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Beneficial effect of arginine vasopressin on hemorrhagic shock through improving the vascular reactivity

Frontiers of Medicine 2008年第3期2卷 248-254页

作者： Tao LI Guangming YANG Jing XU jiancang liu Liangming liu State Key Laboratory of Trauma Burns and Combined Injurythe 2nd Department of Research Institute of SurgeryDaping HospitalThird Military Medical UniversityChongqing 400042China

The vascular reactivity and calcium sensitivity were decreased following hemorrhagic *** vasopressin(AVP)was beneficial to endotoxic,infec-tious/septic and hemorrhagic *** previous studies found that Rho kinase played an important role in the occurrence of calcium desensitization following *** was reported that AVP was with stimulation effect of Rho *** we hypothesized that AVP might have bene-ficial effect on shock via activation of Rho kinase to regu-late the calcium sensitivity and vascular *** shock(40 mmHg for 2 h)Wistar rats in vivo were adopted to observe the effects of small dose of AVP on hemodynamics,24-h survival rate,the pressor effect of norepinephrine(NE)and the contractility of superior mesenteric artery(SMA).Isolated SMAs from hemorrha-gic shock rats were adopted to observe the effects of AVP on vascular reactivity and calcium sensitivity and its rela-tionship to Rho kinase with an isolated organ perfusion *** results show that AVP at the concentration of 0.1 U/kg and 0.4 U/kg significantly improved the hemo-dynamic parameters and the 24-h survival rate of hemor-rhagic shock ***,these dosages of AVP significantly increased the pressor effect of NE and the contractile response of SMA to NE.Y-27632(3 mg/kg),a Rho kinase specific inhibitor,abolished the beneficial effects of *** vitro,the calcium sensitivity and vas-cular reactivity of SMA to calcium and NE were signifi-cantly decreased following hemorrhagic *** at the concentration of 0.5 nmol/L and 5 nmol/L signifi-cantly increased the calcium sensitivity and vascular *** effects of AVP were abolished by Y-27632(10 mmol/L).Taken together,the results suggest that AVP at 0.1 U/kg and 0.4 U/kg is beneficial to hemorrha-gic shock by improving the vascular reactivity,which involves activation of Rho kinase.

关键词： hemorrhagic shock vascular reactivity cal-cium sensitivity Rho kinase arginine vasopressin

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G3合金在高温高H_2S/CO_2分压环境下临界点蚀温度研究

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稀有金属材料与工程 2017年第8期46卷 2144-2148页

作者：李大朋张雷岳小琪刘建苍王竹路民旭北京科技大学北京100083

利用恒电位极化和EIS技术研究G3合金在高温高H_2S/CO_2分压环境下的临界点蚀温度。结果表明,利用恒电位极化技术测试G3合金在高温高H_2S/CO_2分压环境下的临界点蚀温度为58.5℃,而利用EIS方法测试得到G3合金在模拟环境下的临界点蚀温度... 详细信息

利用恒电位极化和EIS技术研究G3合金在高温高H_2S/CO_2分压环境下的临界点蚀温度。结果表明,利用恒电位极化技术测试G3合金在高温高H_2S/CO_2分压环境下的临界点蚀温度为58.5℃,而利用EIS方法测试得到G3合金在模拟环境下的临界点蚀温度在50~60℃之间,分别利用恒电位极化和EIS方法测试所得G3合金在模拟环境下的临界点蚀温度基本一致。

关键词： G3合金临界点蚀温度恒电位极化电化学阻抗谱

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Biomimetic Collagen/Hydroxyapatite Composite Scaffolds: Fabrication and Characterizations

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Journal of Bionic Engineering 2014年第4期11卷 600-609页

作者： jiancang Wang Chaozong liu Department of Ophthalmology Children's Hospital of Hebei Province Shijiazhuang 050031 P. R. China John Scales Centre for Biomedical Engineering Institute of Orthopaedics and Musculoskeletal Science University College London Royal National Orthopaedic Hospital Stanmore London HA7 4LP UK

Biomimetic collagen/hydroxyapatite scaffolds have been prepared by microwave assisted co-titration of phosphorous acid-containing collagen solution and calcium hydroxide-containing solution. The resultant scaffolds have been characterised with respect to their mechanical properties, composition and microstructures. It was observed that the in situ precipitation process could combine collagen fibril formation and hydroxyapatite （HAp） formation in one process step. Collagen fibrils guided hydroxyapatite precipitation to form bone-mimic collagen/hydroxyapatite composite containing both intrafibrillar and interfibrillar hydroxyapatites. The mineral phase was determined as low crystalline calcium-deficient hydroxyapatite with calcium to phosphorus ratio （Ca/P） of 1.4. The obtained 1% （collagen/HAp = 75/25） scaffold has a porosity of 72% and a mean pore size of 69.4 ~tm. The incorporation of hydroxyapatite into collagen matrix improved the mechanical modulus of the scaffold significantly. This could be attributed to hydroxyapatite crystallites in collagen fibrils which restricted the deformation of the collagen fibril network, and the load transfer of the collagen to the higher modulus mineral component of the composite.

关键词： scaffold bone tissue engineering collagen hydroxyapatite biomimetic

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Induced earthquakes in the development of unconventional energy resources

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Science China Earth Sciences 2017年第9期60卷 1632-1644页

作者： YANG HongFeng liu YaJing WEI Meng ZHUANG jiancang ZHOU ShiYong Earth System Science Programme Faculty of Science Chinese University of Hong Kong Hong Kong 999077 China Earth and Planetary Sciences McGill UniversityMontreal Quebec H3A 2A7 Canada Graduate School of Oceanography University of Rhode lsland Narragansett Rhode lsland 02882 USA Institute of Statistical Mathematics Tokyo 190-8562 Japan ITAG Institute of Theoretical and Applied Geophysics Peking University Beijing 100871 China

It has long been known that human activities such as waste fluid disposal and reservoir impoundment may cause earthquakes. Recently, anthropogenic activities to tackle the increasing energy demand and to address climate change issues are also reported to induce earthquakes. These activities have a common attribute in that fluids are injected and extracted underground and induce spatiotemporal changes of pore pressure and stress, which may cause slip on faults. Induced earthquakes not only pose significant impacts on seismic hazard assessment and preparation, but also raise the question to the society as how to balance the economic needs of resources development and the public's concerns about potential environmental impacts. Here we review the observations of fluid-injection/extraction induced earthquakes, ground deformation associated with these activities, and their physical mechanisms. Furthermore, we discuss the influences of induced earthquakes on seismic hazard models, regulatory policies on these anthropogenic activities, and current development of academic, industrial and government initiatives and collaborations in order to understand this intriguing phenomenon and address associated challenges.

关键词： Induced earthquake Fluid injection Energy demand Climate change

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黄芪对IEC-6肠上皮细胞缺氧复氧损伤保护效应的血清药理学研究

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中国药业 2005年第7期14卷 18-20页

作者：史成和陆松敏李进华刘建仓李萍第三军医大学大坪医院野战外科研究所二室重庆400042 第三军医大学大坪医院药剂科重庆400042

目的:探讨黄芪对IEC-6肠上皮细胞缺氧复氧损伤的保护效应。方法:建立IEC-6细胞缺氧复氧损伤模型;采用血清药理学方法,在细胞培养液中加入不同给药剂量制备的黄芪药物血清[一次和间隔1h两次给药10g/kg(DJ-1及SJ-1组),一次和间隔1h两次给... 详细信息

目的:探讨黄芪对IEC-6肠上皮细胞缺氧复氧损伤的保护效应。方法:建立IEC-6细胞缺氧复氧损伤模型;采用血清药理学方法,在细胞培养液中加入不同给药剂量制备的黄芪药物血清[一次和间隔1h两次给药10g/kg(DJ-1及SJ-1组),一次和间隔1h两次给药20g/kg(DJ-2及SJ-2组)]、参附药物血清(间隔1h两次给药20g/kg,SF组)及对照血清。应用噻唑蓝(MTT)法测定LDH漏出量和其细胞生长曲线。结果:与对照组比较,间隔1h两次给药(10g/kg,20g/kg)1h后制备的药物血清能明显减少IEC-6细胞LDH的漏出量,其中SJ-1组的P<0.05,SJ-2组的P<0.01;SJ-2组24h细胞活力明显高于缺氧复氧细胞损伤组及参附血清组(P<0.05),并随时间增加而逐渐增强。结论:黄芪对IEC-6肠上皮细胞缺氧复氧损伤具有显著保护效应。

关键词：缺氧复氧肠上皮细胞黄芪乳酸脱氢酶

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Ultrahigh quantum efficiency photodetector and ultrafast reversible surface wettability transition of square In2O3 nanowires

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Nano Research 2017年第8期10卷 2772-2781页

作者： Ming Meng Xinglong Wu Xiaoli Ji Zhixing Gan Lizhe liu jiancang Shen Paul K. Chu School of Physics and Telecommunication Engineering Zhoukou Normal University Zhoukou 466001 China Key Laboratory of Modern Acoustics MOE Institute of Acoustics Collaborative Innovation Center of Advanced Microstructures Notional Laboratory of Solid State Microstructures Nanjing University Nonjing 210093 China School of Electronic Science and Engineering Nanjing University Nanjing 210093 China Key Laboratory of Optoelectronic Technology of Jiangsu Province School of Physical Science and Technology Nanjing Normal University Nanjing 210023 China Department of Physics and Materials Science City University ofHong Kong Tat Chee Avenue Kowloon Hong Kong China

Due to a large surface-to-volume ratio, the optoelectronic performance of low- dimensional semiconductor nanostructure-based photodetectors depends in principle on chemisorption/photodesorption at the exposed surface, but practical examples that show such an effect are still unavailable. Some theoretical calculations have predicted that the {001} facets of In2O3 can effectively accumulate photogenerated holes under irradiation, providing a model material to examine whether the facet cutting of nanowires （NWs） can boost their optoelectronic performance. Herein, we present the design and construction of a novel nanowire-based photodetector using square In2O3 NWs with four exposed {001} crystal facets. The photodetector delivers excellent optoelectronic performance with excellent repeatability, fast response speed, high spectral responsivity （Rλ）, and high external quantum efficiency （EQE）. The Rλ and EQE values are as high as 4.8 × 10^6 A/W and 1.46 × 10^9%, respectively, which are larger than those of other popular semiconductor photodetectors. In addition, the square In2O3 NWs show hydrophobic wettability as manifested by a contact angle of 118° and a fast photoinduced reversible switching behavior is observed.

关键词： square In2O3 nanowires crystal facet photodetector reversible wettability transition

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Hyphae-mediated bioassembly of carbon fibers derivatives for advanced battery energy storage

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Carbon Energy 2024年第6期6卷 140-150页

作者： Lei Huang Zhong Qiu Ping liu Xinhui Xia Feng Cao Xinping He Chen Wang Wangjun Wan Yongqi Zhang Yang Xia Wenkui Zhang Minghua Chen jiancang Zhou Department of Critical Care Medicine Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouChina State Key Laboratory of Silicon Materials Key Laboratory of Advanced Materials and Applications for Batteries of Zhejiang ProvinceSchool of Materials Science&EngineeringZhejiang UniversityHangzhouChina College of Materials Science&Engineering Zhejiang University of TechnologyHangzhouChina State Key Laboratory of Photocatalysis on Energy and Environment Fuzhou UniversityFuzhouChina Department of Engineering Technology Huzhou CollegeHuzhouChina Zhejiang Academy of Science and Technology for Inspection&Quarantine HangzhouZhejiangChina Institute of Fundamental and Frontier Science University of Electronic Science and Technology of ChinaChengduChina Key Laboratory of Engineering Dielectric and Applications(Ministry of Education) School of Electrical and Electronic EngineeringHarbin University of Science and TechnologyHarbinChina

Ingenious design and fabrication of advanced carbon-based sulfur cathodes are extremely important to the development of high-energy lithium-sulfur batteries,which hold promise as the next-generation power ***,for the first time,we report a novel versatile hyphae-mediated biological assembly technology to achieve scale production of hyphae carbon fibers(HCFs)derivatives,in which different components including carbon,metal compounds,and semiconductors can be homogeneously assembled with HCFs to form composite *** mechanism of biological adsorption assembly is also *** a representative,reduced graphene oxides(rGOs)decorated with hollow carbon spheres(HCSs)successfully co-assemble with HCFs to form HCSs@rGOs/HCFs hosts for sulfur *** this unique architecture,not only large accommodation space for sulfur but also restrained volume expansion and fast charge transport paths are ***,multiscale physical barriers plus chemisorption sites are simultaneously established to anchor soluble lithium ***,the designed HCSs@rGOs/HCFs-S cathodes deliver a high capacity(1189 mA h g^(-1)at 0.1 C)and good high-rate capability(686 mA h g^(-1)at 5 C).Our work provides a new approach for the preparation of high-performance carbon-based electrodes for energy storage devices.

关键词： bioassembly carbon fibers energy storage graphene lithium-sulfur batteries

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Rg_1对失血性休克大鼠肠上皮细胞PGC-1基因表达的影响

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中国医药导报 2012年第11期9卷 24-27页

作者：李伟文陆松敏方传勤刘建仓柏干荣郭素清程凤王正国重庆大坪第三军医大学野战外科研究所二室创伤烧伤与复合伤国家重点实验室重庆400042

目的探讨Rg1对失血性休克大鼠肠上皮细胞PGC-1基因表达的影响,以从基因调控水平探讨Rg1对失血性休克时肠上皮细胞线粒体缺血缺氧性损伤的保护作用。方法用RT-PCR方法观察失血性休克大鼠肠上皮细胞PGC-1基因mRNA量的改变,用Western-blot... 详细信息

目的探讨Rg1对失血性休克大鼠肠上皮细胞PGC-1基因表达的影响,以从基因调控水平探讨Rg1对失血性休克时肠上皮细胞线粒体缺血缺氧性损伤的保护作用。方法用RT-PCR方法观察失血性休克大鼠肠上皮细胞PGC-1基因mRNA量的改变,用Western-blot法检测肠上皮细胞PGC-1蛋白的表达变化。结果失血性休克5 hPGC-1 mRNA表达明显降低(P<0.05),复苏后3 h组其表达量仍低于休克前水平,但较失血性休克组表达有所增强。复苏加Rg1治疗3 h后PGC-1 mRNA明显呈较高水平表达。复苏加SB202190及复苏加茴香霉素对PGC-1mRNA几乎无调节作用;Rg1在SB202190存在时,仍微弱上调PGC-1 mRNA表达,Rg1能增强茴香霉素上调PGC-1mRNA的作用。失血性休克5 h大鼠肠上皮细胞PGC-1蛋白表达量明显降低,复苏加Rg1能上调PGC-1蛋白表达,复苏加SB202190或茴香霉素对PGC-1蛋白表达调节作用较弱。Rg1在SB202190存在时,微弱上调PGC-1蛋白表达,但Rg1和茴香霉素同时作用时蛋白表达量明显增加。结论复苏加Rg1可明显上调PGC-1 mRNA及其蛋白表达。提示PGC-1 mRNA上调可以促进PGC-1蛋白表达,PGC-1蛋白合成在转录后水平的调节非常重要。

关键词：失血性休克 PGC-1基因表达

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基于多源信息融合决策的灌区生态环境评价指标优选

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农业工程学报 2015年第14期31卷 225-231页

作者：杨柳汪妮解建仓荆小龙西安理工大学西北旱区生态水利工程国家重点实验室培育基地西安710048 中国水利水电建设工程咨询西北有限公司西安710061

针对目前灌区生态环境评价研究中指标选取主观化、未成体系化的困境,该研究提出了一种基于指标多源特征信息融合的优选思路与方法。以关中地区泾惠渠灌区为研究对象,通过构建灌区生态环境概念模型,以"灌区资源"定义因素层,逐级确定了31... 详细信息

针对目前灌区生态环境评价研究中指标选取主观化、未成体系化的困境,该研究提出了一种基于指标多源特征信息融合的优选思路与方法。以关中地区泾惠渠灌区为研究对象,通过构建灌区生态环境概念模型,以"灌区资源"定义因素层,逐级确定了31个指标,初步构建了灌区生态环境评价指标库。采集指标灵敏度、均衡度、独立性这3种特征信息,视为3项证据,进而采用DS(Dempster Shafer)证据理论对该3项证据基本信任分配函数值进行融合,计算该3项证据共同支持作用下的指标可信度,依据可信度高低排序结果,即可从繁复、庞大的指标库中进行指标优选。该研究设置了两种融合思路:1指标全体融合、2先分别剔除3项证据下基本信任分配函数值较低的指标,然后对剩余指标进行融合;并进行对比分析研究,结果表明:第2种思路下的计算会提前剔除某些可信度较高的指标,如盐碱化程度、空气相对湿度指标;按照第1种思路,对指标全体进行信息融合,进而根据可信度排序结果,选取可信度较高的指标作为灌区生态环境评价研究的主评指标,为灌区生态环境健康评价提供了支撑。为其他领域评价研究中指标的优选提供了新的思路和决策方法。

关键词：模型灌渠信息融合灌区生态环境评价 DS证据理论指标优选泾惠渠灌区

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飞机发动机混沌振动信号盲分离检测方法

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航空学报 2009年第1期30卷 81-85页

作者：马建仓刘琦马艳玲西北工业大学电子信息学院陕西西安710072

发动机混沌振动信号携带着丰富的状态信息,依据混沌振动信号进行状态监测及故障诊断是一种很有前途的技术手段,但由于混沌信号具有伪随机特性及在低频段具有宽频谱等特点,使得传统的方法很难将其从振动信号中分离。在提取混沌振动信号方... 详细信息

发动机混沌振动信号携带着丰富的状态信息,依据混沌振动信号进行状态监测及故障诊断是一种很有前途的技术手段,但由于混沌信号具有伪随机特性及在低频段具有宽频谱等特点,使得传统的方法很难将其从振动信号中分离。在提取混沌振动信号方面,使用快速独立分量分析(FastICA)盲分离方法分离出飞机发动机振动信号中的混沌信号。利用功率谱和Lyapunov指数(LE)方法进行了判定,根据计算结果对发动机状态做出判断,验证了盲分离方法分离混沌振动信号的有效。盲分离检测混沌振动信号的方法不仅使依据混沌信号判断飞机发动机状态成为可能,也为利用混沌信号进行状态预测和控制提供了一种方法。

关键词：飞机发动机混沌振动信号盲源分离 Lyapunov指数功率谱分析

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