV infection and exhibits a higher total bile acids *** with CHB who carry this variant may have a better prognosis than those carrying wild-type NTCP.

关键词： Bile acid Chronic hepatitis B(CHB) Hepatitis B virus(HBV) Sodium taurocholate co-transporting polypeptide(NTCP)

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电力设计企业数字化转型实践调研分析

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电力勘测设计 2024年第4期 7-10,35页

作者：吴刚黄建城任治军李启宏中国能源建设集团江苏省电力设计院有限公司江苏南京211102 中国电建集团湖北省电力规划设计研究院有限公司湖北武汉430040

数字化转型成为所有企业在数字经济时代面临的巨大挑战。聚焦电力设计企业数字化转型工作,在问卷调查和实地访谈的基础上,总结分析电力设计企业数字化转型的现状与问题、机遇与挑战,并提出数字化转型的实施路径,以期为电力设计企业数字... 详细信息

数字化转型成为所有企业在数字经济时代面临的巨大挑战。聚焦电力设计企业数字化转型工作,在问卷调查和实地访谈的基础上,总结分析电力设计企业数字化转型的现状与问题、机遇与挑战,并提出数字化转型的实施路径,以期为电力设计企业数字化转型提供借鉴参考。

关键词：数字经济数字化转型实施路径业务布局

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Complementary-Label Adversarial Domain Adaptation Fault Diagnosis Network under Time-Varying Rotational Speed and Weakly-Supervised Conditions

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Computers, Materials & Continua 2024年第4期79卷 761-777页

作者： Siyuan Liu Jinying huang jiancheng Ma Licheng Jing Yuxuan Wang School of Data Science and Technology North University of ChinaTaiyuan030051China School of Mechanical Engineering North University of ChinaTaiyuan030051China

Recent research in cross-domain intelligence fault diagnosis of machinery still has some problems,such as relatively ideal speed conditions and sample *** engineering practice,the rotational speed of the machine is often transient and time-varying,which makes the sample annotation increasingly ***,the number of samples collected from different health states is often *** deal with the above challenges,a complementary-label(CL)adversarial domain adaptation fault diagnosis network(CLADAN)is proposed under time-varying rotational speed and weakly-supervised *** the weakly supervised learning condition,machine prior information is used for sample annotation via cost-friendly complementary label learning.A diagnosticmodel learning strategywith discretized category probabilities is designed to avoidmulti-peak distribution of prediction *** adversarial training process,we developed virtual adversarial regularization(VAR)strategy,which further enhances the robustness of the model by adding adversarial perturbations in the target *** experiments on two case studies validated the superior performance of the proposed method.

关键词： Time-varying rotational speed weakly-supervised fault diagnosis domain adaptation

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Intravenous route to choroidal neovascularization by macrophage-disguised nanocarriers for mTOR modulation

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2506-2521页

作者： Weiyi Xia Chao Li Qinjun Chen jiancheng huang Zhenhao Zhao Peixin Liu Kai Xu Lei Li Fangyuan Hu Shujie Zhang Tao Sun Chen Jiang Chen Zhao Department of Ophthalmology and Vision Science Eye&ENT HospitalShanghai Medical SchoolFudan UniversityShanghai 200031China Key Laboratory of Smart Drug Delivery Ministry of EducationDepartment of PharmaceuticsSchool of PharmacyFudan UniversityShanghai 201203China

Retinal pigment epithelial(RPE) is primarily impaired in age-related macular degeneration(AMD), leading to progressive loss of photoreceptors and sometimes choroidal neovascularization(CNV). mTOR has been proposed as a promising therapeutic target, while the usage of its specific inhibitor,rapamycin, was greatly limited. To mediate the mTOR pathway in the retina by a noninvasive approach, we developed novel biomimetic nanocomplexes where rapamycin-loaded nanoparticles were coated with cell membrane derived from macrophages(termed as MRaNPs). Taking advantage of the macrophage-inherited property, intravenous injection of MRaNPs exhibited significantly enhanced accumulation in the CNV lesions, thereby increasing the local concentration of rapamycin. Consequently, MRaNPs effectively downregulated the mTOR pathway and attenuate angiogenesis in the eye. Particularly, MRaNPs also efficiently activated autophagy in the RPE, which was acknowledged to rescue RPE in response to deleterious stimuli. Overall, we design and prepare macrophage-disguised rapamycin nanocarriers and demonstrate the therapeutic advantages of employing biomimetic cell membrane materials for treatment of AMD.

关键词： Choroidal neovascularization Age-related macular degeneration Biomimetic nanoparticles Targeted drug delivery mTOR signaling Rapamycin Macrophage membrane Inflammation

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Subsoil tillage enhances wheat productivity,soil organic carbon and available nutrient status in dryland fields

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Journal of Integrative Agriculture 2024年第1期23卷 251-266页

作者： Qiuyan Yan Linjia Wu Fei Dong Shuangdui Yan Feng Li Yaqin Jia jiancheng Zhang Ruifu Zhang Xiao huang Institute of Wheat Research Shanxi Agricultural UniversityLinfen 041000China State Key Laboratory of Sustainable Dryland Agriculture(in preparation) Shanxi Agricultural UniversityTaiyuan 030031China College of Resources and Environment Shanxi Agricultural UniversityTaigu 030801China Jiangsu Key Lab and Engineering Center for Solid Organic Waste Utilization National Engineering Research Center for Organicbased FertilizersNanjing Agricultural UniversityNanjing 210095China

Tillage practices during the fallow period benefit water storage and yield in dryland wheat ***,there is currently no clarity on the responses of soil organic carbon(SOC),total nitrogen(TN),and available nutrients to tillage practices within the growing *** study evaluated the effects of three tillage practices(NT,no tillage;SS,subsoil tillage;DT,deep tillage)over five years on soil physicochemical *** samples at harvest stage from the fifth year were analyzed to determine the soil aggregate and aggregate-associated C and N *** results indicated that SS and DT improved grain yield,straw biomass and straw carbon return of wheat compared with *** contrast to DT and NT,SS favored SOC and TN concentrations and stocks by increasing the soil organic carbon sequestration rate(SOCSR)and soil nitrogen sequestration rate(TNSR)in the 0-40 cm *** SOC levels under SS and NT were associated with greater aggregate-associated C fractions,while TN was positively associated with soluble organic nitrogen(SON).Compared with DT,the NT and SS treatments improved soil available nutrients in the 0-20 cm *** findings suggest that SS is an excellent practice for increasing soil carbon,nitrogen and nutrient availability in dryland wheat fields in North China.

关键词： tillage dryland wheat fields soil aggregate size soil nutrients soil carbon and nitrogen fractions

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可视喉镜与直接喉镜在全麻气管插管中的细菌学对比研究

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国际麻醉学与复苏杂志 2024年第2期45卷 160-163页

作者：殷茂静韩春莉王丽李凯胡芸刘琼袁文常黄建成新疆军区总医院麻醉科乌鲁木齐830002 新疆军区总医院全军临床检验诊断中心乌鲁木齐830002 广州医科大学金域检验学院广州510182

目的比较可视喉镜和直接喉镜在全麻经口气管插管后细菌学检测结果,为插管方式的选择提供依据。方法选取2020年5月到2021年4月择期行全麻手术的患者90例,按随机数字表法分为可视喉镜组(试验组)和直接喉镜组(对照组),每组45例。试验组用... 详细信息

目的比较可视喉镜和直接喉镜在全麻经口气管插管后细菌学检测结果,为插管方式的选择提供依据。方法选取2020年5月到2021年4月择期行全麻手术的患者90例,按随机数字表法分为可视喉镜组(试验组)和直接喉镜组(对照组),每组45例。试验组用可视喉镜暴露声门,在显示屏引导下插入气管导管;对照组在充分暴露声门的情况下,用直接喉镜插管。观察并记录两组患者气管导管尖端菌株的种类、数量及术后1周肺部感染的发生情况。结果试验组术后1周有3例(6.7%)发生肺部感染,对照组术后1周有1例(2.2%)发生肺部感染,两组差异无统计学意义(P>0.05);两组患者气管导管尖端菌株的种类略有差异,试验组菌株数为61株,占42.36%,对照组菌株数为83株,占57.64%,两组患者菌株占比差异无统计学意义(P>0.05)。结论在全麻经口插管时,使用可视喉镜与直接喉镜相比,没有增加感染的风险。

关键词：麻醉,全身可视喉镜直接喉镜肺感染细菌学

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Thermally Conductive and UV-EMI Shielding Electronic Textiles for Unrestricted and Multifaceted Health Monitoring

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Nano-Micro Letters 2024年第10期16卷 149-162页

作者： Yidong Peng jiancheng Dong Jiayan Long Yuxi Zhang Xinwei Tang Xi Lin Haoran Liu Tuoqi Liu Wei Fan Tianxi Liu Yunpeng huang Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122People's Republic of China

Skin-attachable electronics have garnered considerable research attention in health monitoring and artificial intelligence domains,whereas susceptibility to elec-tromagnetic interference(EMI),heat accumulation issues,and ultraviolet(UV)-induced aging problems pose significant constraints on their potential ***,an ultra-elas-tic,highly breathable,and thermal-comfortable epidermal sensor with exceptional UV-EMI shielding performance and remarkable thermal conductivity is developed for high-fidelity monitoring of multiple human electrophysiological *** filling the elastomeric microfibers with thermally conductive boron nitride nanoparticles and bridging the insulating fiber interfaces by plating Ag nanoparticles(NPs),an interwoven thermal con-ducting fiber network(0.72 W m^(-1) K^(-1))is constructed benefiting from the seamless thermal interfaces,facilitating unimpeded heat dissipation for comfort skin *** excitingly,the elastomeric fiber substrates simultaneously achieve outstanding UV protection(UPF=143.1)and EMI shielding(SET>65,X-band)capabilities owing to the high electrical conductivity and surface plasmon resonance of Ag ***,an electronic textile prepared by printing liquid metal on the UV-EMI shielding and thermally conductive nonwoven textile is finally utilized as an advanced epidermal sensor,which succeeds in monitoring different electrophysiological signals under vigorous electromagnetic *** research paves the way for developing protective and environmentally adaptive epidermal electronics for next-generation health regulation.

关键词： Skin electronics Thermal regulating textiles Electromagnetic interference shielding Ultraviolet proof Health monitoring

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